Abstract：
:An optimal input of nutrients into the metabolic process of the individual subject so as to effect desired therapeutic results is particularly important for the critically ill. A patient-related, individualized nutrients optimization procedure is proposed here. The procedure is applicable to any time-invariant and deterministic metabolic model that is bound by one or more quantitative limiting criteria. As a case in hand, the procedure is used to optimize the individual metabolic needs of critically ill patients. The results indicate that, given a proper metabolic model, the patient may be treated on an individual appropriateness basis rather than on the traditional statistical intuitive approach.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Giladi R,Sideman Sdoi
10.1016/0025-5564(89)90004-7subject
Has Abstractpub_date
1989-12-01 00:00:00pages
179-97issue
2eissn
0025-5564issn
1879-3134pii
0025-5564(89)90004-7journal_volume
97pub_type
杂志文章abstract：:This paper describes an efficient method for tracing interactions between a radiation track and molecular targets in a cell or nucleus. The method is efficient because it ensures that a minimal subset of interactions in the track needs to be tested for each score. It is most useful for high-energy particles since the ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10045-7
更新日期：1998-12-15 00:00:00
abstract：:A grazing population dynamics model is proposed where organisms in a grazed population have a fixed life span. The motivating context is that of ruminants grazing grass-dominant pasture. The model takes the form of a differential-delay equation in which the rate of loss of pasture due to senescence at some time depend...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)90031-0
更新日期：1994-05-01 00:00:00
abstract：:For cDNA array methods that depend on imaging of a radiolabel, we show that bleedover of one spot onto another, due to the gap between the array and the imaging media, can be a major problem. The images can be sharpened, however, using a blind convolution method based on the EM algorithm. The sharpened images look lik...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(01)00101-8
更新日期：2002-03-01 00:00:00
abstract：:Therapeutic enhancement of humoral immune response to microbial attack is addressed as the stochastic optimal control of a dynamic system. Without therapy, the modeled immune response depends upon the initial concentration of pathogens in a simulated attack. Immune response can be augmented by agents that kill the pat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2004.06.004
更新日期：2004-10-01 00:00:00
abstract：:Mutual interference and prey refuge are important drivers of predator-prey dynamics. The "exponent" or degree of mutual interference has been under much debate in theoretical ecology. In the present work, we investigate the interplay of the mutual interference exponent, and prey refuge, on the behavior of a predator-p...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2020.108407
更新日期：2020-08-01 00:00:00
abstract：:It has been shown in the literature that myocytes isolated from the ventricular walls at various intramural depths have different action potential durations (APDs). When these myocytes are embedded in the ventricular wall, their inhomogeneous properties affect the sequence of repolarization and the actual distribution...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.06.002
更新日期：2006-11-01 00:00:00
abstract：:We study the invasion of a top predator into a food chain in a chemostat. For each trophic level, a bioenergetic model is used in which maintenance and energy reserves are taken into account. Bifurcation analysis is performed on the set of nonlinear ordinary differential equations which describe the dynamic behaviour ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10083-4
更新日期：1999-03-15 00:00:00
abstract：:It is well known that in the most general epidemic models with multiple pathogen variants a competitive exclusion principle is valid, such that the variant with the highest reproduction number eliminates the rest. Mechanisms such as super-infection, coinfection, and cross-immunity can lead to pathogen polymorphism whe...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.09.010
更新日期：2007-05-01 00:00:00
abstract：:A new epidemic model is developed that describes the spread of an infectious disease with fatal risk. The model includes as extreme cases the standard general epidemic process (for diseases that confer immunity after infection) and the fatal epidemic process (for diseases that lead inevitably to death). Both determini...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(93)90019-7
更新日期：1993-09-01 00:00:00
abstract：:Many microbial ecosystems can be seen as microbial 'food chains' where the different reaction steps can be seen as such: the waste products of the organisms at a given reaction step are consumed by organisms at the next reaction step. In the present paper we study a model of a two-step biological reaction with feedbac...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.02.008
更新日期：2016-05-01 00:00:00
abstract：:A stochastic model for hospital infection incorporating both direct transmission and indirect transmission via free-living bacteria in the environment is investigated. We examine the long term behavior of the model by calculating a stationary distribution and normal approximation of the distribution. The quasi-station...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.10.002
更新日期：2013-01-01 00:00:00
abstract：:Methods of phylogenetic inference use more and more complex models to generate trees from data. However, even simple models and their implications are not fully understood. Here, we investigate the two-state Markov model on a tripod tree, inferring conditions under which a given set of observations gives rise to such ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.03.001
更新日期：2012-05-01 00:00:00
abstract：:Human solid tumors are believed to be caused by a sequence of genetic abnormalities arising in the tumor cells. The understanding of these sequences is extremely important for improving cancer treatment. Models for the occurrence of the abnormalities include linear structure and a recently proposed tree-based structur...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00086-x
更新日期：2002-04-01 00:00:00
abstract：:There is often large variation in traits across the species of a community. In particular, variation in life history traits affecting population dynamics is likely to affect the species abundance distribution. Applying a dynamic and heterogeneous species abundance model we study how differences in extinction time for ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2007.06.002
