Acinar-islet cell tumor of the pancreas: report of a malignant pancreatic composite tumor.

Abstract:

:An unusual case of malignant pancreatic composite tumor with both components of acinar cell tumor (ACT) and islet cell tumor (ICT) was investigated histologically, immunohistochemically, and ultrastructurally. The pancreatic tumor with central cyst formation was found on computerized tomographic examination of a 72-year-old man reporting appetite and weight loss. The ACT component was present in the original pancreatic region and the ICT region was adjacent to the ACT. ACT was immunohistochemically positive for pancreatic amylase, whereas ICT had argyrophil tumor cells immunohistochemically positive for chromogranin A. There were several tumor cell nests positive for both pancreatic amylase (acinar differentiation) and chromogranin A (islet differentiation). We speculated that ICT may have arisen from the de-differentiated tumor cells in the ACT after the occurrence of ACT.

journal_name

J Clin Gastroenterol

authors

Muramatsu T,Kijima H,Tsuchida T,Konagaya M,Matsubayashi H,Tada N,Nakamura M,Ueyama Y

doi

10.1097/00004836-200009000-00020

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

175-8

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

31

pub_type

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