Dysphagia and esophageal motor dysfunction in gastroesophageal reflux are corrected by fundoplication.

Abstract:

:Abnormalities in esophageal peristaltic function and acid clearance appear to be responsible for prolonged esophageal acid exposure, a major determinant of the reflux esophagitis and esophageal stricture. We evaluated esophageal motility by manometry in 50 healthy controls and in 35 symptomatic reflux patients before, within 6 months, and 1 year after Nissen fundoplication. Preoperative motility was analyzed in relation to the presence or absence of both nonobstructive dysphagia and erosive esophagitis. We found that (a) preoperative dysphagia was related more to peristaltic dysfunction than to esophagitis; (b) peristaltic wave amplitude and duration were significantly lower than control values in patients with reflux, without correlation to degree of esophagitis or lower esophageal sphincter hypotension; (c) dysphagia ceased in most patients after antireflux surgery at the same time that normal motility was restored independently of lower esophageal sphincter pressure increments. These results suggest that motility disturbances are an important cause of dysphagia in reflux disease, and that reflux is the cause of, rather than the consequence of, peristaltic dysfunction.

journal_name

J Clin Gastroenterol

authors

Grande L,Lacima G,Ros E,Pujol A,Garcia-Valdecasas JC,Fuster J,Visa J,Pera C

doi

10.1097/00004836-199102000-00005

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

11-6

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

13

pub_type

杂志文章
  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200003000-00017

    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Sociodemographic characteristics, life stressors, and peptic ulcer. A prospective study.

    abstract::The role of psychosocial factors in peptic ulcer remains controversial. We have investigated the relationship between socioeconomic status, concrete stressors, and ulcers in a longitudinally followed, population-based cohort, taking confounding risk factors into account. A total of 6,928 adults completed the Alameda C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199510000-00004

    authors: Levenstein S,Kaplan GA,Smith M

    更新日期:1995-10-01 00:00:00

  • Small-bowel involvement in dermatitis herpetiformis and in linear-IgA bullous dermatosis.

    abstract::In 23 patients with dermatitis herpetiformis (DH) and five patients with linear-IgA bullous dermatosis (BD), we evaluated the occurrence of histologic jejunal changes and small-bowel function abnormalities. None of the patients showed clinical signs or symptoms of malabsorption. Morphological jejunal changes consisten...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198310000-00010

    authors: deFranchis R,Primignani M,Cipolla M,Vecchi M,Agape D,Monti M,Berti E,Zuccato E,Mussini E

    更新日期:1983-10-01 00:00:00

  • Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Vitamin deficiency is frequently associated with inflammatory bowel disease (IBD). Supplementation of vitamins could thus serve as an adjunctive therapy. The present meta-analysis reviews the deficiencies and alterations in serum fat-soluble vitamins (A, D, E, and K) reported in IBD patients. MATERIALS AND ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000911

    authors: Fabisiak N,Fabisiak A,Watala C,Fichna J

    更新日期:2017-11-01 00:00:00

  • Rapid growth of untreated esophageal squamous-cell carcinoma in 10 patients.

    abstract::We documented the natural history of esophageal carcinoma and its rapid growth by measuring the change in tumor diameter radiographically in 10 patients during an observation period because the diagnosis had been missed. Nine men and one woman (age range, 48-74 years; mean, 60 years) were included in the study. Eight ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199104000-00003

    authors: Haruma K,Tokutomi T,Yoshihara M,Sumii K,Kajiyama G

    更新日期:1991-04-01 00:00:00

  • Sigmoid volvulus in adolescence.

    abstract::Sigmoid volvulus in young adults is rare. It usually presents as chronic recurrent attacks of abdominal pain. The diagnosis is usually delayed because of a low level of suspicion. We present the case of a 17-year-old girl with recurrent episodes of sigmoid volvulus, to illustrate the problem. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198708000-00023

    authors: Krupsky S,Halevy A,Orda R

    更新日期:1987-08-01 00:00:00

  • Efficacy of 5-ASA in the treatment of colonic diverticular disease.

