Abstract：
GOAL:The goal of this study was to investigate the relationship between Helicobacter pylori (H. pylori) infection and short-segment and long-segment Barrett's esophagus (SSBE and LSBE). BACKGROUND:H. pylori infection is reported to be inversely associated with Barrett's esophagus (BE) in western countries. However, the impact of BE segment length on the association between BE and H. pylori infection has scarcely been investigated. MATERIALS AND METHODS:The study subjects were 41,065 asymptomatic Japanese individuals who took medical surveys between October 2010 and September 2017. Using this large database of healthy Japanese subjects, we investigated the association between H. pylori infection and SSBE/LSBE. We used multivariable logistic regression analysis to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS:Among the study subjects, 36,615 were eligible for the analysis. H. pylori seropositivity was significantly associated with a lower rate of LSBE (OR: 0.42; 95% CI: 0.16-0.91) and a higher rate of SSBE (OR: 1.66; 95% CI: 1.56-1.78) after multivariate adjustment. In the subgroup analysis, H. pylori seropositivity was significantly associated with a high rate of SSBE in subjects without reflux esophagitis (RE) (OR: 1.73; 95% CI: 1.61-1.85). However, H. pylori seropositivity was not associated with SSBE in subjects with RE (OR: 1.07; 95% CI: 0.84-1.37). CONCLUSION:In a Japanese population, H. pylori infection was inversely associated with LSBE but significantly associated with SSBE only in subjects without RE. H. pylori may be a risk factor for SSBE, especially in individuals without RE.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Usui G,Sato H,Shinozaki T,Jinno T,Fujibayashi K,Ishii K,Horiuchi H,Morikawa T,Gunji T,Matsuhashi Ndoi
10.1097/MCG.0000000000001264subject
Has Abstractpub_date
2020-05-01 00:00:00pages
439-444issue
5eissn
0192-0790issn
1539-2031journal_volume
54pub_type
杂志文章abstract：BACKGROUND:Twenty-four-hour multichannel intraluminal impedance and pH (MII-pH) esophageal monitoring allows detection of both acid and nonacid gastroesophageal reflux episodes. The MII-pH catheter contains 6 impedance segments placed 3, 5, 7, 9, 15, and 17 cm above the lower esophageal sphincter (LES), plus a pH elect...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0b013e31822a2c61
更新日期：2011-11-01 00:00:00
abstract：:Pyogenic abscesses of the liver occur in association with a variety of diseases. Sometimes they are caused by anaerobic infections of liver metastases. Uncommonly, however, multiple hepatic abscesses caused by anaerobic bacteria are the presenting signs of unsuspected colonic cancer in the absence of liver metastases....
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-199206000-00013
更新日期：1992-06-01 00:00:00
abstract：GOALS:Our objective was to determine whether high serologic IgA tissue transglutaminase antibodies (TTGA) are exclusively associated with celiac disease (CD). BACKGROUND:IgA TTGA are found in the serum of most individuals with CD. This serologic marker is used to screen individuals with suspected CD for duodenal biops...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1097/MCG.0b013e31802e70b1
更新日期：2008-03-01 00:00:00
abstract：:The direct effects of exogenous and endogenous prostaglandins (PGs) on damage to isolated gastric cells caused by ethanol were assessed in rats. 16,16-Dimethyl-PGE2 (dmPGE2) significantly inhibited cellular damage caused by 15% ethanol in three fractions rich in surface epithelial cells, rich in parietal cells, and ri...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-198812001-00007
更新日期：1988-01-01 00:00:00
abstract：:Crohn's disease can be accompanied by extraintestinal manifestations. The authors report on a 39-year-old patient who presented with cheilitis granulomatosa as the first manifestation of Crohn's disease. Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from op...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-200205000-00016
更新日期：2002-05-01 00:00:00
abstract：:The term indeterminate colitis (IC) is an interim, or preliminary, descriptive term used by pathologists for cases of inflammatory bowel disease (IBD) in which a definite diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) cannot be established based on the information available at the time of surgical sign-o...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/01.mcg.0000127686.69276.5b
更新日期：2004-05-01 00:00:00
abstract：:In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with a...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-199203000-00010
更新日期：1992-03-01 00:00:00
abstract：:A randomized, multicenter, double-blind, placebo-controlled study was conducted to determine whether ranitidine 150 mg b.i.d. for 6 weeks would expedite endoscopic healing or relief of symptoms in patients with benign gastric ulcer. Of 203 patients enrolled, 101 received ranitidine and 102 received placebo. Endoscopic...
