Abstract:
:Skeletal muscle is an important secretory organ in mammals, producing myriad chemical mediators ("myokines") with distinct biological action in different tissues, including anti-inflammatory activity. Extracellular vesicles (EVs) have recently been identified as a mode of myokine transport from muscle, facilitating such anti-inflammatory activity. In this report, we have demonstrated that high-intensity ultrasound (US) strongly induces EV secretion from cultured myotubes without a reduction in cell viability. High-intensity US of 3.0 W/cm2 with 20% duty cycle increased the number of EVs by 2-fold compared to control at 6 h. This effect was specific to EVs in the 100-150 nm size range. Thus, high-intensity US is a novel modality for inducing myocellular EV release and may hold therapeutic value.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Maeshige N,Langston PK,Yuan ZM,Kondo H,Fujino Hdoi
10.1016/j.ultras.2020.106243subject
Has Abstractpub_date
2021-02-01 00:00:00pages
106243eissn
0041-624Xissn
1874-9968pii
S0041-624X(20)30182-7journal_volume
110pub_type
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