Risk factors for sessile serrated adenomas.


BACKGROUND:Although sessile serrated adenomas (SSAs) may represent a separate and important pathway for colorectal cancer (CRC), little is known about the risk factors for these lesions. Molecular abnormalities such as BRAF have been observed in SSA and smokers. Our hypothesis is that smoking may be associated with these lesions. METHODS:All patients diagnosed with an SSA from January 2007 to September 2010 were identified retrospectively based on a pathology database query. There were 2 sets of controls. One group had no adenomas, whereas another group had tubular adenomas. These groups were randomly identified from 2007 to 2010. Data collected included age, sex, ethnicity, height, weight, family history of CRC, diabetes mellitus, use of aspirin, statins, and calcium, and serum trigylcerides and cholesterol. We defined smokers as those patients who smoked at least 20 pack-years. RESULTS:We identified 90 patients with an SSA of any size, 90 patients with tubular adenomas, and 200 controls with no adenomas. Of the 90 SSAs, 42 were 6 mm or larger and 19 of them were ≥1 cm. Most of the SSAs was flat (76/90; 84.4%). After multivariate analyses, smokers with at least 20 pack-year exposure were found to have an increased risk [adjusted odds ratio (OR)=7.31; 95% confidence interval (CI), 3.92-13.63] of having any SSAs, SSAs ≥6 mm (adjusted OR=7.77; 95% CI, 3.48-17.35), and large SSAs (adjusted OR=10.20; 95% CI, 3.31-31.41) compared with nonsmokers. We also observed this relationship when comparing patients with SSAs to those with tubular adenomas. CONCLUSIONS:Our data suggest that smoking at least 20 pack-years is strongly associated with any and large SSAs. In addition, diabetes mellitus and obesity seem to be associated with SSAs as well. Our data has implications for CRC screening.


J Clin Gastroenterol


Anderson JC,Rangasamy P,Rustagi T,Myers M,Sanders M,Vaziri H,Wu G,Birk JW,Protiva P




Has Abstract


2011-09-01 00:00:00












  • Unconjugated hyperbilirubinemia in chronic persistent hepatitis.

    abstract::We studied a young man with persistent elevation of transaminases and indirect bilirubin following acute viral hepatitis. Liver biopsy showed chronic persistent hepatitis, and clinical evaluation was otherwise negative for significant liver disease. The indirect-reacting serum bilirubin rose after both caloric restric...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Caldwell JH,Kirschner SD,Spagna VA,Inloes RL

    更新日期:1981-03-01 00:00:00

  • Gunshot cholecystitis.

    abstract::A 15-year-old boy developed traumatic cholecystitis from a BB shot that lodged in his gallbladder. This is an unusual cause of gallbladder disease, and we review the literature. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Petersen JM,Knight TT

    更新日期:1995-12-01 00:00:00

  • Necrotizing granulomatous gastritis and gastric perforation of unknown etiology: a first case report.

    abstract::A unique case of granulomatous gastritis of unknown etiology is reported. The patient, a 43-year-old Haitian woman, suffered a gastric perforation from a disease process limited to the stomach. The stomach was markedly enlarged and edematous with transmural, serpiginous granulomatous tracks throughout the gastric wall...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Compton CC,Von Lichtenberg F

    更新日期:1983-02-01 00:00:00

  • Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases.

    abstract::Etiology of inflammatory bowel disease (IBD) is not yet completely understood, but it is hypothesized that a disruption of the immune tolerance to gut microbiota, due to several potential factors like an abnormal gut microbiota composition and activity, may lead to IBD occurrence. Manipulation of the intestinal microb...

    journal_title:Journal of clinical gastroenterology



    authors: Scarpato E,Russo M,Staiano A

    更新日期:2018-11-01 00:00:00

  • Retreatment with interferon for chronic hepatitis C after transient response.

