Appendectomy and tonsillectomy in patients with inflammatory bowel disease.


:Recent reports of reduced appendectomy rates in patients with ulcerative colitis have not distinguished between primary appendectomy (surgery for appendicitis) and incidental appendectomy (removal of the appendix for other reasons). In the present case control study, we examined the frequency of primary appendectomy in subjects with ulcerative colitis (n = 197) and Crohn's disease (n = 117) compared to a control group of dermatology outpatients (n = 243). A reduced rate of primary appendectomy was found in the ulcerative colitis group (adjusted odds ratio 0.20, 95% confidence intervals 0.070-0.53, p < 0.0005) but not in the Crohn's disease patients (adjusted odds ratio 0.93, 95% confidence intervals 0.39-2.18, p = NS). These data suggest that appendicitis occurs less commonly than would be expected in individuals who develop ulcerative colitis. Environmental or immunoregulatory factors may be responsible. Tonsillectomy rates were also examined in each study group, but no overall differences were found between patients with inflammatory bowel disease and controls.


J Clin Gastroenterol


Smithson JE,Radford-Smith G,Jewell GP




Has Abstract


1995-12-01 00:00:00












  • Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease.

    abstract:BACKGROUND/AIMS:The aim of this exploratory trial was to establish if the probiotic Bifidobacterium natren life start (NLS) strain strain may affect the clinical course and pathophysiological features of patients with untreated celiac disease (CD). Positive findings would be helpful in directing future studies. METHOD...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Smecuol E,Hwang HJ,Sugai E,Corso L,Cherñavsky AC,Bellavite FP,González A,Vodánovich F,Moreno ML,Vázquez H,Lozano G,Niveloni S,Mazure R,Meddings J,Mauriño E,Bai JC

    更新日期:2013-02-01 00:00:00

  • Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. The objective of this study was to describe the recent trend of health care resource utilization and short-term mortality of Medicare beneficiaries with NAFLD. METHODS:This study utilized data from a ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Younossi ZM,Zheng L,Stepanova M,Henry L,Venkatesan C,Mishra A

    更新日期:2015-03-01 00:00:00

  • Drug therapy for peptic ulcer: drugs that act on the gastric mucosa.

    abstract::Antacids, cimetidine, carbenoxolone, colloidal bismuth, and prostaglandins promote healing of gastric and duodenal ulcer at a rate nearly twice that of healing during placebo administration. These short-term, 4-12 week healing rates are nearly the same for each agent, with a 65 to 85% range. Drugs that appear to produ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kauffman GL Jr

    更新日期:1981-01-01 00:00:00

  • Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model.

    abstract:BACKGROUND AND AIM:Intestinal fatty acid-binding protein (I-FABP) is a useful marker in the detection of intestinal ischemia. However, more insight into the test characteristics of I-FABP release is needed. This study aimed to investigate the relationship between plasma I-FABP levels and the severity of ischemic mucosa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Schellekens DH,Grootjans J,Dello SA,van Bijnen AA,van Dam RM,Dejong CH,Derikx JP,Buurman WA

    更新日期:2014-03-01 00:00:00

  • Massive vitamin A intoxication with ascites and pleural effusion.

    abstract::Vitamin A intoxication was diagnosed in a 14-year-old girl who presented with massive exudative ascites and right pleural effusion, impaired liver enzymes, and hypertriglyceridemia. Electron microscopy of liver biopsy material demonstrated numerous perisinusoidal lipid-filled Ito cells. The patient had taken 100-200,0...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Noseda A,Adler M,Ketelbant P,Baran D,Winand J

    更新日期:1985-08-01 00:00:00

  • Distinct clinicopathologic characteristics of diffuse- and intestinal-type gastric cancer in Taiwan.

