Abstract:
:A mathematical analysis of the stability in human respiration, based on the tau-decomposition method, is conducted on a simple, but realistic CO2 model of the respiratory system. This model incorporates a two-compartment representation (lungs and tissues) for the plant and a very general class of controller. By deriving an explicit stability criterion, the stability domain of the respiratory system can be characterized. We quantify the influence of four major parameters of respiratory instability, i.e. transport delay, lung volume, and equilibrium values of lung CO2 partial pressure and controller gain. We demonstrate the existence of a bifurcation point and periodic solutions, giving some characteristics of solutions near the bifurcation point.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Vielle B,Chauvet Gdoi
10.1016/s0025-5564(98)10028-7subject
Has Abstractpub_date
1998-09-01 00:00:00pages
105-22issue
2eissn
0025-5564issn
1879-3134pii
S0025556498100287journal_volume
152pub_type
杂志文章abstract::In this study we investigate the equations governing the transport of oxygen in pulmonary capillaries. We use a mathematical model consisting of a red blood cell completely surrounded by plasma within a cylindrical pulmonary capillary. This model takes account of convection and diffusion of oxygen through plasma, diff...
journal_title:Mathematical biosciences
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doi:10.1016/s0025-5564(00)00060-2
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abstract::A variety of growth curves have been developed to model both unpredated, intraspecific population dynamics and more general biological growth. Most predictive models are shown to be based on variations of the classical Verhulst logistic growth equation. We review and compare several such models and analyse properties ...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(02)00096-2
更新日期:2002-07-01 00:00:00
abstract::HIF (hypoxia inducible factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may be determined by the dynamics of protein levels. We have developed...
journal_title:Mathematical biosciences
pub_type: 杂志文章
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2015.04.002
更新日期:2015-06-01 00:00:00
abstract::A class of models is considered in which the number of unknown parameters exceeds the number of independent equations that are derived from the input/observation configuration. It is shown that, under certain circumstances, if the number of unknown parameters is sufficiently decreased by setting some of the exit param...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/0025-5564(95)00049-6
更新日期:1996-03-01 00:00:00
abstract::Many important results in stochastic epidemic modelling are based on the Reed-Frost model or on other similar models that are characterised by unrealistic temporal dynamics. Nevertheless, they can be extended to many other more realistic models thanks to an argument first provided by Ludwig [Final size distributions f...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2008.08.009
更新日期:2008-11-01 00:00:00
abstract::A significant consideration in modeling systems with stages is to obtain models for the individual stages that have probability density functions (pdfs) of residence times that are close to those of the real system. Consequently, the theory of residence time distributions is important for modeling. Here I show first t...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(02)00110-4
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abstract::The vaccination program for pertussis (whooping cough) in the United States consists of giving multiple doses of pertussis vaccine to young children. A demographic model with a steady-state age distribution is used as a basis for building an epidemiologic model for the transmission of pertussis. This age-structured mo...
journal_title:Mathematical biosciences
pub_type: 历史文章,杂志文章
doi:10.1016/s0025-5564(97)00014-x
更新日期:1997-10-15 00:00:00
abstract::A pandemic of a novel Coronavirus emerged in December of 2019 (COVID-19), causing devastating public health impact across the world. In the absence of a safe and effective vaccine or antivirals, strategies for controlling and mitigating the burden of the pandemic are focused on non-pharmaceutical interventions, such a...
journal_title:Mathematical biosciences
pub_type: 杂志文章
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abstract::In many cicadas, a phenomenon is observed in which the peak of emergence of males precedes that of females (protandry). Generally, it is known that the ecology of emergence of insects is closely related to mating, and protandry is said to be the strategy of males to eclose early and to attempt mating with virgin femal...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2018.08.006
更新日期:2018-11-01 00:00:00
abstract::Traits such as skill at foraging and investment in anti-predator defense may vary among individuals within a species population. This intraspecific variation has implications for community dynamics. The implications of intraspecific variation of a consumer in the intermediate level of a tritrophic food chain are explo...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2013.04.008
更新日期:2013-08-01 00:00:00
abstract::In this paper, a mathematical modeling framework is presented which describes the growth, encapsulation, and transcapsular spread of solid tumors. The model is based on the physical forces and cellular interactions involved in tumorigenesis and is used to test and compare the active (foreign body hypothesis) and passi...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(02)00118-9
更新日期:2002-11-01 00:00:00
abstract::Many microbial ecosystems can be seen as microbial 'food chains' where the different reaction steps can be seen as such: the waste products of the organisms at a given reaction step are consumed by organisms at the next reaction step. In the present paper we study a model of a two-step biological reaction with feedbac...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2016.02.008
更新日期:2016-05-01 00:00:00
abstract::Under the influence of human population distribution, the boyciana-fish ecological system is considered. First, the system can be described as a nonlinear partial differential algebraic equations system (PDAEs) with Neumann boundary conditions and ratio-dependent functional response. Second, we examine the system's pe...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2016.04.012
更新日期:2016-07-01 00:00:00
abstract::A multicompartmental model is proposed to deal with the spread of the HIV epidemic. Stratification with respect to high- and low-risk groups is taken into account, introducing a "fuzzy" decomposition of the compartment of susceptibles. The infectivity period is staged using different levels of CD4 cell counts. Asympto...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/0025-5564(91)90021-a
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abstract::This paper is concerned with the qualitative analysis of two models [S. Bonhoeffer, M. Lipsitch, B.R. Levin, Evaluating treatment protocols to prevent antibiotic resistance, Proc. Natl. Acad. Sci. USA 94 (1997) 12106] for different treatment protocols to prevent antibiotic resistance. Detailed qualitative analysis abo...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2010.06.002
更新日期:2010-09-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2004.07.006
更新日期:2005-02-01 00:00:00
abstract::A Gompertz-type diffusion process characterized by the presence of exogenous factors in the drift term is considered. Such a process is able to describe the dynamics of populations in which both the intrinsic rates are modified by means of time-dependent terms. In order to quantify the effect of such terms the evaluat...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2013.01.001
更新日期:2013-09-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(98)10063-9
更新日期:1999-03-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(02)00149-9
更新日期:2003-01-01 00:00:00
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journal_title:Mathematical biosciences
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2018.12.003
更新日期:2019-02-01 00:00:00
abstract::An inherent problem in studying the behavior of a metabolic pathway is the impossibility of developing a complete, detailed model that includes all the cellular processes that have an impact on the set of fluxes in such a pathway. Lacking this, one requires some means of modeling the interactions between a metabolic p...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/0025-5564(90)90049-5
更新日期:1990-06-01 00:00:00
abstract::In this paper we compare foraging strategies that might be used by predators seeking prey in a patchy environment. The strategies differ in the extent to which predators aggregate in response to prey density. The approach to the comparison is suggested by the idea of evolutionarily stable strategies. A strategy is sai...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(99)00027-9
更新日期:1999-08-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2008.09.002
更新日期:2008-12-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/0025-5564(92)90054-z
更新日期:1992-03-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2003.08.005
更新日期:2003-12-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/s0025-5564(01)00068-2
更新日期:2001-08-01 00:00:00
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journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/j.mbs.2012.03.001
更新日期:2012-05-01 00:00:00
abstract::A structure for representing problems in decision analysis and in expert systems, which reason under uncertainty, is the influence diagram or causal network. A causal network consists of an underlying joint probability distribution and a directed acyclic graph in which a propositional variable that represents a margin...
journal_title:Mathematical biosciences
pub_type: 杂志文章
doi:10.1016/0025-5564(91)90089-2
更新日期:1991-02-01 00:00:00