    abstract:OBJECTIVE:To assess the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in patients with colonic diverticular disease performing a systematic review of the literature. DATA SOURCES:Cochrane Trial Register (until Issue 4, 2008), Medical Literature Analysis and Retrieval System Online (1966 to October 1, 2008), Ex...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181a15864

    authors: Gatta L,Vakil N,Vaira D,Pilotto A,Curlo M,Comparato G,Leandro G,Ferro U,Lera M,Milletti S,Di Mario F

    更新日期:2010-02-01 00:00:00

  • Helicobacter pylori Infection and the Development of Advanced Colorectal Neoplasia.

    abstract:BACKGROUND:An association between Helicobacter pylori infection and colorectal neoplasia has been reported in cross-sectional studies. GOALS:We examined the association between H. pylori infection and the development of advanced colorectal neoplasia (AN) in a screening cohort. STUDY:We identified 3753 adults, who und...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001273

    authors: Ryoo SK,Kim TJ,Kim ER,Hong SN,Kim YH,Chang DK

    更新日期:2020-09-01 00:00:00

  • Role of infectious agents in exacerbations of ulcerative colitis in India. A study of Clostridium difficile.

    abstract::Fifty patients with idiopathic ulcerative colitis--25 with acute exacerbation of the disease (Group I) and 25 in quiescent phase (Group II)--were studied. None of the patients had a history of recent exposure to antimicrobial drugs or hospitalization. Evidence of infection with protozoal and bacterial agents and/or pr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199301000-00008

    authors: Kochhar R,Ayyagari A,Goenka MK,Dhali GK,Aggarwal R,Mehta SK

    更新日期:1993-01-01 00:00:00

  • Use of mesalazine in diverticular disease.

    abstract::Diverticular disease includes a spectrum of conditions sharing the underlying pathology of acquired diverticula of the colon: symptomatic uncomplicated diverticular disease, recurrent symptomatic uncomplicated diverticular disease, and complicated diverticular disease. Goals of therapy in diverticular disease should b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000225509.98041.4b

    authors: Di Mario F,Comparato G,Fanigliulo L,Aragona G,Cavallaro LG,Cavestro GM,Franzé A

    更新日期:2006-08-01 00:00:00

  • Ulcer healing after treatment with sucralfate emulsion or ranitidine. Randomized controlled study in peptic ulcer disease.

    abstract::A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198808000-00006

    authors: Lykkegaard Nielsen MC,Vagn Nielsen O,Moesgaard F

    更新日期:1988-08-01 00:00:00

  • Utility and standards in esophageal manometry.

    abstract::Esophageal manometry is a specialized procedure used to evaluate lower and upper esophageal sphincter pressure, esophageal body contraction amplitude, and peristaltic sequence. The procedure is clinically useful in evaluation of a patient with nonstructural dysphagia, unexplained or noncardiac chest pain, a compendium...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181653a5c

    authors: Katz PO,Menin RA,Gideon RM

    更新日期:2008-05-01 00:00:00

  • Dye-free wire-guided cannulation of the biliary tree during ERCP is associated with high success and low complication rates: outcomes in a single operator experience of 822 cases.

    abstract:BACKGROUND:Deep biliary cannulation (DBC) is a prerequisite to most endoscopic retrograde cholangiopancreatographies (ERCPs). Numerous techniques have been described to maximize success and minimize ERCP-related complications, most notably post-ERCP pancreatitis. Dye-free cannulation by using guidewires with hydrophili...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181aacbd1

    authors: Adler DG,Verma D,Hilden K,Chadha R,Thomas K

    更新日期:2010-03-01 00:00:00

  • Understanding and appreciating sequential therapy for Helicobacter pylori eradication.

    abstract::Despite the fact that sequential therapy has been evaluated in more than 2500 patients and has been shown to on average provide Helicobacter pylori eradication in 90% to 94%, some authorities still question whether it should be a first-line anti-H. pylori regimen. Here, we discuss H. pylori eradication using experienc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31820ac05e

    authors: Graham DY,Rimbara E

    更新日期:2011-04-01 00:00:00

  • Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (type 2) diabetes mellitus.

