Liver disease in hereditary hemorrhagic telangiectasia.

Abstract:

:Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, is an hereditary disorder that results in fibrovascular dysplasia with the development of telangiectasias and arteriovenous malformations. It predominantly involves the skin, mucous membranes, viscera, lungs, and brain. Hereditary hemorrhagic telangiectasia shows great genetic heterogeneity, and its phenotypes have been classified based on the recently identified mutated genes: endoglin (HHT-1) and activin-like kinase receptor-1 (HHT-2). Other families with phenotypic HHT do not bear these mutations; therefore, other genes are probably involved as well. Liver involvement is reported in up to 30% of persons affected by HHT. Large arteriovenous malformations in the liver can lead to significant complications, including high-output congestive heart failure, portal hypertension, hepatic encephalopathy, biliary ischemia, and liver failure. Embolization of large arteriovenous malformations in the liver remains controversial; however, liver transplantation can successfully eradicate these complications.

journal_name

J Clin Gastroenterol

authors

Larson AM

doi

10.1097/00004836-200302000-00013

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

149-58

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

36

pub_type

杂志文章,评审
  • Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults.

    abstract::In our study, we evaluated whether the combination of two endoscopic abnormalities in the duodenum (the "mosaic" appearance and loss of duodenal folds) is significantly associated with duodenal villous atrophy secondary to celiac sprue in adults. Fourteen patients referred for esophagogastroduodenoscopy for suspected ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199410000-00018

    authors: Magazzu G,Bottari M,Tuccari G,Arco A,Pallio S,Lucanto C,Tortora A,Barresi G

    更新日期:1994-10-01 00:00:00

  • Biliary atresia: recent progress.

    abstract::Extrahepatic biliary atresia (EHBA), an inflammatory sclerosing cholangiopathy, is the leading indication for liver transplantation in children. The cause is still unknown, although possible infectious, genetic, and immunologic etiologies have received much recent focus. These theories are often dependent on each othe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181646730

    authors: Bassett MD,Murray KF

    更新日期:2008-07-01 00:00:00

  • Oxides, onions, and other matters gastrointestinal--1996--a perspective.

    abstract::A selection of landmark articles for a given year in any subject risks being somewhat subjective, and subjectivity is best avoided in scientific endeavor. However, the very nature of such a selection process invites judgment. Like most judges, I, too, claim to avoid conscious bias, but no one who has ever graced the b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199704000-00003

    authors: Kapadia CR

    更新日期:1997-04-01 00:00:00

  • Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection.

    abstract::Fulminant hepatic failure as a result of hepatitis A is a rarely diagnosed complication entity in developed countries. With the advent of specific serologic markers for acute hepatitis A virus infection, the incidence and pathology of fulminant hepatitis A can be more clearly defined. We describe four patients (one ad...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199309000-00014

    authors: Masada CT,Shaw BW Jr,Zetterman RK,Kaufman SS,Markin RS

    更新日期:1993-09-01 00:00:00

  • Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.

    abstract:BACKGROUND:Urinary tract infections (UTIs) are the most common bacterial infection in women. Most UTIs are acute uncomplicated cystitis caused by Escherichia coli (86%). This study was undertaken to assess the effectiveness of an association of a cranberry dry extract, D-mannose, a gelling complex composed of the exopo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0000000000000224

    authors: Vicariotto F

    更新日期:2014-11-01 00:00:00

  • Acute acalculous cholecystitis. A review.

    abstract::Acute acalculous cholecystitis is an uncommon but very serious illness, that, if undiagnosed, may lead to gallbladder perforation and death. The condition has numerous causes that result in bile stasis and ischemia leading to inflammation and infection in the gallbladder wall. The bedside diagnosis may be difficult, e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199210000-00014

    authors: Babb RR

    更新日期:1992-10-01 00:00:00

  • Genotypic variability of hepatitis viruses associated with chronic infection and the development of hepatocellular carcinoma.

    abstract::At least five hepatitis viruses are known to date. Infection by enterically transmitted viruses (HAV and HEV) is generally benign compared with the disease caused by parenterally transmitted viruses (HBV, HCV, and HDV). Chronic infection by HBV is common and may evolve to cirrhosis and hepatocellular carcinoma (HCC). ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000170770.49394.92

    authors: Pujol FH,Devesa M

    更新日期:2005-08-01 00:00:00

  • Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment.

    abstract::Immunoproliferative small intestinal disease (IPSID) is a rare lympho-proliferative disorder of the upper small intestine. It is considered a special form of MALT lymphoma with propensity to malignant transformation. This disorder is rare in pediatric literature. We report a case of IPSID in a 16-year-old boy with low...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199807000-00020

    authors: Zamir A,Parasher G,Moukarzel AA,Guarini L,Zeien L,Feldman F

    更新日期:1998-07-01 00:00:00

  • Tacrolimus therapy as an alternative to thiopurines for maintaining remission in patients with refractory ulcerative colitis.

    abstract:BACKGROUND:Although the efficacy of tacrolimus for inducing remission of refractory ulcerative colitis (UC) is established, its efficacy for maintaining remission of UC has not been evaluated. AIM:The aim of this study was to evaluate the efficacy of tacrolimus compared with thiopurines for maintaining remission in pa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0b013e318209cdc4

    authors: Yamamoto S,Nakase H,Matsuura M,Masuda S,Inui K,Chiba T

    更新日期:2011-07-01 00:00:00

  • Recurrent diverticulitis.

    abstract::The term "diverticulitis" indicates the inflammation of a diverticulum or diverticula, which is accompanied by detectable or microscopical perforation. Diverticulitis is a common condition with an estimated incidence of 25%. At present, elective sigmoid resection is recommended after 2 episodes of uncomplicated divert...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181886ee4

    authors: Comparato G,Di Mario F,NDSG.