更新日期：2007-12-01 00:00:00
abstract：:An integrated methodology is developed for the theoretical analysis of solute transport and reaction in cellular biological media, such as tissues, microbial flocs, and biofilms. First, the method of local spatial averaging with a weight function is used to establish the equation which describes solute conservation at...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2007.04.008
更新日期：2007-11-01 00:00:00
abstract：:Some viruses encode proteins that promote cell proliferation while others, such as the human immunodeficiency virus (HIV), encode proteins that prevent cell division. It has been hypothesized that the selective advantage determining which strategy evolves depends on the ability of the virus to induce a cellular enviro...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(00)00020-1
更新日期：2000-07-01 00:00:00
abstract：:Bone modeling and remodeling has been the subject of extensive experimental studies. There have been several mathematical models proposed to explain the observed behavior, as well. A different approach is taken here in which the bone is treated from a macroscopic view point. In this investigation, a one-dimensional an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2010.12.008
更新日期：2011-03-01 00:00:00
abstract：:Recent work has shown that higher-order terms in population dynamics models can increase the stability, promote the diversity, and better explain the dynamics of ecological systems. While it is known that these perceived benefits come from an increasing number of alternative solutions given by the nature of multivaria...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.108222
更新日期：2019-09-01 00:00:00
abstract：:Traits such as skill at foraging and investment in anti-predator defense may vary among individuals within a species population. This intraspecific variation has implications for community dynamics. The implications of intraspecific variation of a consumer in the intermediate level of a tritrophic food chain are explo...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.04.008
更新日期：2013-08-01 00:00:00
abstract：:We consider a population with two types of individuals: those who engage in risky sexual behavior (the core) and those who do not (the majority). We are interested in the situation where the majority would not be able to sustain an epidemic without the presence of a core. We show that even if the core is randomly spre...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(01)00071-2
更新日期：2001-09-01 00:00:00
abstract：:A structure for representing problems in decision analysis and in expert systems, which reason under uncertainty, is the influence diagram or causal network. A causal network consists of an underlying joint probability distribution and a directed acyclic graph in which a propositional variable that represents a margin...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(91)90089-2
更新日期：1991-02-01 00:00:00
abstract：:HIF (hypoxia inducible factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may be determined by the dynamics of protein levels. We have developed...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.09.007
更新日期：2014-12-01 00:00:00
abstract：:The contraction of intestinal smooth muscle cells (ISMCs) involves many coordinated biochemical and mechanical processes. In this work, we present a framework for modeling ISMC contractility that begins with chemical models of calcium dynamics, continues with myosin light chain phosphorylation and force generation, an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.12.009
更新日期：2015-04-01 00:00:00
abstract：:Mathematical models of biological systems often have components that vary on different timescales. This multi-timescale character can lead to problems when doing computer simulations, which can require a great deal of computer time so that the components that change on the fastest time scale can be resolved. Mathemati...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.07.003
更新日期：2017-05-01 00:00:00
abstract：:Transmission of an infectious agent can be quantified from experimental data using the transient-state (TS) algorithm. The TS algorithm is based on the stochastic SIR model and provides a time-dependent probability distribution over the number of infected individuals during an epidemic, with no need for the experiment...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2007.04.009
更新日期：2007-11-01 00:00:00
abstract：:A biofilm material model and a procedure for numerical integration are developed in this article. They enable calculation of a composite Young's modulus that varies in the biofilm and evolves with deformation. The biofilm-material model makes it possible to introduce a modeling example, produced by the Unified Multi-C...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:In the present paper, we propose and analyze an eco-epidemiological model with diffusion to study the dynamics of rabbit populations which are consumed by lynx populations. Existence, boundedness, stability and bifurcation analyses of solutions for the proposed rabbit-lynx model are performed. Results show that in the...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.08.014
更新日期：2016-11-01 00:00:00
abstract：:The article theoretically regards probability density functions (PDFs) for axial ratio (X/Y) of sectioning profiles of elliptical microvessels (MVs) arranged with anisotropy in a biological tissue volume. A technique for the PDF(X/Y) calculations in anisotropy of the elliptical MVs is described. The essence of this te...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2009.03.001
更新日期：2009-06-01 00:00:00
abstract：:To understand how a gene regulatory network functioning as an oscillator is built, a genetic regulatory network with two transcriptional delays is investigated. We show by mathematical analysis and simulation that autorepression of mRNA and protein can provide a mechanism for the intracellular oscillator. Based on the...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.05.004
更新日期：2008-09-01 00:00:00
abstract：:Half-sib, first cousin, half nth cousin, and nth cousin mating systems are robust in that small deviations from the mating structure will not significantly alter the levels of genetic identity or effect qualitative distinctions between the models. Substitution of nearest kin in matings may either increase or decrease ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(91)90026-f
更新日期：1991-04-01 00:00:00
