Risk factors for sessile serrated adenomas.


BACKGROUND:Although sessile serrated adenomas (SSAs) may represent a separate and important pathway for colorectal cancer (CRC), little is known about the risk factors for these lesions. Molecular abnormalities such as BRAF have been observed in SSA and smokers. Our hypothesis is that smoking may be associated with these lesions. METHODS:All patients diagnosed with an SSA from January 2007 to September 2010 were identified retrospectively based on a pathology database query. There were 2 sets of controls. One group had no adenomas, whereas another group had tubular adenomas. These groups were randomly identified from 2007 to 2010. Data collected included age, sex, ethnicity, height, weight, family history of CRC, diabetes mellitus, use of aspirin, statins, and calcium, and serum trigylcerides and cholesterol. We defined smokers as those patients who smoked at least 20 pack-years. RESULTS:We identified 90 patients with an SSA of any size, 90 patients with tubular adenomas, and 200 controls with no adenomas. Of the 90 SSAs, 42 were 6 mm or larger and 19 of them were ≥1 cm. Most of the SSAs was flat (76/90; 84.4%). After multivariate analyses, smokers with at least 20 pack-year exposure were found to have an increased risk [adjusted odds ratio (OR)=7.31; 95% confidence interval (CI), 3.92-13.63] of having any SSAs, SSAs ≥6 mm (adjusted OR=7.77; 95% CI, 3.48-17.35), and large SSAs (adjusted OR=10.20; 95% CI, 3.31-31.41) compared with nonsmokers. We also observed this relationship when comparing patients with SSAs to those with tubular adenomas. CONCLUSIONS:Our data suggest that smoking at least 20 pack-years is strongly associated with any and large SSAs. In addition, diabetes mellitus and obesity seem to be associated with SSAs as well. Our data has implications for CRC screening.


J Clin Gastroenterol


Anderson JC,Rangasamy P,Rustagi T,Myers M,Sanders M,Vaziri H,Wu G,Birk JW,Protiva P




Has Abstract


2011-09-01 00:00:00












  • Fulminant acute Budd-Chiari syndrome stemming from an adrenal tumor.

    abstract::Adrenal neoplasm is a rare cause of Budd-Chiari syndrome. We report a case of fulminant acute Budd-Chiari syndrome due to inferior vena cava thrombosis stemming from invasion by a clinically nonfunctioning adrenal neoplasm. We also review briefly the clinical characteristics of the seven previously reported cases. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Moreira V,Aller R,De Luis DA,San Roman AL,Ferreiro A

    更新日期:1997-03-01 00:00:00

  • Long-term symptom patterns, endoscopic findings, and gastric histology in Helicobacter pylori-infected and -uninfected patients.

    abstract::There is a paucity of data on the long-term behavior of dyspepsia, endoscopic findings, and gastroduodenal histology in patients with or without Helicobacter pylori colonization. We evaluated these parameters during a period of 7 to 19 years (average, 12.3 years) by baseline and follow-up studies. In 36 patients studi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: DeLuca VA Jr,West AB,Haque S,Katz DL,Ciarolla D,Goldenberg S,Fette G

    更新日期:1998-03-01 00:00:00

  • Comparison of magnetic resonance imaging and endoscopy in distinguishing the type and severity of inflammatory bowel disease.

    abstract::Twenty consecutive patients with first-time presentation of suspected inflammatory bowel disease underwent both endoscopy with biopsy and magnetic resonance imaging (MRI) within a 3-day period; the relative abilities of endoscopy and MRI to distinguish ulcerative colitis (UC) from Crohn's disease (CD) and to determine...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Shoenut JP,Semelka RC,Magro CM,Silverman R,Yaffe CS,Micflikier AB

    更新日期:1994-07-01 00:00:00

  • Diarrheal epidemics among Rwandan refugees in 1994. Management and outcome in a field hospital.

    abstract::We describe the clinical course and outcome of Rwandan refugees with cholera-like illness (n = 567) and clinical dysentery (n = 1,062) treated at the Israeli Army field hospital in the disaster region of Goma, Zaire, during the summer of 1994. Vigorous fluid administration was the primary therapy, complemented with an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Heyman SN,Ginosar Y,Shapiro M,Kluger Y,Marx N,Maayan S

    更新日期:1997-12-01 00:00:00

  • Hepatocellular carcinoma: the high-risk patient.