    abstract::The clinicopathologic features of 221 patients with intestinal-type (IT) gastric cancer were compared retrospectively with those of 290 diffuse type (DT). Intestinal type was characterized by an older mean age (65.0 +/- 10.8 years vs. 56.2 +/- 13 years), a higher male-female ratio (2.56 vs. 1.06), predominance of bloo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Wu MS,Yang KC,Shun CT,Hsiao TJ,Lin CC,Wang HP,Chuang SM,Lee WJ,Lin JT

    更新日期:1997-12-01 00:00:00

  • Helicobacter pylori infection rate decreases in symptomatic children: a retrospective analysis of 13 years (1993-2005) from a gastroenterology clinic in West Virginia.

    abstract:BACKGROUND:The rate of Helicobacter pylori is decreasing in the developed countries, but few long-term studies are available from the United States. We retrospectively assessed the annual H. pylori infection rate in symptomatic children seen in our clinic over a 13-year study period. STUDY:A retrospective analysis of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Elitsur Y,Dementieva Y,Rewalt M,Lawrence Z

    更新日期:2009-02-01 00:00:00

  • Adult celiac disease (celiac sprue), pernicious anemia and IgA deficiency. Case report and review of the relationships between vitamin B12 deficiency, small intestinal mucosal disease and immunoglobulin deficiency.

    abstract::A 24-year-old man with addisonian pernicious anemia, adult celiac disease and selective IgA deficiency is presented to emphasize the differential diagnosis of vitamin B12 deficient megaloblastic anemia in association with small intestinal mucosal abnormalities and the relationships between immunoglobulin deficiency, p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Quigley EM,Carmichael HA,Watkinson G

    更新日期:1986-06-01 00:00:00

  • Spontaneous reactivation in chronic hepatitis B: patterns and natural history.

    abstract::We identified spontaneous reactivation of hepatitis B virus (HBV) retrospectively by utilizing serum alanine aminotransferase and HBV DNA in 19 men (79% homosexual), with an estimated annual incidence of 7.3%. In 11 patients, spontaneous reactivation occurred as a single episode and in eight patients, reactivation was...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gupta S,Govindarajan S,Fong TL,Redeker AG

    更新日期:1990-10-01 00:00:00

  • Chronic pancreatitis: pathogenesis and management of pain.

    abstract::Abdominal pain, excruciating and recurrent, is the dominant feature of chronic pancreatitis that initially brings most of the patients to the physician's attention. The pathogenesis of pancreatic pain is often multifactorial and explains why not all patients respond to the same mode of therapy. Increased intraductal p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Pitchumoni CS

    更新日期:1998-09-01 00:00:00

  • Peritoneal mesothelioma in recurrent familial peritonitis.

    abstract::A 39-year-old man had a 2-year history of fatigue, weight loss, drug-resistant ascites, and decreased intestinal motility. During adolescence he began to suffer frequent episodes of acute benign peritonitis that spontaneously subsided at age 35. The fact that his younger brother was taking colchicine for the same symp...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Gentiloni N,Febbraro S,Barone C,Lemmo G,Neri G,Zannoni G,Capelli A,Gasbarrini G

    更新日期:1997-06-01 00:00:00

  • The gut barrier: new acquisitions and therapeutic approaches.

    abstract::The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows nutrient absorption and second, it defends the body from dangerous macromolecule penetration. It is a complex multilayer system, consisting of an external "anatomic" barrier and an inner "functional" immunological b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Scaldaferri F,Pizzoferrato M,Gerardi V,Lopetuso L,Gasbarrini A

    更新日期:2012-10-01 00:00:00

  • Is smoking still important in the pathogenesis of peptic ulcer disease?

    abstract::The pathogenesis of peptic ulcer disease is multifactorial, including the effects of Helicobacter pylori, gastric acid, pepsin, gastroduodenal motility, smoking and nicotine, and the complex interaction of an array of other so-called aggressive and protective factors. Since the discovery and acceptance of H. pylori as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Eastwood GL

    更新日期:1997-01-01 00:00:00

  • Alcohol consumption is inversely correlated with insulin resistance, independent of metabolic syndrome factors and fatty liver diseases.

