Abstract:
:The ultrasound-induced harmonic microbubble response spectrum is known to shift to lower frequencies with increasing tissue attenuation. We hypothesized that this shift could be reproducibly detected in received broadband radiofrequency spectra. We used an automatic Gaussian curve-fitting technique to measure the mean harmonic response generated by three different contrast agents at six incremental levels of attenuation. Analytical curve fitting identified a consistent, reproducible, and statistically significant shift in mean harmonic frequency with increasing attenuation. The presented method could be a step toward attenuation estimation by contrast harmonic imaging; optimization of harmonic signal reception by ultrasound systems; and, ultimately, automatic detection of contrast agents in tissue.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Bartleson VB,Viggen K,Asanuma T,Kinnick RR,Belohlavek Mdoi
10.1016/s0041-624x(02)00397-9subject
Has Abstractpub_date
2003-03-01 00:00:00pages
75-81issue
2eissn
0041-624Xissn
1874-9968pii
S0041624X02003979journal_volume
41pub_type
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