    更新日期:2008-11-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200305000-00007

    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • Increased cytokine production by gastric mucosa in patients with Helicobacter pylori infection.

    abstract::To determine the mechanisms of gastric mucosal injury associated with Helicobacter pylori infection, we investigated the contents of cytokines and inflammatory cell infiltration in the gastric mucosa. Ninety-six patients with dyspepsia were studied (58 gastric ulcer, 38 nonulcer dyspepsia). Of the 96 patients, 63 were...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199700001-00033

    authors: Katagiri M,Asaka M,Kobayashi M,Kudo M,Kato M,Takeda H

    更新日期:1997-01-01 00:00:00

  • Polymerase chain reaction in gastroenterology.

    abstract::Polymerase chain reaction (PCR) has had a major impact on molecular biology and is beginning to change our perception of certain disease processes and diagnostic tests. PCR allows the identification and amplification of very rare nucleic acid sequences. This is resulting in our identification of previously elusive inf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199306000-00014

    authors: Hayashi PH,Zeldis JB

    更新日期:1993-06-01 00:00:00

  • Development of Image-enhanced Endoscopy of the Gastrointestinal Tract: A Review of History and Current Evidences.

    abstract::Endoscopy imaging of the gastrointestinal (GI) tract has evolved tremendously over the last few decades. Key milestones in the development of endoscopy imaging include the use of various dyes for chromoendoscopy, the application of optical magnification in endoscopy, the introduction of high-definition image capturing...

    journal_title:Journal of clinical gastroenterology

    pub_type: 历史文章,杂志文章

    doi:10.1097/MCG.0000000000000960

    authors: Ho SH,Uedo N,Aso A,Shimizu S,Saito Y,Yao K,Goh KL

    更新日期:2018-04-01 00:00:00

  • Disparities in Liver Cancer Surveillance Among People With Disabilities: A National Database Study in Korea.

    abstract:GOAL:The goal of this study was to determine disparities in liver cancer surveillance among people with disabilities is the goal of this study. BACKGROUND:Using the linked administrative database in Korea, we sought to investigate (1) whether there are disparities in liver cancer surveillance according to degree and t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001405

    authors: Seo JY,Shin DW,Yu SJ,Jung JH,Han K,Cho IY,Kim SY,Choi KS,Park JH,Park JH,Kawachi I

    更新日期:2020-09-04 00:00:00

  • Constipation--a sign of a disease to be treated surgically, or a symptom to be deciphered as nonverbal communication?

    abstract::Constipation is not a sign but a symptom, which is not measurable scientifically. It has emotional components and must be dealt with in a holistic manner. The scientific approach aims only at the physiological derangement and serves to place the complaint in a more objective perspective. An algorithm can be constructe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,社论

    doi:

    authors: Devroede G

    更新日期:1992-10-01 00:00:00

  • Understanding and appreciating sequential therapy for Helicobacter pylori eradication.

    abstract::Despite the fact that sequential therapy has been evaluated in more than 2500 patients and has been shown to on average provide Helicobacter pylori eradication in 90% to 94%, some authorities still question whether it should be a first-line anti-H. pylori regimen. Here, we discuss H. pylori eradication using experienc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31820ac05e

    authors: Graham DY,Rimbara E

    更新日期:2011-04-01 00:00:00

  • Crohn's disease: what about the pancreas?

    abstract::Crohn's disease (CD) is now accepted as a systemic illness. The importance of extraintestinal manifestations is underlined by the fact that such "complications" can be more prominent and even more difficult to control than the intestinal disease itself. Lately, evidence for a more than accidental association of pancre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Piontek M,Hengels KJ,Strohmeyer G

    更新日期:1990-10-01 00:00:00

  • The lower esophageal sphincter in gastroesophageal reflux in children.

    abstract::Esophageal function was evaluated in 51 children less than 2 years of age with radiologic evidence of gastroesophageal reflux. Detection of an acid esophageal pH was a sensitive measure of gastroesophageal reflux. Lower esophageal sphincter pressures were greater in reflux patients with respiratory symptoms (18.0 +/- ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-197906000-00004

    authors: Herbst JJ,Book LS,Johnson DG,Jolley S

    更新日期:1979-06-01 00:00:00

  • Hepatitis C treatment candidacy and outcomes among 4318 US veterans with chronic hepatitis C virus infection: does a history of injection drug use matter?

    abstract:BACKGROUND/GOALS:Many patients with a history of injection drug use (IDU) are excluded from hepatitis C virus (HCV) treatment. This prospective multicenter study aimed to determine the impact of IDU history on HCV treatment candidacy and outcomes. STUDY:Between 1999 and 2001, 4318 HCV-infected patients seen at 24 VA M...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.mcg.0000212644.82853.51

    authors: Seal KH,Currie SL,Shen H,Anand BS,Bini EJ,Brau N,Jeffers L,Wright TL,VA HCV-001 Study Group.

