Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection.


:To assess the effects of the mucoprotective drug sofalcone, which has direct and indirect effects on Helicobacter pylori in vitro, the eradication rate, adverse effects, and the quality of healing peptic ulcers were evaluated. Each study patient was given 500 mg t.i.d. amoxicillin and 200 mg t.i.d. clarithromycin. In addition, three different treatment regimens were compared: a standard dose (20 mg q.d.) of the proton pump inhibitor omeprazole (OAC), a double dose (20 mg b.i.d.) of omeprazole (Ox2AC), and a standard dose of omeprazole and a standard dose (100 mg t.i.d.) of sofalcone (OACS). Thirty-one H. pylori-positive patients were treated with OAC, 37 with Ox2AC, and 41 with OACS therapy. With an intention-to-treat analysis, the eradication rates were 74.2% for OAC, 86.2% for Ox2AC, and 85.0% for OACS therapy. The incidence of side effects was 9.6% for patients given OAC therapy, 86.5% for Ox2AC, and only 7.5% for OACS-treated patients, which was significantly lower than the incidence in the Ox2AC group. High-quality peptic ulcer scars were observed after eradication therapy which included solfacone. Although it is necessary to conduct a randomized double-blind study to obtain definitive conclusions, our results indicate that this novel quadruple eradication therapy with solfacone is an efficacious regimen with a high eradication rate and positive effects on ulcer healing, combined with a low incidence of adverse events.


J Clin Gastroenterol


Sakaki N,Arakawa T,Kozawa H,Yamada Y,Kato H,Kamisawa T,Momma K




Has Abstract


1998-01-01 00:00:00








27 Suppl 1


  • Predictors for Celiac Disease in Adult Cases of Duodenal Intraepithelial Lymphocytosis.

    abstract:BACKGROUND:Duodenal intraepithelial lymphocytosis (D-IEL) is an early marker for celiac disease (CD). However, the majority of cases are due to non-CD-related conditions. GOALS:To identify the predictors of CD when presented with D-IEL. METHODS:A total of 215 adult patients with D-IEL had undergone prospective and sy...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Aziz I,Key T,Goodwin JG,Sanders DS

    更新日期:2015-07-01 00:00:00

  • Effects of microencapsulated vs. enteric-coated acetylsalicylic acid on gastric and duodenal mucosa: an endoscopic study.

    abstract::Two preparations of acetylsalicylic acid (ASA) were tested for their effects on gastroduodenal mucosa in a randomized crossover double-blind study that involved 12 healthy volunteers. Medication M (Monobeltin) consisted of 1,050 mg ASA provided with an enteric coat and medication C (Colfarit) consisted of 1,000 mg of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Malfertheiner P,Stanescu A,Rogatti W,Ditschuneit H

    更新日期:1988-06-01 00:00:00

  • Motility of the transverse colon used for esophageal replacement.

    abstract::The authors studied the motility of transverse colon used for reconstruction of the pharyngogastric transit after esophagectomy. The study included 10 patients who underwent esophagectomy 15 to 201 months (median, 48.5 months) before motility evaluation. Nine patients underwent operation because of caustic injury and ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Dantas RO,Mamede RC

    更新日期:2002-03-01 00:00:00

  • Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

    abstract:BACKGROUND:The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients. GOALS:We aimed to determine the incidence of and risk factors for meningitis in IBD patients. STUDY:We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kochar B,Jiang Y,Long MD

    更新日期:2020-05-29 00:00:00

  • Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Vitamin deficiency is frequently associated with inflammatory bowel disease (IBD). Supplementation of vitamins could thus serve as an adjunctive therapy. The present meta-analysis reviews the deficiencies and alterations in serum fat-soluble vitamins (A, D, E, and K) reported in IBD patients. MATERIALS AND ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Fabisiak N,Fabisiak A,Watala C,Fichna J

    更新日期:2017-11-01 00:00:00

  • HCV hepatitis associated with anticardiolipin antibody and a cerebrovascular accident. Response to interferon therapy.

