Glucagonoma, chronic recurrent peptic ulcer disease, and enhanced amylase-creatinine clearance ratio. Report of a case with review of the literature.

Abstract:

:A 53-year-old white woman developed diabetes mellitus, migratory erythema, and anemia, clinical features suggesting the presence of a "glucagonoma." Ten years earlier, after laparotomy and pancreatic biopsy, she had been told that she had an inoperable pancreatic carcinoma. Review of that biopsy together with current hormonal assay now confirms the diagnosis of glucagonoma. The recurrent peptic ulcer in this patient despite high levels of glucagon, a gastric inhibitory agent, is noted but not explained. An enhanced amylase-creatinine clearance ratio supports the notion that glucagon increases the clearances of amylase.

journal_name

J Clin Gastroenterol

authors

Pitchumoni CS,Thelmo W,Ahmed KS,Kumar A,Davidian M,Einhorn R,Adler J,McCarthy J

doi

10.1097/00004836-197909000-00005

subject

Has Abstract

pub_date

1979-09-01 00:00:00

pages

219-23

issue

3

eissn

0192-0790

issn

1539-2031

journal_volume

1

pub_type

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