    abstract:BACKGROUND AND AIM:The role of alcohol consumption in insulin resistance remains unclear. The aim of this study was to examine the association between alcohol consumption and insulin resistance in a large asymptomatic population. METHODS:A total of 2463 asymptomatic Japanese men aged 28 years or above undergoing a com...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gunji T,Matsuhashi N,Sato H,Iijima K,Fujibayashi K,Okumura M,Sasabe N,Urabe A

    更新日期:2011-10-01 00:00:00

  • HCV hepatitis associated with anticardiolipin antibody and a cerebrovascular accident. Response to interferon therapy.

    abstract::A 54-year-old man with chronic hepatitis C virus (HCV) developed quadrihemianopsia caused by lacunar brain infarction. Extensive evaluation revealed high titers of anticardiolipin antibodies (ACA). Following interferon treatment (6 x 10(6), three times a week for 2 months and 3 x 10(6) for another 7 months), liver tra...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Malnick SD,Abend Y,Evron E,Sthoeger ZM

    更新日期:1997-01-01 00:00:00

  • Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease.

    abstract:GOAL:The goal of this study is to determine factors associated with performance of duodenal biopsy during upper endoscopy. BACKGROUND:Celiac disease (CD) prevalence approaches 1% in the United States and Europe, yet CD remains underdiagnosed, in part because of low rates of duodenal biopsy during upper endoscopy. We a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pitman M,Sanders DS,Green PHR,Lebwohl B

    更新日期:2019-02-01 00:00:00

  • Utility of hepatitis C virus RNA levels for predicting the therapeutic efficacy of interferon.

    abstract::We studied the levels of serum hepatitis C virus (HCV)-RNA, the HCV genotype before interferon therapy, and the kinetics of serum HCV-RNA at the initial stages of therapy to determine their utility in predicting the therapeutic efficacy of interferon in 44 patients with chronic hepatitis C infection. We also looked at...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kato J,Komatsu M,Ono T,Ishii T,Hoshino T,Toyoshima I,Chiba M,Masamune O

    更新日期:1997-10-01 00:00:00

  • Dysphagia and esophageal motor dysfunction in gastroesophageal reflux are corrected by fundoplication.

    abstract::Abnormalities in esophageal peristaltic function and acid clearance appear to be responsible for prolonged esophageal acid exposure, a major determinant of the reflux esophagitis and esophageal stricture. We evaluated esophageal motility by manometry in 50 healthy controls and in 35 symptomatic reflux patients before,...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Grande L,Lacima G,Ros E,Pujol A,Garcia-Valdecasas JC,Fuster J,Visa J,Pera C

    更新日期:1991-02-01 00:00:00

  • Diagnostic workup strategies for patients with HIV-related chronic diarrhea. What is the end result?

    abstract::The intensity of diagnostic workup of patients with human immunodeficiency virus (HIV)-related chronic diarrhea is controversial. In the ideal setting in which an enteric pathogen is detected with minimal evaluation (stool tests) and in which specific treatment clears the diarrhea, eradicates the pathogen, and improve...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Rabeneck L

    更新日期:1993-04-01 00:00:00

  • Cyclic vomiting associated with excessive dopamine in Riley-day syndrome.

    abstract:GOALS:To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome. BACKGROUND:One of the most disabling features of patients with Riley-day syndrome are recurrent attacks of severe nausea/retching/vomiting accompanied by hypertension, tachycardia, and sk...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Norcliffe-Kaufmann LJ,Axelrod FB,Kaufmann H

    更新日期:2013-02-01 00:00:00

  • A twenty-year experience with endoscopic therapy for symptomatic primary sclerosing cholangitis.

    abstract:GOALS:The current study presents 1 tertiary endoscopy center's 20-year experience using endoscopic therapy to treat patients with symptomatic primary sclerosing cholangitis (PSC). BACKGROUND:Endoscopic therapy for patients with PSC and dominant strictures has been used for more than 20 years, but there is concern that...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gluck M,Cantone NR,Brandabur JJ,Patterson DJ,Bredfeldt JE,Kozarek RA

