Pilot study of the relationship between histologic progression and hepatic iron concentration in chronic hepatitis C.


:Hepatic iron deposition is common in patients with chronic hepatitis C (HCV) and may play a role in progression of liver disease. This pilot study examines the relationship between hepatic iron concentration (HIC) and histologic progression over time in patients with HCV. HIC was retrospectively measured in 14 patients with HCV who had 2 serial liver biopsies prior to the era of interferon therapy. The mean interval between biopsies was 56 +/- 46 months. Mean Knodell score worsened between first and second biopsies (10.0 +/- 2.8 versus 12.4 +/- 3.3; P = 0.007). There was increased portal inflammation (3.2 +/- 0.4 versus 3.6 +/- 0.5; P = 0.028) and fibrosis (1.8 +/- 1.3 versus 2.7 +/- 1.2; P = 0.002), but no significant change in piecemeal necrosis or lobular degeneration. There was no significant change in HIC between first and second biopsy (P = 0.66). However, HIC was noted to increase significantly among patients with cirrhosis on initial biopsy or those who progressed to cirrhosis (P = 0.009). In this pilot study, histologic progression in patients with precirrhotic HCV was not associated with an increase in HIC, whereas hepatic iron accumulation was observed in 3 patients once cirrhosis was present. The interaction between progression of hepatitis C and iron deposition warrants further study.


J Clin Gastroenterol


Larson AM,Taylor SL,Bauermeister D,Rosoff L Jr,Kowdley KV




Has Abstract


2003-11-01 00:00:00












  • Hepatocellular adenoma and nodular regenerative hyperplasia of the liver in a young man.

    abstract::A 26-year-old man had a massive intraabdominal hemorrhage from a hepatocellular adenoma (HCA). The tumor arose within a liver that demonstrated generalized nodular regenerative hyperplasia. The patient had no factors predisposing to either HCA or nodular regenerative hyperplasia (NRH) of the liver. Although rare, HCA ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Nguyen TD,Oakes D,Fogel MR,Williams L,Sherck JP,Kozar M

    更新日期:1986-08-01 00:00:00

  • Diagnostic yield of spiral enteroscopy when performed for the evaluation of abnormal capsule endoscopy findings.

    abstract:BACKGROUND:Spiral enteroscopy (SE) has emerged as a new alternative for deep intubation of the small intestine. SE is most often used to evaluate abnormal findings on capsule endoscopy (CE). OBJECTIVE:Investigate the ability of SE to reproduce abnormal findings detected on preceding CE. DESIGN:Prospective study. SET...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Buscaglia JM,Richards R,Wilkinson MN,Judah JR,Lam Y,Nagula S,Draganov PV

    更新日期:2011-04-01 00:00:00

  • Reversible hepatitis associated with diclofenac.

    abstract::We describe the clinical features, liver histology, and ultrastructure in reversible diclofenac-induced hepatitis and review previous reports of this entity. Although rarely reported, diclofenac hepatitis may be severe, and even fatal. Symptoms, which develop from 1 week to 11 months after starting the drug, include j...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Ouellette GS,Slitzky BE,Gates JA,Lagarde S,West AB

    更新日期:1991-04-01 00:00:00

  • Adjuvant therapy for Helicobacter pylori eradication: role of lansoprazole shown in vitro.

    abstract::The recognition of Helicobacter pylori (H. pylori) as a major cause of gastroduodenal diseases has led to the use of antibiotics to treat these diseases. However, antibiotics used alone are not very effective, and adjuvant therapy is required. The most potent adjuvant therapy consists of increasing the stomach pH with...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Mégraud F

    更新日期:1995-01-01 00:00:00

  • Higher Thioguanine Nucleotide Metabolite Levels are Associated With Better Long-term Outcomes in Patients With Inflammatory Bowel Diseases.

    abstract:GOALS:The aim of this study was to assess whether sustained 6-thioguaninenucleotide (6-TGN) levels were associated with improved long-term outcomes in patients with inflammatory bowel diseases (IBD). BACKGROUND:Cross-sectional data have shown that thiopurine metabolites are correlated with clinical efficacy in patient...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yarur AJ,Gondal B,Hirsch A,Christensen B,Cohen RD,Rubin DT

    更新日期:2018-07-01 00:00:00

  • Rapid development of pancreatitis following reuse of 6-mercaptopurine.

    abstract::A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Cappell MS,Das KM

    更新日期:1989-12-01 00:00:00

  • Celiac plexus block as treatment for refractory pain related to sclerosing cholangitis in AIDS patients.

    abstract::Sclerosing cholangitis may be a cause of refractory pain in patients infected with the human immunodeficiency virus. We performed celiac plexus block in three such patients with sever pain from sclerosing cholangitis and a poor response to conventional analgesia. The pain had been centered in the epigastrium and/or up...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Collazos J,Mayo J,Martínez E,Callejo A,Blanco I

    更新日期:1996-07-01 00:00:00

  • Motility of the transverse colon used for esophageal replacement.

