Abstract：
:The contraction of intestinal smooth muscle cells (ISMCs) involves many coordinated biochemical and mechanical processes. In this work, we present a framework for modeling ISMC contractility that begins with chemical models of calcium dynamics, continues with myosin light chain phosphorylation and force generation, and ends with a cell model of the ISMC undergoing contraction-relaxation. The motivation for developing this comprehensive framework is to study the effects of edema (excess fluid build-up in the muscle tissue) on ISMC contractility. The hypothesis is that more fluid equates to dilution of an external stimulis, eventually leading to reduced contractility. We compare our results to experimental data collected from normal versus edematous intestinal muscle tissue.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Young J,Ozisik S,Riviere B,Shamim Mdoi
10.1016/j.mbs.2014.12.009subject
Has Abstractpub_date
2015-04-01 00:00:00pages
206-13eissn
0025-5564issn
1879-3134pii
S0025-5564(15)00014-0journal_volume
262pub_type
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