    更新日期:2008-10-01 00:00:00

  • A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis.

    abstract:BACKGROUND:Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis. GOALS:To identify low-risk patients who can be spared upper endoscopy irrespective of a diagnosis of cirrhosis. STUDY:We evaluated 13 nonendosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gentile I,Viola C,Graf M,Liuzzi R,Quarto M,Cerini R,Piazza M,Borgia G

    更新日期:2009-01-01 00:00:00

  • Glycosphingolipid composition of the gastric mucosa. A role of sulfatides in gastrointestinal mucosal defense?

    abstract::The glycosphingolipid (GSL) compositions of the human, rabbit, and rat gastric mucosa were studied and compared. In neutral GSLs, although GalCer was the most abundant component in every tissue examined, species-specific differences were clearly observed in their composition. Acidic GSLs were composed of sulfatides an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Natomi H,Sugano K,Takaku F,Iwamori M

    更新日期:1990-01-01 00:00:00

  • Postpartum Laboratory Follow-up in Women With Hepatitis B in Massachusetts From 2007 to 2012.

    abstract:GOALS:To determine postpartum hepatitis B virus (HBV) laboratory testing rates and identify factors associated with a lack of follow-up testing in Massachusetts. BACKGROUND:Screening for HBV infection in pregnant women is standard of care. Guidelines recommend that patients with chronic HBV have ongoing care and labor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Chang MS,Barton K,Crockett M,Tuomala RE,Rutherford AE,Mutinga ML,Andersson KL,Brown RS Jr,Oken E,Ukomadu C

    更新日期:2016-07-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • Erythrocyte sedimentation as a measure of Crohn's disease activity: opposite trends in ileitis versus colitis.

    abstract::To test our hypothesis that the erythrocytic sedimentation rate (ESR) correlates well with clinical activity in inflammatory disease of the colon, but not of the small bowel, we stratified 49 Crohn's disease patients according to their anatomic involvement and then measured the correlations between ESR and clinical ac...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sachar DB,Luppescu NE,Bodian C,Shlien RD,Fabry TL,Gumaste VV

    更新日期:1990-12-01 00:00:00

  • Eleven-year survey of safety and efficacy of endoscopic injection sclerotherapy using 2% sodium tetradecyl sulfate and contrast medium.

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Iwase H,Suga S,Shimada M,Yamada H,Horiuchi Y,Oohashi M

    更新日期:1996-01-01 00:00:00

  • Mucosal healing in inflammatory bowel disease.

    abstract::It is becoming increasingly recognized that purely clinical endpoints may not be sufficient in the treatment of patients with inflammatory bowel disease. As such, mucosal disease assessment has become a prominent component of the majority of recent clinical trials in Crohn's disease and ulcerative colitis. There is mo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Osterman MT

    更新日期:2013-03-01 00:00:00

  • Older Patients With Hepatocellular Carcinoma Have More Advanced Disease, Lower Rates of Treatment, and Lower Survival.

    abstract:GOALS:To evaluate age-specific disparities in cancer stage at diagnosis, receipt of treatment, and survival among adults with hepatocellular carcinoma (HCC). BACKGROUND:HCC has become the fastest rising cause of cancer-related deaths in the United States. The aging population coupled with the rising incidence of HCC w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yan M,Ha J,Aguilar M,Liu B,Frenette CT,Bhuket T,Wong RJ

    更新日期:2017-04-01 00:00:00

  • Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition.

    abstract:GOALS:To describe the epidemiology and microbiologic characteristics of bloodstream infections (BSIs) in patients receiving long-term total parenteral nutrition (TPN). BACKGROUND:Home TPN therapy has been reported as a risk factor for BSI. However, little knowledge exists regarding the epidemiology of BSIs in this pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Marra AR,Opilla M,Edmond MB,Kirby DF

    更新日期:2007-01-01 00:00:00