Abstract：
:Several experimental studies have demonstrated that ultrasound (US) can accelerate enzymatic fibrinolysis and this effect is further enhanced in the presence of ultrasound contrast agents (UCA). Although UCA have been shown to be safe when administered to ischemic stroke patients, safety information of these agents in the thrombolysis setting is limited. Therefore, in this study we investigated potential adverse effects of acoustic cavitation generated by UCA on alteplase (t-PA), the drug used for treatment of ischemic stroke patients. A volume of 0.9 mL of alteplase was dispensed into a custom-made polyester sample tube. For treatments in the presence or absence of cavitation either 0.1 mL Optison or phosphate buffer saline was combined with alteplase. Three independent samples of each treatment group were exposed to ultrasound of 2 MHz frequency at three different peak negative acoustic pressures of 0.5, 1.7, and 3.5 MPa for a duration of 60 min. All treatments were carried out in a cavitation detection system which was used to insonify the samples and record acoustic emissions generated within the sample. After ultrasound exposure, the treated samples and three untreated drug samples were tested for their enzymatic activity using a chromogenic substrate. The insonified samples containing Optison demonstrated cavitational activity proportional to acoustic pressure. No significant cavitation activity was observed in the absence of Optison. Enzymatic activity of alteplase in both insonified groups was comparable to that in the control group. These tests demonstrated that exposure of alteplase to 60 min of 2 MHz ultrasound at acoustic pressures ranging from 0.5 MPa to 3.5 MPa, in the presence or absence of Optison had no adverse effects on the stability of this therapeutic compound.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Soltani A,Prokop AF,Vaezy Sdoi
10.1016/j.ultras.2007.10.003subject
Has Abstractpub_date
2008-04-01 00:00:00pages
109-16issue
2eissn
0041-624Xissn
1874-9968pii
S0041-624X(07)00101-1journal_volume
48pub_type
杂志文章相关文献
ULTRASONICS文献大全abstract：:The importance of the analysis of the radiofrequency signal is by now recognized in the field of tissue characterization via ultrasound. The RF signal contains a wealth of information and structural details that are usually lost in the B-Mode representation. The HyperSPACE (Hyper SPectral Analysis for Characterization...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2016.02.010
更新日期：2016-05-01 00:00:00
abstract：:Nitric oxide (NO) has been implicated in smooth muscle relaxation. Its use has been widespread in cardiology. Due to the effective scavenging of NO by hemoglobin, however, the drug has to be applied locally or in large quantities, to have the effect desired. We propose the use of encapsulated microbubbles that act as ...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2006.06.003
更新日期：2006-12-22 00:00:00
abstract：:The propagation of ultrasound through an austenitic weld is investigated experimentally as well as in a numerical simulation. The weld is insonified at normal incidence to the fusion line with a longitudinal contact transducer. In order to experimentally trace the ultrasound through the weld, slices of different thick...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/s0041-624x(99)00103-1
更新日期：2000-03-01 00:00:00
abstract：:Ultrasonics is an important diagnostic tool for bone diseases, as it allows for non-invasive assessment of bone tissue quality through mass density-elasticity relationships. The latter are, however, quite complex for fluid-filled porous media, which motivates us to develop a rigorous multiscale poromicrodynamics appro...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2013.12.005
更新日期：2014-07-01 00:00:00
abstract：:This paper introduces a new beamformer, which combines the eigenspace based minimum variance (ESBMV) beamformer with a subarray coherence based postfilter (SCBP), for improving the quality of ultrasound plane-wave imaging. The ESBMV beamformer has been validated in improving the imaging contrast, but the difficulty in...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2015.10.026
