Abstract：
:For cDNA array methods that depend on imaging of a radiolabel, we show that bleedover of one spot onto another, due to the gap between the array and the imaging media, can be a major problem. The images can be sharpened, however, using a blind convolution method based on the EM algorithm. The sharpened images look like a set of donuts, which concurs with our knowledge of the spotting process. Oversharpened images are actually useful as well, in locating the centers of each spot.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Therneau T,Tschumper RC,Jelinek Ddoi
10.1016/s0025-5564(01)00101-8subject
Has Abstractpub_date
2002-03-01 00:00:00pages
1-15issue
1eissn
0025-5564issn
1879-3134pii
S0025556401001018journal_volume
176pub_type
杂志文章abstract：:Therapeutic enhancement of humoral immune response to microbial attack is addressed as the stochastic optimal control of a dynamic system. Without therapy, the modeled immune response depends upon the initial concentration of pathogens in a simulated attack. Immune response can be augmented by agents that kill the pat...
journal_title：Mathematical biosciences
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