Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

Abstract:

:A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2alpha,4alpha-dihydroxy-7alphaH,8alphaH,10alphaH-guaia-1(5),11(13)-dien-8beta,12-olide (1), 1alpha,2alpha-epoxy-4beta-hydroxy-5alphaH,7alphaH,8alphaH,10alphaH-guaia-11(13)-en-8beta,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8+/-0.2 microM) in a human bladder carcinoma cell line, EJ-138.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Stavri M,Mathew KT,Gordon A,Shnyder SD,Falconer RA,Gibbons S

doi

10.1016/j.phytochem.2008.03.012

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1915-8

issue

9

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(08)00149-0

journal_volume

69

pub_type

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