Ulcer healing after treatment with sucralfate emulsion or ranitidine. Randomized controlled study in peptic ulcer disease.

Abstract:

:A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prepyloric area within a distance of 2 cm from the pylorus were included. A total of 97 patients were randomized and 85 completed the trial. The endoscopically proven healing rate at 2 weeks of 41% for both sucralfate and ranitidine improved to 76% for sucralfate and 73% for ranitidine at 4 weeks and to 95% and 96%, respectively, at 12 weeks. The difference between the two treatment groups was not statistically significant, and the 95% confidence interval for the difference in ulcer healing efficacy of sucralfate emulsion compared with ranitidine was -0.15 to +0.21 at 4 weeks and -0.10 to +0.08 at 12 weeks.

journal_name

J Clin Gastroenterol

authors

Lykkegaard Nielsen MC,Vagn Nielsen O,Moesgaard F

doi

10.1097/00004836-198808000-00006

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

377-9

issue

4

eissn

0192-0790

issn

1539-2031

journal_volume

10

pub_type

临床试验,杂志文章,随机对照试验
  • New regulatory trends for probiotics.

    abstract::The aim of this paper (presented in Rome, Italy, at the 2nd Congress of Probiotics, Prebiotics, and New Food, September 7-9, 2003) was to provide an objective view of the regulatory trends at the European level specifically referring to probiotics, because until now they have never been directly mentioned nor official...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000128733.79515.c4

    authors: Prevot MB

    更新日期:2004-07-01 00:00:00

  • Gastrointestinal and hepatic manifestations of Sjogren syndrome.

    abstract::Sjogren syndrome (SS) is an autoimmune disease that affects exocrine glands and therefore may affect the gastrointestinal system, from the mouth, esophagus, and bowel to the liver and pancreas. Oral involvement in SS is mainly characterized by dryness, with a wide spectrum of symptoms, from mild-to-severe xerostomia w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3182329d9c

    authors: Ebert EC

    更新日期:2012-01-01 00:00:00

  • Copper deficiency in celiac disease.

    abstract::Copper deficiency is an uncommonly reported complication of celiac disease that has not received much attention in recent years. Copper deficiency may result in anemia and thrombocytopenia and also irreversible myeloneuropathy if it is not detected and treated appropriately. The prevalence of copper deficiency in pati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181354294

    authors: Halfdanarson TR,Kumar N,Hogan WJ,Murray JA

    更新日期:2009-02-01 00:00:00

  • The parathyroids and the gut.

    abstract::This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck. Hyperparathyroidism is usually from adenomas or hyperplasia. Hypoparathyroidism is as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181cd9d4c

    authors: Ebert EC

    更新日期:2010-08-01 00:00:00

  • Tormentil for active ulcerative colitis: an open-label, dose-escalating study.

    abstract:BACKGROUND:Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS:To assess the safety, pharmacology, and clinical effects of different doses of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31804b2173

    authors: Huber R,Ditfurth AV,Amann F,Güthlin C,Rostock M,Trittler R,Kümmerer K,Merfort I

    更新日期:2007-10-01 00:00:00

  • Primary choledochoduodenostomy for benign obstructive biliary tract disease.

    abstract::Repeated surgical interventions on the biliary ductal system increase morbidity and mortality, particularly in the geriatric patient. In an attempt to prevent these complications, side-to-side choledochoduodenostomy was performed as the primary operative procedure in 54 patients, age 72 +/- 13 years. This was the pati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199008000-00013

    authors: Berlatzky Y,Freund HR

    更新日期:1990-08-01 00:00:00

  • Efficacy of 5-ASA in the treatment of colonic diverticular disease.

    abstract:OBJECTIVE:To assess the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in patients with colonic diverticular disease performing a systematic review of the literature. DATA SOURCES:Cochrane Trial Register (until Issue 4, 2008), Medical Literature Analysis and Retrieval System Online (1966 to October 1, 2008), Ex...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181a15864

    authors: Gatta L,Vakil N,Vaira D,Pilotto A,Curlo M,Comparato G,Leandro G,Ferro U,Lera M,Milletti S,Di Mario F