    abstract::Approximately half of all patients with chronic hepatitis C show an initial biochemical response to interferon, but only 15% to 20% of patients achieve a sustained response. We studied the efficacy of retreatment with interferon for patients with chronic hepatitis C who showed transient biochemical responses to initia...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Iyoda K,Yuki N,Kato M,Sugiyasu Y,Komori M,Fujii E,Kakiuchi Y,Kaneko A,Yamamoto K,Kurosawa K,Ikeda M,Masuzawa M

    更新日期:2000-12-01 00:00:00

  • Esophageal tuberculosis presenting as intramural esophagogastric hematoma in a hemophiliac patient.

    abstract::A spontaneous intramural esophagogastric hematoma developed in a patient with hemophilia A. The hematoma did not resolve after antihemophiliac factor replacement but ruptured into the stomach causing massive gastrointestinal bleeding. The associated enlarged right tracheobronchial gland and the histopathological findi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Intragumtornchai T,Israsena S,Benjacholamard V,Lerdlum S,Benjavongkulchai S

    更新日期:1992-03-01 00:00:00

  • Campylobacter pylori. Diagnosis and treatment.

    abstract::There is now a plethora of methods to diagnose colonization of the human stomach with Campylobacter pylori, such as microbiological culture on various media, identification of C. pylori in biopsies or biopsy smears using various stains or neurological methods, serological demonstration of specific anti-C. pylori antib...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tytgat GN,Rauws EA,de Koster EH

    更新日期:1989-01-01 00:00:00

  • Barrett esophagus: endoscopic findings and what to biopsy.

    abstract::Barrett esophagus (BE) is considered the precursor for nearly all cases of esophageal adenocarcinoma. The potential sequence from intestinal metaplasia to dysplasia to cancer can best be monitored by careful endoscopic observation and surveillance biopsies. The ability to diagnose BE, biopsy accurately, and appropriat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Boyce HW

    更新日期:2003-05-01 00:00:00

  • Copper deficiency in celiac disease.

    abstract::Copper deficiency is an uncommonly reported complication of celiac disease that has not received much attention in recent years. Copper deficiency may result in anemia and thrombocytopenia and also irreversible myeloneuropathy if it is not detected and treated appropriately. The prevalence of copper deficiency in pati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Halfdanarson TR,Kumar N,Hogan WJ,Murray JA

    更新日期:2009-02-01 00:00:00

  • Simultaneous appearance of a unique common epitope in fetal colon, skin, and biliary epithelial cells. A possible link for extracolonic manifestations in ulcerative colitis.

    abstract::The tissue distribution of a previously identified M(r) 40 K epithelial autoantigen in ulcerative colitis was examined in situ in the fetal tissue by immunocytochemical method, using an immunoglobulin M (IgM) monoclonal antibody (7E12H12). Fetal-autopsy tissue from 9 to 19 weeks of development (11-21 gestational weeks...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Das KM,Squillante L,Chitayet D,Kalousek DK

    更新日期:1992-12-01 00:00:00

  • Evaluation of the Esophagogastric Junction on High Resolution Manometry.

    abstract::The esophagogastric junction (EGJ) is a complex barrier between the thoracic and abdominal luminal gut compartments, comprised primarily of the lower esophageal sphincter (LES) and crural diaphragm. Although closed at rest, the EGJ relaxes to allow antegrade bolus transit and retrograde venting of air. Abnormal relaxa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Rogers BD,Gyawali CP

    更新日期:2021-02-01 00:00:00

  • Importance of Patients' Knowledge of Their Prescribed Medication in Improving Treatment Adherence in Inflammatory Bowel Disease.

    abstract:GOALS:To investigate the association between treatment nonadherence and patients' knowledge of the prescribed medication among individuals with inflammatory bowel disease (IBD), and evaluate the impact of nonadherence on relapse. BACKGROUND:The patient's knowledge of the prescribed medication has been identified as an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tae CH,Jung SA,Moon HS,Seo JA,Song HK,Moon CM,Kim SE,Shim KN,Jung HK

