Abstract：
:In this study we investigate the equations governing the transport of oxygen in pulmonary capillaries. We use a mathematical model consisting of a red blood cell completely surrounded by plasma within a cylindrical pulmonary capillary. This model takes account of convection and diffusion of oxygen through plasma, diffusion of oxygen through the red blood cell, and the reaction between oxygen and haemoglobin molecules. The velocity field within the plasma is calculated by solving the slow flow equations. We investigate the effect on the solution of the governing equations of: (i) mixed-venous blood oxygen partial pressure (the initial conditions); (ii) alveolar gas oxygen partial pressure (the boundary conditions); (iii) neglecting the convection term; and (iv) assuming an instantaneous reaction between the oxygen and haemoglobin molecules. It is found that: (a) equilibrium is reached much more rapidly for high values of mixed-venous blood and alveolar gas oxygen partial pressure; (b) the convection term has a negligible effect on the time taken to reach a prescribed degree of equilibrium; and (c) an instantaneous reaction may be assumed. Explanations are given for each of these results.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Whiteley JP,Gavaghan DJ,Hahn CEdoi
10.1016/s0025-5564(00)00060-2subject
Has Abstractpub_date
2001-02-01 00:00:00pages
153-72issue
2eissn
0025-5564issn
1879-3134pii
S0025-5564(00)00060-2journal_volume
169pub_type
杂志文章abstract：:A model was developed for novel prediction of N-linked glycan branching pattern classification for CHO-derived N-linked glycoproteins. The model consists of 30 independent recurrent neural networks and uses predicted quantities of secondary structure elements and residue solvent accessibility as an input vector. The m...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2007.10.005
更新日期：2008-01-01 00:00:00
abstract：:A simulation method is presented for the demographic and genetic variation of age structured haploid populations. First, we use matrix analytic methods to derive an equilibrium distribution for the age class sizes conditioned on the total population size. Knowledge of this distribution eliminates the need of a burn-in...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2015.08.003
更新日期：2015-10-01 00:00:00
abstract：:Traits such as skill at foraging and investment in anti-predator defense may vary among individuals within a species population. This intraspecific variation has implications for community dynamics. The implications of intraspecific variation of a consumer in the intermediate level of a tritrophic food chain are explo...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.04.008
更新日期：2013-08-01 00:00:00
abstract：:A mathematical multi-cell model for the in vitro kinetics of the anti-cancer agent topotecan (TPT) following administration into a culture medium containing a population of human breast cancer cells (MCF-7 cell line) is described. This non-linear compartmental model is an extension of an earlier single-cell type model...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.03.008
更新日期：2008-06-01 00:00:00
abstract：:In biodiversity conservation it is often necessary to prioritize the species to conserve. Existing approaches to prioritization, e.g. the Fair Proportion Index and the Shapley Value, are based on phylogenetic trees and rank species according to their contribution to overall phylogenetic diversity. However, in many cas...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.02.005
更新日期：2018-04-01 00:00:00
abstract：:This paper investigates problems of disease prevention and epidemic control (DPEC), in which we optimize two sets of decisions: (i) vaccinating individuals and (ii) closing locations, given respective budgets with the goal of minimizing the expected number of infected individuals after intervention. The spread of dise...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.09.007
更新日期：2013-11-01 00:00:00
abstract：:The problem of testing for treatment effect when some subjects in the treatment group may be unaffected by the treatment is considered. A form of the Lehmann alternative suggested by Conover and Salsburg is used that assumes that each control score has the same distribution as the minimum of the known number of respon...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(92)90052-x
更新日期：1992-04-01 00:00:00
abstract：:For cDNA array methods that depend on imaging of a radiolabel, we show that bleedover of one spot onto another, due to the gap between the array and the imaging media, can be a major problem. The images can be sharpened, however, using a blind convolution method based on the EM algorithm. The sharpened images look lik...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(01)00101-8
更新日期：2002-03-01 00:00:00
abstract：:Aptamer-protein interacting pairs play important roles in physiological functions and structural characterization. Identifying aptamer-protein interacting pairs is challenging and limited, despite of the tremendous applications of aptamers. Therefore, it is vital to construct a high prediction performance model for id...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.01.009
更新日期：2019-05-01 00:00:00
abstract：:We present an axiomatic approach for multilocus informativeness measures for determining the amount of information that a set of polymorphic genetic markers provides about individual ancestry. We then reveal several surprising properties of a decision-theoretic based measure that is consistent with the set of proposed...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.10.011
更新日期：2018-12-01 00:00:00
abstract：:The resurgence of tuberculosis in the 1990s and the emergence of drug-resistant tuberculosis in the first decade of the 21st century increased the importance of epidemiological models for the disease. Due to slow progression of tuberculosis, the transmission dynamics and its long-term effects can often be better obser...
