Excluding gastroesophageal reflux disease as the cause of chronic cough.


:Gastroesophageal reflux disease (GERD) is recognized to be present in 10-20% of cases of chronic cough. Proving that it is the cause of the cough is more difficult. This problem is illustrated by way of a case report demonstrating that GERD can still be the cause, even when the patient is unresponsive to conventional use of proton pump inhibitors. In the commentary following the case history, we review the medical literature to confirm that GERD and cough may each precipitate the other. The role of esophageal pH monitoring in difficult cases of chronic cough is explored; we emphasize the use of pH monitoring while the patient is on therapy to prove or disprove the link.


J Clin Gastroenterol


Johnston BT,Gideon RM,Castell DO




Has Abstract


1996-04-01 00:00:00












  • Impaired plasma cyclic AMP response to exogenous glucagon in acute liver injury.

    abstract::The response of plasma cyclic AMP to glucagon was investigated in 18 patients with acute liver injury to determine its value as a marker for the severity of the hepatic damage. We also investigated the interrelationship between plasma cyclic AMP response and the hyperglucagonemia often seen in this disease. Plasma cyc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Miyakoshi H,Noda Y,Uchida S,Tanaka N,Noto Y,Kato Y,Kawai K,Hayakawa H,Kobayashi K,Hattori N

    更新日期:1984-08-01 00:00:00

  • Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD.

    abstract::The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD). Considering the heterogenous results of probiotics in clinical studies, the model of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pagnini C,Martorelli M,Lanini C,Delle Fave G

    更新日期:2016-11-01 00:00:00

  • Managing acid peptic disease in the Helicobacter pylori era.

    abstract::The advent of new diagnostic and therapeutic modalities for Helicobacter pylori allows any physician to offer curative antibiotic regimens to patients with peptic ulcer disease and gastritis. This article describes new management strategies and discusses the advantages of each. In the old strategy, endoscopy was perfo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Marshall BJ

    更新日期:1995-01-01 00:00:00

  • Clinical and Fecal Microbial Changes With Diet Therapy in Active Inflammatory Bowel Disease.

    abstract:GOAL:To determine the effect of the specific carbohydrate diet (SCD) on active inflammatory bowel disease (IBD). BACKGROUND:IBD is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Diet is a potential therapeutic option for IBD based on the hypothesis that changing the fecal dysbio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Suskind DL,Cohen SA,Brittnacher MJ,Wahbeh G,Lee D,Shaffer ML,Braly K,Hayden HS,Klein J,Gold B,Giefer M,Stallworth A,Miller SI

    更新日期:2018-02-01 00:00:00

  • Emergency Department Burden of Gastroparesis in the United States, 2006 to 2013.

    abstract:BACKGROUND AND AIMS:Gastroparesis, a chronic gastrointestinal disorder defined by delayed stomach emptying in the absence of obstruction, is often associated with frequent and costly visits to the emergency department (ED). The aim of this study was to analyze trends in gastroparesis-related ED visits from 2006 to 2013...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Hirsch W,Nee J,Ballou S,Petersen T,Friedlander D,Lee HN,Cheng V,Lembo A

    更新日期:2019-02-01 00:00:00

  • Simultaneous appearance of a unique common epitope in fetal colon, skin, and biliary epithelial cells. A possible link for extracolonic manifestations in ulcerative colitis.

    abstract::The tissue distribution of a previously identified M(r) 40 K epithelial autoantigen in ulcerative colitis was examined in situ in the fetal tissue by immunocytochemical method, using an immunoglobulin M (IgM) monoclonal antibody (7E12H12). Fetal-autopsy tissue from 9 to 19 weeks of development (11-21 gestational weeks...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Das KM,Squillante L,Chitayet D,Kalousek DK

    更新日期:1992-12-01 00:00:00

  • Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn's disease.

    abstract::Crohn's disease can be accompanied by extraintestinal manifestations. The authors report on a 39-year-old patient who presented with cheilitis granulomatosa as the first manifestation of Crohn's disease. Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from op...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: van de Scheur MR,van der Waal RI,van Bodegraven AA,Völker-Dieben HJ,Starink TM,van der Waal I

