Reversing Hyperammonemia in Neuroendocrine Tumors.

Abstract:

:Ammonia is a neurotoxin that is normally cleared by the intact liver and if not, hyperammonemia results in hepatic encephalopathy. Hyperammonemia may be owing to primary or secondary causes. Early diagnosis is important to prevent permanent brain damage. Advanced malignancy involving the liver is associated with hyperammonemia as a result of abnormality of the portal venous system or massive hepatic tumor burdon. Neuroendocrine tumors are an example of a malignant process that frequently involves the liver but despite this, may still have a relatively good prognosis, and are often characterized by chronic manageable symptoms and slow progression. Hyperammonemia in neuroendocrine tumor would represent a potentially reversible but ongoing process associated with an indolent malignancy. We present 2 cases that are examples of this diagnosis and discuss the diagnostic and management issues that may arise.

journal_name

J Clin Gastroenterol

authors

Broadbridge V,Townsend A,Pittman K,Kimber R,Patterson W,Sukumaran S,Price TJ

doi

10.1097/MCG.0b013e3181d96aad

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

e186-9

issue

8

eissn

0192-0790

issn

1539-2031

journal_volume

44

pub_type

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