Acinar-islet cell tumor of the pancreas: report of a malignant pancreatic composite tumor.


:An unusual case of malignant pancreatic composite tumor with both components of acinar cell tumor (ACT) and islet cell tumor (ICT) was investigated histologically, immunohistochemically, and ultrastructurally. The pancreatic tumor with central cyst formation was found on computerized tomographic examination of a 72-year-old man reporting appetite and weight loss. The ACT component was present in the original pancreatic region and the ICT region was adjacent to the ACT. ACT was immunohistochemically positive for pancreatic amylase, whereas ICT had argyrophil tumor cells immunohistochemically positive for chromogranin A. There were several tumor cell nests positive for both pancreatic amylase (acinar differentiation) and chromogranin A (islet differentiation). We speculated that ICT may have arisen from the de-differentiated tumor cells in the ACT after the occurrence of ACT.


J Clin Gastroenterol


Muramatsu T,Kijima H,Tsuchida T,Konagaya M,Matsubayashi H,Tada N,Nakamura M,Ueyama Y




Has Abstract


2000-09-01 00:00:00












  • Hepatocellular carcinoma related to hepatitis B virus in a patient with Waldenström's macroglobulinemia.

    abstract::A patient with long-standing Waldenström's disease and cryoglobulinemia, treated with chlorambucil, developed hepatocellular carcinoma. Although HBs antigen, anti-HBs, and anti-HBc antibodies were not detected in his serum by conventional polyclonal radioimmunoassays, immunofluorescence techniques showed HBs antigen t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lotz JP,Colbert N,Degott C,Pariente EA

    更新日期:1985-10-01 00:00:00

  • Extent of colonic visualization with the fiberoptic sigmoidoscope.

    abstract::Forty-two patients underwent flexible sigmoidoscopy in the radiology department. After maximal insertion of the sigmoidoscope, a supine abdominal film documented the position of the tip of the instrument. Correlation with barium enema in all patients determined the extent of visualization of the colon relative to the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Ott DJ,Wu WC,Gelfand DW

    更新日期:1982-08-01 00:00:00

  • Ornithine transcarbamylase deficiency unmasked because of gastrointestinal bleeding.

    abstract::Ornithine transcarbamylase (OTC) is a mitochondrial-matrix enzyme that catalyzes conversion of ornithine and carbamyl phosphate to citrulline, the second step in the urea cycle. The urea cycle is the most important pathway to detoxification of ammonia in human beings. Ornithine transcarbamylase deficiency (OTCD) is th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Trivedi M,Zafar S,Spalding MJ,Jonnalagadda S

    更新日期:2001-04-01 00:00:00

  • A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial.

    abstract:GOAL:We hypothesized that sleeping left-side down with the head/torso elevated reduces recumbent gastroesophageal reflux (GER). BACKGROUND:Previous studies show that sleeping with head of bed elevated or on wedge reduces GER and lying left-side down reduces GER versus right-side down and supine. No prior studies have ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Person E,Rife C,Freeman J,Clark A,Castell DO

    更新日期:2015-09-01 00:00:00

  • Defining a clinically significant adverse impact of diagnosing Barrett's esophagus.

    abstract:BACKGROUND:Diagnosing a potentially life-threatening disease may adversely affect patient quality of life (QOL) independent of biologic effects. It is unknown whether the mere diagnosis of Barrett's esophagus (BE) adversely impacts patients' preferences (health-state utility) sufficiently to impair the cost-effectivene...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Rubenstein JH,Inadomi JM

    更新日期:2006-02-01 00:00:00

  • Utility of hepatitis C virus RNA levels for predicting the therapeutic efficacy of interferon.

    abstract::We studied the levels of serum hepatitis C virus (HCV)-RNA, the HCV genotype before interferon therapy, and the kinetics of serum HCV-RNA at the initial stages of therapy to determine their utility in predicting the therapeutic efficacy of interferon in 44 patients with chronic hepatitis C infection. We also looked at...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kato J,Komatsu M,Ono T,Ishii T,Hoshino T,Toyoshima I,Chiba M,Masamune O

    更新日期:1997-10-01 00:00:00

  • From Birth to "Immunohealth," Allergies and Enterocolitis.

    abstract::Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. After birth and initial colonization, the immune system must be...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Houghteling PD,Walker WA

    更新日期:2015-11-01 00:00:00

  • Prevalence of hepatitis-B viral markers in patients with inflammatory bowel disease in a hepatitis-B-endemic area: inadequate protective antibody levels in young patients.

    abstract:BACKGROUND:There are few data regarding the prevalence of hepatitis-B virus (HBV) markers in inflammatory bowel disease (IBD) patients in Korea, which is a hepatitis-B-endemic area. The aim of this study was to assess the prevalence of HBV markers in IBD patients in comparison with controls. METHODS:We enrolled 513 IB...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Kim ES,Cho KB,Park KS,Jang BI,Kim KO,Jeon SW,Kim EY,Yang CH,Kim WJ,Daegugyeongbuk Gastrointestinal Study Group (DGSG).

