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Therapeutic opportunities in biological responses of ultrasound.

Abstract：

:The therapeutic benefits of several existing ultrasound-based therapies such as facilitated drug delivery, tumor ablation and thrombolysis derive largely from physical or mechanical effects. In contrast, ultrasound can also trigger various time-dependent biochemical responses in the exposed biological milieu. Several biological responses to ultrasound exposure have been previously described in the literature but only a handful of these provide therapeutic opportunities. These include the use of ultrasound for healing of soft tissues and bones, the use of ultrasound for inducing non-necrotic tumor atrophy as well as for potentiation of chemotherapeutic drugs, activation of the immune system, angiogenesis and suppression of phagocytosis. A review of these therapeutic opportunities is presented with particular emphasis on their mechanisms. Overall, this review presents the increasing importance of ultrasound's role as a biological sensitizer enabling novel therapeutic strategies.

journal_name

Ultrasonics

journal_title

Ultrasonics

authors

Paliwal S,Mitragotri S

doi

10.1016/j.ultras.2008.02.002

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

271-8

issue

4

eissn

0041-624X

issn

1874-9968

pii

S0041-624X(08)00029-2

journal_volume

48

pub_type

杂志文章,评审

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