Association of helicobacter pylori dupA with the failure of primary eradication.


GOALS:To determine whether the presence of dupA Helicobacter pylori (H. pylori) influences the cure rate of primary eradication therapy. BACKGROUND:Several virulence factors of H. pylori have been reported to affect the efficacy of the eradication rate. However, no study has investigated whether the presence of dupA affects eradication failure. STUDY:The presence of dupA was evaluated in 142 H. pylori strains isolated from 142 patients with gastrointestinal diseases. Of these patients, 104 received primary eradication therapy for 1 week. The risk factors for eradication failure were determined using univariate and multivariate analyses. RESULTS:Among 142 strains, 44 (31.0%) were dupA positive. There was no association between dupA status and gastroduodenal diseases (P>0.05). The clarithromycin (CLR) resistance rate was generally lower in the dupA-positive than in the dupA-negative group (20.4% vs. 35.7%, P=0.06). However, dupA prevalence was higher in the eradication failure group than in the success group (36.3% vs. 21.9%). Among the CLR-resistant H. pylori infected group, the successful eradication rate was significantly lower in patients infected with dupA-positive H. pylori than dupA-negative H. pylori (P=0.04). In multivariate analysis adjusted for age, sex, and type of disease, not only CLR resistance but also dupA presence was independent risk factors for eradication failure (adjusted odds ratio=3.71; 95% confidence interval,1.07-12.83). CONCLUSIONS:Although CLR resistant was more reliable predictor, the presence of dupA may also be an independent risk factor for eradication failure.


J Clin Gastroenterol


Shiota S,Nguyen LT,Murakami K,Kuroda A,Mizukami K,Okimoto T,Kodama M,Fujioka T,Yamaoka Y




Has Abstract


2012-04-01 00:00:00












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    abstract:OBJECTIVE:To assess the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in patients with colonic diverticular disease performing a systematic review of the literature. DATA SOURCES:Cochrane Trial Register (until Issue 4, 2008), Medical Literature Analysis and Retrieval System Online (1966 to October 1, 2008), Ex...

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    更新日期:2010-02-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

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    authors: Sugai E,Srur G,Vazquez H,Benito F,Mauriño E,Boerr LA,Bai JC

    更新日期:1994-10-01 00:00:00

  • Development of Image-enhanced Endoscopy of the Gastrointestinal Tract: A Review of History and Current Evidences.

    abstract::Endoscopy imaging of the gastrointestinal (GI) tract has evolved tremendously over the last few decades. Key milestones in the development of endoscopy imaging include the use of various dyes for chromoendoscopy, the application of optical magnification in endoscopy, the introduction of high-definition image capturing...

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    pub_type: 历史文章,杂志文章


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    更新日期:2018-04-01 00:00:00

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  • Neostigmine Administered With MoviPrep Improves Bowel Preparation for Elective Colonoscopy in Patients With Spinal Cord Injury: A Randomized Study.

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    journal_title:Journal of clinical gastroenterology

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    更新日期:2008-08-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    journal_title:Journal of clinical gastroenterology

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    更新日期:2005-11-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    authors: Fromm H

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    更新日期:1982-06-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    更新日期:2013-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Ng FH,Wong SY,Ng WF,Wong BC

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    abstract:BACKGROUND:Twenty-four-hour multichannel intraluminal impedance and pH (MII-pH) esophageal monitoring allows detection of both acid and nonacid gastroesophageal reflux episodes. The MII-pH catheter contains 6 impedance segments placed 3, 5, 7, 9, 15, and 17 cm above the lower esophageal sphincter (LES), plus a pH elect...

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    更新日期:2011-11-01 00:00:00

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    更新日期:1991-06-01 00:00:00

  • Aortoesophageal fistula after perigraft abscess with characteristic CT findings.

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    journal_title:Journal of clinical gastroenterology

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    authors: Osawa H,Sugano K,Igari T,Tai T,Iwamori M,Kawakami M

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    journal_title:Journal of clinical gastroenterology

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    authors: Furukawa O,Okabe S

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    journal_title:Journal of clinical gastroenterology

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    pub_type: 杂志文章


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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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