    abstract::Although relatively frequent. diabetic involvement of digestive tract motility has not been investigated extensively in different organs. The authors studied esophageal, gastric, and gallbladder motor function in 35 type 2 (noninsulin-dependent) diabetic patients to determine the extent of gut involvement. Of these pa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199909000-00014

    authors: Annese V,Bassotti G,Caruso N,De Cosmo S,Gabbrielli A,Modoni S,Frusciante V,Andriulli A

    更新日期:1999-09-01 00:00:00

  • Efficacy of tacrolimus in the treatment of steroid refractory autoimmune hepatitis.

    abstract:BACKGROUND:Autoimmune hepatitis (AIH) is an immune mediated chronic liver disease with a prevalence of 17 cases/100,000. Resistance to the standard treatment of AIH (prednisone and azathioprine) occurs in 15% to 20%. There is currently no standard treatment of patients with steroid refractory AIH. GOALS:Determine the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mcg.0000139050.67178.be

    authors: Aqel BA,Machicao V,Rosser B,Satyanarayana R,Harnois DM,Dickson RC

    更新日期:2004-10-01 00:00:00

  • Acetaminophen hepatotoxicity and acute liver failure.

    abstract::Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most eff...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31818a3854

    authors: Chun LJ,Tong MJ,Busuttil RW,Hiatt JR

    更新日期:2009-04-01 00:00:00

  • Origin of fistulas in Crohn's disease.

    abstract::In 236 resection specimens of Crohn's disease (127 first excisions and 109 reexcisions) there were 60 specimens with fistulas (excluding anal fistulas): 44 in first excisions and 16 in reexcisions. In primary excisions, 36 fistulas arose in the ileum, three in the colon and five in the ileocecal valve. The majority we...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198904000-00015

    authors: Kelly JK,Preshaw RM

    更新日期:1989-04-01 00:00:00

  • Biofeedback improvement of lower esophageal sphincter pressures and reflux symptoms.

    abstract::During a course of 10 biofeedback sessions in a single subject, the lower esophageal sphincter pressure measured with an open-tipped perfused catheter assembly showed significant and progressive increase with each session, until it reached normal levels. There was also a decrease in symptomatic reflux episodes, from t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198306000-00008

    authors: Gordon A,Gordon E,Berelowitz M,Bremner CH,Bremner CG

    更新日期:1983-06-01 00:00:00

  • Heterotopic liver of the jejunum. Report of a case and a review.

    abstract::A case of heterotopic liver of the jejunum confirmed by electron microscopy in a 2-year-old girl is described. We review the literature regarding heterotopic liver and discuss its embryogenesis. We suggest that in our case, there was trapping of hepatocyte-destined mesenchyme prior to biliary tree development. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-198908000-00024

    authors: Newland JR,Markin RS,Wilson RB,Jones JW

    更新日期:1989-08-01 00:00:00

  • Issues in hyperlipidemic pancreatitis.

    abstract::Hypertriglyceridemia (HTG) is a rare cause of pancreatitis. Pancreatitis secondary to HTG, presents typically as an episode of acute pancreatitis (AP) or recurrent AP, rarely as chronic pancreatitis. A serum triglyceride (TG) level of more than 1,000 to 2,000 mg/dL in patients with type I, IV, or V hyperlipidemia (Fre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200301000-00016

    authors: Yadav D,Pitchumoni CS

    更新日期:2003-01-01 00:00:00

  • Autoantibodies in the diagnosis and management of liver disease.

    abstract::Autoantibodies are nonpathogenic manifestations of immune reactivity, and they may occur in acute and chronic liver diseases. Autoantibodies may be consequences rather than causes of the liver injury, and they should be regarded as diagnostic clues rather than etiologic markers. Conventional autoantibodies used in the...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200310000-00011

    authors: Czaja AJ,Norman GL

    更新日期:2003-10-01 00:00:00

  • Inability to noninvasively diagnose gastric intestinal metaplasia in Hispanics or reverse the lesion with Helicobacter pylori eradication.

