Abstract:
INTRODUCTION:Capsule endoscopy (CE) can detect Crohn's disease in patients with suggestive symptoms but with negative results from the traditional diagnostic work-up (ileocolonoscopy and small bowel follow-through). The objective of this study was to determine which clinical features predict the diagnosis of Crohn's disease by CE in this subgroup of patients. MATERIAL AND METHODS:Twenty-three patients (7 men, 16 women; mean age: 40+/-15 y) with negative results from conventional imaging techniques were prospectively included in the study because of suspicion of Crohn's disease (long-standing abdominal pain and/or diarrhea and at least one of the following symptoms: anemia, weight loss, long-standing fever, perianal disease, extraintestinal manifestations typical of inflammatory bowel disease, elevated inflammatory parameters, or family history of inflammatory bowel disease). RESULTS:CE diagnosed Crohn's disease in 6 patients (26%). Crohn's disease diagnosis was more frequent in patients with a combination of anemia and elevated inflammatory parameters than in patients without this combination (57% vs. 12.5%; P=0.04). The only statistically significant association between an inflammatory parameter and Crohn's disease was an increased platelet count. CONCLUSIONS:CE is a useful tool for the diagnosis of subtle small bowel Crohn's disease. The diagnostic yield of CE in patients with suspicion of Crohn's disease but negative results from the traditional diagnostic work-up is significantly higher in patients with anemia and increased platelet count than in patients without this combination of clinical features.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Valle J,Alcántara M,Pérez-Grueso MJ,Navajas J,Muñoz-Rosas C,Legaz ML,Cuena R,Carrobles JMdoi
10.1097/00004836-200609000-00006subject
Has Abstractpub_date
2006-09-01 00:00:00pages
692-6issue
8eissn
0192-0790issn
1539-2031pii
00004836-200609000-00006journal_volume
40pub_type
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