journal_title：Mathematical biosciences
pub_type： 杂志文章,评审
doi：10.1016/j.mbs.2012.02.003
更新日期：2012-04-01 00:00:00
abstract：:This paper considers the geometry of plants with golden spiral phyllotaxis, i.e. growing leaf by leaf on a spiral with golden divergence angle, via the simplest mathematical model, a cylinder with regular arrangement of points on its surface. As is well-known, Fibonacci numbers appear by means of the order of parastic...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.05.003
更新日期：2018-07-01 00:00:00
abstract：:Proteins with multiple binding sites play important roles in cell signaling systems by nucleating protein complexes in which, for example, enzymes and substrates are co-localized. Proteins that specialize in this function are called by a variety names, including adapter, linker and scaffold. Scaffold-mediated nucleati...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2011.06.003
更新日期：2011-08-01 00:00:00
abstract：:The ICING model has been successfully used to guide clinical decisions on insulin administration in critical illness. However, insulin pharmacokinetics in the ICING model can be improved to better describe both intravenous (IV) bolus and infusion insulin administration. Patient data from 217 Dynamic Insulin Sensitivit...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.08.005
更新日期：2016-11-01 00:00:00
abstract：:Many situations in population biology involve a rate--typically a contact or recruitment rate--which increases linearly for small populations but reaches a maximum value (saturates) for large populations. Models for populations of variable size need to incorporate both characteristics to predict behavior accurately. T...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2004.11.001
更新日期：2004-12-01 00:00:00
abstract：:An experiment design procedure is proposed for nonlinear parameter estimation studies that formally incorporates prior parameter uncertainty. The design criterion derives from information theory considerations and involves an asymptotic interpretation of the expected posterior information provided by an experiment. A ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(90)90141-k
更新日期：1990-04-01 00:00:00
abstract：:In this paper, we propose an iterative learning rule that allows the imprinting of correlated oscillatory patterns in a model of the hippocampus able to work as an associative memory for oscillatory spatio-temporal patterns. We analyze the dynamics in the Fourier domain, showing how the network selectively amplify or ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.10.001
更新日期：2007-06-01 00:00:00
abstract：:In this work, we derive and analyze a 2n+1-dimensional deterministic differential equation modeling the transmission and treatment of HIV (Human Immunodeficiency Virus) disease. The model is extended to a stochastic differential equation by introducing noise in the transmission rate of the disease. A theoretical treat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.03.013
更新日期：2018-05-01 00:00:00
abstract：:Estimation of the immunity coverage required to effectively control disease transmission is an important public health problem. Using data on the eventual size of a major epidemic, we compare estimates based on the simplifying assumption that the community consists of uniformly mixing individuals with estimates obtain...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(97)00079-5
更新日期：1998-01-01 00:00:00
abstract：:Under the influence of randomly occurring disasters, the eventual extinction probability, q, of a birth and death process, Z, is a random variable. In this paper, we obtain an integral expression for the probability density function g(x) of q under the assumption that the population process Z is a time homogeneous lin...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(99)00059-0
更新日期：2000-03-01 00:00:00
abstract：:Understanding the evolution of dispersal is an important issue in evolutionary ecology. For continuous time models in which individuals disperse throughout their lifetime, it has been shown that a balanced dispersal strategy, which results in an ideal free distribution, is evolutionary stable in spatially varying but ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:We investigate an SIR epidemic model with discrete age groups to understand the transmission dynamics of an infectious disease in a host population with an age structure. We derive the basic reproduction number R0 and show that it is a sharp threshold parameter. If R0≤1, the disease-free equilibrium E0 is globally sta...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.12.003
更新日期：2019-02-01 00:00:00
abstract：:Half-sib, first cousin, half nth cousin, and nth cousin mating systems are robust in that small deviations from the mating structure will not significantly alter the levels of genetic identity or effect qualitative distinctions between the models. Substitution of nearest kin in matings may either increase or decrease ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(91)90026-f
更新日期：1991-04-01 00:00:00
abstract：:Many important results in stochastic epidemic modelling are based on the Reed-Frost model or on other similar models that are characterised by unrealistic temporal dynamics. Nevertheless, they can be extended to many other more realistic models thanks to an argument first provided by Ludwig [Final size distributions f...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.08.009
更新日期：2008-11-01 00:00:00
abstract：:Cooperating behaviors abound across all domains of life, but are vulnerable to invasion by cheaters. An important evolutionary question is to determine mechanisms that stabilize and maintain cooperation levels and prevent population collapse. Policing is one strategy populations may employ to achieve this goal, and it...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.108257
更新日期：2019-10-01 00:00:00
abstract：:The transmission dynamics of a communicable disease in a subdivided population where the spread among groups follows the proportionate mixing model while the within-group transmission can correspond to preferred mixing, proportionate mixing among subgroups, or mixing between social and nonsocial subgroups, is analyzed...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(89)90061-8
更新日期：1989-10-01 00:00:00
abstract：:The influence of intrinsic channel noise on the spiking activity of excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels does affect the electric properties of the cell-membrane patches. ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.08.024
更新日期：2007-06-01 00:00:00
abstract：:Two-component systems (TCSs) are widely employed by bacteria to sense specific external signals and conduct an appropriate response via a phosphorylation cascade within the cell. The TCS of the agr operon in the bacterium Staphylococcus aureus forms part of a regulatory process termed quorum sensing, a cell-to-cell co...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2010.03.001
更新日期：2010-06-01 00:00:00
abstract：:There has been important progress in understanding ecological dynamics through the development of the theory of ecological stoichiometry. For example, modeling under this framework allows food quality to affect consumer dynamics. While the effects of nutrient deficiency on consumer growth are well understood, recent d...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.04.011
更新日期：2013-08-01 00:00:00
abstract：:The methods of Laplace transform were used to solve a mathematical model developed for percutaneous drug absorption. This model includes application and removal of the vehicle from the skin. A system of two linear partial differential equations was solved for the application period. The concentration of the medicinal ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2005.07.002
更新日期：2005-10-01 00:00:00