    更新日期:2014-07-01 00:00:00

  • Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection?

    abstract::A great deal is known about methods to diminish intragastric acid concentration, but far less is known about the ability of the gastroduodenal mucosa to resist injury or accelerate its healing. One group of compounds that plays a key role in the endogenous ability of the mucosa to protect itself against injury and per...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Hollander D,Tarnawski A

    更新日期:1991-01-01 00:00:00

  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Postpartum Laboratory Follow-up in Women With Hepatitis B in Massachusetts From 2007 to 2012.

    abstract:GOALS:To determine postpartum hepatitis B virus (HBV) laboratory testing rates and identify factors associated with a lack of follow-up testing in Massachusetts. BACKGROUND:Screening for HBV infection in pregnant women is standard of care. Guidelines recommend that patients with chronic HBV have ongoing care and labor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Chang MS,Barton K,Crockett M,Tuomala RE,Rutherford AE,Mutinga ML,Andersson KL,Brown RS Jr,Oken E,Ukomadu C

    更新日期:2016-07-01 00:00:00

  • Bleeding Meckel's diverticulum in an adult.

    abstract::The 99mtechnetium pertechnetate nuclear red blood cell scan proved to be a valuable diagnostic tool in localizing the site of bleeding, from a Meckel's diverticulum, in a 41-year-old man. When peptic ulcer or colorectal disease has been excluded by panendoscopy, bleeding Meckel's diverticulum remains a diagnostic cons...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Farr CM,Iqbal R,Bezmalinovic Z,Gladen HE,Stern R

    更新日期:1989-04-01 00:00:00

  • Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.

    abstract::In view of therapeutic advances, we carried out meta-analysis of results from 18 randomized, controlled clinical studies to update a previous meta-analysis and to provide an overview of clinical trials involving treatment of functional dyspepsia. The studies were included only if they satisfied inclusion and exclusion...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Finney JS,Kinnersley N,Hughes M,O'Bryan-Tear CG,Lothian J

    更新日期:1998-06-01 00:00:00

  • Small-bowel involvement in dermatitis herpetiformis and in linear-IgA bullous dermatosis.

    abstract::In 23 patients with dermatitis herpetiformis (DH) and five patients with linear-IgA bullous dermatosis (BD), we evaluated the occurrence of histologic jejunal changes and small-bowel function abnormalities. None of the patients showed clinical signs or symptoms of malabsorption. Morphological jejunal changes consisten...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: deFranchis R,Primignani M,Cipolla M,Vecchi M,Agape D,Monti M,Berti E,Zuccato E,Mussini E

    更新日期:1983-10-01 00:00:00

  • Mesenteric node enlargement as a cause of intestinal variceal hemorrhage in nodular lymphoid hyperplasia.

    abstract::Jejunal varices were a cause of recurrent gastrointestinal hemorrhage in an 18-year-old man with common variable immunodeficiency and nodular lymphoid hyperplasia of the small intestine. Despite numerous procedures, including upper gastrointestinal endoscopy, colonoscopy, arteriography, and exploratory laparotomy no a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Freiman JS,Gallagher ND

    更新日期:1985-10-01 00:00:00

  • Capsule Endoscopy Crohn's Disease Activity Index (CECDAIic or Niv Score) for the Small Bowel and Colon.

    abstract:BACKGROUND AND THE STUDY AIM:Crohn's disease (CD) is a chronic inflammatory disorder defined as a transmural inflammation of the bowel wall, affecting the small and large intestine. The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI or Niv score) was devised to measure mucosal disease activity. We extended th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Niv Y,Gal E,Gabovitz V,Hershkovitz M,Lichtenstein L,Avni I

    更新日期:2018-01-01 00:00:00

  • Carcinoma of the colon, sclerosing cholangitis, pericholangitis, and bronchiectasis in a patient with chronic ulcerative colitis.

    abstract::We report a patient with long-standing ulcerative colitis who developed carcinoma of the colon, sclerosing cholangitis, pericholangitis, and bronchiectasis over the course of 10-15 years. Occurrence of these rare conditions in the same patient supports their reported association and reemphasizes that there may be mult...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pang JA,Vicary FR

    更新日期:1984-08-01 00:00:00

  • Disposable endoscopic biopsy forceps: comparison with standard forceps of sample size and adequacy of specimen.

    abstract::Disposable biopsy forceps have recently been introduced into the field of endoscopy. We have analyzed biopsy size and histologic interpretation of samples obtained with the disposable forceps and compared them to those obtained with reusable forceps. In the 18 patients studied, 49 samples were collected with the reusa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Turk DJ,Kozarek RA,Botoman VA,Patterson DJ,Ball TJ

    更新日期:1991-02-01 00:00:00

  • Hypertrophic gastropathy symptoms responsive to prednisone. A case report and a review of the literature.