    更新日期:2002-05-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • Hepatitis C virus seroconversion and genotype prevalence in patients and staff on chronic hemodialysis.

    abstract::The prevalence of hepatitis C virus (HCV)-RNA positivity among hemodialysis patients varies between 10 and 70%. Few previous surveys revealed high frequency of seroconversion of HCV-RNA-negative patients over the years of hemodialysis. Only few studies reported HCV genotype variability. We evaluated all 65 patients on...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Zamir D,Storch S,Zonder HB,Zamir C,Weiner P

    更新日期:1999-01-01 00:00:00

  • Prolonged storage of frozen unbuffered rapid urease test.

    abstract::Unbuffered rapid urease test (RUT) is an accurate, rapid, and inexpensive method of detecting Helicobacter pylori. However, it is generally recommended to prepare the reagent daily. This prospective study was undertaken to evaluate the shelf-life of our unbuffered RUT at -20 degrees C. Two sets of antral biopsies (X2)...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Ng FH,Wong SY,Ng WF,Wong BC

    更新日期:2000-09-01 00:00:00

  • Reversing Hyperammonemia in Neuroendocrine Tumors.

    abstract::Ammonia is a neurotoxin that is normally cleared by the intact liver and if not, hyperammonemia results in hepatic encephalopathy. Hyperammonemia may be owing to primary or secondary causes. Early diagnosis is important to prevent permanent brain damage. Advanced malignancy involving the liver is associated with hyper...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Broadbridge V,Townsend A,Pittman K,Kimber R,Patterson W,Sukumaran S,Price TJ

    更新日期:2010-09-01 00:00:00

  • Giant bulla in pneumatosis cystoides intestinalis.

    abstract::In pneumatosis cystoides intestinalis the air sacs are generally small and the mesentery is rarely involved. We describe a 23-year-old woman with mixed connective tissue disease and known esophageal ulcer who developed hematemesis and abdominal distention. Colonoscopy showed pneumatosis coli. A computed tomography (CT...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lanspa SJ,Liu MW,Jenkins HJ Jr

    更新日期:1988-08-01 00:00:00

  • Cytomegalovirus-associated perianal ulcerations in AIDS.

    abstract::We report two patients with the acquired immune deficiency syndrome and cytomegalovirus associated perianal ulcerations. Both complained of chronic, painful, nonhealing ulcers that required surgical intervention for diagnosis and palliation. One patient developed diffuse cytomegalovirus infection and both had poor res...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kamel PL

    更新日期:1992-03-01 00:00:00

  • Digital Single-operator Cholangioscopy (DSOC) Improves Interobserver Agreement (IOA) and Accuracy for Evaluation of Indeterminate Biliary Strictures: The Monaco Classification.

    abstract:BACKGROUND:Visual characteristics seen during digital single-operator cholangioscopy (DSOC) have not been validated. The aim of this 2-phase study was to define terminology by consensus for the visual diagnosis of biliary lesions to develop a model for optimization of the diagnostic performance of DSOC. MATERIALS AND ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sethi A,Tyberg A,Slivka A,Adler DG,Desai AP,Sejpal DV,Pleskow DK,Bertani H,Gan SI,Shah R,Arnelo U,Tarnasky PR,Banerjee S,Itoi T,Moon JH,Kim DC,Gaidhane M,Raijman I,Peterson BT,Gress FG,Kahaleh M

    更新日期:2020-02-07 00:00:00

  • Cyclic vomiting associated with excessive dopamine in Riley-day syndrome.

    abstract:GOALS:To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome. BACKGROUND:One of the most disabling features of patients with Riley-day syndrome are recurrent attacks of severe nausea/retching/vomiting accompanied by hypertension, tachycardia, and sk...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Norcliffe-Kaufmann LJ,Axelrod FB,Kaufmann H

    更新日期:2013-02-01 00:00:00

  • Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

    abstract:BACKGROUND:The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients. GOALS:We aimed to determine the incidence of and risk factors for meningitis in IBD patients. STUDY:We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kochar B,Jiang Y,Long MD

