A survey of hepatitis C treatment clinical practice patterns using the newly approved protease inhibitors.

Abstract:

GOALS:To describe current hepatitis C virus (HCV) treatment practices in the United States and identify physician characteristics associated with the use of first generation direct-acting antivirals (DAAs). BACKGROUND:HCV treatment practice patterns have not been assessed after the introduction of DAA, which are now considered standard of care for most HCV genotype 1 patients. STUDY:We sampled nationally representative physicians treating HCV patients with DAAs through a web-based survey. Stepwise multivariate logistic regression was performed to identify physician characteristics associated with the use of DAAs in 4 clinical vignettes (early stage fibrosis, prior null response, human immunodeficiency virus (HIV) co-infection, and post-liver transplantation). RESULTS:Of 1658 deliverable emails, 337 (20.3%) clinicians responded. Fifty percent of providers recommended DAA therapy for treatment-naive patients with early stage fibrosis, whereas 49% of providers would await new therapies. For prior null responders with significant fibrosis, 74% would attempt retreatment using DAAs and 26% would await new therapies. Off-label use of DAAs was recommended by 69% of providers for patients with HIV infection and 48% of providers for post-liver transplant patients. Academic affiliation was significantly associated with higher rates of off-label use in both HIV and post-liver transplant patients. CONCLUSIONS:Despite more potent and less toxic therapies on the horizon, many physicians recommended DAAs in treatment-naive patients with early stage fibrosis. Providers also frequently recommended DAAs for off-label uses, such as treating post-liver transplant patients and those coinfected with HIV.

journal_name

J Clin Gastroenterol

authors

Chen EY,Lee WM,Hynan LS,Singal AG

doi

10.1097/MCG.0b013e31828a37c0

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

800-6

issue

9

eissn

0192-0790

issn

1539-2031

journal_volume

47

pub_type

杂志文章
  • Duodenal polyps: diagnosis and management.

    abstract::Forty-five polyps were encountered at duodenoscopy between 1973 and 1978. Upper gastrointestinal x-rays were helpful in 25 patients, 13 of whom had duodenal polyps and 12 duodenal deformity or mass lesions. Polyps in 23 patients were larger than 1 cm in size. Biopsies were done in 38 patients; in 19 there was only nor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198106000-00007

    authors: Reddy RR,Schuman BM,Priest RJ

    更新日期:1981-06-01 00:00:00

  • Change in antibiotic resistance of Helicobacter pylori strains and the effect of A2143G point mutation of 23S rRNA on the eradication of H. pylori in a single center of Korea.

    abstract:BACKGROUND:The current prevalence of primary antibiotic resistance of H. pylori is not known in Korea. This study was done to evaluate the prevalence of primary antibiotic resistance of H. pylori, and to evaluate the effect of point mutations of 23S rRNA on the rate of eradication of H. pylori. METHODS:H. pylori were ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181d04592

    authors: Hwang TJ,Kim N,Kim HB,Lee BH,Nam RH,Park JH,Lee MK,Park YS,Lee DH,Jung HC,Song IS

    更新日期:2010-09-01 00:00:00

  • Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease.

    abstract:GOALS:Our objective was to determine whether high serologic IgA tissue transglutaminase antibodies (TTGA) are exclusively associated with celiac disease (CD). BACKGROUND:IgA TTGA are found in the serum of most individuals with CD. This serologic marker is used to screen individuals with suspected CD for duodenal biops...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0b013e31802e70b1

    authors: Donaldson MR,Book LS,Leiferman KM,Zone JJ,Neuhausen SL

    更新日期:2008-03-01 00:00:00

  • Treating Budd-Chiari Syndrome: making rational choices from a myriad of options.

    abstract::Budd-Chiari syndrome represents a spectrum of disorders characterized by obstruction to hepatic venous drainage. Originally described as an "obliterating endophlebitis of the hepatic veins," this condition has come to refer to the manifestations of hepatic venous outflow obstruction anywhere above the level of the hep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200003000-00007

    authors: Olzinski AT,Sanyal AJ

    更新日期:2000-03-01 00:00:00

  • Surveillance for hepatocellular carcinoma in a Medicaid cirrhotic population.