    abstract::The authors studied the motility of transverse colon used for reconstruction of the pharyngogastric transit after esophagectomy. The study included 10 patients who underwent esophagectomy 15 to 201 months (median, 48.5 months) before motility evaluation. Nine patients underwent operation because of caustic injury and ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Dantas RO,Mamede RC

    更新日期:2002-03-01 00:00:00

  • Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain?

    abstract::The goal of every routine endoscopy in the gut is the early diagnosis of malignant and premalignant changes of the mucosa. Chromo- and magnifying endoscopes are exciting new tools and offer detailed analysis of the colonic mucosal surface and pit pattern architecture. This review summarizes recent advances in endoscop...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Kiesslich R,Jung M,DiSario JA,Galle PR,Neurath MF

    更新日期:2004-01-01 00:00:00

  • Leiomyosarcoma of the duodenum recognized preoperatively.

    abstract::We report the preoperative histologic diagnosis of leiomyosarcoma of the duodenum and review the clinical aspects and treatment of this tumor. The endoscopic techniques were critical in obtaining the diagnosis and deciding the treatment plan. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Holst L,Burstein S,Morankar V,Goldberg M

    更新日期:1983-10-01 00:00:00

  • Cannabinoids: A Guide for Use in the World of Gastrointestinal Disease.

    abstract::Cannabinoids have been known as the primary component of cannabis for decades, but the characterization of the endocannabinoid system (ECS) in the 1990s opened the doors for cannabis' use in modern medicine. The 2 main receptors of this system, cannabinoid receptors 1 and 2, are found on cells of various tissues, with...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Unal E,Anderson B,Helber A,Marks JH

    更新日期:2020-10-01 00:00:00

  • Multiple lymphomatous polyposis of the gut.

    abstract::Multiple lymphomatous polyposis is very rare. We report two cases affecting duodenum, small intestine and colon/rectum, both with extensive disease, making radical surgery impossible and chemotherapy the treatment of choice. One patient died 23 days after initial treatment of myocardial infiltration, and the other is ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Norum J,Hovde O,Stalsberg H

    更新日期:1994-09-01 00:00:00

  • Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.

    abstract::Bleeding caused by ectopic varices is an uncommon but important and life-threatening complication of portal hypertension. Spontaneous external hemorrhage from a recanalized umbilical varix is an extremely rare source of ectopic variceal bleeding. We report on the acute presentation of a patient with a bleeding umbilic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Assis DN,Pollak J,Schilsky ML,Emre S

    更新日期:2012-02-01 00:00:00

  • Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections.

    abstract::In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. Aminosalicylates (5-ASAs) are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. Si...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,杂志文章


    authors: Ehrenpreis ED,Kruchko DH

    更新日期:2020-08-01 00:00:00

  • Juvenile chronic pancreatitis--a cause of painless jaundice in a patient with multiple somatic abnormalities.

    abstract::Juvenile chronic pancreatitis presenting with painless obstructive jaundice is extremely rare. Pancreatic disease in association with multiple somatic abnormalities presenting in late childhood is uncommon. We report such a case. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Isaacs JD,Keshavarzian A,Blumgart LH,Hodgson HJ

    更新日期:1985-12-01 00:00:00

  • Long-term symptom patterns, endoscopic findings, and gastric histology in Helicobacter pylori-infected and -uninfected patients.

    abstract::There is a paucity of data on the long-term behavior of dyspepsia, endoscopic findings, and gastroduodenal histology in patients with or without Helicobacter pylori colonization. We evaluated these parameters during a period of 7 to 19 years (average, 12.3 years) by baseline and follow-up studies. In 36 patients studi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: DeLuca VA Jr,West AB,Haque S,Katz DL,Ciarolla D,Goldenberg S,Fette G

    更新日期:1998-03-01 00:00:00

  • Utility of hepatitis C virus RNA levels for predicting the therapeutic efficacy of interferon.

    abstract::We studied the levels of serum hepatitis C virus (HCV)-RNA, the HCV genotype before interferon therapy, and the kinetics of serum HCV-RNA at the initial stages of therapy to determine their utility in predicting the therapeutic efficacy of interferon in 44 patients with chronic hepatitis C infection. We also looked at...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kato J,Komatsu M,Ono T,Ishii T,Hoshino T,Toyoshima I,Chiba M,Masamune O

    更新日期:1997-10-01 00:00:00

  • Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. The objective of this study was to describe the recent trend of health care resource utilization and short-term mortality of Medicare beneficiaries with NAFLD. METHODS:This study utilized data from a ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Younossi ZM,Zheng L,Stepanova M,Henry L,Venkatesan C,Mishra A

    更新日期:2015-03-01 00:00:00

  • Risk factors for sessile serrated adenomas.

