Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.

Abstract:

OBJECTIVE:JC virus (JCV) is thought to infect approximately 80% of the human population. Antibodies against JCV can be found in the sera of many people with and without colorectal carcinoma (CRC). We hypothesized that JCV antibody titer will be higher in CRC patients than in healthy controls. AIM:To evaluate this hypothesis in a cohort of patients undergoing colonoscopy. We compared JCV antibody titers in patients with simple adenoma, advanced adenomatous polyp (AAP), CRC, and healthy controls, and evaluated JCV DNA in the tissue. METHODS:Ninety-seven patients undergoing colonoscopy offered to participate in the study. Normal colonoscopy, simple adenoma, AAP, and CRC were found in 41, 19, 12, and 25 cases, respectively. A blood sample was taken for JCV DNA isolation and serology. In 18 patients with CRC or AAP tissue samples were taken for JCV DNA isolation and T-antigen (T-Ag) detection. RESULTS:A positive correlation was found between a JCV antibody titer and advanced colonic pathology. The average titer for normal controls, simple polyp, AAP, and CRC was 2.61+/-0.72, 2.95+/-0.77, 3.33+/-0.76, and 3.30+/-0.50 log, respectively (P<0.001). Viral DNA could not be shown in the serum. The presence of neoplastic tissue T-Ag (in 33.3% of the patients) was not associated with a difference in the log titer of serum antibody. CONCLUSIONS:In this study we showed that patients with advanced neoplasia, compared with patients with normal colonoscopy, harbor a higher JCV antibody titer in the serum. If confirmed, our finding may serve as a marker for CRC or for an earlier stage of AAP.

journal_name

J Clin Gastroenterol

authors

Niv Y,Vilkin A,Levi Z

doi

10.1097/MCG.0b013e3181d7a347

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

489-94

issue

7

eissn

0192-0790

issn

1539-2031

journal_volume

44

pub_type

杂志文章
  • Risk factors for nocturnal reflux in a large GERD cohort.

    abstract:BACKGROUND:Nocturnal gastroesophageal reflux disease (GERD) has been associated with severe complications including erosive esophagitis, peptic stricture, and even esophageal adenocarcinoma and is known to cause a decreased health-related quality of life. However, there is limited information on independent predictors ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318205e164

    authors: Gaddam S,Maddur H,Wani S,Gupta N,Singh M,Singh V,Moloney B,Puli SR,Rastogi A,Bansal A,Sharma P

    更新日期:2011-10-01 00:00:00

  • Fulminant acute Budd-Chiari syndrome stemming from an adrenal tumor.

    abstract::Adrenal neoplasm is a rare cause of Budd-Chiari syndrome. We report a case of fulminant acute Budd-Chiari syndrome due to inferior vena cava thrombosis stemming from invasion by a clinically nonfunctioning adrenal neoplasm. We also review briefly the clinical characteristics of the seven previously reported cases. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199703000-00015

    authors: Moreira V,Aller R,De Luis DA,San Roman AL,Ferreiro A

    更新日期:1997-03-01 00:00:00

  • Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection.

    abstract::To assess the effects of the mucoprotective drug sofalcone, which has direct and indirect effects on Helicobacter pylori in vitro, the eradication rate, adverse effects, and the quality of healing peptic ulcers were evaluated. Each study patient was given 500 mg t.i.d. amoxicillin and 200 mg t.i.d. clarithromycin. In ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199800001-00031

    authors: Sakaki N,Arakawa T,Kozawa H,Yamada Y,Kato H,Kamisawa T,Momma K

    更新日期:1998-01-01 00:00:00

  • Crohn's disease: what about the pancreas?

    abstract::Crohn's disease (CD) is now accepted as a systemic illness. The importance of extraintestinal manifestations is underlined by the fact that such "complications" can be more prominent and even more difficult to control than the intestinal disease itself. Lately, evidence for a more than accidental association of pancre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Piontek M,Hengels KJ,Strohmeyer G

    更新日期:1990-10-01 00:00:00

  • The efficacy of intravenous contrast-enhanced 16-raw multidetector CT colonography for detecting patients with colorectal polyps in an asymptomatic population in Korea.

