Ulcerative colitis and Crohn's disease health status scales for research and clinical practice.

Abstract:

:We report the development of ulcerative colitis (UC) and Crohn's disease (CD) Health Status Scales that improve on existing inflammatory bowel disease (IBD) activity measures by their added association with health status. We surveyed 991 members of the Crohn's and Colitis Foundation of America (CCFA) and analyzed the half with greater disease activity (114 UC, 330 CD, ostomies excluded). Our analysis strategy involved (a) identification of items that discriminated active from inactive disease, (b) factor analysis to reduce the items to clusters sharing common symptom relationships, and (c) regression analysis to select those variables best associated with a composite measure of health status (health care use, daily function, psychologic distress). The factor analyses yielded two indexes for UC and CD: "Diarrhea," and "Other GI symptoms" (Cronbach's alpha 0.59-0.84). The regression analyses for both diseases showed that poorer well-being, the Diarrhea index, and dependence on medication for pain were associated with poorer health status. For UC, lower educational attainment and lower steroid dose, and for CD, the Other GI symptoms index and eye disease, also correlated with poorer health status. By design, the UC and CD Scales are better predictors of health status than the survey version of the CD Activity Index (CDAI), explaining 17 and 21% more of the variance of the health status measure. The final UC and CD Health Status Scales can be used in research and clinical care. They contain symptom items used to assess disease activity and also correlate with health status. Prospective assessment is needed to confirm their accuracy in assessing prognosis and treatment response.

journal_name

J Clin Gastroenterol

authors

Drossman DA,Li Z,Leserman J,Patrick DL

doi

10.1097/00004836-199209000-00005

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

104-12

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

15

pub_type

杂志文章
  • A pregnant woman with hepatitis A and Guillain-Barré.

    abstract::Guillain-Barré syndrome (GBS) is often preceded by an infectious disease. A case of GBS after hepatitis A in a pregnant woman is described. The patient was treated with intravenous immunoglobulin and had full recovery with no neurologic sequelae. She gave birth in term to a healthy baby. This is the first reported cas...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200102000-00020

    authors: Breuer GS,Morali G,Finkelstein Y,Halevy J

    更新日期:2001-02-01 00:00:00

  • A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial.

    abstract:GOAL:We hypothesized that sleeping left-side down with the head/torso elevated reduces recumbent gastroesophageal reflux (GER). BACKGROUND:Previous studies show that sleeping with head of bed elevated or on wedge reduces GER and lying left-side down reduces GER versus right-side down and supine. No prior studies have ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000000359

    authors: Person E,Rife C,Freeman J,Clark A,Castell DO

    更新日期:2015-09-01 00:00:00

  • Granular cell myoblastoma of the esophagus.

    abstract::Granular cell myoblastoma, a rare, but generally benign tumor, is being encountered with increasing frequency in the digestive tract. Seventy-two cases have been described in the esophagus; we report two additional cases. A follow-up, available in 13 patients (including ours), reveals a low likelihood of malignant tra...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198404000-00003

    authors: Subramanyam K,Shannon CR,Patterson M,Davis M,Gourley WK

    更新日期:1984-04-01 00:00:00

  • Probiotics in critically ill patients.

    abstract::Severe sepsis with associated multisystem organ dysfunction is a leading cause of death in patients hospitalized in intensive care units. The gastrointestinal system plays a key role in the pathogenesis of multisystem organ dysfunction owing to a breakdown of intestinal barrier function and increased translocation of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31817283cb

    authors: Madsen K

    更新日期:2008-09-01 00:00:00

  • Relatively low expression of multidrug resistance-1 (MDR-1) and its possible clinical implication in gastric cancers.

