Esophageal Function Abnormalities in Patients With Barrett's Esophagus.

Abstract:

:Various esophageal functional abnormalities have been described in patients with Barrett's esophagus (BE). A significantly higher esophageal acid exposure especially in the supine position has been documented in BE, as compared with the other gastroesophageal reflux disease phenotypes. In addition, weakly acidic reflux and duodenogastroesophageal reflux are more common in BE patients. The presence of Barrett's mucosa reduces esophageal mucosal impedance, occasionally to a level that prevents detection of reflux episodes. Reduced amplitude contractions and lower esophageal sphincter basal pressure are more common in BE patients as compared with the other gastroesophageal reflux disease groups. Ineffective esophageal motility is the most commonly defined motor disorder in BE. Reduced chemoreceptor and mechanoreceptor sensitivity to acid and balloon distention, respectively, have been suggested to explain lack or significantly less reports of reflux-related symptoms by BE patients.

journal_name

J Clin Gastroenterol

authors

Fass R,Teramoto O,Kurin M,Khalessi A,Kitayama Y,Shibli F

doi

10.1097/MCG.0000000000001358

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

485-492

issue

6

eissn

0192-0790

issn

1539-2031

journal_volume

54

pub_type

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