    更新日期:2016-02-01 00:00:00

  • Lactobacillus casei subsp. rhamnosus sepsis in a patient with ulcerative colitis.

    abstract::Lactobacillus species are part of normal gastrointestinal flora and are an uncommon cause of bacteremia. Lactobacillus casei subsp. rhamnosus was repeatedly isolated in the blood cultures of a 43-year-old woman with ulcerative colitis. Lactobacillus spp. could be considered a potential opportunistic pathogen whenever ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Farina C,Arosio M,Mangia M,Moioli F

    更新日期:2001-09-01 00:00:00

  • Juvenile chronic pancreatitis--a cause of painless jaundice in a patient with multiple somatic abnormalities.

    abstract::Juvenile chronic pancreatitis presenting with painless obstructive jaundice is extremely rare. Pancreatic disease in association with multiple somatic abnormalities presenting in late childhood is uncommon. We report such a case. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Isaacs JD,Keshavarzian A,Blumgart LH,Hodgson HJ

    更新日期:1985-12-01 00:00:00

  • Endoscopic management of a bronchobiliary fistula.

    abstract::A bronchobiliary fistula is a rare entity that manifests as bilioptysis. We report a 73-year-old woman with a hepato-cellular carcinoma who developed a bronchobiliary fistula. Endoscopic biliary sphincterotomy and insertion of a prosthesis led to successful resolution of symptoms and restoration of normal bile flow. W...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Khandelwal M,Inverso N,Conter R,Campbell D

    更新日期:1996-09-01 00:00:00

  • The Dieulafoy's Lesion: An Update on Evaluation, Diagnosis, and Management.

    abstract::Dieulafoy's lesion (DL) is a persistently wide caliber artery that is observed more frequently at the fifth decade of life in the male population with multiple comorbidities. There are a variety of endoscopic therapies that have been used to treat DL; however, there are no clear guidelines on the best treatment modali...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Nguyen DC,Jackson CS

    更新日期:2015-08-01 00:00:00

  • Push enteroscopy in the era of capsule endoscopy.

    abstract:GOALS:To evaluate the diagnostic yield of push enteroscopy in relation to indication and compare the yield in patients who had capsule endoscopy followed by push enteroscopy against capsule endoscopy naive patients. BACKGROUND:With the advent of capsule endoscopy the role of push enteroscopy needs to be reevaluated. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sidhu R,McAlindon ME,Kapur K,Hurlstone DP,Wheeldon MC,Sanders DS

    更新日期:2008-01-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • Liver disease in hereditary hemorrhagic telangiectasia.

    abstract::Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, is an hereditary disorder that results in fibrovascular dysplasia with the development of telangiectasias and arteriovenous malformations. It predominantly involves the skin, mucous membranes, viscera, lungs, and brain. Hereditary he...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Larson AM

    更新日期:2003-02-01 00:00:00

  • Early recognition of toxic megacolon.

    abstract::Increased amounts of small bowel gas are a frequent finding on plain abdominal films in toxic megacolon (TMC), but they may also be found in patients with severe colitis. We studied 69 consecutive patients with severe ulcerative colitis to evaluate whether an increased gas content of the small intestine may identify p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Caprilli R,Vernia P,Latella G,Torsoli A

    更新日期:1987-04-01 00:00:00

  • Leiomyosarcoma of the duodenum recognized preoperatively.

    abstract::We report the preoperative histologic diagnosis of leiomyosarcoma of the duodenum and review the clinical aspects and treatment of this tumor. The endoscopic techniques were critical in obtaining the diagnosis and deciding the treatment plan. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Holst L,Burstein S,Morankar V,Goldberg M

    更新日期:1983-10-01 00:00:00

  • Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections.

    abstract::In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. Aminosalicylates (5-ASAs) are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. Si...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,杂志文章


    authors: Ehrenpreis ED,Kruchko DH

    更新日期:2020-08-01 00:00:00

  • A long-term comparison of plication configurations for endoluminal gastroplication: circumferential versus helical.