    abstract::The mechanism of drug resistance of gastric cancer cells has rarely been investigated. We specifically examine the magnitude and the biologic significance of multidrug resistance-1 (MDR-1) expression in human gastric cancer. All patients had previously been treated in prospective clinical trials for advanced gastric c...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199806000-00012

    authors: Yeh KH,Chen CL,Shun CT,Lin JT,Lee WJ,Lee PH,Chen YC,Cheng AL

    更新日期:1998-06-01 00:00:00

  • Necrotizing granulomatous gastritis and gastric perforation of unknown etiology: a first case report.

    abstract::A unique case of granulomatous gastritis of unknown etiology is reported. The patient, a 43-year-old Haitian woman, suffered a gastric perforation from a disease process limited to the stomach. The stomach was markedly enlarged and edematous with transmural, serpiginous granulomatous tracks throughout the gastric wall...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198302000-00013

    authors: Compton CC,Von Lichtenberg F

    更新日期:1983-02-01 00:00:00

  • Sigmoid volvulus in adolescence.

    abstract::Sigmoid volvulus in young adults is rare. It usually presents as chronic recurrent attacks of abdominal pain. The diagnosis is usually delayed because of a low level of suspicion. We present the case of a 17-year-old girl with recurrent episodes of sigmoid volvulus, to illustrate the problem. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198708000-00023

    authors: Krupsky S,Halevy A,Orda R

    更新日期:1987-08-01 00:00:00

  • A review of Silybum marianum (milk thistle) as a treatment for alcoholic liver disease.

    abstract::Silybum marianum (milk thistle) and its derivatives have been used for centuries for the treatment of liver disease. This review focuses exclusively on published literature pertaining to the potential use of Silybum marianum or its derivatives for the treatment of alcoholic liver disease. Clinical studies have varied ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000165668.79530.a0

    authors: Ball KR,Kowdley KV

    更新日期:2005-07-01 00:00:00

  • Lactic acidosis associated with cirrhosis, hepatoma, hemoperitoneum, and hyperphosphatemia.

    abstract::A patient with cirrhosis developed hemoperitoneum, lactic acidosis, and hyperphosphatemia in the absence of shock. At post-mortem examination occult multicentric hepatocellular carcinoma eroding the liver capsule was present. The case emphasizes the central role of the liver in lactic acidosis, indicates that hemoperi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198604000-00025

    authors: Berenson MM,Lee RG

    更新日期:1986-04-01 00:00:00

  • Microbiota, innate immune system, and gastrointestinal muscle: ongoing studies.

    abstract:AIM:To test the activities of culture-extracted or commercially available toll-like receptors (TLRs) ligands to establish their direct impact on target gastrointestinal motor cells. METHODS:Short-term and long-term effects of Shigella flexneri M90T and Escherichia coli K-2 strains-extracted lipopolysaccharides (LPS), ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318265ea7d

    authors: Tattoli I,Petitta C,Scirocco A,Ammoscato F,Cicenia A,Severi C

    更新日期:2012-10-01 00:00:00

  • Should gastric carcinoid tumors associated with pernicious anemia be treated aggressively?

    abstract::Two patients with pernicious anemia developed gastric carcinoid, one 20 years and the other 1 year after diagnosis of pernicious anemia. One of the patients underwent successful resection of the tumor, while the second, with diffuse gastric carcinoid, was managed conservatively. She is well and asymptomatic 32 months ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198710000-00006

    authors: Stalnikowicz R,Eliakim R,Steiner D,Gross D,Okon E

    更新日期:1987-10-01 00:00:00

  • Potential relationship between gastroesophageal reflux disease and atrial arrhythmias.

    abstract::A potential reduction in symptoms related to atrial fibrillation after treatment of gastroesophageal reflux disease symptoms with proton pump inhibitor therapy has been previously described. However, illustration of this relationship by combined 24-hour pH and ambulatory Holter monitoring has not been performed. We re...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225571.42890.a5

    authors: Gerson LB,Friday K,Triadafilopoulos G

    更新日期:2006-10-01 00:00:00

  • Celiac (solar) plexus syndrome. A frequently overlooked source of abdominal pain.

