Prolonged cholestasis after cyproheptadine-induced acute hepatitis.

Abstract:

:We report a patient in whom cyproheptadine-induced hepatitis was followed by prolonged cholestasis marked by elevation of serum alkaline phosphatase levels, gammaglutamyltransferase and bile acid levels, and disappearance of small bile ducts. Chlorpromazine and imipramine, which can induce a similar acute hepatitis followed by protracted cholestasis, have a close chemical structure (i.e., a tricyclic ring). We suggest that this structure might be involved in this type of hepatotoxicity.

journal_name

J Clin Gastroenterol

authors

Larrey D,Geneve J,Pessayre D,Machayekhi JP,Degott C,Benhamou JP

doi

10.1097/00004836-198702000-00026

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

102-4

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

9

pub_type

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