Abstract:
GOALS:To determine whether the presence of dupA Helicobacter pylori (H. pylori) influences the cure rate of primary eradication therapy. BACKGROUND:Several virulence factors of H. pylori have been reported to affect the efficacy of the eradication rate. However, no study has investigated whether the presence of dupA affects eradication failure. STUDY:The presence of dupA was evaluated in 142 H. pylori strains isolated from 142 patients with gastrointestinal diseases. Of these patients, 104 received primary eradication therapy for 1 week. The risk factors for eradication failure were determined using univariate and multivariate analyses. RESULTS:Among 142 strains, 44 (31.0%) were dupA positive. There was no association between dupA status and gastroduodenal diseases (P>0.05). The clarithromycin (CLR) resistance rate was generally lower in the dupA-positive than in the dupA-negative group (20.4% vs. 35.7%, P=0.06). However, dupA prevalence was higher in the eradication failure group than in the success group (36.3% vs. 21.9%). Among the CLR-resistant H. pylori infected group, the successful eradication rate was significantly lower in patients infected with dupA-positive H. pylori than dupA-negative H. pylori (P=0.04). In multivariate analysis adjusted for age, sex, and type of disease, not only CLR resistance but also dupA presence was independent risk factors for eradication failure (adjusted odds ratio=3.71; 95% confidence interval,1.07-12.83). CONCLUSIONS:Although CLR resistant was more reliable predictor, the presence of dupA may also be an independent risk factor for eradication failure.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Shiota S,Nguyen LT,Murakami K,Kuroda A,Mizukami K,Okimoto T,Kodama M,Fujioka T,Yamaoka Ydoi
10.1097/MCG.0b013e318243201csubject
Has Abstractpub_date
2012-04-01 00:00:00pages
297-301issue
4eissn
0192-0790issn
1539-2031journal_volume
46pub_type
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journal_title:Journal of clinical gastroenterology
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abstract::Esophageal intramural pseudodiverticulosis (EIP) is a rare disease, characterized by multiple, small flask-shaped diverticula in the esophageal wall, and best demonstrated on single-contrast barium examination. Though the condition is often associated with reflux esophagitis, Candida esophagitis, and esophageal dysmot...
journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1097/00004836-199601000-00007
更新日期:1996-01-01 00:00:00
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