    abstract::Of the nonorganic abdominal disorders the celiac/solar plexus syndrome represents a frequently seen entity characterized by the typical association of epigastric pain and "lambda-type" tenderness. It is a special type of abdominal neurosis in which the pain arises in the periaortic nervous plexuses. Its clinical impor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Maratka Z

    更新日期:1993-03-01 00:00:00

  • The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia.

    abstract:BACKGROUND:Iron deficiency anemia (IDA) may be the sole manifestation of celiac disease. The role of routine small bowel biopsies obtained during endoscopy in the evaluation of IDA is unclear. This study assessed the usefulness of routine small bowel biopsies in patients presenting with IDA. STUDY:Evaluation of 103 co...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000139034.38568.51

    authors: Grisolano SW,Oxentenko AS,Murray JA,Burgart LJ,Dierkhising RA,Alexander JA

    更新日期:2004-10-01 00:00:00

  • Current Therapeutic Options for Esophageal Motor Disorders as Defined by the Chicago Classification.

    abstract::With the development of high-resolution manometry and specific metrics to characterize esophageal motility, the Chicago Classification has become the gold standard for the diagnosis of esophageal motor disorders. Major and significant disorders, that is, never observed in healthy subjects, are achalasia, esophagogastr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000317

    authors: Zerbib F,Roman S

    更新日期:2015-07-01 00:00:00

  • Nonspecific ulcerative colitis as a sequel to amebic dysentery.

    abstract::In two patients, treatment of amebic dysentery was followed (despite the disappearance of the infecting organism) by an illness with the clinical, pathological, and radiological characteristics of nonspecific ulcerative colitis. Their case histories indicate that in addition to persistent or recurrent amebic infection...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198306000-00004

    authors: Rampton DS,Salmon PR,Clark CG

    更新日期:1983-06-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181945942

    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • The Interaction Between Celiac Disease and Intestinal Microbiota.

    abstract::Celiac disease (CD) is the most common autoimmune enteropathy, triggered by a deregulated immune response to gliadin. It has been hypothesized that human intestinal microbiota may interfere with the pathogenesis of the disease and in the clinical course of CD. In the present review, we analyzed the microbiota alterati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000682

    authors: Losurdo G,Principi M,Iannone A,Ierardi E,Di Leo A

    更新日期:2016-11-01 00:00:00

  • Clarithromycin for the eradication of Helicobacter pylori.

    abstract::Helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. Antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. Clarithromycin has potential advantages over other macrolides to which H. pylori is susceptible because of its acid...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199306000-00004

    authors: Graham DY,Opekun AR,Klein PD

    更新日期:1993-06-01 00:00:00

  • Smoking and hyperpepsinogenemia are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients.

    abstract:BACKGROUND:Although Helicobacter pylori has been established as a major etiologic factor of chronic gastritis and makes an important contribution to peptic ulceration, the reason why H. pylori causes different gastroduodenal diseases in different people is at present not clear. GOALS:The aim of this study is to identi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000173854.55172.ee

    authors: Chen TS,Lee YC,Li FY,Chang FY

    更新日期:2005-09-01 00:00:00

  • Does duodenal ulcer lead to an early diagnosis of gastric cancer?

    abstract::In four of five patients with gastric cancer who also had a chronic duodenal ulcer, the histologic type was "early gastric cancer," which offers a better prognosis than the more common type. Patients with duodenal ulcer who develop gastric cancer may have a better prognosis than patients with gastric cancer without du...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198702000-00009

    authors: Neeman A,Shoenfeld Y,Kadish U

    更新日期:1987-02-01 00:00:00

  • Increased prostaglandin E2 and leukotriene B4 synthesis in isolated colonic mucosal cells in inflammatory bowel disease. a preliminary report.

    abstract::The synthesis of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in colonic mucosal cells was investigated in 7 patients and 10 controls. Biopsies obtained from the descending colon were isolated biochemically by a special technique and the suspension of isolated colonic cells was incubated during 45 min. Compared w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199603000-00009

    authors: Baumeister B,Schmidt C,Helisch A,Kipnowski J

    更新日期:1996-03-01 00:00:00

  • Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain?

