Extraesophageal malignancies among patients with Barrett esophagus.

Abstract:

GOALS:To evaluate the incidence of extraesophageal malignancies among patients with Barrett esophagus (BE). BACKGROUND:Gastroesophageal reflux disease has been reported to be associated with upper aerodigestive malignancies. BE is considered a consequence of long-standing gastroesophageal reflux disease; however, the association of BE with extraesophageal malignancies is controversial. STUDY:The database of the largest health service provider in Israel was queried for all patients diagnosed with BE between 2000 and 2010. Data regarding medical background and diagnosis of malignancy were recorded. Malignancy rates were compared with subjects without BE or malignancy and matched for age, sex, and smoking status (1:4 ratio). Patients in whom a malignancy was diagnosed within 1 year of BE diagnosis were excluded. RESULTS:A total of 3669 patients with BE and 14,676 controls were included. Several nonesophageal malignancies were significantly more prevalent among BE patients: colorectal cancer (relative risk 1.98, P<0.001) and prostate cancer (relative risk 1.99, P<0.001), but not cancer of the upper aerodigestive tract. Multivariate analysis revealed that Jewish origin and the presence of BE were associated with higher malignancy risk [hazard ratio (HR) 1.83, HR 1.41, respectively; P<0.001]; body mass index was inversely associated with malignancy risk (HR 0.98; P<0.005). CONCLUSIONS:BE seems to be associated with colorectal and prostate cancer. Further research is necessary to determine whether this is a causative relationship and, consequently, whether a change in the screening policy for colorectal cancer in patients with BE is warranted.

journal_name

J Clin Gastroenterol

authors

Pines G,Dickman R,Niv Y,Kashtan H,Birkenfeld S

doi

10.1097/MCG.0b013e31828bf26f

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

e8-e11

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

48

pub_type

杂志文章
  • Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection?

    abstract::A great deal is known about methods to diminish intragastric acid concentration, but far less is known about the ability of the gastroduodenal mucosa to resist injury or accelerate its healing. One group of compounds that plays a key role in the endogenous ability of the mucosa to protect itself against injury and per...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199112001-00012

    authors: Hollander D,Tarnawski A

    更新日期:1991-01-01 00:00:00

  • Sonographic evaluation of bowel wall thickness in patients with cystic fibrosis.

    abstract:GOALS AND BACKGROUND:Fibrosing colonopathy causing severe thickening of the colon wall was recently described in cystic fibrosis (CF). Since it has been suspected that subclinical colon-wall thickening is a common feature in CF patients, bowel-wall thickness was measured in a series of patients and compared with contro...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200307000-00014

    authors: Dialer I,Hundt C,Bertele-Harms RM,Harms HK

    更新日期:2003-07-01 00:00:00

  • Early recognition of toxic megacolon.

    abstract::Increased amounts of small bowel gas are a frequent finding on plain abdominal films in toxic megacolon (TMC), but they may also be found in patients with severe colitis. We studied 69 consecutive patients with severe ulcerative colitis to evaluate whether an increased gas content of the small intestine may identify p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198704000-00010

    authors: Caprilli R,Vernia P,Latella G,Torsoli A

    更新日期:1987-04-01 00:00:00

  • Effect of calcitonin on gastric emptying and on serum insulin and gastrin concentrations after ingestion of a mixed solid-liquid meal in humans.

    abstract::In a double-blind placebo-controlled study, we examined the effect of calcitonin on gastric emptying, and on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after a mixed solid-liquid meal in 11 healthy men. Synthetic salmon calcitonin was administered as a 415 pmol i.v. bolus injection foll...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199002000-00007

    authors: Jonderko K,Jonderko G,Gołab T

    更新日期:1990-02-01 00:00:00

  • Adult celiac disease (celiac sprue), pernicious anemia and IgA deficiency. Case report and review of the relationships between vitamin B12 deficiency, small intestinal mucosal disease and immunoglobulin deficiency.