    abstract::Hepatocellular carcinoma (HCC) is the most common hepatic malignancy worldwide. The primary risk factor for the development of HCC is cirrhosis. Even patients without cirrhosis who develop HCC are typically found to have some underlying hepatic abnormality, such as steatohepatitis or chronic viral hepatitis. Although ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Nissen NN,Martin P

    更新日期:2002-11-01 00:00:00

  • From Birth to "Immunohealth," Allergies and Enterocolitis.

    abstract::Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. After birth and initial colonization, the immune system must be...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Houghteling PD,Walker WA

    更新日期:2015-11-01 00:00:00

  • Effects of probiotics for the prevention and treatment of radiation-induced diarrhea.

    abstract:BACKGROUND AND AIMS:Probiotic supplementation seems to provide beneficial effects in the prevention and treatment of radiation-induced diarrhea. We performed a systematic review and meta-analysis to estimate the efficacy of probiotic supplementation for prevention and treatment of radiation-induced diarrhea. METHODS:T...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Fuccio L,Guido A,Eusebi LH,Laterza L,Grilli D,Cennamo V,Ceroni L,Barbieri E,Bazzoli F

    更新日期:2009-07-01 00:00:00

  • Gastrointestinal and hepatic manifestations of Sjogren syndrome.

    abstract::Sjogren syndrome (SS) is an autoimmune disease that affects exocrine glands and therefore may affect the gastrointestinal system, from the mouth, esophagus, and bowel to the liver and pancreas. Oral involvement in SS is mainly characterized by dryness, with a wide spectrum of symptoms, from mild-to-severe xerostomia w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Ebert EC

    更新日期:2012-01-01 00:00:00

  • "Healed" experimental gastric ulcers remain histologically and ultrastructurally abnormal.

    abstract::The present study was designed to assess histologic and ultrastructural features of gastric mucosa in the areas of grossly healed ulcers (acetic acid-induced gastric ulcers) in rats. The specific question we studied was whether the structure and cellular composition of the gastric mucosa in an area of grossly healed u...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tarnawski A,Hollander D,Krause WJ,Dabros W,Stachura J,Gergely H

    更新日期:1990-01-01 00:00:00

  • Long-term Outcomes of Per-oral Endoscopic Myotomy in Spastic Esophageal Motility Disorders: A Large, Single-Center Study.

    abstract:BACKGROUND AND AIMS:Spastic esophageal motility disorders (SEMD) are a rare group of motility disorders including type III achalasia, distal esophageal spasm (DES), and Jackhammer esophagus (JHE). Limited data suggest that per-oral endoscopic myotomy (POEM) may be effective in these disorders. In this study, we aimed t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Nabi Z,Chavan R,Ramchandani M,Basha J,Jagtap N,Karyampudi A,Darisetty S,Tandan M,Goud R,Rao GV,Reddy DN

    更新日期:2020-07-10 00:00:00

  • Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants.

    abstract:GOALS:To describe the association of untreated celiac disease with hyperhomocysteinemia and variants of the methylenetetrahydrofolicacid reductase (MTHFR) gene found in clinical practice. STUDY:Case studies with description of associated clinical, biochemical, and genetic findings and review of literature. RESULTS:Fi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Wilcox GM,Mattia AR

    更新日期:2006-08-01 00:00:00

  • Small-volume gallbladders and decreased motility in patients with achalasia.

    abstract:AIM/BACKGROUND:Achalasia may be associated with extraesophageal dysmotility. However, this relation is still poorly understood. In the present study, we used noninvasive real-time ultrasonography to examine the motility function of the gallbladder in the patients with achalasia. MATERIALS AND METHODS:Thirty-three acha...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Alagozlu H,Unal S,Karakan T,Cindoruk M,Ergun M

    更新日期:2008-02-01 00:00:00

  • Age-related changes in the microvessels of the human stomach: an ultrastructural study.

    abstract::The ultrastructure of microvessels in the gastric mucosa of patients with atrophic gastritis was investigated. In the gastric mucosa of atrophic gastritis, the endothelial cells of microvessels were irregularly swollen and subendothelial spaces were enlarged. The basement membrane underlying the endothelium was thicke...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Taniguchi Y,Kimura K,Yoshida Y,Seki M,Kumakura Y,Satoh K,Kihira K,Ido K,Mato M

    更新日期:1993-01-01 00:00:00

  • Acute pancreatitis associated with anomalous union of the pancreaticobiliary ductal system.