    abstract:GOALS:To estimate the hepatocellular carcinoma surveillance in the Medicaid cirrhotic population. BACKGROUND:Most studies predate 2005 American Association for the Study of Liver Diseases surveillance recommendations and do not examine the primary target population, cirrhotics. STUDY:From 2006 to 2007, we identified ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318286fd97

    authors: Palmer LB,Kappelman MD,Sandler RS,Hayashi PH

    更新日期:2013-09-01 00:00:00

  • Pathology of indeterminate colitis.

    abstract::The term indeterminate colitis (IC) is an interim, or preliminary, descriptive term used by pathologists for cases of inflammatory bowel disease (IBD) in which a definite diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) cannot be established based on the information available at the time of surgical sign-o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000127686.69276.5b

    authors: Odze RD

    更新日期:2004-05-01 00:00:00

  • Nephrolithiasis and intestinal disease.

    abstract::Kidney stones in patients with inflammatory bowel disease are usually composed of calcium oxalate. Two factors are important in the increased absorption of dietary oxalate which is responsible for those stones: 1) increased absorption of oxalate in the presence of steatorrhea, and 2) increased permeability of the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198502000-00002

    authors: Dobbins JW

    更新日期:1985-02-01 00:00:00

  • Change in serum hepatitis B surface antigen level and its clinical significance in treatment-naïve, hepatitis B e antigen-positive patients receiving entecavir.

    abstract:BACKGROUND/AIM:We investigated changes in hepatitis B surface antigen (HBsAg) level and its correlation with clinical outcomes in treatment-naive chronic hepatitis B (CHB) patients undergoing entecavir therapy. PATIENTS AND METHODS:Among 51 hepatitis B e antigen (HBeAg)-positive treatment-naive CHB patients receiving ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0b013e3181d52946

    authors: Jung YK,Kim JH,Lee YS,Lee HJ,Yoon E,Jung ES,Hong SK,Joo MK,Yeon JE,Park JJ,Kim JS,Bak YT,Byun KS

    更新日期:2010-10-01 00:00:00

  • Can pancreatitis be associated with amiodarone hepatotoxicity?

    abstract::We report a patient with classical features of amiodarone hepatotoxicity who died of progressive liver failure. Throughout the course of his illness, he had epigastric pain, nausea, vomiting, and persistent mild to moderate elevation of amylase and lipase in his serum and peritoneal fluid. Pancreatitis due to amiodaro...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199002000-00018

    authors: Sastri SV,Diaz-Arias AA,Marshall JB

    更新日期:1990-02-01 00:00:00

  • The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection: a prospective multicenter study.

    abstract:BACKGROUND:It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. GOALS:The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/MCG.0b013e3182160c9c

    authors: Kim YS,Kim YH,Kim JS,Cheon JH,Ye BD,Jung SA,Park YS,Choi CH,Jang BI,Han DS,Yang SK,Kim WH,IBD Study Group of the Korean Association for the Study of Intestinal Diseases.

    更新日期:2012-01-01 00:00:00

  • Adult celiac disease (celiac sprue), pernicious anemia and IgA deficiency. Case report and review of the relationships between vitamin B12 deficiency, small intestinal mucosal disease and immunoglobulin deficiency.

    abstract::A 24-year-old man with addisonian pernicious anemia, adult celiac disease and selective IgA deficiency is presented to emphasize the differential diagnosis of vitamin B12 deficient megaloblastic anemia in association with small intestinal mucosal abnormalities and the relationships between immunoglobulin deficiency, p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198606000-00016

    authors: Quigley EM,Carmichael HA,Watkinson G

    更新日期:1986-06-01 00:00:00

  • Effect of Consent and Educational Adjuncts to Consent on Patient Perceptions About Colonoscopy.

    abstract:BACKGROUND AND AIMS:Informed consent is a vital preprocedural step for endoscopy but there are substantial variations in its delivery. We therefore sought to assess a multifaceted intervention to improve the consent process. METHODS:Gastroenterologists at a tertiary center were educated on the recommended components o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001093

    authors: Fudman DI,Papamichael K,Roemi L,Rao V,Falchuk KR,Leffler DA,Feuerstein JD

    更新日期:2019-09-01 00:00:00

  • Dysphagia as a primary manifestation of hyperthyroidism.

    abstract::A 69-year old woman suffered from severe dysphagia, abdominal pain, and weight loss. The dysphagia was accompanied by nasal speech, nasal regurgitation of food, weakness, and wasting of the proximal muscles of the upper and lower girdles. Laboratory data revealed T3 sephadex uptake 65.2%; T4 15.1 mcg%; and T3 250 ng%....

