CEA-producing mucin-negative gastric signet-ring cell carcinoma with neuroendocrine markers: a case report.

Abstract:

:Biopsy and autopsy materials excised from a 69-year-old woman were investigated. Serum carcinoembryonic antigen (CEA) showed a high value of 955 ng/mL. A plateaulike tumor was located in the gastric cardia and fundus to the entire gastric body. It showed severe proliferation and infiltration from the mucosa to the serosa. The tumor was comprised of signet-ring cells and poorly differentiated adenocarcinoma cells, which spread into the submucosa of the pylorus, duodenum, and jejunum. Signet-ring cells had a large, eccentric vesicular nucleus and a pale cytoplasmic inclusion. Poorly differentiated adenocarcinoma cells had a pleomorphic nucleus, small eosinophilic nucleolus, and abundant eosinophilic cytoplasm. Both neoplastic cells were positive for CEA, epithelial membrane antigen, Leu-7 (CD57), and neuron-specific enolase, and were negative for cytokeratin, vimentin, and periodic acid-Schiff, Alcian blue, and mucicarmine stains. Electron microscopy showed endocrine granules with a limiting membrane measuring approximately 238 nm in diameter in the cytoplasm. The authors diagnosed this patient as having mucin-negative gastric signet-ring cell carcinoma with neuroendocrine markers, which is suggested to exist among poorly differentiated adenocarcinoma, undifferentiated carcinoma, and signet-ring cell carcinoma.

journal_name

J Clin Gastroenterol

authors

Morii S,Oka K,Hakozaki H,Nihei T,Mori N

doi

10.1097/00004836-199907000-00021

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

82-5

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

29

pub_type

杂志文章
  • Characteristics and occurrence of appendicitis in the black population in Johannesburg, South Africa.

    abstract::In black patients seen at Baragwanath Hospital, Johannesburg, appendicitis occurs most frequently in the 10-19-year-old age group. There is a pronounced male bias. Parasitic ova in the appendix are very seldom observed (3.6%). Fecaliths, present in 20% of diseased appendices, are noted far less frequently than are rep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198610000-00007

    authors: Segal I,Paterson A,Walker AR

    更新日期:1986-10-01 00:00:00

  • The refusal to treat: abandonment and AIDS.

    abstract::In this paper, I have focused on the issue of the clinical gastroenterologist who refuses to evaluate and endoscope the patient with AIDS. The discussion centers around the legal and ethical properties of such a decision, and the legal doctrine of abandonment. Finally, I have reviewed recent recommendations regarding ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Plumeri PA

    更新日期:1984-06-01 00:00:00

  • Effect of Consent and Educational Adjuncts to Consent on Patient Perceptions About Colonoscopy.

    abstract:BACKGROUND AND AIMS:Informed consent is a vital preprocedural step for endoscopy but there are substantial variations in its delivery. We therefore sought to assess a multifaceted intervention to improve the consent process. METHODS:Gastroenterologists at a tertiary center were educated on the recommended components o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001093

    authors: Fudman DI,Papamichael K,Roemi L,Rao V,Falchuk KR,Leffler DA,Feuerstein JD

    更新日期:2019-09-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181945942

    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • Management of Chronic Hepatitis B in Pregnancy.

    abstract::Chronic hepatitis B virus (HBV) infection due to mother-to-child transmission during the perinatal period remains an important global health problem. Despite standard passive-active immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine in neonates, up to 8.5% of newborns still acquire HBV infection...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000908

    authors: Li J,Chang MS,Tran TT,Nguyen MH

    更新日期:2017-10-01 00:00:00

  • Defining a clinically significant adverse impact of diagnosing Barrett's esophagus.