    abstract::Between 1978 and 1989, 13 of 48 patients with anomalous union of the pancreaticobiliary ductal system (AUPBD) were diagnosed as having acute pancreatitis. We have studied the clinical, radiologic, and surgical features of these 13 patients. A transient rise in the intraductal pressure of the pancreatic duct during an ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Mori K,Nagakawa T,Ohta T,Nakano T,Kadoya N,Kayahara M,Kanno M,Akiyama T,Ueno K,Konishi I

    更新日期:1991-12-01 00:00:00

  • Diverticular Disease and Colorectal Cancer: Incidental Diagnosis or Real Association? Final Answer.

    abstract::Associations between diverticular disease of the colon and the colorectal cancer has been studied for >60 years. Observational, cross-sectional, and case-control studies as well as large population-based studies gave conflicting results and association was not fully proven. Obtaining the proof was difficult because bo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Regula J

    更新日期:2016-10-01 00:00:00

  • A Large Multicenter Experience With Endoscopic Suturing for Management of Gastrointestinal Defects and Stent Anchorage in 122 Patients: A Retrospective Review.

    abstract:GOALS:To describe a multicenter experience using an endoscopic suturing device for management of gastrointestinal (GI) defects and stent anchorage. BACKGROUND:Endoscopic closure of GI defects including perforations, fistulas, and anastomotic leaks as well as stent anchorage has improved with technological advances. An...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Sharaiha RZ,Kumta NA,DeFilippis EM,Dimaio CJ,Gonzalez S,Gonda T,Rogart J,Siddiqui A,Berg PS,Samuels P,Miller L,Khashab MA,Saxena P,Gaidhane MR,Tyberg A,Teixeira J,Widmer J,Kedia P,Loren D,Kahaleh M,Sethi A

    更新日期:2016-05-01 00:00:00

  • Clinical features of nongangrenous ischemic colitis. A comparison of stricturing and transient forms.

    abstract::Forty cases of nongangrenous ischemic colitis were studied to find the different clinical features between stricturing form and transient form. Clinical and laboratory findings were compared between two groups, 15 cases of stricturing form and 25 of transient form, which were diagnosed by follow-up barium enema radiog...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Iida M,Matsui T,Fuchigami T,Iwashita A,Yao T,Fujishima M

    更新日期:1986-12-01 00:00:00

  • Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.

    abstract::In view of therapeutic advances, we carried out meta-analysis of results from 18 randomized, controlled clinical studies to update a previous meta-analysis and to provide an overview of clinical trials involving treatment of functional dyspepsia. The studies were included only if they satisfied inclusion and exclusion...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Finney JS,Kinnersley N,Hughes M,O'Bryan-Tear CG,Lothian J

    更新日期:1998-06-01 00:00:00

  • Acceptance of telemanagement is high in patients with inflammatory bowel disease.

    abstract:GOALS:Assess acceptance and attitudes regarding telemanagement (HAT) in patients with inflammatory bowel disease (IBD). BACKGROUND:Noncompliance is a barrier to successful outcomes in patients with IBD. Novel methods for monitoring and assessing compliance are needed. STUDY:HAT consists of a laptop connected to a wei...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Cross RK,Arora M,Finkelstein J

    更新日期:2006-03-01 00:00:00

  • Liver tests in hyperthyroidism: effect of antithyroid therapy.

    abstract::Changes in liver biochemical test results have been described in hyperthyroid patients before and after antithyroid therapy. In the present study, we analyzed liver tests at diagnosis and after 6 weeks of treatment with propylthiouracil (PTU) in 43 patients with hyperthyroidism. At diagnosis, 60.5% of the patients had...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gürlek A,Cobankara V,Bayraktar M

    更新日期:1997-04-01 00:00:00

  • Hydrogen peroxide colitis: a report of three patients.

    abstract::We have seen three patients with acute ulcerative colitis after hydrogen peroxide enemas. The colitis is probably the result of the explosive entrance of gas into the loose connective tissues of the mucosa and submucosa of the rectum and sigmoid. Fortunately, it is transitory in nature, but it should be distinguished ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Meyer CT,Brand M,DeLuca VA,Spiro HM

    更新日期:1981-03-01 00:00:00

  • Origin of fistulas in Crohn's disease.