    abstract:PURPOSE:The purpose of this study is to compare the sensitivity of computed tomography (CT) colonography (CTC) with that of colonoscopy for detecting patients with colorectal polyps in an asymptomatic screening population in Korea, thus to evaluate a possibility, whether CTC could be used as a screening tool for colore...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31811edcb7

    authors: Kim YS,Kim N,Kim SH,Park MJ,Lim SH,Yim JY,Cho KR,Kim SS,Kim DH,Eun HW,Cho KS,Kim JH,Choi BI,Jung HC,Song IS,Shin CS,Cho SH,Oh BH

    更新日期:2008-08-01 00:00:00

  • Hepatotoxicity due to antituberculosis therapy. Clinical profile and reintroduction of therapy.

    abstract::The clinical profile of antituberculosis treatment (ATT)-induced hepatotoxicity is variable, and the reintroduction of ATT in patients who have developed such injury is controversial. We conducted a prospective study to determine the clinical profile in patients with ATT-induced hepatotoxicity and to test a predefined...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199604000-00012

    authors: Singh J,Garg PK,Tandon RK

    更新日期:1996-04-01 00:00:00

  • Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma.

    abstract::Hepatic cavernous hemangioma is the most common benign tumor of the liver. Appropriate management of this tumor remains a controversial topic. We have accumulated a number of cases with successful management of local hepatic tumors. Here we report a case where we performed an ultrasound-guided percutaneous radiofreque...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000196404.07487.1d

    authors: Tak WY,Park SY,Jeon SW,Cho CM,Kweon YO,Kim SK,Choi YH,Chung JM

    更新日期:2006-02-01 00:00:00

  • Long-term Outcomes of Per-oral Endoscopic Myotomy in Spastic Esophageal Motility Disorders: A Large, Single-Center Study.

    abstract:BACKGROUND AND AIMS:Spastic esophageal motility disorders (SEMD) are a rare group of motility disorders including type III achalasia, distal esophageal spasm (DES), and Jackhammer esophagus (JHE). Limited data suggest that per-oral endoscopic myotomy (POEM) may be effective in these disorders. In this study, we aimed t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001395

    authors: Nabi Z,Chavan R,Ramchandani M,Basha J,Jagtap N,Karyampudi A,Darisetty S,Tandan M,Goud R,Rao GV,Reddy DN

    更新日期:2020-07-10 00:00:00

  • Racial Disparity in the Sex Distribution, the Prevalence, and the Incidence of Dysplasia in Barrett's Esophagus.

    abstract:GOALS:Our aim was to study the prevalence of dysplasia and progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) in African Americans (AA) with Barrett's esophagus (BE) and compare it with that of non-Hispanic white (NHW) controls. BACKGROUND:BE, a precursor of EAC, is a disease of predominantl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000559

    authors: Thota PN,Zackria S,Sanaka MR,Patil D,Goldblum J,Lopez R,Chak A

    更新日期:2017-05-01 00:00:00

  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200003000-00017

    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease.

    abstract:BACKGROUND:Elevated plasma total homocysteine (tHcy) is associated with a higher risk of thrombosis. Crohn's disease (CD) is associated with hypercoagulability of undefined etiology. We investigated tHcy in patients with CD and its relationship with vitamin status, disease activity, location, duration, and history of t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200108000-00008

    authors: Vasilopoulos S,Saiean K,Emmons J,Berger WL,Abu-Hajir M,Seetharam B,Binion DG

    更新日期:2001-08-01 00:00:00

  • Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study.

    abstract:GOALS:To determine whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition, fecal enzyme activity, and short-chain fatty acids production and symptom profile in patients suffering from constipation. BACKGROUND:Constipation is a common gastroin...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0b013e3181d2dca4

    authors: Valerio F,Russo F,de Candia S,Riezzo G,Orlando A,Lonigro SL,Lavermicocca P

    更新日期:2010-09-01 00:00:00

  • Esophageal Function Abnormalities in Patients With Barrett's Esophagus.

    abstract::Various esophageal functional abnormalities have been described in patients with Barrett's esophagus (BE). A significantly higher esophageal acid exposure especially in the supine position has been documented in BE, as compared with the other gastroesophageal reflux disease phenotypes. In addition, weakly acidic reflu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001358

    authors: Fass R,Teramoto O,Kurin M,Khalessi A,Kitayama Y,Shibli F

    更新日期:2020-07-01 00:00:00

  • Simultaneous appearance of a unique common epitope in fetal colon, skin, and biliary epithelial cells. A possible link for extracolonic manifestations in ulcerative colitis.