    更新日期:2020-05-29 00:00:00

  • Sturge-Weber syndrome: a rare cause of gastrointestinal hemorrhage.

    abstract::A case of Sturge-Weber syndrome (SWS) with gastrointestinal hemorrhage is presented. SWS is a neurocutaneous disorder characterized by cutaneous facial angioma leptomeningeal angioma with seizures and other neurologic complications. Associated anomalies beyond the encephalofacial territory are very rare. The patient p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Castilla-Guerra L,Fernández-Moreno MC,Franco E

    更新日期:2000-01-01 00:00:00

  • Infection with hepatitis C virus genotype 4 in the United States.

    abstract:BACKGROUND:Hepatitis C virus genotype differences seem to be of considerable clinical significance because they affect responses to antiviral therapy. HCV genotype 4 is rare in the United States and there are few published data regarding response to therapy in patients with HCV genotype 4 infection. OBJECTIVES:To asse...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lyra AC,Ramrakhiani S,Bacon BR,Di Bisceglie AM

    更新日期:2004-01-01 00:00:00

  • The Cronkhite-Canada syndrome with focus on immunity and infection. Report of a case.

    abstract::A 64-year-old man developed diffuse gastrointestinal polyposis, protein-losing enteropathy, skin pigmentation, hair loss, and unique nail changes. He also exhibited pulmonary tuberculosis and impaired immunity with skin anergy, poor lymphocyte mitogens stimulation test, and low serum immunoglobulin. We discuss the rel...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lin HJ,Tsai YT,Lee SD,Lai KH,Ng WW,Tam TN,Lin HC,Liou LB,Tsay SH

    更新日期:1987-10-01 00:00:00

  • Orocecal transit time and bacterial overgrowth in patients with Crohn's disease.

    abstract::Bacterial overgrowth is frequent in patients with Crohn's disease (CD) and can contribute to symptoms. Motility abnormalities can predispose to bacterial overgrowth. The hydrogen (H2) and methane (CH4) breath test is a sensitive and simple tool for the diagnosis of bacterial overgrowth and for the evaluation of orocec...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Castiglione F,Del Vecchio Blanco G,Rispo A,Petrelli G,Amalfi G,Cozzolino A,Cuccaro I,Mazzacca G

    更新日期:2000-07-01 00:00:00

  • Willingness to undergo a repeat liver biopsy among HIV/hepatitis C virus-coinfected and hepatitis C virus-monoinfected patients.

    abstract:BACKGROUND:Guidelines for chronic hepatitis C virus (HCV) management have recommended that a liver biopsy be repeated at 3-year intervals for HIV/HCV-coinfected patients and 5-year intervals for those with HCV monoinfection to assess fibrosis progression. However, it is unclear if patients are willing to repeat this pr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Amorosa VK,Aibana O,Shire NJ,Dorey-Stein Z,Ferrara T,Gilmore J,Kostman JR,Lo Re V 3rd

    更新日期:2013-05-01 00:00:00

  • The efficacy of intravenous contrast-enhanced 16-raw multidetector CT colonography for detecting patients with colorectal polyps in an asymptomatic population in Korea.

    abstract:PURPOSE:The purpose of this study is to compare the sensitivity of computed tomography (CT) colonography (CTC) with that of colonoscopy for detecting patients with colorectal polyps in an asymptomatic screening population in Korea, thus to evaluate a possibility, whether CTC could be used as a screening tool for colore...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kim YS,Kim N,Kim SH,Park MJ,Lim SH,Yim JY,Cho KR,Kim SS,Kim DH,Eun HW,Cho KS,Kim JH,Choi BI,Jung HC,Song IS,Shin CS,Cho SH,Oh BH

    更新日期:2008-08-01 00:00:00

  • Spontaneous regression of primary malignant lymphoma of the stomach in two nontreated Japanese.