    abstract::A 54-year-old man with chronic hepatitis C virus (HCV) developed quadrihemianopsia caused by lacunar brain infarction. Extensive evaluation revealed high titers of anticardiolipin antibodies (ACA). Following interferon treatment (6 x 10(6), three times a week for 2 months and 3 x 10(6) for another 7 months), liver tra...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Malnick SD,Abend Y,Evron E,Sthoeger ZM

    更新日期:1997-01-01 00:00:00

  • Infection with hepatitis C virus genotype 4 in the United States.

    abstract:BACKGROUND:Hepatitis C virus genotype differences seem to be of considerable clinical significance because they affect responses to antiviral therapy. HCV genotype 4 is rare in the United States and there are few published data regarding response to therapy in patients with HCV genotype 4 infection. OBJECTIVES:To asse...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lyra AC,Ramrakhiani S,Bacon BR,Di Bisceglie AM

    更新日期:2004-01-01 00:00:00

  • Life-threatening enterocolitis after gold salt therapy.

    abstract::Two patients developed life-threatening enterocolitis after receiving gold salt therapy. This disorder is attended by a mortality rate of 50% but the intestinal lesion appears to be reversible. The mechanism of the drug toxicity is not known. The course may be fulminant and recovery may occur only after many weeks. To...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sckolnick BR,Katz LA,Kozower M

    更新日期:1979-06-01 00:00:00

  • Elevated serum gastrin levels in patients with colorectal neoplasia.

    abstract::Gastrin stimulates the growth of some human colon adenocarcinomas grown in vitro or as xenografts in nude mice. To evaluate the possibility of elevated plasma gastrin levels in patients with adenomatous polyps or colorectal cancer, we carried out a radioimmunoassay in subjects fasting overnight and undergoing colonosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Seitz JF,Giovannini M,Gouvernet J,Gauthier AP

    更新日期:1991-10-01 00:00:00

  • Isolated gastric sarcoidosis. Unique remnant of disseminated disease.

    abstract::Isolated granulomatous disease was identified in a gastrectomy specimen after a gastrointestinal hemorrhage in a 61-year-old white woman. She died postoperatively. No other areas of granulomatous tissue were identified at autopsy. Ten years previously, pulmonary sarcoidosis was proven on lung biopsy. Conceivable, othe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Panella VS,Katz S,Kahn E,Ulberg R

    更新日期:1988-06-01 00:00:00

  • Duodenal polyps: diagnosis and management.

    abstract::Forty-five polyps were encountered at duodenoscopy between 1973 and 1978. Upper gastrointestinal x-rays were helpful in 25 patients, 13 of whom had duodenal polyps and 12 duodenal deformity or mass lesions. Polyps in 23 patients were larger than 1 cm in size. Biopsies were done in 38 patients; in 19 there was only nor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Reddy RR,Schuman BM,Priest RJ

    更新日期:1981-06-01 00:00:00

  • Hypereosinophilic syndrome resembling chronic inflammatory bowel disease with primary sclerosing cholangitis.

    abstract::A patient who presented with chronic inflammation of the colon, and initially also the terminal ileum, accompanied by marked diarrhea, is described. Repeated high-dose steroid therapy was only temporarily successful, and symptoms recurred upon dose reduction. During the further course of the disease, a marked elevatio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Scheurlen M,Mörk H,Weber P

    更新日期:1992-01-01 00:00:00

  • CapsoCam SV-1 Versus PillCam SB 3 in the Detection of Obscure Gastrointestinal Bleeding: Results of a Prospective Randomized Comparative Multicenter Study.

    abstract:BACKGROUND AND STUDY AIM:Newer capsule with a panoramic viewing mode is available and might increase the detection rate of bleeding lesions in patients with obscure gastrointestinal bleeding (OGIB). Furthermore, an improved patient acceptance rate is expected. MATERIALS AND METHODS:In a randomized prospective comparat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zwinger LL,Siegmund B,Stroux A,Adler A,Veltzke-Schlieker W,Wentrup R,Jürgensen C,Wiedenmann B,Wiedbrauck F,Hollerbach S,Liceni T,Bojarski C