    abstract:BACKGROUND:Helicobacter pylori infection has been linked with the development of gastric adenocarcinoma and its precursor lesion, intestinal metaplasia (IM). The presence of gastric IM is not associated with symptoms, which makes identification of individuals with this lesion difficult. It is not clear whether eradicat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004836-200105000-00008

    authors: Morales TG,Sampliner RE,Camargo E,Marquis S,Garewal HS,Fennerty MB

    更新日期:2001-05-01 00:00:00

  • A randomized, controlled trial of interactive, multimedia software for patient colonoscopy education.

    abstract::The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200102000-00010

    authors: Shaw MJ,Beebe TJ,Tomshine PA,Adlis SA,Cass OW

    更新日期:2001-02-01 00:00:00

  • Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rat.

    abstract::We sought to clarify the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) during healing of rat gastric ulcers. After gastric ulcers were induced by acetic acid, rats were treated with vehicle, N(G)-nitro-L-arginine methyl ester (L-NAME), aminoguanidine (AG), and dexamethasone (Dex) by gastric int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199800001-00011

    authors: Akiba Y,Nakamura M,Mori M,Suzuki H,Oda M,Kimura H,Miura S,Tsuchiya M,Ishii H

    更新日期:1998-01-01 00:00:00

  • Celecoxib Monotherapy Maintained Small Intestinal Mucosa Better Compared With Loxoprofen Plus Lansoprazole Treatment: A Double-blind, Randomized, Controlled Trial.

    abstract:GOALS:The aim of this study was to compare celecoxib with loxoprofen for protection of small intestine. BACKGROUND:RCT studies report that COX-2 selective inhibitor celecoxib induces fewer small intestinal injuries than nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a prodrug nonselective NS...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000000372

    authors: Fujimori S,Hanada R,Hayashida M,Sakurai T,Ikushima I,Sakamoto C

    更新日期:2016-03-01 00:00:00

  • Celiac Disease is Misdiagnosed Based on Serology Only in a Substantial Proportion of Patients.

    abstract:BACKGROUND:Although the diagnostic process in celiac disease (CeD) has been addressed in several international guidelines, little is known about the actual proceeding in current clinical practice. This study investigated the initial presentation, the diagnostic process, follow-up evaluations, and adherence to a gluten-...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000676

    authors: Vavricka SR,Stelzer T,Lattmann J,Stotz M,Lehmann R,Zeitz J,Scharl M,Misselwitz B,Pohl D,Fried M,Tutuian R,Fasano A,Schoepfer AM,Rogler G,Biedermann L,Greuter T

    更新日期:2018-01-01 00:00:00

  • Predicting the outcome of corticoid therapy for acute ulcerative colitis. Results of a prospective, randomized, double-blind clinical trial.

    abstract::We looked for factors predicting the therapeutic outcome in 66 patients with severe ulcerative colitis treated with intravenous hydrocortisone or corticotropin (ACTH) for 10 days. Patients were randomized before therapy within strata defined by whether they had received oral corticosteroids continuously before the stu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198702000-00013

    authors: Meyers S,Lerer PK,Feuer EJ,Johnson JW,Janowitz HD

    更新日期:1987-02-01 00:00:00

  • Atypical cystic carcinoid tumors of the liver.

    abstract::Carcinoid metastases in the liver are typically solid, hypervascular lesions. We report 3 cases of cystic carcinoid tumors in the liver with radiographic findings. Two were metastatic from primary carcinoid tumors of the small intestine and one was not associated with any extra hepatic lesion at presentation or during...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181da7714

    authors: Salamone L,McCarthy S,Salem RR

    更新日期:2010-11-01 00:00:00

  • Hypoxic hepatitis occurring in cirrhosis after variceal bleeding: still a lethal disease.

    abstract:BACKGROUND:Hypoxic hepatitis (HH) occurring after gastrointestinal bleeding in cirrhotic patients has been scarcely studied and is reported as a rare occurrence carrying a severe prognosis. The management of bleeding from esophageal varices (BEV) and similarly the prognosis has improved in the last decades. GOALS:To e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318254e9d4

    authors: Amitrano L,Guardascione MA,Martino R,Manguso F,Menchise A,Balzano A

    更新日期:2012-08-01 00:00:00