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198410000-00009

    authors: Branski D,Levy J,Globus M,Aviad I,Keren A,Chowers I

    更新日期:1984-10-01 00:00:00

  • Acceptance of telemanagement is high in patients with inflammatory bowel disease.

    abstract:GOALS:Assess acceptance and attitudes regarding telemanagement (HAT) in patients with inflammatory bowel disease (IBD). BACKGROUND:Noncompliance is a barrier to successful outcomes in patients with IBD. Novel methods for monitoring and assessing compliance are needed. STUDY:HAT consists of a laptop connected to a wei...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200603000-00006

    authors: Cross RK,Arora M,Finkelstein J

    更新日期:2006-03-01 00:00:00

  • Serum nitric oxide levels in children with celiac disease.

    abstract:OBJECTIVES:To determine serum nitric oxide levels in pediatric patients with celiac disease and to compare them with the results obtained after 1 year of gluten-free diet. METHODS:We studied serum nitric oxide levels in 41 newly diagnosed patients with celiac disease. Serum levels of nitric oxide were reevaluated afte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000177240.67215.da

    authors: Ertekin V,Selimoğlu MA,Türkan Y,Akçay F

    更新日期:2005-10-01 00:00:00

  • Rates of Suboptimal Preparation for Colonoscopy Differ Markedly Between Providers: Impact on Adenoma Detection Rates.

    abstract:GOALS:We sought to determine if providers who have higher standards for optimal bowel preparation might be more fastidious in their examination of the colon and, therefore, have higher adenoma detection rates (ADRs). BACKGROUND:ADRs are a reliable and objective marker of colonoscopy performance. Suboptimal bowel prepa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000210

    authors: Mahadev S,Green PH,Lebwohl B

    更新日期:2015-10-01 00:00:00

  • Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. The objective of this study was to describe the recent trend of health care resource utilization and short-term mortality of Medicare beneficiaries with NAFLD. METHODS:This study utilized data from a ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000071

    authors: Younossi ZM,Zheng L,Stepanova M,Henry L,Venkatesan C,Mishra A

    更新日期:2015-03-01 00:00:00

  • Hypertrophic gastropathy symptoms responsive to prednisone. A case report and a review of the literature.

    abstract::We describe a 33-year-old man with giant hypertrophic gastropathy (Menetrier's disease), which, on operative biopsy of the stomach, showed a significant inflammatory component. The patient was treated with prednisone and quickly responded. Although a review of the literature revealed only two cases similarly treated, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199108000-00014

    authors: Davis GE,O'Rourke MC,Metz JR,Kindig WV,Sweeney JG,Kane KN

    更新日期:1991-08-01 00:00:00

  • Clinical applications of magnetic resonance cholangiopancreatography.

    abstract::Magnetic resonance cholangiopancreatography (MRCP) is a novel imaging technique used for noninvasive work-up of patients with pancreaticobiliary disease. Magnetic resonance cholangiopancreatography is useful in the evaluation of a host of pancreaticobiliary disorders, such as congenital disorders, calculus disease, bi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200111000-00004

    authors: Prasad SR,Sahani D,Saini S

    更新日期:2001-11-01 00:00:00

  • Ureteropelvic junction obstruction.

    abstract::Physicians sometimes forget nongastrointestinal causes of abdominal pain. Yet, abdominal pain was the major complaint of three patients with ureteropelvic junction obstruction (UPJ). Definitive diagnosis can be made either by a "hydration" intravenous pyelogram or by an intravenous pyelogram during an attack. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-197912000-00011

    authors: Butler ML

    更新日期:1979-12-01 00:00:00

  • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.

    abstract:BACKGROUND:although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections. Thiopurine methyltransferase (TPMT) is an enzyme responsible for the metabolism of AZA, and its activity is inversely related to the risk of developing acute l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200209000-00008

    authors: Regueiro M,Mardini H

    更新日期:2002-09-01 00:00:00

  • Successful food elimination therapy in adult eosinophilic esophagitis: not all patients are the same.

    abstract::Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated, esophageal disease characterized by esophageal dysfunction and eosinophilic inflammation, manifested mainly as dysphagia and frequent food impaction. EoE is recognized into the spectrum of food allergy, but food sensitization studies used not to be ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3182432259

    authors: González-Cervera J,Angueira T,Rodriguez-Domínguez B,Arias A,Yagüe-Compadre JL,Lucendo AJ