    更新日期:2019-03-01 00:00:00

  • Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection.

    abstract::Fulminant hepatic failure as a result of hepatitis A is a rarely diagnosed complication entity in developed countries. With the advent of specific serologic markers for acute hepatitis A virus infection, the incidence and pathology of fulminant hepatitis A can be more clearly defined. We describe four patients (one ad...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Masada CT,Shaw BW Jr,Zetterman RK,Kaufman SS,Markin RS

    更新日期:1993-09-01 00:00:00

  • Mesenteric node enlargement as a cause of intestinal variceal hemorrhage in nodular lymphoid hyperplasia.

    abstract::Jejunal varices were a cause of recurrent gastrointestinal hemorrhage in an 18-year-old man with common variable immunodeficiency and nodular lymphoid hyperplasia of the small intestine. Despite numerous procedures, including upper gastrointestinal endoscopy, colonoscopy, arteriography, and exploratory laparotomy no a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Freiman JS,Gallagher ND

    更新日期:1985-10-01 00:00:00

  • A randomized, controlled trial of interactive, multimedia software for patient colonoscopy education.

    abstract::The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shaw MJ,Beebe TJ,Tomshine PA,Adlis SA,Cass OW

    更新日期:2001-02-01 00:00:00

  • Reflections on Crohn's disease and healing.

    abstract::One patient's story is recounted. Relatively asymptomatic for 20 years, the patient reflects on factors that contributed to his healing. Psychosocial and spiritual dimensions are described as well as biomedical aspects. The story concludes that dealing with Crohn's disease triggered a spiritual quest which in turn con...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论


    authors: Sheehan DR

    更新日期:1998-06-01 00:00:00

  • The symptomatic and histologic response to a gluten-free diet in patients with borderline enteropathy.

    abstract:GOALS:A clinical problem is posed by patients with symptoms suggestive of gluten sensitivity (diarrhea, weight loss, unresponsive iron-deficiency anemia, etc.); however, small intestinal biopsies reveal only minor abnormalities, such as lymphocytosis with or without crypt hyperplasia (Marsh I-II). Our aim was to assess...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tursi A,Brandimarte G

    更新日期:2003-01-01 00:00:00

  • The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:The clinical effect of probiotics on irritable bowel syndrome (IBS) is still controversial. AIMS:We aimed to evaluate the effects of a probiotic mixture on IBS symptoms and the composition of fecal microbiota in patients with diarrhea-dominant IBS (D-IBS). METHODS:Fifty patients with D-IBS were randomized ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Ki Cha B,Mun Jung S,Hwan Choi C,Song ID,Woong Lee H,Joon Kim H,Hyuk J,Kyung Chang S,Kim K,Chung WS,Seo JG

    更新日期:2012-03-01 00:00:00

  • Serous cystadenoma in communication with the pancreatic duct: an unusual radiologic and pathologic entity.

    abstract::Cross-sectional imaging is frequently used in the diagnosis of pancreatic cysts, but there can be overlap in radiographic appearance. We present a case of a patient with presumed intraductal papillary mucinous neoplasm (IPMN) who was ultimately found to have a serous cystadenoma in communication with the pancreatic du...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Berman L,Mitchell KA,Israel G,Salem RR

    更新日期:2010-07-01 00:00:00

  • The efficacy of intravenous contrast-enhanced 16-raw multidetector CT colonography for detecting patients with colorectal polyps in an asymptomatic population in Korea.

    abstract:PURPOSE:The purpose of this study is to compare the sensitivity of computed tomography (CT) colonography (CTC) with that of colonoscopy for detecting patients with colorectal polyps in an asymptomatic screening population in Korea, thus to evaluate a possibility, whether CTC could be used as a screening tool for colore...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kim YS,Kim N,Kim SH,Park MJ,Lim SH,Yim JY,Cho KR,Kim SS,Kim DH,Eun HW,Cho KS,Kim JH,Choi BI,Jung HC,Song IS,Shin CS,Cho SH,Oh BH