    abstract::In 236 resection specimens of Crohn's disease (127 first excisions and 109 reexcisions) there were 60 specimens with fistulas (excluding anal fistulas): 44 in first excisions and 16 in reexcisions. In primary excisions, 36 fistulas arose in the ileum, three in the colon and five in the ileocecal valve. The majority we...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kelly JK,Preshaw RM

    更新日期:1989-04-01 00:00:00

  • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.

    abstract:BACKGROUND:although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections. Thiopurine methyltransferase (TPMT) is an enzyme responsible for the metabolism of AZA, and its activity is inversely related to the risk of developing acute l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Regueiro M,Mardini H

    更新日期:2002-09-01 00:00:00

  • The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis.

    abstract:BACKGROUND:There has been constant speculation about the association between metabolic syndrome (MetS) and colorectal neoplasia (CN); however, the published results are conflicting. The aims of this study are to conduct a systematic search, and assess the literature to determine the available evidence on the associatio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Jinjuvadia R,Lohia P,Jinjuvadia C,Montoya S,Liangpunsakul S

    更新日期:2013-01-01 00:00:00

  • Candida overgrowth after treatment of duodenal ulcer. A comparison of cimetidine, famotidine, and omeprazole.

    abstract::Acid-reducing drugs can cause increased growth of microbes, including fungus, because of high gastric pH. Our purpose was to evaluate the occurrence of mycotic infection in patients with duodenal ulcer on anti-ulcer therapy and to compare the effects of cimetidine, famotidine, and omeprazole. Eighty patients with duod...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goenka MK,Kochhar R,Chakrabarti A,Kumar A,Gupta O,Talwar P,Mehta SK

    更新日期:1996-07-01 00:00:00

  • Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition.

    abstract:GOALS:To describe the epidemiology and microbiologic characteristics of bloodstream infections (BSIs) in patients receiving long-term total parenteral nutrition (TPN). BACKGROUND:Home TPN therapy has been reported as a risk factor for BSI. However, little knowledge exists regarding the epidemiology of BSIs in this pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Marra AR,Opilla M,Edmond MB,Kirby DF

    更新日期:2007-01-01 00:00:00

  • Accuracy of endoscopic ultrasonography and magnetic resonance cholangiopancreatography for the diagnosis of chronic pancreatitis: a prospective comparison study.

    abstract:BACKGROUND:The diagnosis of chronic pancreatitis (CP) remains challenging. Endoscopic ultrasound (EUS) and magnetic resonance cholangiopancreatography (MRCP) have been proposed as highly accurate diagnostic modalities. Although endoscopic retrograde cholangiopancreatography (ERCP) has been previously used as a gold sta...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Pungpapong S,Wallace MB,Woodward TA,Noh KW,Raimondo M

    更新日期:2007-01-01 00:00:00

  • Early or delayed endoscopy for patients with peptic ulcer bleeding. A prospective randomized study.

    abstract::The benefit of early endoscopy in the management of peptic ulcer bleeding remains controversial. In this study we looked at the role of early endoscopy in bleeding peptic ulcer patients with clear, "coffee grounds," or bloody nasogastric aspirate. A consecutive series of 325 patients with peptic ulcer bleeding were in...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lin HJ,Wang K,Perng CL,Chua RT,Lee FY,Lee CH,Lee SD

    更新日期:1996-06-01 00:00:00

  • Comparison of commercially available serologic kits for the detection of celiac disease.

    abstract:BACKGROUND:The sensitivity and specificity of current antihuman tissue transglutaminase (tTG) IgA assays used to detect celiac disease reportedly approach 100%. In addition, the sensitivity of new generation deamidated gliadin peptide (alpha-DGP) antibody assays has also been reported to be similar to the tTG IgA assay...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Naiyer AJ,Hernandez L,Ciaccio EJ,Papadakis K,Manavalan JS,Bhagat G,Green PH

    更新日期:2009-03-01 00:00:00

  • Nasal continuous positive airway pressure. A new treatment for nocturnal gastroesophageal reflux?

    abstract::Nasal continuous positive airway pressure (CPAP) reduces nocturnal gastroesophageal reflux (GER) in obstructive sleep apnea syndrome (OSAS) patients. The primary objectives of our investigation were to determine if CPAP could reduce reflux in non-OSAS patients and, if so, by what mechanism. Esophageal pH was monitored...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kerr P,Shoenut JP,Steens RD,Millar T,Micflikier AB,Kryger MH

    更新日期:1993-12-01 00:00:00