    abstract:BACKGROUND:Diagnosing a potentially life-threatening disease may adversely affect patient quality of life (QOL) independent of biologic effects. It is unknown whether the mere diagnosis of Barrett's esophagus (BE) adversely impacts patients' preferences (health-state utility) sufficiently to impair the cost-effectivene...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000196186.19426.4a

    authors: Rubenstein JH,Inadomi JM

    更新日期:2006-02-01 00:00:00

  • Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-alpha.

    abstract::The authors report a rare case of hepatocellular carcinoma (HCC) that developed 6 years after a sustained and complete response to interferon (IFN) therapy for chronic hepatitis C. A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treated with IFN-alpha a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199909000-00024

    authors: Yamaguchi K,Omagari K,Kinoshita H,Yoshioka S,Furusu H,Takeshima F,Nanashima A,Yamaguchi H,Kohno S

    更新日期:1999-09-01 00:00:00

  • Predictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy.

    abstract:GOALS:The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD. BACKGROUND:Gastrin elevation is a known but variable consequence of proton pump inhibitor ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001200

    authors: Helgadóttir H,Lund SH,Gizurarson S,Metz DC,Björnsson ES

    更新日期:2020-03-01 00:00:00

  • The role of endogenous free radical scavengers on tissue recovery in the experimental ulcer model.

    abstract::The role of lipid peroxidation and endogenous oxygen-derived free radical scavengers on ischemia-reperfusion injury and tissue recovery in rat ulcer model corresponding to the gastric histopathology was investigated. Male Wistar rats weighting 200-250 g were heparinized before occlusion of the celiac axis for 1.5 h. E...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199001001-00011

    authors: Oshima A,Asayama K,Sakai N,Kitajima M

    更新日期:1990-01-01 00:00:00

  • Intestinal Failure: Adaptation, Rehabilitation, and Transplantation.

    abstract::Intestinal failure (IF) is a state in which the nutritional demands are not met by the gastrointestinal absorptive surface. A majority of IF cases are associated with short-bowel syndrome, which is a result of malabsorption after significant intestinal resection for numerous reasons, some of which include Crohn's dise...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000512

    authors: Bharadwaj S,Tandon P,Meka K,Rivas JM,Jevenn A,Kuo NT,Steiger E

    更新日期:2016-05-01 00:00:00

  • Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections.

    abstract::In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. Aminosalicylates (5-ASAs) are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. Si...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,杂志文章

    doi:10.1097/MCG.0000000000001371

    authors: Ehrenpreis ED,Kruchko DH

    更新日期:2020-08-01 00:00:00

  • Cruveilhier-Baumgarten syndrome without esophageal varices: ultrasonographic diagnosis and echo-Doppler study.

    abstract::Two cases of Cruveilhier-Baumgarten syndrome not clinically evident and without esophageal varices in patients with liver cirrhosis and portal hypertension are presented. The diagnosis was made by real-time ultrasonography, which showed echographic caput medusae with large afferent umbilical veins and efferent inferio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Caturelli E,Sperandeo G,Squillante MM,Mangia A,Gabbrielli L

    更新日期:1989-06-01 00:00:00

  • Acinar-islet cell tumor of the pancreas: report of a malignant pancreatic composite tumor.

    abstract::An unusual case of malignant pancreatic composite tumor with both components of acinar cell tumor (ACT) and islet cell tumor (ICT) was investigated histologically, immunohistochemically, and ultrastructurally. The pancreatic tumor with central cyst formation was found on computerized tomographic examination of a 72-ye...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200009000-00020

    authors: Muramatsu T,Kijima H,Tsuchida T,Konagaya M,Matsubayashi H,Tada N,Nakamura M,Ueyama Y

    更新日期:2000-09-01 00:00:00

  • Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis.

    abstract:BACKGROUND AND AIMS:The efficacy of 6-mercaptopurine (6-MP) in the treatment and long-term maintenance of remission of inflammatory bowel disease and prevention of recurrence after resection in Crohn's disease have been established. Concern about 6-MP toxicity remains, especially the development of neoplasm. The aim of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200309000-00006

    authors: Warman JI,Korelitz BI,Fleisher MR,Janardhanam R

    更新日期:2003-09-01 00:00:00

  • Esophageal tuberculosis presenting as intramural esophagogastric hematoma in a hemophiliac patient.