    abstract::We describe a 33-year-old man with giant hypertrophic gastropathy (Menetrier's disease), which, on operative biopsy of the stomach, showed a significant inflammatory component. The patient was treated with prednisone and quickly responded. Although a review of the literature revealed only two cases similarly treated, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Davis GE,O'Rourke MC,Metz JR,Kindig WV,Sweeney JG,Kane KN

    更新日期:1991-08-01 00:00:00

  • Acceptance of telemanagement is high in patients with inflammatory bowel disease.

    abstract:GOALS:Assess acceptance and attitudes regarding telemanagement (HAT) in patients with inflammatory bowel disease (IBD). BACKGROUND:Noncompliance is a barrier to successful outcomes in patients with IBD. Novel methods for monitoring and assessing compliance are needed. STUDY:HAT consists of a laptop connected to a wei...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Cross RK,Arora M,Finkelstein J

    更新日期:2006-03-01 00:00:00

  • Should gastric carcinoid tumors associated with pernicious anemia be treated aggressively?

    abstract::Two patients with pernicious anemia developed gastric carcinoid, one 20 years and the other 1 year after diagnosis of pernicious anemia. One of the patients underwent successful resection of the tumor, while the second, with diffuse gastric carcinoid, was managed conservatively. She is well and asymptomatic 32 months ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Stalnikowicz R,Eliakim R,Steiner D,Gross D,Okon E

    更新日期:1987-10-01 00:00:00

  • Ursodeoxycholic acid for adjuvant therapy with extracorporeal shock wave lithotripsy of gallstones.

    abstract::Extracorporeal shock wave lithotripsy (ESWL) of gallstones is a new and experimental treatment. Recent data seem to indicate that the use of ursodeoxycholic acid (UDCA) after ESWL may optimize the results of the shock wave treatment. Most of the published data on the clinical use of such therapy emanate from two studi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,评审


    authors: Fromm H

    更新日期:1988-01-01 00:00:00

  • The parathyroids and the gut.

    abstract::This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck. Hyperparathyroidism is usually from adenomas or hyperplasia. Hypoparathyroidism is as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Ebert EC

    更新日期:2010-08-01 00:00:00

  • Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.

    abstract::A 79-year-old woman visiting our hospital with chief complaints of epigastric pain and jaundice was emergently admitted. Her alpha-fetoprotein (AFP) level was as high as 2265 ng/mL at admission. Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Miyazawa M,Torii T,Toshimitsu Y,Kamizasa N,Suzuki T,Shinozuka N,Ishizawa K,Koyama I

    更新日期:2006-07-01 00:00:00

  • Utility and standards in esophageal manometry.

    abstract::Esophageal manometry is a specialized procedure used to evaluate lower and upper esophageal sphincter pressure, esophageal body contraction amplitude, and peristaltic sequence. The procedure is clinically useful in evaluation of a patient with nonstructural dysphagia, unexplained or noncardiac chest pain, a compendium...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Katz PO,Menin RA,Gideon RM

    更新日期:2008-05-01 00:00:00

  • Fecal microbiota transplantation inducing remission in Crohn's colitis and the associated changes in fecal microbial profile.

    abstract::Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine of unclear etiology. Increasing evidence has pointed to intestinal dysbiosis as a potential factor in a genetically susceptible individual. Fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease with var...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kao D,Hotte N,Gillevet P,Madsen K

    更新日期:2014-08-01 00:00:00

  • Nodules less than 20 mm and vascular invasion are predictors of survival in small hepatocellular carcinoma.

    abstract:BACKGROUND:The aims of this study were to analyze the overall survival of patients with cirrhosis and small hepatocellular carcinoma (HCC) and identify independent pretreatment predictors of survival in Brazil. METHODS:Between 1998 and 2003, 74 patients with cirrhosis and small HCC were evaluated. Predictors of surviv...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kikuchi LO,Paranaguá-Vezozzo DC,Chagas AL,Mello ES,Alves VA,Farias AQ,Pietrobon R,Carrilho FJ

    更新日期:2009-02-01 00:00:00

  • Appendectomy and tonsillectomy in patients with inflammatory bowel disease.

    abstract::Recent reports of reduced appendectomy rates in patients with ulcerative colitis have not distinguished between primary appendectomy (surgery for appendicitis) and incidental appendectomy (removal of the appendix for other reasons). In the present case control study, we examined the frequency of primary appendectomy i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Smithson JE,Radford-Smith G,Jewell GP

    更新日期:1995-12-01 00:00:00

  • Effects of radiation on the human gastrointestinal tract.

    abstract::Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particul...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Novak JM,Collins JT,Donowitz M,Farman J,Sheahan DG,Spiro HM

    更新日期:1979-03-01 00:00:00

  • Excluding gastroesophageal reflux disease as the cause of chronic cough.

    abstract::Gastroesophageal reflux disease (GERD) is recognized to be present in 10-20% of cases of chronic cough. Proving that it is the cause of the cough is more difficult. This problem is illustrated by way of a case report demonstrating that GERD can still be the cause, even when the patient is unresponsive to conventional ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论,评审


    authors: Johnston BT,Gideon RM,Castell DO

    更新日期:1996-04-01 00:00:00