    更新日期:2008-08-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

    abstract::A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reporte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: O'Reilly DJ,Craig RM,Lorenzo G,Yokoo H

    更新日期:1983-04-01 00:00:00

  • Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy.

    abstract:BACKGROUND:Moderate sedation has been standard for noninvasive gastrointestinal procedures for decades yet there are limited data on reversal agent use and outcomes associated with need for reversal of sedation. AIM:To determine prevalence and clinical significance of reversal agent use during endoscopies and colonosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Hung A,Marshall J,Barnett S,Falchuk ZM,Sawhney M,Leffler DA

    更新日期:2016-03-01 00:00:00

  • Splenosis presenting as an ulcerated gastric mass: endoscopic and endoscopic ultrasonographic imaging.

    abstract::A case of an ulcerated gastric wall mass ultimately found to be splenosis is presented in which the index patient had endoscopic and endoscopic ultrasonographic evaluation prior to resection. Although no visual features identified this mass as a splenic implant preoperatively, the lesion appeared to be atypical for le...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Deutsch JC,Sandhu IS,Lawrence SP

    更新日期:1999-04-01 00:00:00

  • Hypoxic hepatitis occurring in cirrhosis after variceal bleeding: still a lethal disease.

    abstract:BACKGROUND:Hypoxic hepatitis (HH) occurring after gastrointestinal bleeding in cirrhotic patients has been scarcely studied and is reported as a rare occurrence carrying a severe prognosis. The management of bleeding from esophageal varices (BEV) and similarly the prognosis has improved in the last decades. GOALS:To e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Amitrano L,Guardascione MA,Martino R,Manguso F,Menchise A,Balzano A

    更新日期:2012-08-01 00:00:00

  • Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?

    abstract:GOALS:To assess the effect of unilateral versus bilateral lung transplantation (LTx) on esophageal motility and gastroesophageal reflux, and the association with the development of obstructive chronic lung allograft dysfunction (o-CLAD). BACKGROUND:We have shown that esophagogastric junction outflow obstruction, incom...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tangaroonsanti A,Lee AS,Vela MF,Crowell MD,Erasmus D,Keller C,Mallea J,Alvarez F,Almansa C,DeVault KR,Houghton LA

    更新日期:2019-04-01 00:00:00

  • Could alpha 1 antitrypsin deficiency have any role in the development of celiac sprue after gastric operations?

    abstract::We report a 50-year-old woman with alpha 1 antitrypsin deficiency (PiSZ phenotype) who developed clinical features of malabsorption after vagotomy and pyloroplasty. The intestinal biopsy demonstrated total villous atrophy with hypertrophy of the crypts. After gluten withdrawal, digestive function and the appearance of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pons Romero F,Casafont F,Rodriguez de Lope C,San Miguel G,Artiñano E,Cagigas J

    更新日期:1986-10-01 00:00:00

  • Neostigmine Administered With MoviPrep Improves Bowel Preparation for Elective Colonoscopy in Patients With Spinal Cord Injury: A Randomized Study.

    abstract:BACKGROUND:Poor preparation for elective colonoscopy is exceedingly common in persons with spinal cord injury (SCI). This unsatisfactory outcome is likely due to long-standing difficulty with evacuation and decreased colonic motility, which may result in inadequate responses to conventional bowel preparation regimens. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Korsten MA,Spungen AM,Radulovic M,Rosman AS,Hunt K,Galea MD,Kornfeld SD,Lyons BL,Yen C,Bauman WA

    更新日期:2015-10-01 00:00:00

  • Current Therapeutic Options for Esophageal Motor Disorders as Defined by the Chicago Classification.

    abstract::With the development of high-resolution manometry and specific metrics to characterize esophageal motility, the Chicago Classification has become the gold standard for the diagnosis of esophageal motor disorders. Major and significant disorders, that is, never observed in healthy subjects, are achalasia, esophagogastr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Zerbib F,Roman S

    更新日期:2015-07-01 00:00:00