journal_title：Journal of clinical gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004836-198606002-00008
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Inactive and active phases of hepatitis B e antigen-negative chronic hepatitis B virus (HBV) infection are diagnosed by serum HBV DNA levels, with cutoff at 2000 IU/mL. However, it is difficult to distinguish inactive carriers at a single time point because HBV DNA levels can transiently decrease to <2000 IU...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0b013e3182a4711d
更新日期：2014-02-01 00:00:00
abstract：:Food sensitivities are constantly increasing in "westernized" countries and may pose serious health risks to sensitized individuals. Severe allergy episodes have also been reported after the intake of probiotic products containing milk protein residues, especially in children. The need for safe and effective probiotic...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章,评审
doi：10.1097/MCG.0b013e31818063ed
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Ultrasound-guided percutaneous acetic acid injection (PAI) therapy is effective for hepatocellular carcinoma (HCC). Posttreatment fever (>37.5 degrees C) may occur owing to acetic acid-induced tumor necrosis, but its incidence and clinical significance are not clear. METHODS:A total of 402 treatment session...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-200608000-00017
更新日期：2006-08-01 00:00:00
abstract：:A spontaneous intramural esophagogastric hematoma developed in a patient with hemophilia A. The hematoma did not resolve after antihemophiliac factor replacement but ruptured into the stomach causing massive gastrointestinal bleeding. The associated enlarged right tracheobronchial gland and the histopathological findi...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-199203000-00017
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:Clostridium difficile is a bacterial pathogen associated with significant morbidity and mortality in patients with cirrhosis. GOALS:Our primary aim is to identify variables that are predictive of poor outcomes in cirrhosis patients with C. difficile infection (CDI). We also aim to further characterize the r...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0000000000000868
更新日期：2018-09-01 00:00:00
abstract：:Helicobacter pylori antibody testing is accurate for diagnosing untreated patients. Rapid serum testing is as accurate as formal enzyme-linked immunosorbent assay (ELISA) testing. As whole blood fingerstick tests may become the diagnostic method of choice if they are of similar accuracy, 51 patients were studied who h...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-199807000-00010
更新日期：1998-07-01 00:00:00
abstract：:The main issue regarding the approach to the patient with uninvestigated dyspepsia is whether the symptoms are the result of an important clinical illness, which then determines the appropriate management strategy for the treatment of the symptoms. An initial trial of empiric antisecretory drugs is recommended for tho...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章,评审
doi：10.1097/MCG.0b013e3181c64c69
更新日期：2010-03-01 00:00:00
abstract：:Sucralfate binds to duodenal and gastric ulcers and to gastric erosions produced by ethanol and anti-inflammatory drugs. The affinity of sucralfate for defective mucosa is explained by the drug's viscous adhesiveness and the formation of polyvalent bridges between the negatively charged sucralfate polyanions and posit...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Colorectal cancer (CRC), gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), and nonalcoholic fatty liver disease are considered important emerging diseases in the Asia Pacific (AP) region. The incidence rate of CRC is the highest among gastrointestinal cancers in the region surpassing that of ga...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章,评审
doi：10.1097/MCG.0000000000000847
更新日期：2017-07-01 00:00:00
abstract：:To determine whether the urease-based CLOtest or low-dose 14C urea breath test can predict severity of gastritis or the presence of peptic ulcers, we studied 84 patients presenting for upper endoscopy. Antral biopsies were obtained for histologic analysis and CLOtesting, and urea breath testing was performed. The time...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-199709000-00003
更新日期：1997-09-01 00:00:00
