Acetaminophen hepatotoxicity and acute liver failure.

Abstract:

:Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

journal_name

J Clin Gastroenterol

authors

Chun LJ,Tong MJ,Busuttil RW,Hiatt JR

doi

10.1097/MCG.0b013e31818a3854

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

342-9

issue

4

eissn

0192-0790

issn

1539-2031

pii

00004836-200904000-00010

journal_volume

43

pub_type

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