Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats.

Abstract:

:This study was designed to clarify the role of leukotrienes (LTs) in gastric injury induced by ischemia-reperfusion in rats. Gastric lesions were produced by clamping of the celiac artery and by reoxygenation following clamping. Administration of AA-861, a lipoxygenase inhibitor, significantly inhibited the increase in the total area of the gastric erosions and the increase in thiobarbituric acid-reactive substances in the gastric mucosa. Administration of YM-638, a peptide LT antagonist, showed protective effects similar to AA-861. These results suggest that the protective effects of AA-861 and YM-638 against ischemia-reperfusion-induced gastric injury were due to their antioxidative action.

journal_name

J Clin Gastroenterol

authors

Yoshikawa T,Ichikawa H,Naito Y,Kondo M

doi

10.1097/00004836-199206001-00012

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

S68-70

eissn

0192-0790

issn

1539-2031

journal_volume

14 Suppl 1

pub_type

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