    abstract::A 24-year-old man with addisonian pernicious anemia, adult celiac disease and selective IgA deficiency is presented to emphasize the differential diagnosis of vitamin B12 deficient megaloblastic anemia in association with small intestinal mucosal abnormalities and the relationships between immunoglobulin deficiency, p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198606000-00016

    authors: Quigley EM,Carmichael HA,Watkinson G

    更新日期:1986-06-01 00:00:00

  • Esophageal tuberculosis presenting as intramural esophagogastric hematoma in a hemophiliac patient.

    abstract::A spontaneous intramural esophagogastric hematoma developed in a patient with hemophilia A. The hematoma did not resolve after antihemophiliac factor replacement but ruptured into the stomach causing massive gastrointestinal bleeding. The associated enlarged right tracheobronchial gland and the histopathological findi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199203000-00017

    authors: Intragumtornchai T,Israsena S,Benjacholamard V,Lerdlum S,Benjavongkulchai S

    更新日期:1992-03-01 00:00:00

  • Rapid development of pancreatitis following reuse of 6-mercaptopurine.

    abstract::A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198912000-00017

    authors: Cappell MS,Das KM

    更新日期:1989-12-01 00:00:00

  • Distinct clinicopathologic characteristics of diffuse- and intestinal-type gastric cancer in Taiwan.

    abstract::The clinicopathologic features of 221 patients with intestinal-type (IT) gastric cancer were compared retrospectively with those of 290 diffuse type (DT). Intestinal type was characterized by an older mean age (65.0 +/- 10.8 years vs. 56.2 +/- 13 years), a higher male-female ratio (2.56 vs. 1.06), predominance of bloo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199712000-00019

    authors: Wu MS,Yang KC,Shun CT,Hsiao TJ,Lin CC,Wang HP,Chuang SM,Lee WJ,Lin JT

    更新日期:1997-12-01 00:00:00

  • Primary small bowel malignancies: single-center results of three decades.

    abstract::We highlight one medical center's experiences with primary malignancies of the small bowel. During a 27-year period, 79 patients were treated for small bowel tumors. Of these, 15 (20%) were lost to follow-up; thus, 64 patients were reviewed retrospectively with emphasis on histological distribution and their topograph...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200004000-00017

    authors: Ojha A,Zacherl J,Scheuba C,Jakesz R,Wenzl E

    更新日期:2000-04-01 00:00:00

  • Factors associated with failure of metronidazole in Clostridium difficile-associated disease.

    abstract:GOAL:To identify patients likely to fail metronidazole as initial treatment of C. difficile infection. BACKGROUND:For moderate to severe Clostridium difficile-associated diarrhea, metronidazole is the drug of choice for treatment. Oral vancomycin is given to patients who fail metronidazole or have intolerable side eff...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200405000-00005

    authors: Fernandez A,Anand G,Friedenberg F

    更新日期:2004-05-01 00:00:00

  • Persistent Increased Enteric Glial Expression of S100β is Associated With Low-grade Inflammation in Patients With Diverticular Disease.

    abstract:BACKGROUND:Diverticular disease (DD) is a common gastrointestinal inflammatory disorder associated with an enteric neuropathy. Although enteric glial cells (EGCs) are essential regulators of intestinal inflammation and motility functions, their contribution to the pathophysiology of DD remains unclear. Therefore, we an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001011

    authors: Cossais F,Leuschner S,Barrenschee M,Lange C,Ebsen M,Vogel I,Böttner M,Wedel T

    更新日期:2019-07-01 00:00:00

  • Circulating interferon-like activity in inflammatory bowel disease.

    abstract::Inflammatory bowel diseases (IBD) has been characterized as having an autoimmune background. We studied the presence of immune interferon in the sera of a small number of patients with IBD. Antiviral activity was detectable in the sera of our patients with well-controlled IBD but it was mainly weak-positive (50% inhib...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198610000-00008

    authors: Christodoulopoulou G,Havredaki M,Christodoulopoulos J

    更新日期:1986-10-01 00:00:00

  • Recurrent diverticulitis.

    abstract::The term "diverticulitis" indicates the inflammation of a diverticulum or diverticula, which is accompanied by detectable or microscopical perforation. Diverticulitis is a common condition with an estimated incidence of 25%. At present, elective sigmoid resection is recommended after 2 episodes of uncomplicated divert...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181886ee4

    authors: Comparato G,Di Mario F,NDSG.

