Ulcer healing after treatment with sucralfate emulsion or ranitidine. Randomized controlled study in peptic ulcer disease.


:A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prepyloric area within a distance of 2 cm from the pylorus were included. A total of 97 patients were randomized and 85 completed the trial. The endoscopically proven healing rate at 2 weeks of 41% for both sucralfate and ranitidine improved to 76% for sucralfate and 73% for ranitidine at 4 weeks and to 95% and 96%, respectively, at 12 weeks. The difference between the two treatment groups was not statistically significant, and the 95% confidence interval for the difference in ulcer healing efficacy of sucralfate emulsion compared with ranitidine was -0.15 to +0.21 at 4 weeks and -0.10 to +0.08 at 12 weeks.


J Clin Gastroenterol


Lykkegaard Nielsen MC,Vagn Nielsen O,Moesgaard F




Has Abstract


1988-08-01 00:00:00












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    journal_title:Journal of clinical gastroenterology

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    authors: Prevot MB

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    authors: Halfdanarson TR,Kumar N,Hogan WJ,Murray JA

    更新日期:2009-02-01 00:00:00

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    journal_title:Journal of clinical gastroenterology

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    authors: Ebert EC

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    pub_type: 杂志文章


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    authors: Berlatzky Y,Freund HR

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  • Fever and infectious complications after percutaneous acetic acid injection therapy for hepatocellular carcinoma: incidence and risk factor analysis.

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    journal_title:Journal of clinical gastroenterology

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    authors: Celik AF,Ozaras R,Ozbay G

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    journal_title:Journal of clinical gastroenterology

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    pub_type: 杂志文章


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    journal_title:Journal of clinical gastroenterology

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    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Novak JM,Collins JT,Donowitz M,Farman J,Sheahan DG,Spiro HM

    更新日期:1979-03-01 00:00:00