    更新日期:2010-02-01 00:00:00

  • Fever and infectious complications after percutaneous acetic acid injection therapy for hepatocellular carcinoma: incidence and risk factor analysis.

    abstract:BACKGROUND:Ultrasound-guided percutaneous acetic acid injection (PAI) therapy is effective for hepatocellular carcinoma (HCC). Posttreatment fever (>37.5 degrees C) may occur owing to acetic acid-induced tumor necrosis, but its incidence and clinical significance are not clear. METHODS:A total of 402 treatment session...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200608000-00017

    authors: Huo TI,Huang YH,Huang HC,Wu JC,Lee PC,Chang FY,Lee SD

    更新日期:2006-08-01 00:00:00

  • Epidemiology of Crohn's Disease.

    abstract::Although our current understanding is limited, epidemiologic investigation of Crohn's disease holds great promise. Certain aspects of the epidemiology are clear. The incidence of Crohn's disease, which has increased over the past few decades, may have reached a plateau. The disease has its peak onset in early life, wi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198604000-00011

    authors: Sandler RS,Golden AL

    更新日期:1986-04-01 00:00:00

  • Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Vitamin deficiency is frequently associated with inflammatory bowel disease (IBD). Supplementation of vitamins could thus serve as an adjunctive therapy. The present meta-analysis reviews the deficiencies and alterations in serum fat-soluble vitamins (A, D, E, and K) reported in IBD patients. MATERIALS AND ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000911

    authors: Fabisiak N,Fabisiak A,Watala C,Fichna J

    更新日期:2017-11-01 00:00:00

  • Serum nitric oxide levels in children with celiac disease.

    abstract:OBJECTIVES:To determine serum nitric oxide levels in pediatric patients with celiac disease and to compare them with the results obtained after 1 year of gluten-free diet. METHODS:We studied serum nitric oxide levels in 41 newly diagnosed patients with celiac disease. Serum levels of nitric oxide were reevaluated afte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000177240.67215.da

    authors: Ertekin V,Selimoğlu MA,Türkan Y,Akçay F

    更新日期:2005-10-01 00:00:00

  • Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases.

    abstract::Etiology of inflammatory bowel disease (IBD) is not yet completely understood, but it is hypothesized that a disruption of the immune tolerance to gut microbiota, due to several potential factors like an abnormal gut microbiota composition and activity, may lead to IBD occurrence. Manipulation of the intestinal microb...

    journal_title:Journal of clinical gastroenterology

    pub_type:

    doi:10.1097/MCG.0000000000001095

    authors: Scarpato E,Russo M,Staiano A

    更新日期:2018-11-01 00:00:00

  • Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults.

    abstract:BACKGROUND:The prevalence of nonalcoholic fatty liver disease (NAFLD) is rarely reported in Taiwan. GOALS:To determine the prevalence and risk factors of NAFLD in an adult population of Taiwan. STUDY:The cross-sectional community study examined 3245 adults in a rural village of Taiwan. The diagnostic criteria for NAF...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200609000-00016

    authors: Chen CH,Huang MH,Yang JC,Nien CK,Yang CC,Yeh YH,Yueh SK

    更新日期:2006-09-01 00:00:00

  • Smoking and hyperpepsinogenemia are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients.

    abstract:BACKGROUND:Although Helicobacter pylori has been established as a major etiologic factor of chronic gastritis and makes an important contribution to peptic ulceration, the reason why H. pylori causes different gastroduodenal diseases in different people is at present not clear. GOALS:The aim of this study is to identi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000173854.55172.ee

    authors: Chen TS,Lee YC,Li FY,Chang FY

    更新日期:2005-09-01 00:00:00

  • Esophageal pressure topography, body position, and hiatal hernia.

    abstract:INTRODUCTION:Whether body position affects lower esophageal sphincter (LES) function and detection of hiatal hernia is unknown. Moreover, the yield of high-resolution esophageal pressure topography (HREPT) when compared with endoscopy for detection of hiatal hernia is unclear. AIM:The aims of this study were to examin...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000057

    authors: Hashmi S,Rao SS,Summers RW,Schulze K

    更新日期:2014-03-01 00:00:00

  • Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma.