    abstract::The tissue distribution of a previously identified M(r) 40 K epithelial autoantigen in ulcerative colitis was examined in situ in the fetal tissue by immunocytochemical method, using an immunoglobulin M (IgM) monoclonal antibody (7E12H12). Fetal-autopsy tissue from 9 to 19 weeks of development (11-21 gestational weeks...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199212000-00009

    authors: Das KM,Squillante L,Chitayet D,Kalousek DK

    更新日期:1992-12-01 00:00:00

  • Multiple esophageal webs: treatment and follow-up of seven patients.

    abstract::We have treated seven patients with multiple esophageal webs without a predisposing disorder. The patients ranged in age from 34 to 61 years and had suffered from dysphagia for 4 to 26 years. None had skin disease, a history of ingestion of a potentially caustic substance, or evidence of gastroesophageal reflux diseas...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199706000-00003

    authors: Longstreth GF,Sitzer ME

    更新日期:1997-06-01 00:00:00

  • Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERD: A Double-Blind Randomized Trial.

    abstract:GOALS:To determine the proportion of patients with gastroesophageal reflux disease who are on proton pump inhibitors (PPIs) who could reduce their prior dosage by half, and identify predictors of successful step-down. BACKGROUND:Appropriate hypergastrinemia results from gastric acid inhibition. A gender difference in ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000000542

    authors: Helgadóttir H,Metz DC,Lund SH,Gizurarson S,Jacobsen EI,Asgeirsdóttir GA,Yngadóttir Y,Björnsson ES

    更新日期:2017-07-01 00:00:00

  • A laboratory score in the diagnosis of autoimmune atrophic gastritis: a prospective study.

    abstract:BACKGROUND:Several biomarkers have been proposed for the diagnosis of autoimmune atrophic gastritis (AAG), but at the present there is no appropriate testing strategy for the disease. GOALS:The aim of this study was to develop and validate a laboratory score able to address the diagnosis of AAG in a general practice s...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000101

    authors: Miceli E,Padula D,Lenti MV,Gallia A,Albertini R,Di Stefano M,Klersy C,Corazza GR

    更新日期:2015-01-01 00:00:00

  • Acceptance of telemanagement is high in patients with inflammatory bowel disease.

    abstract:GOALS:Assess acceptance and attitudes regarding telemanagement (HAT) in patients with inflammatory bowel disease (IBD). BACKGROUND:Noncompliance is a barrier to successful outcomes in patients with IBD. Novel methods for monitoring and assessing compliance are needed. STUDY:HAT consists of a laptop connected to a wei...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200603000-00006

    authors: Cross RK,Arora M,Finkelstein J

    更新日期:2006-03-01 00:00:00

  • Ultrasound diagnosis of fatty liver in patients with chronic liver disease: a retrospective observational study.

    abstract:OBJECTIVES:Hepatic ultrasound (US) is readily available and physicians usually trust the results of an US report suggesting fatty liver, but there are conflicting reports on its accuracy, especially in patients with chronic liver disease (CLD). Therefore, we retrospectively examined liver biopsies in patients with CLD ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225680.45088.01

    authors: Perez NE,Siddiqui FA,Mutchnick MG,Dhar R,Tobi M,Ullah N,Saksouk FA,Wheeler DE,Ehrinpreis MN

    更新日期:2007-07-01 00:00:00

  • Gastric polyps.

    abstract::We suggest an approach to patients with gastric polyps, based on a study of 73 patients seen at this institution over a 5-year period. There were 40 cases of adenomatous and 20 cases of hamartomatous polyps. Differentiation between these two groups of polyps was not possible on the basis of clinical presentation, labo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198202000-00004

    authors: Fabry TL,Frankel A,Waye JD

    更新日期:1982-02-01 00:00:00

  • Digital Chromoendoscopy With i-Scan for In Vivo Prediction of Advanced Colorectal Neoplasia: A Multicenter Study.

    abstract:BACKGROUND:Recent studies have analyzed the potential of advanced endoscopic imaging techniques for differentiating hyperplastic and adenomatous colorectal lesions. Latest endoscopic resection techniques now also allow for treatment of more advanced staged lesions including treatment of early cancerous lesions. AIMS:T...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000527

    authors: Albrecht H,Nägel A,Tasdelen H,Rath T,Grauer M,Vieth M,Neurath MF,Neumann H