    abstract:GOALS:To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. BACKGROUND:Endoluminal gastroplication is an intriguing therapy for gastroesophageal reflux disease. We conducted a retrospective review of a prospective experience of patient cohorts compari...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Davis RE,Iqbal A,Gerhardt JD,Welch RA,Turaga K,Tierney B,Haider M,Filipi CJ

    更新日期:2005-11-01 00:00:00

  • Inadequate Bowel Cleansing Efficacy of Split-dose Polyethylene Glycol for Colonoscopy in Type 2 Diabetic Patients: A Prospective and Blinded Study.

    abstract:BACKGROUND/AIMS:Split-dose polyethylene glycol (PEG) is considered a standard bowel preparation regimen for colonoscopy in the general population. However, it is not clear whether the regimen is optimal for colonoscopy in diabetic patients. The aim of this study was to compare the efficacy and tolerability of split-dos...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Kim YH,Seo EH,Lee JS,Lee SH,Park HS,Choi SH,Park JY,Lee CW

    更新日期:2017-03-01 00:00:00

  • Endoscopic diagnosis of duodenal neoplasms causing upper gastrointestinal bleeding.

    abstract::Duodenal neoplasms are a rare and not often considered cause of massive upper gastrointestinal bleeding. During a 4-year period, 859 endoscopies in patients with upper gastrointestinal bleeding revealed a duodenal tumor to be the cause of bleeding in eight patients. Three patients had a primary duodenal neoplasm, two ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sharon P,Stalnikovicz R,Rachmilewitz D

    更新日期:1982-02-01 00:00:00

  • Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease.

    abstract:BACKGROUND/AIMS:The aim of this exploratory trial was to establish if the probiotic Bifidobacterium natren life start (NLS) strain strain may affect the clinical course and pathophysiological features of patients with untreated celiac disease (CD). Positive findings would be helpful in directing future studies. METHOD...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Smecuol E,Hwang HJ,Sugai E,Corso L,Cherñavsky AC,Bellavite FP,González A,Vodánovich F,Moreno ML,Vázquez H,Lozano G,Niveloni S,Mazure R,Meddings J,Mauriño E,Bai JC

    更新日期:2013-02-01 00:00:00

  • Computerized phonoenterography: the clinical investigation of a new system.

    abstract::We assessed bowel sounds in controls and patients with acute abdominal conditions using a new computer-aided sound analysis system (C.A.S.A.S.). Sixty-three controls and 61 patients with an acute abdomen had 10-min recordings of bowel sounds in a silent environment with computer analysis of the digitized acoustic sign...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sugrue M,Redfern M

    更新日期:1994-03-01 00:00:00

  • Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial.

    abstract:GOAL:To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients. BACKGROUND:Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitaliz...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Velasco M,Requena T,Delgado-Iribarren A,Peláez C,Guijarro C

    更新日期:2019-11-01 00:00:00

  • Role of hepatitis B surface antigen (HBsAg) in identifying true inactive HBsAg carriers infected with genotype C hepatitis B virus.

    abstract:BACKGROUND:Inactive and active phases of hepatitis B e antigen-negative chronic hepatitis B virus (HBV) infection are diagnosed by serum HBV DNA levels, with cutoff at 2000 IU/mL. However, it is difficult to distinguish inactive carriers at a single time point because HBV DNA levels can transiently decrease to <2000 IU...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yim SY,Um SH,Jung JY,Seo YS,Yim HJ,Ryu HS,Chun HJ,Jeen YT,Kim CD,Keum B,Lee HS

    更新日期:2014-02-01 00:00:00

  • A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection.

    abstract:GOAL:To assess the number of chronic hepatitis C patients eligible for therapy. BACKGROUND:Recent studies have shown improved response rates to treatment of chronic hepatitis C infection. However, treatment with interferon alfa has major side effects, and many patients may not be eligible for therapy. STUDY:One hundr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Muir AJ,Provenzale D

    更新日期:2002-03-01 00:00:00