    abstract::Two patients with primary malignant lymphoma underwent spontaneous regression. One was a 40-year-old woman with a large ulcerating tumor on the greater curvature of the gastric antrum. This tumor shrank spontaneously, leaving only a small shallow ulcer. The resected specimen showed a minute focus of malignant lymphoma...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Shigematsu A,Iida M,Lien GS,Imamura T,Okada M,Fuchigami T,Fujishima M,Itoh H,Iwashita A

    更新日期:1989-10-01 00:00:00

  • Genotypes of hepatitis C virus in Taiwan and the progression of liver disease.

    abstract::The existence of four genotypes of hepatitis C virus (HCV)--types 1a, 1b, 2a, and 2b--has been suggested based on variations in nucleotide sequences of the core region. The aim of this study was to investigate the prevalence of HCV genotypes in chronic type C liver disease in Taiwan and correlate distinct genotypes to...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

    更新日期:1995-10-01 00:00:00

  • Subclinical Ascites Does Not Affect the Long-term Prognosis in Hepatitis B Virus-related Cirrhosis Patients Receiving Antivirals.

    abstract:BACKGROUND AND AIMS:This study evaluated the clinical significance of subclinical ascites in patients with hepatitis B virus-related cirrhosis treated with lamivudine (LMV) or entecavir (ETV). METHODS:This multicenter retrospective study involved 8 hospitals. Patients were classified by degree of ascites: (1) no ascit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Yim SY,Lee JH,Ahn H,Kim SU,Kim SG,Kim YS,Kim JH,Choe WH,Kim TY,Jung YK,Suh SJ,Suk KT,An H,Yim HJ,Seo YS,Um SH

    更新日期:2016-09-01 00:00:00

  • Fever and infectious complications after percutaneous acetic acid injection therapy for hepatocellular carcinoma: incidence and risk factor analysis.

    abstract:BACKGROUND:Ultrasound-guided percutaneous acetic acid injection (PAI) therapy is effective for hepatocellular carcinoma (HCC). Posttreatment fever (>37.5 degrees C) may occur owing to acetic acid-induced tumor necrosis, but its incidence and clinical significance are not clear. METHODS:A total of 402 treatment session...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Huo TI,Huang YH,Huang HC,Wu JC,Lee PC,Chang FY,Lee SD

    更新日期:2006-08-01 00:00:00

  • Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment.

    abstract::Immunoproliferative small intestinal disease (IPSID) is a rare lympho-proliferative disorder of the upper small intestine. It is considered a special form of MALT lymphoma with propensity to malignant transformation. This disorder is rare in pediatric literature. We report a case of IPSID in a 16-year-old boy with low...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Zamir A,Parasher G,Moukarzel AA,Guarini L,Zeien L,Feldman F

    更新日期:1998-07-01 00:00:00

  • Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease.

    abstract:GOALS:Our objective was to determine whether high serologic IgA tissue transglutaminase antibodies (TTGA) are exclusively associated with celiac disease (CD). BACKGROUND:IgA TTGA are found in the serum of most individuals with CD. This serologic marker is used to screen individuals with suspected CD for duodenal biops...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Donaldson MR,Book LS,Leiferman KM,Zone JJ,Neuhausen SL

    更新日期:2008-03-01 00:00:00

  • Fulminant acute Budd-Chiari syndrome stemming from an adrenal tumor.

    abstract::Adrenal neoplasm is a rare cause of Budd-Chiari syndrome. We report a case of fulminant acute Budd-Chiari syndrome due to inferior vena cava thrombosis stemming from invasion by a clinically nonfunctioning adrenal neoplasm. We also review briefly the clinical characteristics of the seven previously reported cases. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Moreira V,Aller R,De Luis DA,San Roman AL,Ferreiro A

    更新日期:1997-03-01 00:00:00

  • Unconjugated hyperbilirubinemia in chronic persistent hepatitis.

    abstract::We studied a young man with persistent elevation of transaminases and indirect bilirubin following acute viral hepatitis. Liver biopsy showed chronic persistent hepatitis, and clinical evaluation was otherwise negative for significant liver disease. The indirect-reacting serum bilirubin rose after both caloric restric...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Caldwell JH,Kirschner SD,Spagna VA,Inloes RL

    更新日期:1981-03-01 00:00:00