    abstract::The goal of every routine endoscopy in the gut is the early diagnosis of malignant and premalignant changes of the mucosa. Chromo- and magnifying endoscopes are exciting new tools and offer detailed analysis of the colonic mucosal surface and pit pattern architecture. This review summarizes recent advances in endoscop...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200401000-00004

    authors: Kiesslich R,Jung M,DiSario JA,Galle PR,Neurath MF

    更新日期:2004-01-01 00:00:00

  • Spontaneous umbilical fistula in Crohn's disease.

    abstract::Spontaneous umbilical fistula developed in two young women with Crohn's disease. This peculiar complication of Crohn's disease has been rarely reported. In view of the complete closure of the fistulas with medical treatment, we recommended conservative medical management, at least initially, in such patients. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-198904000-00016

    authors: Veloso FT,Cardoso V,Fraga J,Carvalho J,Dias LM

    更新日期:1989-04-01 00:00:00

  • Management of Chronic Hepatitis B in Pregnancy.

    abstract::Chronic hepatitis B virus (HBV) infection due to mother-to-child transmission during the perinatal period remains an important global health problem. Despite standard passive-active immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine in neonates, up to 8.5% of newborns still acquire HBV infection...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000908

    authors: Li J,Chang MS,Tran TT,Nguyen MH

    更新日期:2017-10-01 00:00:00

  • Barrett's esophagus and adenocarcinoma. The need for a consensus conference.

    abstract::The fear of cancer has evoked calls for intensive surveillance programs in Barrett's esophagus. Two evolving issues are fueling this fire: (a) the rising risk of adenocarcinoma of the esophagus over the past 20 years and (b) the coincidental increase in the recognized prevalence of Barrett's esophagus in the general p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:10.1097/00004836-199609000-00002

    authors: Richter JE,Falk GW

    更新日期:1996-09-01 00:00:00

  • Calcium and acid rebound: a reappraisal.

    abstract::We review acid rebound, the seemingly paradoxical increase in acid secretion resulting from administration of an antacid. Primarily a laboratory observation, the demonstration of the phenomenon was a major contributing factor to the swift, and possibly unjustified, fall from grace of calcium carbonate in the therapy o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1097/00004836-199207000-00010

    authors: Hade JE,Spiro HM

    更新日期:1992-07-01 00:00:00

  • Isolated gastric sarcoidosis. Unique remnant of disseminated disease.

    abstract::Isolated granulomatous disease was identified in a gastrectomy specimen after a gastrointestinal hemorrhage in a 61-year-old white woman. She died postoperatively. No other areas of granulomatous tissue were identified at autopsy. Ten years previously, pulmonary sarcoidosis was proven on lung biopsy. Conceivable, othe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Panella VS,Katz S,Kahn E,Ulberg R

    更新日期:1988-06-01 00:00:00

  • Allergen-free probiotics.

    abstract::Food sensitivities are constantly increasing in "westernized" countries and may pose serious health risks to sensitized individuals. Severe allergy episodes have also been reported after the intake of probiotic products containing milk protein residues, especially in children. The need for safe and effective probiotic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31818063ed

    authors: Mogna G,Strozzi GP,Mogna L

    更新日期:2008-09-01 00:00:00

  • Hepatoblastoma presenting as isosexual precocity. The clinical importance of histologic and serologic parameters.

    abstract::A 2-year-old boy presented with sexual precocity secondary to a hormone-producing hepatoblastoma. The tumor demonstrated an aggressive histologic pattern and stained immunohistochemically for alpha-fetoprotein and beta-subunit human chorionic gonadotrophin. After a successful liver transplant these tumor markers were ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Heimann A,White PF,Riely CA,Ritchey AK,Flye MW,Barwick KW

    更新日期:1987-02-01 00:00:00