Urease-based tests for Helicobacter pylori gastritis. Accurate for diagnosis but poor correlation with disease severity.


:To determine whether the urease-based CLOtest or low-dose 14C urea breath test can predict severity of gastritis or the presence of peptic ulcers, we studied 84 patients presenting for upper endoscopy. Antral biopsies were obtained for histologic analysis and CLOtesting, and urea breath testing was performed. The time to a positive CLOtest and the breath test peak values were correlated with endoscopic findings, severity of gastritis, and bacterial burden. Twenty-four patients had positive urea breath test results (22 with positive CLOtests). Patients with positive breath test results were more likely to have duodenal ulcers, higher grades of gastritis, and increased bacterial burden (p < 0.01 for all comparisons). Correlation between the time to a positive CLOtest or peak breath test values and gastritis severity or bacterial burden was poor (p > 0.05 for all comparisons). In patients with positive tests, no difference was observed between the time to a positive CLOtest or peak breath test value in patients with or without peptic ulcers (p < 0.2 for all comparisons). The low-dose 14C urea breath test and the CLOtest are both accurate for Helicobacter pylori diagnosis. However, neither test predicts the severity of the gastritis, the degree of bacterial burden, or the presence of peptic ulcers.


J Clin Gastroenterol


Lewis JD,Kroser J,Bevan J,Furth EE,Metz DC




Has Abstract


1997-09-01 00:00:00












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    abstract:BACKGROUND:Women with irritable bowel syndrome (IBS) frequently report chronic pelvic pain, however, it is still unanswered whether these are truly separate entities. IBS negatively impacts on quality of life, but the impact of IBS on sexual function is not clear. GOALS:We aimed to (1) describe the impact of IBS on se...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Choung RS,Herrick LM,Locke GR 3rd,Zinsmeister AR,Talley NJ

    更新日期:2010-11-01 00:00:00

  • Acute pancreatitis in childhood: analysis of literature data.

    abstract:GOALS:To review the published experience with acute pancreatitis in childhood. STUDY:Computerized search of the English medical literature since 1965 using MEDLINE. RESULTS:Details of 589 patients were reviewed. Mean age was 9.2 +/- 2.4 years (range: 1 week to 21 years). Male to female ratio was 1.2. Etiologies inclu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Benifla M,Weizman Z

    更新日期:2003-08-01 00:00:00

  • Nonspecific ulcerative colitis as a sequel to amebic dysentery.

    abstract::In two patients, treatment of amebic dysentery was followed (despite the disappearance of the infecting organism) by an illness with the clinical, pathological, and radiological characteristics of nonspecific ulcerative colitis. Their case histories indicate that in addition to persistent or recurrent amebic infection...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Rampton DS,Salmon PR,Clark CG

    更新日期:1983-06-01 00:00:00

  • Effectiveness of cisapride in gastric ulcer. Results of a double-blind randomized trial versus ranitidine and versus cisapride plus ranitidine.

    abstract::Among the factors involved in the pathogenesis of gastric ulcer, the reduced clearing capacity of the stomach seems to play an important role. On this basis, cisapride, which improves gastrointestinal motility, enhances gastric emptying, and prevents duodenogastric reflux, may be effective in the treatment of the gast...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Testoni PA,Bagnolo F,Buizza M,Masci E,Toti GL,Spinelli A,Manzi G

    更新日期:1993-07-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Meyers S,Lerer PK,Feuer EJ,Johnson JW,Janowitz HD

    更新日期:1987-02-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kohli Y,Takeda S,Kawai K

    更新日期:1981-03-01 00:00:00

  • Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model.

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    pub_type: 杂志文章


    authors: Schellekens DH,Grootjans J,Dello SA,van Bijnen AA,van Dam RM,Dejong CH,Derikx JP,Buurman WA

    更新日期:2014-03-01 00:00:00

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    abstract::Helicobacter pylori has been implicated in the pathogenesis of a number of digestive tract disorders, such as chronic active gastritis, peptic ulceration, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. Disease outcome is dependent on many factors, including bacterial genotype, host physiology and gene...

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    更新日期:2007-07-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2003-03-01 00:00:00

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    authors: Chen EY,Lee WM,Hynan LS,Singal AG

    更新日期:2013-10-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    更新日期:2000-09-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 社论,评审


    authors: Johnston BT,Gideon RM,Castell DO

    更新日期:1996-04-01 00:00:00

  • Impaired plasma cyclic AMP response to exogenous glucagon in acute liver injury.

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    authors: Miyakoshi H,Noda Y,Uchida S,Tanaka N,Noto Y,Kato Y,Kawai K,Hayakawa H,Kobayashi K,Hattori N

    更新日期:1984-08-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Meyer CT,Brand M,DeLuca VA,Spiro HM

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    journal_title:Journal of clinical gastroenterology

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    authors: Freiman JS,Gallagher ND

    更新日期:1985-10-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    authors: Weiss AA,Yoshida EM,Poulin M,Gascoyne RD,Owen DA

    更新日期:1997-07-01 00:00:00

  • Follow-up care after a diagnosis of Helicobacter pylori infection in an Asian immigrant cohort.

    abstract:GOAL:To study the rate at which Helicobacter pylori infection is treated in an immigrant cohort after diagnosis by esophagogastroduodenoscopy (EGD). BACKGROUND:Gastric cancer is the second leading cause of cancer death worldwide, and is especially prevalent in East Asia; immigrants from this part of the world remain a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


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    更新日期:2006-01-01 00:00:00

  • Hepatitis C virus seroconversion and genotype prevalence in patients and staff on chronic hemodialysis.

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Zamir D,Storch S,Zonder HB,Zamir C,Weiner P

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    journal_title:Journal of clinical gastroenterology

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Fuccio L,Guido A,Eusebi LH,Laterza L,Grilli D,Cennamo V,Ceroni L,Barbieri E,Bazzoli F

    更新日期:2009-07-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    authors: Zucker GM,Otis C,Korowski K,Navab F

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  • Predictors of Mortality in Cirrhosis Inpatients With Clostridium difficile Infection.

    abstract:BACKGROUND:Clostridium difficile is a bacterial pathogen associated with significant morbidity and mortality in patients with cirrhosis. GOALS:Our primary aim is to identify variables that are predictive of poor outcomes in cirrhosis patients with C. difficile infection (CDI). We also aim to further characterize the r...

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    authors: Di Stefano M,Miceli E,Armellini E,Missanelli A,Corazza GR

    更新日期:2004-07-01 00:00:00

  • Costs and risks in the management of patients with gastric acid hypersecretion.

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    authors: Hirschowitz BI,Fineberg N,Wilcox CM,Mohnen J,Worthington J

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    journal_title:Journal of clinical gastroenterology

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    journal_title:Journal of clinical gastroenterology

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    authors: Fabisiak N,Fabisiak A,Watala C,Fichna J

    更新日期:2017-11-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Szabo S

    更新日期:1991-01-01 00:00:00

  • Co-occurrence of hepatocellular carcinoma and lymphoma in patients with hepatitis C virus cirrhosis.

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Shapira MY,Muszkat M,Braunstein I,Gotsman I

    更新日期:2001-04-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Hollander D,Tarnawski A

    更新日期:1991-01-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sillero JM,Calvet X,Musulen E,Diaz-Ruiz MJ,Tolosa C,Pardo A,Corcuera A,Malet A,Font J

    更新日期:2001-03-01 00:00:00