Effects of radiation on the human gastrointestinal tract.


:Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particularly in the vascular channels occur. This paper describes and characterizes injuries to the esophagus, stomach, small intestine and colon. It emphasizes the importance of recognizing radiation-induced damage to the gut which may occur early or late after radiation.


J Clin Gastroenterol


Novak JM,Collins JT,Donowitz M,Farman J,Sheahan DG,Spiro HM




Has Abstract


1979-03-01 00:00:00












  • Nasal continuous positive airway pressure. A new treatment for nocturnal gastroesophageal reflux?

    abstract::Nasal continuous positive airway pressure (CPAP) reduces nocturnal gastroesophageal reflux (GER) in obstructive sleep apnea syndrome (OSAS) patients. The primary objectives of our investigation were to determine if CPAP could reduce reflux in non-OSAS patients and, if so, by what mechanism. Esophageal pH was monitored...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kerr P,Shoenut JP,Steens RD,Millar T,Micflikier AB,Kryger MH

    更新日期:1993-12-01 00:00:00

  • Hyper-CK-emia in pediatric celiac disease: prevalence and clinical importance.

    abstract::Hyper-transaminasemia (HT) is a well-known laboratory sign of celiac disease (CD); however, hyper-creatine phosphokinase (CK)-emia (HCK) is not so familiar. As there are reported cases of myopathy associated CD in the literature, we aimed to investigate serum CK levels of children with CD. Newly diagnosed 126 children...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Selimoglu MA,Ertekin V,Altinkaynak S

    更新日期:2007-08-01 00:00:00

  • Older Patients With Hepatocellular Carcinoma Have More Advanced Disease, Lower Rates of Treatment, and Lower Survival.

    abstract:GOALS:To evaluate age-specific disparities in cancer stage at diagnosis, receipt of treatment, and survival among adults with hepatocellular carcinoma (HCC). BACKGROUND:HCC has become the fastest rising cause of cancer-related deaths in the United States. The aging population coupled with the rising incidence of HCC w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yan M,Ha J,Aguilar M,Liu B,Frenette CT,Bhuket T,Wong RJ

    更新日期:2017-04-01 00:00:00

  • Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis.

    abstract::We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver tran...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Jorgensen RA,Lindor KD,Sartin JS,LaRusso NF,Wiesner RH

    更新日期:1995-04-01 00:00:00

  • Chronic Epstein-Barr virus infection: a cause of granulomatous hepatitis?

    abstract::A 37-year-old man had fever, weight loss, malaise, right upper quadrant pain, lymphadenopathy, and a twofold elevation of serum alkaline phosphatase, transaminases, and gamma glutamyl transpeptidase. Granulomas were found on liver biopsy after 2 1/2 months of illness. Treatment with isoniazid and rifampin for 2 months...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Biest S,Schubert TT

    更新日期:1989-06-01 00:00:00

  • Detection and localization of active gastrointestinal bleeding with multidetector row computed tomography angiography: a 5-year prospective study in one medical center.

    abstract:GOAL:To prospectively assess the utility of multidetector row computed tomography angiography (MDCTA) in the diagnosis of active gastrointestinal bleeding (GIB). BACKGROUND:MDCTA is a relatively recent advance in CT scanning technology enabling excellent vascular visualization and detection of various vascular abnorma...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sun H,Jin Z,Li X,Qian J,Yu J,Zhu F,Zhu H

    更新日期:2012-01-01 00:00:00

  • Cytomegalovirus-associated perianal ulcerations in AIDS.

    abstract::We report two patients with the acquired immune deficiency syndrome and cytomegalovirus associated perianal ulcerations. Both complained of chronic, painful, nonhealing ulcers that required surgical intervention for diagnosis and palliation. One patient developed diffuse cytomegalovirus infection and both had poor res...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kamel PL

    更新日期:1992-03-01 00:00:00

  • Allergen-free probiotics.

    abstract::Food sensitivities are constantly increasing in "westernized" countries and may pose serious health risks to sensitized individuals. Severe allergy episodes have also been reported after the intake of probiotic products containing milk protein residues, especially in children. The need for safe and effective probiotic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Mogna G,Strozzi GP,Mogna L

    更新日期:2008-09-01 00:00:00

  • Accuracy of endoscopic ultrasonography and magnetic resonance cholangiopancreatography for the diagnosis of chronic pancreatitis: a prospective comparison study.

    abstract:BACKGROUND:The diagnosis of chronic pancreatitis (CP) remains challenging. Endoscopic ultrasound (EUS) and magnetic resonance cholangiopancreatography (MRCP) have been proposed as highly accurate diagnostic modalities. Although endoscopic retrograde cholangiopancreatography (ERCP) has been previously used as a gold sta...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pungpapong S,Wallace MB,Woodward TA,Noh KW,Raimondo M

    更新日期:2007-01-01 00:00:00

  • Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine.

    abstract::Ranitidine and cimetidine are competitive antagonists of histamine at H2-receptor sites in the gastric mucosa. Both drugs reduce output of basal and stimulated gastric acid and pepsin secretion in normal healthy subjects and duodenal ulcer patients. Pharmacodynamic and pharmacokinetic differences exist between the dru...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Richards DA

