Automated quantitative analysis of the shift of frequency spectra generated by attenuated signals from contrast microbubbles.

Abstract:

:The ultrasound-induced harmonic microbubble response spectrum is known to shift to lower frequencies with increasing tissue attenuation. We hypothesized that this shift could be reproducibly detected in received broadband radiofrequency spectra. We used an automatic Gaussian curve-fitting technique to measure the mean harmonic response generated by three different contrast agents at six incremental levels of attenuation. Analytical curve fitting identified a consistent, reproducible, and statistically significant shift in mean harmonic frequency with increasing attenuation. The presented method could be a step toward attenuation estimation by contrast harmonic imaging; optimization of harmonic signal reception by ultrasound systems; and, ultimately, automatic detection of contrast agents in tissue.

journal_name

Ultrasonics

journal_title

Ultrasonics

authors

Bartleson VB,Viggen K,Asanuma T,Kinnick RR,Belohlavek M

doi

10.1016/s0041-624x(02)00397-9

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

75-81

issue

2

eissn

0041-624X

issn

1874-9968

pii

S0041624X02003979

journal_volume

41

pub_type

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