    更新日期:2007-02-01 00:00:00

  • Barrett esophagus in sexagenarian identical twins.

    abstract::Identical twins presented as sexagenarians with heartburn, regurgitation, and dysphagia; each had a Barrett esophagus remarkably similar to the other. This instance suggests a hereditary influence upon the development of mucosal dysplasia in some patients with this condition. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198306000-00011

    authors: Gelfand MD

    更新日期:1983-06-01 00:00:00

  • Serum nitric oxide levels in children with celiac disease.

    abstract:OBJECTIVES:To determine serum nitric oxide levels in pediatric patients with celiac disease and to compare them with the results obtained after 1 year of gluten-free diet. METHODS:We studied serum nitric oxide levels in 41 newly diagnosed patients with celiac disease. Serum levels of nitric oxide were reevaluated afte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000177240.67215.da

    authors: Ertekin V,Selimoğlu MA,Türkan Y,Akçay F

    更新日期:2005-10-01 00:00:00

  • Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis.

    abstract::We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver tran...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199504000-00011

    authors: Jorgensen RA,Lindor KD,Sartin JS,LaRusso NF,Wiesner RH

    更新日期:1995-04-01 00:00:00

  • Update in medical therapy of ulcerative colitis: a practical approach.

    abstract::The bewildering array of medications in the therapy of inflammatory bowel disease (IBD) often confounds the clinician in the choice of specific agents regarding the balance between safety and efficacy. This review surveys and evaluates currently available IBD therapies as well as those used in clinical trials of ulcer...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200204000-00004

    authors: Katz S

    更新日期:2002-04-01 00:00:00

  • A randomized, controlled trial of interactive, multimedia software for patient colonoscopy education.

    abstract::The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200102000-00010

    authors: Shaw MJ,Beebe TJ,Tomshine PA,Adlis SA,Cass OW

    更新日期:2001-02-01 00:00:00

  • Hepatitis B Surface Antigen Levels Are Related to Spontaneous Hepatitis B Surface Antigen Seroconversion in Inactive Hepatitis B Carriers.

    abstract:BACKGROUND:The cure for hepatitis B is defined as the hepatitis B surface antigen (HBsAg) seroclearance and/or seroconversion. Predictors of spontaneous seroconversion are not well described. The objective of this study is to identify predictors of spontaneous HBsAg seroconversion from community practice. METHODS:We p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001324

    authors: Wu CF,Fong TM,Wu SS,Saab S

    更新日期:2020-07-01 00:00:00

  • Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population.

    abstract:BACKGROUND:Diagnosis of gastroesophageal reflux disease (GERD) based on subjective evaluation of symptoms alone is challenging. GOALS:To test the validity and reliability of a graded response questionnaire to identify patients with GERD. STUDY:Patients presenting with upper abdominal symptoms for more than a month, a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3180653613

    authors: Ho KY,Gwee KA,Khor JL,Selamat DS,Yeoh KG

    更新日期:2008-07-01 00:00:00

  • Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rat.

    abstract::We sought to clarify the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) during healing of rat gastric ulcers. After gastric ulcers were induced by acetic acid, rats were treated with vehicle, N(G)-nitro-L-arginine methyl ester (L-NAME), aminoguanidine (AG), and dexamethasone (Dex) by gastric int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199800001-00011

    authors: Akiba Y,Nakamura M,Mori M,Suzuki H,Oda M,Kimura H,Miura S,Tsuchiya M,Ishii H

    更新日期:1998-01-01 00:00:00

  • Antimitochondrial antibody-negative chronic nonsuppurative destructive cholangitis. Atypical primary biliary cirrhosis or autoimmune cholangitis?

    abstract::We investigated whether autoimmune cholangitis (AC) has specific features that constitute an entity other than primary biliary cirrhosis (PBC). We compared clinical, laboratory, and liver biopsy features; response to treatment; and the follow-up of two groups of patients. The first group comprised seven patients with ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199610000-00007

    authors: Sánchez-Pobre P,Castellano G,Colina F,Dominguez P,Rodriguez S,Canga F,Herruzo JA

    更新日期:1996-10-01 00:00:00

  • Helicobacter pylori Infection and the Development of Advanced Colorectal Neoplasia.

    abstract:BACKGROUND:An association between Helicobacter pylori infection and colorectal neoplasia has been reported in cross-sectional studies. GOALS:We examined the association between H. pylori infection and the development of advanced colorectal neoplasia (AN) in a screening cohort. STUDY:We identified 3753 adults, who und...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001273

    authors: Ryoo SK,Kim TJ,Kim ER,Hong SN,Kim YH,Chang DK

    更新日期:2020-09-01 00:00:00