    abstract::A spontaneous intramural esophagogastric hematoma developed in a patient with hemophilia A. The hematoma did not resolve after antihemophiliac factor replacement but ruptured into the stomach causing massive gastrointestinal bleeding. The associated enlarged right tracheobronchial gland and the histopathological findi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199203000-00017

    authors: Intragumtornchai T,Israsena S,Benjacholamard V,Lerdlum S,Benjavongkulchai S

    更新日期:1992-03-01 00:00:00

  • Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

    abstract::A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reporte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198304000-00014

    authors: O'Reilly DJ,Craig RM,Lorenzo G,Yokoo H

    更新日期:1983-04-01 00:00:00

  • The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis.

    abstract:BACKGROUND:The metabolic syndrome (MetS) and/or its individual components have been linked to the development of cancer. Recent studies have suggested a similar link to hepatocellular carcinoma (HCC). The aim of this study was to evaluate the direction and magnitude of the association between the MetS and HCC. METHODS...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0b013e3182a030c4

    authors: Jinjuvadia R,Patel S,Liangpunsakul S

    更新日期:2014-02-01 00:00:00

  • Nortriptyline-induced fulminant hepatic failure.

    abstract::We describe, to our knowledge, the first reported case of nortriptyline-induced fulminant hepatic failure. This tricyclic antidepressant drug was taken by a postmenopausal woman for 64 days before her presentation. The absence of fever, rash, or marked eosinophilia, the predominant zone 3 necrosis with bridging, and t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199501000-00014

    authors: Berkelhammer C,Kher N,Berry C,Largosa A

    更新日期:1995-01-01 00:00:00

  • Oxides, onions, and other matters gastrointestinal--1996--a perspective.

    abstract::A selection of landmark articles for a given year in any subject risks being somewhat subjective, and subjectivity is best avoided in scientific endeavor. However, the very nature of such a selection process invites judgment. Like most judges, I, too, claim to avoid conscious bias, but no one who has ever graced the b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199704000-00003

    authors: Kapadia CR

    更新日期:1997-04-01 00:00:00

  • The parathyroids and the gut.

    abstract::This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck. Hyperparathyroidism is usually from adenomas or hyperplasia. Hypoparathyroidism is as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181cd9d4c

    authors: Ebert EC

    更新日期:2010-08-01 00:00:00

  • Small bowel preparations for capsule endoscopy with mannitol and simethicone: a prospective, randomized, clinical trial.

    abstract:BACKGROUND AND OBJECTIVE:There is no consensus concerning small bowel preparation before capsule endoscopy (CE). This study evaluated the effects of 4 regimens on small bowel cleansing and diagnostic yield. METHODS:Patients were randomly divided into 4 groups. Group A consumed a clear liquid diet after lunch on the da...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0b013e3181f0f3a3

    authors: Chen HB,Huang Y,Chen SY,Song HW,Li XL,Dai DL,Xie JT,He S,Zhao YY,Huang C,Zhang SJ,Yang LN

    更新日期:2011-04-01 00:00:00

  • Serum nitric oxide levels in children with celiac disease.

    abstract:OBJECTIVES:To determine serum nitric oxide levels in pediatric patients with celiac disease and to compare them with the results obtained after 1 year of gluten-free diet. METHODS:We studied serum nitric oxide levels in 41 newly diagnosed patients with celiac disease. Serum levels of nitric oxide were reevaluated afte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000177240.67215.da

    authors: Ertekin V,Selimoğlu MA,Türkan Y,Akçay F

    更新日期:2005-10-01 00:00:00

  • Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue.