    abstract:BACKGROUND:Although sessile serrated adenomas (SSAs) may represent a separate and important pathway for colorectal cancer (CRC), little is known about the risk factors for these lesions. Molecular abnormalities such as BRAF have been observed in SSA and smokers. Our hypothesis is that smoking may be associated with the...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Anderson JC,Rangasamy P,Rustagi T,Myers M,Sanders M,Vaziri H,Wu G,Birk JW,Protiva P

    更新日期:2011-09-01 00:00:00

  • Multiple abscesses of the liver caused by Campylobacter jejuni.

    abstract::A 37-year-old woman developed multiple liver abscesses caused by Campylobacter jejuni, as a consequence of unrecognized and inadequately treated Campylobacter enteritis. The diagnosis was established by isolation of Campylobacter jejuni from blood and pus obtained from one of the liver abscesses during laparoscopy. Th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Brmbolić B

    更新日期:1995-06-01 00:00:00

  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Modified barium swallow does not affect how often PEGs are placed after stroke.

    abstract::Dysphagia frequently follows stroke, but often resolves quickly. Percutaneous endoscopic gastrostomy (PEG) or other feeding tubes are placed to improve nutrition and hydration, and reduce the risk of aspiration pneumonitis. We evaluated the impact of modified barium swallow in determining PEG placements and the influe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Akpunonu BE,Mutgi AB,Roberts C,Khuder SA,Federman DJ,Lee L

    更新日期:1997-03-01 00:00:00

  • Acute renal dysfunction in salmonella gastroenteritis.

    abstract:GOALS:To determine the incidence of renal function deterioration in adult patients with Salmonella infection. BACKGROUND:Renal impairment has been described during severe Salmonella infection and is mainly due to shock, dehydration, or rhabdomyolysis. However, it is unclear whether less severe Salmonella infection als...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Janssen van Doorn K,Pierard D,Spapen H

    更新日期:2006-11-01 00:00:00

  • Younger hepatocellular carcinoma patients have better prognosis after percutaneous radiofrequency ablation therapy.

    abstract:GOALS:To evaluate the impact of age on the prognosis of patients with hepatocellular carcinoma (HCC) undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND:Whether age plays an important role in the outcomes of HCC after RFA remains controversial. STUDY:Two hundred fifty-eight consecutive treatment naive H...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kao WY,Chiou YY,Hung HH,Su CW,Chou YH,Huo TI,Huang YH,Wu WC,Lin HC,Lee SD,Wu JC

    更新日期:2012-01-01 00:00:00

  • Cyclic vomiting associated with excessive dopamine in Riley-day syndrome.

    abstract:GOALS:To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome. BACKGROUND:One of the most disabling features of patients with Riley-day syndrome are recurrent attacks of severe nausea/retching/vomiting accompanied by hypertension, tachycardia, and sk...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Norcliffe-Kaufmann LJ,Axelrod FB,Kaufmann H

    更新日期:2013-02-01 00:00:00

  • Hydrogen peroxide colitis: a report of three patients.

    abstract::We have seen three patients with acute ulcerative colitis after hydrogen peroxide enemas. The colitis is probably the result of the explosive entrance of gas into the loose connective tissues of the mucosa and submucosa of the rectum and sigmoid. Fortunately, it is transitory in nature, but it should be distinguished ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Meyer CT,Brand M,DeLuca VA,Spiro HM

    更新日期:1981-03-01 00:00:00

  • Androgenic/Anabolic steroid-induced toxic hepatitis.

    abstract::Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice in just a small number of recipients. We present a 26-year-old male bodybuilder who self-administered high doses of androgenic/anabolic steroids that induced liver damage. One mont...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Stimac D,Milić S,Dintinjana RD,Kovac D,Ristić S

    更新日期:2002-10-01 00:00:00

  • Calcitonin gene-related peptide in hepatorenal syndrome. A possible mediator of peripheral vasodilation?

    abstract::In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gupta S,Morgan TR,Gordan GS

    更新日期:1992-03-01 00:00:00

  • Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine.

    abstract::We examined the effects of lansoprazole and famotidine on gastric basic fibroblast growth factor (bFGF) levels and ulcer healing in patients with gastric ulcer. Sixteen patients with active gastric ulcer were divided into two groups and received treatment with lansoprazole 30 mg/day or famotidine 40 mg/day. They were ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tsuji S,Kawano S,Higashi T,Mukuda T,Imaizumi T,Tatsumi T,Miura N,Miyajima K,Fukuda M,Noguchi M

    更新日期:1995-01-01 00:00:00

  • Genetic Variations at rs3129891 and rs77005575 are Associated With Reduced Expression of Enteric α-defensins in IBD Patients.

    abstract:BACKGROUND AND AIMS:Human enteric antimicrobial peptides composed predominantly of human enteric α-defensins (HD5 and HD6) are important in the mucosal antimicrobial barrier. Previous studies have identified that genetic variations at rs2066844, rs2066845, rs2066847 are associated with diminished enteric α-defensins in...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Deng Q,Tan G,Deng F,Zhi F

    更新日期:2020-07-01 00:00:00