    更新日期:2012-11-01 00:00:00

  • Alcoholic recidivism after liver transplantation for alcoholic cirrhosis.

    abstract::Liver transplantation (LT) for alcoholic cirrhosis remains controversial. This controversy surrounding LT in alcoholics focuses on the risk of alcohol recidivism and on potential noncompliance with the immunosuppressive regimen, both of which result in graft failure. Our study examined alcohol recidivism after LT by m...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199804000-00011

    authors: Fábrega E,Crespo J,Casafont F,De las Heras G,de la Peña J,Pons-Romero F

    更新日期:1998-04-01 00:00:00

  • Acute acalculous cholecystitis. A review.

    abstract::Acute acalculous cholecystitis is an uncommon but very serious illness, that, if undiagnosed, may lead to gallbladder perforation and death. The condition has numerous causes that result in bile stasis and ischemia leading to inflammation and infection in the gallbladder wall. The bedside diagnosis may be difficult, e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199210000-00014

    authors: Babb RR

    更新日期:1992-10-01 00:00:00

  • Colonic findings in cirrhotics with portal hypertension. A prospective colonoscopic and histological study.

    abstract::Total colonoscopy was performed in 38 consecutive cirrhotics (15 alcoholic, 19 postviral, four unknown) with portal hypertension, 32 of whom were enrolled in a program of esophageal sclerotherapy because of variceal bleeding (Child's grading: A, 13; B, 21; C, 4 patients). In 34 of them, multiple biopsies from the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199406000-00014

    authors: Scandalis N,Archimandritis A,Kastanas K,Spiliadis C,Delis B,Manika Z

    更新日期:1994-06-01 00:00:00

  • Jejunal adenocarcinoma in congenital heterotopic gastric mucosa.

    abstract::We describe an adenocarcinoma of the jejunum that developed in congenital heterotopic gastric mucosa, a rare event. In our patient, the absence of other intestinal malformation and the presence of gastric glands with variable grades of dysplasia, together with the histological pattern of the tumor, strongly favor the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198802000-00020

    authors: Caruso ML,Marzullo F

    更新日期:1988-02-01 00:00:00

  • Aortoesophageal fistula after perigraft abscess with characteristic CT findings.

    abstract::Aortoesophageal fistula is a rare cause of massive gastrointestinal hemorrhage, and may occur as a sequela to prosthetic replacement of the thoracic aorta. Esophageal compression necrosis with leakage of microorganisms into the proximal suture line is probably central to pathogenesis. Like the more common aortoduodena...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198412000-00009

    authors: Tierney LM Jr,Wall SD,Jacobs RA

    更新日期:1984-12-01 00:00:00

  • Sonographic evaluation of bowel wall thickness in patients with cystic fibrosis.

    abstract:GOALS AND BACKGROUND:Fibrosing colonopathy causing severe thickening of the colon wall was recently described in cystic fibrosis (CF). Since it has been suspected that subclinical colon-wall thickening is a common feature in CF patients, bowel-wall thickness was measured in a series of patients and compared with contro...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200307000-00014

    authors: Dialer I,Hundt C,Bertele-Harms RM,Harms HK

    更新日期:2003-07-01 00:00:00

  • Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome.

    abstract:GOALS:To assess the impact of interferon treatment on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcome. BACKGROUND:Hepatitis C is associated with autoimmunity, which can be exacerbated by interferon treatment. Cases of celiac disease activation during interferon treatment ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200411000-00014

    authors: Durante-Mangoni E,Iardino P,Resse M,Cesaro G,Sica A,Farzati B,Ruggiero G,Adinolfi LE

    更新日期:2004-11-01 00:00:00

  • Intrasphincteric botulinum toxin versus pneumatic balloon dilation for treatment of primary achalasia.

    abstract:GOALS:Despite a high success rate, pneumatic dilatation for achalasia is accompanied by a significant risk of esophageal perforation. Injection of botulinum toxin (botox) into the lower esophageal sphincter (LES) can lead to improvement in symptoms with reduced risk of complications. Direct comparisons of the two techn...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200303000-00005

    authors: Bansal R,Nostrant TT,Scheiman JM,Koshy S,Barnett JL,Elta GH,Chey WD

    更新日期:2003-03-01 00:00:00