    更新日期:1983-01-01 00:00:00

  • "Healed" experimental gastric ulcers remain histologically and ultrastructurally abnormal.

    abstract::The present study was designed to assess histologic and ultrastructural features of gastric mucosa in the areas of grossly healed ulcers (acetic acid-induced gastric ulcers) in rats. The specific question we studied was whether the structure and cellular composition of the gastric mucosa in an area of grossly healed u...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tarnawski A,Hollander D,Krause WJ,Dabros W,Stachura J,Gergely H

    更新日期:1990-01-01 00:00:00

  • Costs and risks in the management of patients with gastric acid hypersecretion.

    abstract:GOALS:To define both risks and costs of optimal care of patients with gastric acid hypersecretion. BACKGROUND:The management of Zollinger-Ellison syndrome and other gastric acid hypersecretory disorders remains challenging. The optimal strategy for follow-up including gastric acid analysis, laboratory studies, and end...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Hirschowitz BI,Fineberg N,Wilcox CM,Mohnen J,Worthington J

    更新日期:2010-01-01 00:00:00

  • Cerebellar metastasis as a unique presenting feature of gastric cancer.

    abstract::Gastric cancer is often diagnosed in middle-aged patients undergoing upper gastrointestinal endoscopy for abdominal complaints or constitutional symptoms, such as dyspepsia, vomiting or anorexia, weight loss, anemia, jaundice, and ascites. Sometimes, all of these symptoms may be absent, and gastric cancer is diagnosed...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Perri F,Bisceglia M,Giannatempo GM,Andriulli A

    更新日期:2001-07-01 00:00:00

  • Colonic findings in cirrhotics with portal hypertension. A prospective colonoscopic and histological study.

    abstract::Total colonoscopy was performed in 38 consecutive cirrhotics (15 alcoholic, 19 postviral, four unknown) with portal hypertension, 32 of whom were enrolled in a program of esophageal sclerotherapy because of variceal bleeding (Child's grading: A, 13; B, 21; C, 4 patients). In 34 of them, multiple biopsies from the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Scandalis N,Archimandritis A,Kastanas K,Spiliadis C,Delis B,Manika Z

    更新日期:1994-06-01 00:00:00

  • Eleven-year survey of safety and efficacy of endoscopic injection sclerotherapy using 2% sodium tetradecyl sulfate and contrast medium.

    abstract::We conducted a retrospective 11-year survey to evaluate the post-treatment course in 285 patients with esophagogastric varices following administration of endoscopic injection sclerotherapy as an emergency, elective, or prophylactic procedure using freshly prepared 2% sodium tetradecyl sulfate not containing benzyl al...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Iwase H,Suga S,Shimada M,Yamada H,Horiuchi Y,Oohashi M

    更新日期:1996-01-01 00:00:00

  • Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.

    abstract::A 79-year-old woman visiting our hospital with chief complaints of epigastric pain and jaundice was emergently admitted. Her alpha-fetoprotein (AFP) level was as high as 2265 ng/mL at admission. Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Miyazawa M,Torii T,Toshimitsu Y,Kamizasa N,Suzuki T,Shinozuka N,Ishizawa K,Koyama I

    更新日期:2006-07-01 00:00:00

  • Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.

    abstract:BACKGROUND:Urinary tract infections (UTIs) are the most common bacterial infection in women. Most UTIs are acute uncomplicated cystitis caused by Escherichia coli (86%). This study was undertaken to assess the effectiveness of an association of a cranberry dry extract, D-mannose, a gelling complex composed of the exopo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Vicariotto F

    更新日期:2014-11-01 00:00:00

  • Successful food elimination therapy in adult eosinophilic esophagitis: not all patients are the same.

    abstract::Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated, esophageal disease characterized by esophageal dysfunction and eosinophilic inflammation, manifested mainly as dysphagia and frequent food impaction. EoE is recognized into the spectrum of food allergy, but food sensitization studies used not to be ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: González-Cervera J,Angueira T,Rodriguez-Domínguez B,Arias A,Yagüe-Compadre JL,Lucendo AJ

    更新日期:2012-11-01 00:00:00

  • Lactic acidosis associated with cirrhosis, hepatoma, hemoperitoneum, and hyperphosphatemia.

    abstract::A patient with cirrhosis developed hemoperitoneum, lactic acidosis, and hyperphosphatemia in the absence of shock. At post-mortem examination occult multicentric hepatocellular carcinoma eroding the liver capsule was present. The case emphasizes the central role of the liver in lactic acidosis, indicates that hemoperi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Berenson MM,Lee RG

    更新日期:1986-04-01 00:00:00

  • Small intestinal changes in enterocolitis complicating Hirschsprung's disease.

    abstract::Hirschsprung's disease is one of the more common causes of childhood bowel obstruction. The disease can cause enterocolitis which, untreated, may result in considerable mortality. We describe our evaluation of two infants who suffered from intractable diarrhea of infancy secondary to Hirschsprung's disease. We found t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Branski D,Lebenthal E