更新日期：2016-02-01 00:00:00
abstract：:The ultrasound-induced harmonic microbubble response spectrum is known to shift to lower frequencies with increasing tissue attenuation. We hypothesized that this shift could be reproducibly detected in received broadband radiofrequency spectra. We used an automatic Gaussian curve-fitting technique to measure the mean...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/s0041-624x(02)00397-9
更新日期：2003-03-01 00:00:00
abstract：:The accurate estimation of time of flight (TOF) of an ultrasonic signal is essential in ultrasonic non-destructive testing (NDT). A novel method for TOF estimation based on the short-time Fourier transform (STFT) is proposed in this paper. Firstly, the time and frequency components of ultrasonic echoes are represented...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2020.106104
更新日期：2020-04-01 00:00:00
abstract：:Thallium bromide iodide crystal also known as KRS-5 is the well known material used in far infrared radiation applications for optical windows and lenses fabrication. The main advantage of this material is the transparency in wide band of wavelengths from 0.53 to 50μm. Despite such advantages as transparency and large...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2016.11.019
更新日期：2017-03-01 00:00:00
abstract：:An improved method for ultrasonic location of multiple flaws using perpendicular ultrasonic arrays, working in near-field conditions, is presented. The method uses the pulse-echo technique and is based on the processing of the information acquired by both the elemental emitting transducers and their adjacent ones. Thi...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2006.05.107
更新日期：2006-12-22 00:00:00
abstract：:In practical cardiology, a stethoscope based auscultation has been used to reveal the patient's clinical status. Recently, several hand-held echo devices are going on market and they are expected to play a role as "visible" auscultation instead of stethoscope. We have developed a portable and inexpensive echo device w...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2003.11.009
更新日期：2004-04-01 00:00:00
abstract：:Angle beam wedge transducers are widely used in nonlinear Rayleigh wave experiments as they can generate Rayleigh wave easily and produce high intensity nonlinear waves for detection. When such a transducer is used, the spurious harmonics (source nonlinearity) and wave diffraction may occur and will affect the measure...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2018.05.004
更新日期：2018-09-01 00:00:00
abstract：:To improve the integrated performance of a representative bimodal linear ultrasonic motor under continuous operation, this paper proposes a novel dual-frequency asymmetric excitation method for such motors which can operate under traditional single-phase asymmetric or two-phase symmetric excitation modes. In particula...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2020.106224
更新日期：2020-12-01 00:00:00
abstract：:This paper establishes a model evaluating the signal loss of double transmitted acoustic beams through random rough liquid-solid surfaces based on Fresnel approximation and the phase-screen approximation. The numerical solution is replaced with a simple analytical solution through using the exponential substitution ap...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2010.05.007
更新日期：2011-01-01 00:00:00
abstract：:Sonothrombolysis is one of the most feasible methods for enhancing clot lysis with a recombinant tissue plasminogen activator (rt-PA) in cases of acute ischemic strokes. For safe and efficient clinical practices of sonothrombolysis, accurate estimation of ultrasound transmittance through the human skull is critical. P...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2017.02.012
更新日期：2017-05-01 00:00:00
abstract：:An electrical sensory perception threshold technique has been developed for use with human volunteers. This technique has been used to reproducibly quantify the effects of three different commercially available topical anaesthetic preparations on superficial sensory cells (nociceptors) in the skin. Low intensities (0....