    abstract::Uncontrolled hemorrhage and multisystem organ failure developed in a patient with celiac sprue, lymphocytic gastritis, and diffuse gastric ulceration. A proximal small bowel biopsy showed villous atrophy and lymphoplasmacytic infiltration consistent with celiac sprue. At autopsy, there were no gross or histologic find...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199707000-00013

    authors: Weiss AA,Yoshida EM,Poulin M,Gascoyne RD,Owen DA

    更新日期:1997-07-01 00:00:00

  • Fibrinous pericarditis in alcoholic liver disease.

    abstract::The autopsy data at the University of Southern California Liver Unit was studied during a 6-year period to investigate the relationship of fibrinous pericarditis with liver diseases. We found 18 cases of fibrinous pericarditis in 220 patients with alcoholic liver disease but none in 32 patients with fulminant and suba...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198902000-00012

    authors: Yang SS,Kanel G

    更新日期:1989-02-01 00:00:00

  • Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding.

    abstract::In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS). Rebleeding was more common in the placebo group so that at 5 days bleeding remained under control in 54% of patients treated with terlipressin compared with o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198902000-00014

    authors: Freeman JG,Cobden I,Record CO

    更新日期:1989-02-01 00:00:00

  • Are Anti-Tumor Necrosis Factor Trough Levels Predictive of Mucosal Healing in Patients With Inflammatory Bowel Disease?: A Systematic Review and Meta-Analysis.

    abstract:GOALS:Our primary goal was to evaluate whether anti-tumor necrosis factor (TNF)-α trough levels above author-determined thresholds are associated with increased rates of mucosal healing among patients with Crohn's disease and ulcerative colitis. BACKGROUND:The introduction of anti-TNF agents has considerably advanced ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000441

    authors: Barnes EL,Allegretti JR

    更新日期:2016-10-01 00:00:00

  • Extent of colonic visualization with the fiberoptic sigmoidoscope.

    abstract::Forty-two patients underwent flexible sigmoidoscopy in the radiology department. After maximal insertion of the sigmoidoscope, a supine abdominal film documented the position of the tip of the instrument. Correlation with barium enema in all patients determined the extent of visualization of the colon relative to the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198208000-00009

    authors: Ott DJ,Wu WC,Gelfand DW

    更新日期:1982-08-01 00:00:00

  • Increased cytokine production by gastric mucosa in patients with Helicobacter pylori infection.

    abstract::To determine the mechanisms of gastric mucosal injury associated with Helicobacter pylori infection, we investigated the contents of cytokines and inflammatory cell infiltration in the gastric mucosa. Ninety-six patients with dyspepsia were studied (58 gastric ulcer, 38 nonulcer dyspepsia). Of the 96 patients, 63 were...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199700001-00033

    authors: Katagiri M,Asaka M,Kobayashi M,Kudo M,Kato M,Takeda H

    更新日期:1997-01-01 00:00:00

  • Intestinal myiasis caused by larvae of Telmatoscopus albipunctatus in a Taiwanese man.

    abstract::Here we reported the first case in Taiwan of human intestinal myiasis caused by larvae of Telmatoscopus albipunctatus. The 21-year-old male patient experienced gastroenteritis and anal itching. During the patient's first hospital visit the doctor suspected Enterobius infection. After treatment with anthelmintic mebend...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000212615.66713.ba

    authors: Tu WC,Chen HC,Chen KM,Tang LC,Lai SC

    更新日期:2007-04-01 00:00:00

  • Gastroesophageal reflux and voice changes: objective assessment of voice quality and impact of antireflux therapy.

    abstract:BACKGROUND AND AIM:Voice-related complaints are the most common extraesophageal manifestation of gastroesophageal reflux disease (GERD). The aim of this study was to compare objectively measured voice parameters in normal subjects and patients with GERD and to assess the impact of antireflux surgery on these parameters...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31822f386e

    authors: Ayazi S,Pearson J,Hashemi M

    更新日期:2012-02-01 00:00:00