    更新日期:2016-11-01 00:00:00

  • Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. The objective of this study was to describe the recent trend of health care resource utilization and short-term mortality of Medicare beneficiaries with NAFLD. METHODS:This study utilized data from a ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000071

    authors: Younossi ZM,Zheng L,Stepanova M,Henry L,Venkatesan C,Mishra A

    更新日期:2015-03-01 00:00:00

  • Primary biliary cirrhosis and chronic pancreatitis in a patient with ulcerative colitis.

    abstract::A 65-year-old Japanese woman had primary biliary cirrhosis (PBC) and chronic pancreatitis associated with ulcerative colitis. The association of PBC and ulcerative colitis may prove to be valid. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198510000-00011

    authors: Kato Y,Morimoto H,Unoura M,Kobayashi K,Hattori N,Nakanuma Y

    更新日期:1985-10-01 00:00:00

  • Cytomegalovirus gastritis associated with pseudolymphoma.

    abstract::A man who previously had several episodes of upper gastrointestinal hemorrhage from erosive gastritis developed recurrent hemorrhage. Endoscopy showed punctate hemorrhages in the fundus and body of the stomach, plus a discrete area of thickened folds in the anterior wall. Biopsies revealed a dense mucosal infiltrate t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199404000-00011

    authors: Zucker GM,Otis C,Korowski K,Navab F

    更新日期:1994-04-01 00:00:00

  • The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleeding.

    abstract:GOALS:The aim of this study was to determine the effect ofoctreotide on active or recent gastrointestinal bleeding from benign peptic ulcers. STUDY:This is a prospective, randomized study including 110 patients with gastric or duodenal peptic ulcers presenting with active spurting or oozing bleeding or nonbleeding vis...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200403000-00009

    authors: Nikolopoulou VN,Thomopoulos KC,Katsakoulis EC,Vasilopoulos AG,Margaritis VG,Vagianos CE

    更新日期:2004-03-01 00:00:00

  • Thalidomide as "salvage" therapy for patients with delayed hypersensitivity response to infliximab: a case series.

    abstract::Infliximab is efficacious for refractory Crohn's disease, but delayed hypersensitivity reactions preclude retreatment for patients experiencing this complication. We report the results of four patients offered enrollment in an open label trial of thalidomide as "salvage" therapy for their refractory disease. Two patie...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-200208000-00006

    authors: Kane S,Stone LJ,Ehrenpreis E

    更新日期:2002-08-01 00:00:00

  • Sturge-Weber syndrome: a rare cause of gastrointestinal hemorrhage.

    abstract::A case of Sturge-Weber syndrome (SWS) with gastrointestinal hemorrhage is presented. SWS is a neurocutaneous disorder characterized by cutaneous facial angioma leptomeningeal angioma with seizures and other neurologic complications. Associated anomalies beyond the encephalofacial territory are very rare. The patient p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200001000-00019

    authors: Castilla-Guerra L,Fernández-Moreno MC,Franco E

    更新日期:2000-01-01 00:00:00

  • Effects of sodium tetradecyl sulfate endoscopic variceal sclerotherapy on the esophagus. A prospective clinical and histopathologic study.

    abstract::A prospective clinical, endoscopic, and histopathologic study of the esophagus was carried out in 24 patients with advanced liver disease who underwent esophageal variceal sclerotherapy (EVS) and who eventually came to autopsy. Patients were arbitrarily divided into three groups: acute (group I), intermediate (group I...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198712000-00006

    authors: Kage M,Korula J,Harada A,Mucientes F,Kanel G,Peters RL

    更新日期:1987-12-01 00:00:00

  • Can pancreatitis be associated with amiodarone hepatotoxicity?

    abstract::We report a patient with classical features of amiodarone hepatotoxicity who died of progressive liver failure. Throughout the course of his illness, he had epigastric pain, nausea, vomiting, and persistent mild to moderate elevation of amylase and lipase in his serum and peritoneal fluid. Pancreatitis due to amiodaro...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199002000-00018

    authors: Sastri SV,Diaz-Arias AA,Marshall JB

    更新日期:1990-02-01 00:00:00

  • Glycosphingolipid composition of the gastric mucosa. A role of sulfatides in gastrointestinal mucosal defense?

    abstract::The glycosphingolipid (GSL) compositions of the human, rabbit, and rat gastric mucosa were studied and compared. In neutral GSLs, although GalCer was the most abundant component in every tissue examined, species-specific differences were clearly observed in their composition. Acidic GSLs were composed of sulfatides an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Natomi H,Sugano K,Takaku F,Iwamori M

    更新日期:1990-01-01 00:00:00