    更新日期:1979-09-01 00:00:00

  • Exclusion of the meal period improves the clinical reliability of esophageal pH monitoring.

    abstract::Meal period exclusion from 24-h pH testing allows better separation between controls and patients with gastroesophageal reflux disease. We reviewed the results of 24-h pH studies of 350 patients with reflux symptoms. They were divided into two groups based on the 95th percentile of the total percentage of time when pH...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Ter RB,Johnston BT,Castell DO

    更新日期:1997-07-01 00:00:00

  • The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleeding.

    abstract:GOALS:The aim of this study was to determine the effect ofoctreotide on active or recent gastrointestinal bleeding from benign peptic ulcers. STUDY:This is a prospective, randomized study including 110 patients with gastric or duodenal peptic ulcers presenting with active spurting or oozing bleeding or nonbleeding vis...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nikolopoulou VN,Thomopoulos KC,Katsakoulis EC,Vasilopoulos AG,Margaritis VG,Vagianos CE

    更新日期:2004-03-01 00:00:00

  • Disposable endoscopic biopsy forceps: comparison with standard forceps of sample size and adequacy of specimen.

    abstract::Disposable biopsy forceps have recently been introduced into the field of endoscopy. We have analyzed biopsy size and histologic interpretation of samples obtained with the disposable forceps and compared them to those obtained with reusable forceps. In the 18 patients studied, 49 samples were collected with the reusa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Turk DJ,Kozarek RA,Botoman VA,Patterson DJ,Ball TJ

    更新日期:1991-02-01 00:00:00

  • Swallow evaluation during multichannel intraluminal impedance and pH: an alternate method to assess esophageal transit.

    abstract:BACKGROUND:Twenty-four-hour multichannel intraluminal impedance and pH (MII-pH) esophageal monitoring allows detection of both acid and nonacid gastroesophageal reflux episodes. The MII-pH catheter contains 6 impedance segments placed 3, 5, 7, 9, 15, and 17 cm above the lower esophageal sphincter (LES), plus a pH elect...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Hila A,Chowdhury N,Hajar N,Castell DO

    更新日期:2011-11-01 00:00:00

  • Ureteropelvic junction obstruction.

    abstract::Physicians sometimes forget nongastrointestinal causes of abdominal pain. Yet, abdominal pain was the major complaint of three patients with ureteropelvic junction obstruction (UPJ). Definitive diagnosis can be made either by a "hydration" intravenous pyelogram or by an intravenous pyelogram during an attack. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Butler ML

    更新日期:1979-12-01 00:00:00

  • Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment.

    abstract::Immunoproliferative small intestinal disease (IPSID) is a rare lympho-proliferative disorder of the upper small intestine. It is considered a special form of MALT lymphoma with propensity to malignant transformation. This disorder is rare in pediatric literature. We report a case of IPSID in a 16-year-old boy with low...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Zamir A,Parasher G,Moukarzel AA,Guarini L,Zeien L,Feldman F

    更新日期:1998-07-01 00:00:00

  • Excluding gastroesophageal reflux disease as the cause of chronic cough.

    abstract::Gastroesophageal reflux disease (GERD) is recognized to be present in 10-20% of cases of chronic cough. Proving that it is the cause of the cough is more difficult. This problem is illustrated by way of a case report demonstrating that GERD can still be the cause, even when the patient is unresponsive to conventional ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论,评审


    authors: Johnston BT,Gideon RM,Castell DO

    更新日期:1996-04-01 00:00:00

  • Atypical familial presentation of FAMMM syndrome with a high incidence of pancreatic cancer: case finding of asymptomatic individuals by EUS surveillance.

    abstract:BACKGROUND:Pancreatic cancer (PC) is one of the leading causes of cancer death in Western countries. An increased risk for PC is known in a number of hereditary tumor syndromes. In selected individuals at high risk of developing PC, surveillance of the pancreas might be able to detect premalignant lesions and early inv...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kluijt I,Cats A,Fockens P,Nio Y,Gouma DJ,Bruno MJ

    更新日期:2009-10-01 00:00:00

  • Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells.

    abstract:AIM:To define whether human colonic mucosa exposure to Lactobacillus rhamnosus GG (LGG), American Type Culture Collection (ATCC) 53103, may influence intestinal muscle cell contractility. METHODS:Human colon specimens were obtained from disease-free margins of resected segments for cancer. The mucosa and submucosa, af...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Guarino MP,Altomare A,Stasi E,Marignani M,Severi C,Alloni R,Dicuonzo G,Morelli L,Coppola R,Cicala M

    更新日期:2008-09-01 00:00:00

  • Aortoesophageal fistula. Review of clinical, radiographic, and endoscopic features.

    abstract::Primary aortoesophageal fistula is a rare cause of severe and often fatal gastrointestinal bleeding. The classic diagnostic triad consists of midthoracic pain and sentinel hemorrhage, followed by fatal exsanguination. A prompt, definitive diagnosis at the time of the initial bleeding episode is essential for timely, l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Khawaja FI,Varindani MK

    更新日期:1987-06-01 00:00:00