Factors associated with failure of metronidazole in Clostridium difficile-associated disease.

Abstract:

GOAL:To identify patients likely to fail metronidazole as initial treatment of C. difficile infection. BACKGROUND:For moderate to severe Clostridium difficile-associated diarrhea, metronidazole is the drug of choice for treatment. Oral vancomycin is given to patients who fail metronidazole or have intolerable side effects. STUDY:Retrospective review identified all patients treated for C. difficile-associated diarrhea during hospitalization from January 2000 to September 2001. C difficile was documented by a positive toxin assay or pseudomembranes on colonoscopy. Metronidazole failure was defined as persistent symptoms of C. difficile-associated diarrhea after 5 days of uninterrupted therapy. Response was defined as improvement in symptoms at day 5 of therapy including reduction of diarrhea to

journal_name

J Clin Gastroenterol

authors

Fernandez A,Anand G,Friedenberg F

doi

10.1097/00004836-200405000-00005

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

414-8

issue

5

eissn

0192-0790

issn

1539-2031

pii

00004836-200405000-00005

journal_volume

38

pub_type

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