abstract：:This is the first report in the American literature of a recently described histologic variant of primary sclerosing cholangitis (PSC). Only six examples of this unique entity, called cholangitis glandularis proliferans (CGP), or proliferative cholangitis, have previously been reported. This disorder typically present...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：GOALS:To evaluate the impact of age on the prognosis of patients with hepatocellular carcinoma (HCC) undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND:Whether age plays an important role in the outcomes of HCC after RFA remains controversial. STUDY:Two hundred fifty-eight consecutive treatment naive H...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0b013e31822b36cc
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Whether body position affects lower esophageal sphincter (LES) function and detection of hiatal hernia is unknown. Moreover, the yield of high-resolution esophageal pressure topography (HREPT) when compared with endoscopy for detection of hiatal hernia is unclear. AIM:The aims of this study were to examin...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0000000000000057
更新日期：2014-03-01 00:00:00
abstract：:A 64-year-old man developed diffuse gastrointestinal polyposis, protein-losing enteropathy, skin pigmentation, hair loss, and unique nail changes. He also exhibited pulmonary tuberculosis and impaired immunity with skin anergy, poor lymphocyte mitogens stimulation test, and low serum immunoglobulin. We discuss the rel...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-198710000-00018
更新日期：1987-10-01 00:00:00
abstract：:The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD). Considering the heterogenous results of probiotics in clinical studies, the model of ...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0000000000000698
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The metabolic fates of copper and iron are closely linked through ceruloplasmin and hephaestin. Ceruloplasmin is the principal copper carrying protein and decreases in acquired copper deficiency. Congenital absence of ceruloplasmin (aceruloplasminemia) results in tissue iron overload. Animal studies suggest ...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0b013e3181dc25f7
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Current methods to diagnose malignant biliary strictures are of low sensitivity. Confocal endomicroscopy is a new approach that may improve the diagnosis of indeterminate biliary strictures. The purpose of this study was to evaluate indeterminate biliary strictures using probe-based confocal laser e...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0b013e3181fbdc38
更新日期：2011-03-01 00:00:00
abstract：:A 37-year-old man had fever, weight loss, malaise, right upper quadrant pain, lymphadenopathy, and a twofold elevation of serum alkaline phosphatase, transaminases, and gamma glutamyl transpeptidase. Granulomas were found on liver biopsy after 2 1/2 months of illness. Treatment with isoniazid and rifampin for 2 months...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-198906000-00021
更新日期：1989-06-01 00:00:00
abstract：:Ranitidine and cimetidine are competitive antagonists of histamine at H2-receptor sites in the gastric mucosa. Both drugs reduce output of basal and stimulated gastric acid and pepsin secretion in normal healthy subjects and duodenal ulcer patients. Pharmacodynamic and pharmacokinetic differences exist between the dru...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章,评审
doi：10.1097/00004836-198312001-00008
更新日期：1983-01-01 00:00:00
abstract：:Sigmoid volvulus in young adults is rare. It usually presents as chronic recurrent attacks of abdominal pain. The diagnosis is usually delayed because of a low level of suspicion. We present the case of a 17-year-old girl with recurrent episodes of sigmoid volvulus, to illustrate the problem. ...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-198708000-00023
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Gastroparesis, a chronic gastrointestinal disorder defined by delayed stomach emptying in the absence of obstruction, is often associated with frequent and costly visits to the emergency department (ED). The aim of this study was to analyze trends in gastroparesis-related ED visits from 2006 to 2013...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/MCG.0000000000000972
更新日期：2019-02-01 00:00:00
abstract：:Thirty-five consecutive patients with acute hematochezia, negative gastric aspirates, and negative sigmoidoscopy underwent urgent colonoscopy after Golytely purgation. Mucosal visualization was excellent. Colonic bleeding lesions were identified in 24 of 35 patients, and hemorrhage originating proximal to the ileoceal...
journal_title：Journal of clinical gastroenterology
pub_type： 杂志文章
doi：10.1097/00004836-198602000-00010
更新日期：1986-02-01 00:00:00