    更新日期:2008-11-01 00:00:00

  • Altered Expression of the Epithelial Mucin MUC1 Accompanies Endoscopic Recurrence of Postoperative Crohn's Disease.

    abstract:BACKGROUND:MUC1-glycoprotein is expressed at low levels and in fully glycosylated form on epithelial cells. Inflammation causes MUC1 overexpression and hypoglycosylation. We hypothesized that overexpression of hypoglycosylated MUC1 would be found in postoperative Crohn's disease (CD) recurrence and could be considered ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001340

    authors: Hashash JG,Beatty PL,Critelli K,Hartman DJ,Regueiro M,Tamim H,Regueiro MD,Binion DG,Finn OJ

    更新日期:2021-02-01 00:00:00

  • Humoral intestinal immunity in systemic lupus erythematosus.

    abstract::Forty-five patients with systemic lupus erythematosus (SLE) underwent a cross-sectional study to evaluate intestinal secretory immunity. Peroral jejunal biopsy with histologic and immunohistochemical assessment of the mucosa were carried out in the patients and in 12 healthy volunteers. It was observed that an altered...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200001000-00009

    authors: Elia C,Souza H,Carvalho AT,Madi K,Mello CA,Oliveira A,Cuckier R,Papi JA

    更新日期:2000-01-01 00:00:00

  • Colonic findings in cirrhotics with portal hypertension. A prospective colonoscopic and histological study.

    abstract::Total colonoscopy was performed in 38 consecutive cirrhotics (15 alcoholic, 19 postviral, four unknown) with portal hypertension, 32 of whom were enrolled in a program of esophageal sclerotherapy because of variceal bleeding (Child's grading: A, 13; B, 21; C, 4 patients). In 34 of them, multiple biopsies from the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199406000-00014

    authors: Scandalis N,Archimandritis A,Kastanas K,Spiliadis C,Delis B,Manika Z

    更新日期:1994-06-01 00:00:00

  • Regression of amyloid in Crohn's disease after bowel resection. A 19-year follow-up.

    abstract::A 41-year-old man, who in 1969 had Crohn's disease and extensive hepatic and renal amyloidosis, has done well for 19 years after intestinal resection, with regression of massive proteinuria and maintenance of normal renal and hepatic function tests, although renal amyloidosis persists. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198906000-00016

    authors: Mandelstam P,Simmons DE,Mitchell B

    更新日期:1989-06-01 00:00:00

  • Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.

    abstract:BACKGROUND:Urinary tract infections (UTIs) are the most common bacterial infection in women. Most UTIs are acute uncomplicated cystitis caused by Escherichia coli (86%). This study was undertaken to assess the effectiveness of an association of a cranberry dry extract, D-mannose, a gelling complex composed of the exopo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0000000000000224

    authors: Vicariotto F

    更新日期:2014-11-01 00:00:00

  • Inflammatory bowel disease in 64 black patients: analysis of course, complications, and surgery.

    abstract::Sixty-four black patients with inflammatory bowel disease (IBD) were seen from 1960 to 1987 at the Medical College of Georgia, representing 22% of all patients with IBD: 38 of them had Crohn's disease (CD) and 26 had ulcerative colitis (UC). In those with CD, the small intestine alone was involved in 16% and ileocolit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198906000-00010

    authors: Simsek H,Schuman BM

    更新日期:1989-06-01 00:00:00

  • A randomized, controlled trial of interactive, multimedia software for patient colonoscopy education.

    abstract::The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200102000-00010

    authors: Shaw MJ,Beebe TJ,Tomshine PA,Adlis SA,Cass OW

    更新日期:2001-02-01 00:00:00

  • Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.

    abstract::Bleeding caused by ectopic varices is an uncommon but important and life-threatening complication of portal hypertension. Spontaneous external hemorrhage from a recanalized umbilical varix is an extremely rare source of ectopic variceal bleeding. We report on the acute presentation of a patient with a bleeding umbilic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31822b7f9a

    authors: Assis DN,Pollak J,Schilsky ML,Emre S

    更新日期:2012-02-01 00:00:00

  • Surveillance for hepatocellular carcinoma in a Medicaid cirrhotic population.