    abstract::Hepatic cavernous hemangioma is the most common benign tumor of the liver. Appropriate management of this tumor remains a controversial topic. We have accumulated a number of cases with successful management of local hepatic tumors. Here we report a case where we performed an ultrasound-guided percutaneous radiofreque...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000196404.07487.1d

    authors: Tak WY,Park SY,Jeon SW,Cho CM,Kweon YO,Kim SK,Choi YH,Chung JM

    更新日期:2006-02-01 00:00:00

  • Follow-up of a patient with chronic hepatitis C-associated cryoglobulinemia during four and a half years of maintenance interferon treatment.

    abstract::In this report, we present a patient with chronic hepatitis C-associated cryoglobulinemia who was kept on maintenance interferon treatment because of flare-ups in cryoglobulinemia-associated signs and hepatitis after withdrawal, dose reduction, and increase in dose intervals of interferon. This type of interferon use ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200110000-00015

    authors: Celik AF,Ozaras R,Ozbay G

    更新日期:2001-10-01 00:00:00

  • Eleven-year survey of safety and efficacy of endoscopic injection sclerotherapy using 2% sodium tetradecyl sulfate and contrast medium.

    abstract::We conducted a retrospective 11-year survey to evaluate the post-treatment course in 285 patients with esophagogastric varices following administration of endoscopic injection sclerotherapy as an emergency, elective, or prophylactic procedure using freshly prepared 2% sodium tetradecyl sulfate not containing benzyl al...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199601000-00017

    authors: Iwase H,Suga S,Shimada M,Yamada H,Horiuchi Y,Oohashi M

    更新日期:1996-01-01 00:00:00

  • A long-term comparison of plication configurations for endoluminal gastroplication: circumferential versus helical.

    abstract:GOALS:To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. BACKGROUND:Endoluminal gastroplication is an intriguing therapy for gastroesophageal reflux disease. We conducted a retrospective review of a prospective experience of patient cohorts compari...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000180632.99936.6f

    authors: Davis RE,Iqbal A,Gerhardt JD,Welch RA,Turaga K,Tierney B,Haider M,Filipi CJ

    更新日期:2005-11-01 00:00:00

  • Microbiota, innate immune system, and gastrointestinal muscle: ongoing studies.

    abstract:AIM:To test the activities of culture-extracted or commercially available toll-like receptors (TLRs) ligands to establish their direct impact on target gastrointestinal motor cells. METHODS:Short-term and long-term effects of Shigella flexneri M90T and Escherichia coli K-2 strains-extracted lipopolysaccharides (LPS), ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318265ea7d

    authors: Tattoli I,Petitta C,Scirocco A,Ammoscato F,Cicenia A,Severi C

    更新日期:2012-10-01 00:00:00

  • Patient outcomes related to percutaneous endoscopic gastrostomy placement.

    abstract::Although many aspects of percutaneous endoscopic gastrostomy (PEG) have been addressed in the literature, attention to psychologic and social outcomes of PEG has been limited. Our goal was to assess a range of physical, psychologic, and social outcomes related to PEG feeding. This study is a follow-up survey of patien...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200101000-00012

    authors: Verhoef MJ,Van Rosendaal GM

    更新日期:2001-01-01 00:00:00

  • Right colon adenocarcinoma presenting as Bacteroides fragilis liver abscesses.

    abstract::Pyogenic abscesses of the liver occur in association with a variety of diseases. Sometimes they are caused by anaerobic infections of liver metastases. Uncommonly, however, multiple hepatic abscesses caused by anaerobic bacteria are the presenting signs of unsuspected colonic cancer in the absence of liver metastases....

