Abstract:
:Human solid tumors are believed to be caused by a sequence of genetic abnormalities arising in the tumor cells. The understanding of these sequences is extremely important for improving cancer treatment. Models for the occurrence of the abnormalities include linear structure and a recently proposed tree-based structure. In this paper we extend the pure oncogenetic tree model by introducing false positive and false negative observations. We state conditions sufficient for the reconstruction of the generating tree. As an example we analyze a comparative genomic hybridization data set and show that addition of the error model significantly improves the ability of the model to describe the data.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Szabo A,Boucher Kdoi
10.1016/s0025-5564(02)00086-xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
219-36issue
2eissn
0025-5564issn
1879-3134pii
S002555640200086Xjournal_volume
176pub_type
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