    abstract:GOALS:To estimate the hepatocellular carcinoma surveillance in the Medicaid cirrhotic population. BACKGROUND:Most studies predate 2005 American Association for the Study of Liver Diseases surveillance recommendations and do not examine the primary target population, cirrhotics. STUDY:From 2006 to 2007, we identified ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318286fd97

    authors: Palmer LB,Kappelman MD,Sandler RS,Hayashi PH

    更新日期:2013-09-01 00:00:00

  • The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection: a prospective multicenter study.

    abstract:BACKGROUND:It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. GOALS:The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/MCG.0b013e3182160c9c

    authors: Kim YS,Kim YH,Kim JS,Cheon JH,Ye BD,Jung SA,Park YS,Choi CH,Jang BI,Han DS,Yang SK,Kim WH,IBD Study Group of the Korean Association for the Study of Intestinal Diseases.

    更新日期:2012-01-01 00:00:00

  • Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn's disease.

    abstract::Crohn's disease can be accompanied by extraintestinal manifestations. The authors report on a 39-year-old patient who presented with cheilitis granulomatosa as the first manifestation of Crohn's disease. Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from op...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200205000-00016

    authors: van de Scheur MR,van der Waal RI,van Bodegraven AA,Völker-Dieben HJ,Starink TM,van der Waal I

    更新日期:2002-05-01 00:00:00

  • Gastric acid secretion and serum gastrin levels in children with recurrent abdominal pain, gastric and duodenal ulcers.

    abstract::Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no d...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198009000-00007

    authors: Liebman WM

    更新日期:1980-09-01 00:00:00

  • Calcium and acid rebound: a reappraisal.

    abstract::We review acid rebound, the seemingly paradoxical increase in acid secretion resulting from administration of an antacid. Primarily a laboratory observation, the demonstration of the phenomenon was a major contributing factor to the swift, and possibly unjustified, fall from grace of calcium carbonate in the therapy o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1097/00004836-199207000-00010

    authors: Hade JE,Spiro HM

    更新日期:1992-07-01 00:00:00

  • Diarrheal epidemics among Rwandan refugees in 1994. Management and outcome in a field hospital.

    abstract::We describe the clinical course and outcome of Rwandan refugees with cholera-like illness (n = 567) and clinical dysentery (n = 1,062) treated at the Israeli Army field hospital in the disaster region of Goma, Zaire, during the summer of 1994. Vigorous fluid administration was the primary therapy, complemented with an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199712000-00009

    authors: Heyman SN,Ginosar Y,Shapiro M,Kluger Y,Marx N,Maayan S

    更新日期:1997-12-01 00:00:00

  • Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia.

    abstract:BACKGROUND AND GOALS:Neurohormonal factors might play a role in the pathogenesis of functional dyspepsia (FD). However, the role of ghrelin, a gastrointestinal hormone that stimulates gastric motility, in FD is not yet clearly defined. The present study was designed to investigate plasma ghrelin levels and their relati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225614.94470.47

    authors: Takamori K,Mizuta Y,Takeshima F,Akazawa Y,Isomoto H,Ohnita K,Ohba K,Omagari K,Shikuwa S,Kohno S

    更新日期:2007-05-01 00:00:00

  • The Psychobiological Etiology of Gastrointestinal Distress in Sport: A Review.

    abstract::Gastrointestinal (GI) disturbances are common during training and competition, especially among endurance athletes. Historically, little attention has been paid to the psychobiological etiology of GI problems in sport. The aim of this review is to: (1) provide a physiological overview of how psychological stress and a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001308

    authors: Wilson PB

    更新日期:2020-04-01 00:00:00

  • Comparison of Disease-related Knowledge of Patients With Inflammatory Bowel Disease Between the West and the East Using an Updated Questionnaire (IBD-KNOW).

    abstract:GOALS:The study aimed to compare the level and characteristics of disease-related knowledge of patients with inflammatory bowel disease (IBD) between the West and the East using an international version of a questionnaire regarding knowledge of inflammatory bowel disease (IBD-KNOW). BACKGROUND:The authors recently dev...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001283

    authors: Kim JY,Yoon H,Hwang JS,Yang SK,Park SH,Loftus EV Jr

    更新日期:2020-09-01 00:00:00