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199206000-00013

    authors: Lonardo A,Grisendi A,Pulvirenti M,Della Casa G,Melini L,Di Gregorio C,Nasi G,Sarti M,Tamborrino E,Lonardo F

    更新日期:1992-06-01 00:00:00

  • Are Anti-Tumor Necrosis Factor Trough Levels Predictive of Mucosal Healing in Patients With Inflammatory Bowel Disease?: A Systematic Review and Meta-Analysis.

    abstract:GOALS:Our primary goal was to evaluate whether anti-tumor necrosis factor (TNF)-α trough levels above author-determined thresholds are associated with increased rates of mucosal healing among patients with Crohn's disease and ulcerative colitis. BACKGROUND:The introduction of anti-TNF agents has considerably advanced ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000441

    authors: Barnes EL,Allegretti JR

    更新日期:2016-10-01 00:00:00

  • Immunohistochemical study of sulfatide expression in gastric carcinoma: alteration of sulfatide expression.

    abstract::Immunohistochemical staining using a specific monoclonal antibody against sulfatide was performed to examine cellular localization of sulfatides in normal human gastric mucosa and in various types of gastric carcinoma. In normal gastric mucosa without Helicobacter pylori infection, both epithelial and glandular cells ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199700001-00023

    authors: Osawa H,Sugano K,Igari T,Tai T,Iwamori M,Kawakami M

    更新日期:1997-01-01 00:00:00

  • High frequency of genotype D and spontaneous hepatitis B virus genomic mutations among Haitians in a multiethnic North American population.

    abstract:GOALS/BACKGROUND:The importance of hepatitis B virus (HBV) genotype and mutations has been increasingly recognized. We aimed to determine HBV genotype, precore (PC), and basal core promoter region (BCP) mutations in a HBV multiethnic South Florida population. STUDY:Samples from 213 patients were tested for HBV-DNA usi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318268003b

    authors: Couto CA,Levy C,Morris CJ,Hill M,de Medina M,Sanborn MR,Cloherty GA,Schiff ER,Martin P

    更新日期:2013-01-01 00:00:00

  • Development of a Score to Predict Positive Colonic Histology in Chronic Diarrhea Assessed in Open-access Colonoscopy.

    abstract:GOALS:To evaluate the diagnostic yield of colonoscopy and esophagogastroduodenoscopy with biopsies and to identify predictors of positive colonic histology in patients with chronic diarrhea. BACKGROUND:Colonoscopy with biopsies is performed in chronic diarrhea with negative initial work-up. STUDY:We reviewed electron...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001414

    authors: Atieh J,Chedid V,Khoshbin K,Kane S,Camilleri M

    更新日期:2020-08-21 00:00:00

  • Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition.

    abstract:GOALS:To describe the epidemiology and microbiologic characteristics of bloodstream infections (BSIs) in patients receiving long-term total parenteral nutrition (TPN). BACKGROUND:Home TPN therapy has been reported as a risk factor for BSI. However, little knowledge exists regarding the epidemiology of BSIs in this pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000212606.13348.f7

    authors: Marra AR,Opilla M,Edmond MB,Kirby DF

    更新日期:2007-01-01 00:00:00

  • Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study.

    abstract::To investigate the influence of the brain-gut interactions on the pathophysiology of irritable bowel syndrome (IBS), we compared such patients (n = 10) with healthy control subjects (n = 11) by measuring the pressure of the colon and small intestine simultaneously with analysis of power spectrum of the electroencephal...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199309000-00009

    authors: Fukudo S,Nomura T,Muranaka M,Taguchi F

    更新日期:1993-09-01 00:00:00

  • Inflammatory bowel disease and pregnancy.

    abstract::Inflammatory bowel disease (IBD) commonly affects women of childbearing age, leading to concerns about the effects of the disease on fertility and pregnancy, the effect of pregnancy on the disease, and the diagnosis and treatment of IBD in the pregnancy women. The literature regarding these issues is reviewed, and a r...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-198206000-00008

    authors: Vender RJ,Spiro HM

    更新日期:1982-06-01 00:00:00

  • Effects of radiation on the human gastrointestinal tract.

    abstract::Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particul...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-197903000-00003

    authors: Novak JM,Collins JT,Donowitz M,Farman J,Sheahan DG,Spiro HM

    更新日期:1979-03-01 00:00:00