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/0041-624x(90)90075-y
更新日期：1990-05-01 00:00:00
abstract：:Spatial dispersion is the variation of wave speed with wavelength. It sets in when the acoustic wavelength approaches the natural scale of length of the medium, which could, for example, be the lattice constant of a crystal, the repeat distance in a superlattice, or the grain size in a granular material. In centrosymm...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2006.05.215
更新日期：2006-12-22 00:00:00
abstract：:Molecular techniques are transforming our understanding of cellular function and disease. However, accurate molecular analysis methods will be limited if the input DNA, RNA, or protein is not derived from pure population of cells or is contaminated by the wrong cells. A novel Ultrasonic Vibration Micro-dissection (UVM...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2006.06.010
更新日期：2006-12-22 00:00:00
abstract：:Classically, rotary motors with gears and spindle mechanisms are used to achieve translatory motion. In means of miniaturization and weight reduction piezoelectric linear motors are of interest. Several ultrasonic linear motors found in literature base on the use of two different vibration modes. Most often flexural a...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2006.05.056
更新日期：2006-12-22 00:00:00
abstract：:Elasticity assessment based on bulk wave velocity (BWV) measurements is the most popular technique to characterize the anisotropic stiffness tensor in cortical bone. Typically, a cuboid bone specimen is cut with its sides along the different anatomical directions. Then, the velocity of shear and longitudinal waves pro...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2017.05.009
更新日期：2017-09-01 00:00:00
abstract：:A cylindrical standing wave ultrasonic motor using bending vibration transducer was proposed in this paper. The proposed stator contains a cylinder and a bending vibration transducer. The two combining sites between the cylinder and the transducer locate at the adjacent wave loops of bending vibration of the transduce...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2010.12.007
更新日期：2011-07-01 00:00:00
abstract：:A numerical study is presented to show the potential for using vibroacoustic-based experiments to identify elastic material properties of orthotropic cylindrical vessels immersed in fluids. Sensitivity analyses and a simulated inverse problem are shown to quantify the potential for material characterization through th...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2008.07.004
更新日期：2008-11-01 00:00:00
abstract：:This paper investigates the dependence of ultrasonic velocity in rabbit liver on the water content and tissue structure. The results obtained indicate that the composition and water content of the liver tissue but not its structure determine the value of velocity. ...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/0041-624x(87)90040-0
更新日期：1987-07-01 00:00:00
abstract：:3D ultrasound is a promising imaging modality for clinical diagnosis and treatment monitoring. Its cost is relatively low in comparison with CT and MRI, no intensive training and radiation protection is required for its operation, and its hardware is movable and can potentially be portable. In this study, we developed...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2004.05.003
更新日期：2005-01-01 00:00:00
abstract：:This paper presents a method which combines electromagnetic simulation and ultrasonic simulation to build EMAT array models. For a specific sensor configuration, Lorentz forces are calculated using the finite element method (FEM), which then can feed through to ultrasonic simulations. The propagation of ultrasound wav...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2015.10.020
更新日期：2016-03-01 00:00:00
abstract：:An ultrasonic backscattering model is developed for textured polycrystalline materials with orthotropic or trigonal grains of ellipsoidal shape. The model allows us to simulate realistic microstructures and orthotropic macroscopic material textures resulting from thermomechanical processing for a broad variety of mate...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2014.02.020
更新日期：2014-09-01 00:00:00
abstract：:An experimental ultrasonic sonar for use as a sensory aid with blind children is described. Novel signal processing techniques make the aid relatively simple to construct, yet allow many of its parameters to be changed in the field. In particular, the aid has two features, a variable range code and an automatic level...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/0041-624x(79)90010-6
更新日期：1979-01-01 00:00:00
abstract：:In spite of many advances in analytical and numerical modeling techniques for solving different engineering problems, an efficient solution technique for wave propagation modeling of an electromagnetic acoustic transducer (EMAT) system is still missing. Distributed point source method (DPSM) is a newly developed semi-...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2009.12.003
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:This paper aims to apply median filters for reducing interpolation error and improving the quality of 3D images in a freehand 3D ultrasound (US) system. BACKGROUND AND MOTIVATION:Freehand 3D US imaging has been playing an important role in obtaining the entire 3D impression of tissues and organs. Reconstruc...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2007.11.005
更新日期：2008-07-01 00:00:00
abstract：:Ultrasound wave propagation in nanofluids and its rheological behavior has been studied as a function of solid volume fraction, temperature and magnetic field for magnetic nanofluids synthesized in kerosene and transformer oil. Ultrasonic velocity decreases while viscosity increases with increasing volume fraction. Th...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2014.08.017
更新日期：2015-01-01 00:00:00
abstract：:Since the identification of micro-cracks in engineering materials is very valuable in understanding the initial and slight changes in mechanical properties of materials under complex working environments, numerical simulations on the propagation of the low frequency S0 Lamb wave in thin plates with randomly distribute...
journal_title：Ultrasonics
pub_type： 杂志文章
doi：10.1016/j.ultras.2017.04.004
更新日期：2017-08-01 00:00:00
