Abstract:
:Chronic atrophic gastritis (CAG) is closely correlated with gastric cancer and is predominant in Japan. Epidemiologically, food habits are the primary factor in both CAG and gastric cancer. Two potential serum markers for CAG have recently been investigated, i.e., the concentration of serum pepsinogen (PG) and the presence of serum antibodies against Helicobacter pylori. Serum PG I and II and the PG I:PG II ratio have been reported to be useful as indicators of recurrent peptic ulcer and for screening of patients at risk from gastric cancer. In this study, we examined PG I and II in serum from 483 patients by RIA (DAINABOT), and endoscopic examination performed in the same patients before serological assay revealed CAG in 68, peptic ulcer in 91, and gastric cancer in 48. Analysis of the mean values according to patients age showed that CAG patients in their forties to eighties had low (< 40 ng/ml) levels of PG I, peptic ulcer patients in their teens to eighties had high (> or = 70 ng/ml) levels, except for those in their seventies, and gastric cancer patients in their twenties to sixties had low (< 3.0) PG I:PG II ratios, except for those in their sixties. Thus serum PG assay has potential utility for detection of CAG, peptic ulcer, and gastric cancer.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Matsukura N,Onda M,Tokunaga A,Fujita I,Okuda T,Mizutani T,Kyono S,Yamashita Kdoi
10.1097/00004836-199312001-00026subject
Has Abstractpub_date
1993-01-01 00:00:00pages
S146-50eissn
0192-0790issn
1539-2031journal_volume
17 Suppl 1pub_type
杂志文章abstract::During the past three decades, important advances in our understanding of the pathophysiology of chronic pancreatitis (CP), improved results of major pancreatic resections (including pancreatoduodenectomy), and integration of sophisticated diagnostic methods in clinical practice resulted in significant changes in our ...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/00004836-200201000-00014
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abstract:BACKGROUND:Clostridium difficile is a bacterial pathogen associated with significant morbidity and mortality in patients with cirrhosis. GOALS:Our primary aim is to identify variables that are predictive of poor outcomes in cirrhosis patients with C. difficile infection (CDI). We also aim to further characterize the r...
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journal_title:Journal of clinical gastroenterology
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doi:10.1097/00004836-199807000-00010
更新日期:1998-07-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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更新日期:2006-11-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 评论,杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198610000-00008
更新日期:1986-10-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198712000-00006
更新日期:1987-12-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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doi:10.1097/00004836-198704000-00010
更新日期:1987-04-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199901000-00005
更新日期:1999-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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pub_type: 杂志文章,meta分析,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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更新日期:1989-12-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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