Abstract:
BACKGROUND:Although Helicobacter pylori has been established as a major etiologic factor of chronic gastritis and makes an important contribution to peptic ulceration, the reason why H. pylori causes different gastroduodenal diseases in different people is at present not clear. GOALS:The aim of this study is to identify risk factors associated with duodenal ulcers in H. pylori-infected patients in a multivariate context. STUDY:Demographic data, personal habits, stressful life events, psychologic distress, severity of histology of antral mucosa, and serum pepsinogen I concentrations were studied in 54 consecutive dyspeptic patients with duodenal ulcers and 40 patients with functional dyspepsia. RESULTS:As compared with functional dyspepsia patients, duodenal ulcer patients had more smokers (53.7% vs. 12.5%, P=0.000), higher pepsinogen I levels (median 96.0 vs. 74.5 ng/mL; P=0.002), more males (74.1% vs. 42.5%, P=0.004), more single (22.6% vs. 7.5%, P<0.05), and less in religion belief (44% vs. 70%, P<0.05). Only smoking remained significant on multivariate analysis (odds ratio=10.86, 95% CI=2.92-40.41, P<0.001). Among nonsmokers, only serum pepsinogen I level was found higher in duodenal ulcer patients as compared with functional dyspepsia patients (88 vs. 71, P<0.05). CONCLUSIONS:Smoking and hyperpepsinogenemia are associated with increased risk for duodenal ulcer in H. pylori-infected patients.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Chen TS,Lee YC,Li FY,Chang FYdoi
10.1097/01.mcg.0000173854.55172.eesubject
Has Abstractpub_date
2005-09-01 00:00:00pages
699-703issue
8eissn
0192-0790issn
1539-2031pii
00004836-200509000-00010journal_volume
39pub_type
杂志文章abstract::The clinical profile of antituberculosis treatment (ATT)-induced hepatotoxicity is variable, and the reintroduction of ATT in patients who have developed such injury is controversial. We conducted a prospective study to determine the clinical profile in patients with ATT-induced hepatotoxicity and to test a predefined...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199604000-00012
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abstract::Crohn's disease (CD) is now accepted as a systemic illness. The importance of extraintestinal manifestations is underlined by the fact that such "complications" can be more prominent and even more difficult to control than the intestinal disease itself. Lately, evidence for a more than accidental association of pancre...
journal_title:Journal of clinical gastroenterology
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abstract::Steatocrit is a semiquantitative method for determination of fat content in fecal samples. Previous studies, mostly performed in children, reported controversial results. The aim of our study was to compare the determination of fat content in 148 fecal samples by two methods: the conventional van de Kamer and the stea...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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abstract:BACKGROUND AND GOALS:The C282Y and H63D mutations of HFE gene are associated with hereditary hemochromatosis (HH), the most common autosomal recessive disorder in European population. This is the first Turkish population study of, the prevalence of these mutations. STUDY:2677 healthy volunteer blood donors were screen...
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-07-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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