Issues in hyperlipidemic pancreatitis.

Abstract:

:Hypertriglyceridemia (HTG) is a rare cause of pancreatitis. Pancreatitis secondary to HTG, presents typically as an episode of acute pancreatitis (AP) or recurrent AP, rarely as chronic pancreatitis. A serum triglyceride (TG) level of more than 1,000 to 2,000 mg/dL in patients with type I, IV, or V hyperlipidemia (Fredrickson's classification) is an identifiable risk factor. The typical clinical profile of hyperlipidemic pancreatitis (HLP) is a patient with a preexisting lipid abnormality along with the presence of a secondary factor (e.g., poorly controlled diabetes, alcohol use, or a medication) that can induce HTG. Less commonly, a patient with isolated hyperlipidemia (type V or I) without a precipitating factor presents with pancreatitis. Interestingly, serum pancreatic enzymes may be normal or only minimally elevated, even in the presence of severe pancreatitis diagnosed by imaging studies. The clinical course in HLP is not different from that of pancreatitis of other causes. Routine management of AP caused by hyperlipidemia should be similar to that of other causes. A thorough family history of lipid abnormalities should be obtained, and an attempt to identify secondary causes should be made. Reduction of TG levels to well below 1,000 mg/dL effectively prevents further episodes of pancreatitis. The mainstay of treatment includes dietary restriction of fat and lipid-lowering medications (mainly fibric acid derivatives). Experiences with plasmapheresis, lipid pheresis, and extracorporeal lipid elimination are limited.

journal_name

J Clin Gastroenterol

authors

Yadav D,Pitchumoni CS

doi

10.1097/00004836-200301000-00016

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

54-62

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

36

pub_type

杂志文章,评审
  • Idiopathic pylephlebitis and idiopathic sclerosing peritonitis in a man with protein S deficiency.

    abstract::Idiopathic pylephlebitis and primary sclerosing peritonitis are two highly unusual entities. To our knowledge, the association of the two diseases has not been described previously. We report a 42-year-old patient with a protein S deficiency who presented with fever and chills, in whom idiopathic pylephlebitis was dia...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200103000-00020

    authors: Sillero JM,Calvet X,Musulen E,Diaz-Ruiz MJ,Tolosa C,Pardo A,Corcuera A,Malet A,Font J

    更新日期:2001-03-01 00:00:00

  • Effects of growth factors on acid-induced damage to rat gastric epithelial cells.

    abstract::We previously established a model of cell damage induced by an acidified medium in the rat gastric epithelial cell line RGM1. Treatment of the cells with epidermal growth factor (EGF, 1-10 ng/ml) for 4 h prevented acid-induced cell damage in a concentration-dependent manner. In contrast, basic fibroblast growth factor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199700001-00013

    authors: Furukawa O,Okabe S

    更新日期:1997-01-01 00:00:00

  • Prolonged storage of frozen unbuffered rapid urease test.

    abstract::Unbuffered rapid urease test (RUT) is an accurate, rapid, and inexpensive method of detecting Helicobacter pylori. However, it is generally recommended to prepare the reagent daily. This prospective study was undertaken to evaluate the shelf-life of our unbuffered RUT at -20 degrees C. Two sets of antral biopsies (X2)...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200009000-00010

    authors: Ng FH,Wong SY,Ng WF,Wong BC

    更新日期:2000-09-01 00:00:00

  • Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy.

    abstract:BACKGROUND:Gastrointestinal angiodysplasias (GIAD) are commonly diagnosed in the small bowel but can be located in other areas of the gastrointestinal tract. About half of patients diagnosed with GIAD have more than 1 lesion and 20% of patients have GIAD in both the small bowel and a source outside of the small bowel (...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000836

    authors: Mai SH,Chao DC,Liao SY,Jackson CS

    更新日期:2018-09-01 00:00:00

  • Campylobacter pylori. Diagnosis and treatment.

    abstract::There is now a plethora of methods to diagnose colonization of the human stomach with Campylobacter pylori, such as microbiological culture on various media, identification of C. pylori in biopsies or biopsy smears using various stains or neurological methods, serological demonstration of specific anti-C. pylori antib...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Tytgat GN,Rauws EA,de Koster EH

    更新日期:1989-01-01 00:00:00

  • Lactic acidosis associated with cirrhosis, hepatoma, hemoperitoneum, and hyperphosphatemia.

    abstract::A patient with cirrhosis developed hemoperitoneum, lactic acidosis, and hyperphosphatemia in the absence of shock. At post-mortem examination occult multicentric hepatocellular carcinoma eroding the liver capsule was present. The case emphasizes the central role of the liver in lactic acidosis, indicates that hemoperi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198604000-00025

    authors: Berenson MM,Lee RG

    更新日期:1986-04-01 00:00:00

  • Small-bowel involvement in dermatitis herpetiformis and in linear-IgA bullous dermatosis.

    abstract::In 23 patients with dermatitis herpetiformis (DH) and five patients with linear-IgA bullous dermatosis (BD), we evaluated the occurrence of histologic jejunal changes and small-bowel function abnormalities. None of the patients showed clinical signs or symptoms of malabsorption. Morphological jejunal changes consisten...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198310000-00010

    authors: deFranchis R,Primignani M,Cipolla M,Vecchi M,Agape D,Monti M,Berti E,Zuccato E,Mussini E

    更新日期:1983-10-01 00:00:00

  • Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

    abstract:BACKGROUND:The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients. GOALS:We aimed to determine the incidence of and risk factors for meningitis in IBD patients. STUDY:We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001365

    authors: Kochar B,Jiang Y,Long MD

    更新日期:2020-05-29 00:00:00

  • Rapid development of pancreatitis following reuse of 6-mercaptopurine.

    abstract::A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198912000-00017

    authors: Cappell MS,Das KM

    更新日期:1989-12-01 00:00:00

  • Jejunal water and sodium secretion occurs in chronic idiopathic intestinal pseudo-obstruction.

    abstract::We observed jejunal water and sodium secretion in two patients with chronic idiopathic intestinal pseudo-obstruction by standard perfusion techniques. The ability of glucose to reverse this secretory state was impaired. These observations suggest that a jejunal secretory state may contribute to the diarrhea in chronic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199004000-00008

    authors: Rolston DD,Hunt JB,Fairclough PD,Wilks M,Levison DA,Clark ML,Farthing MJ

    更新日期:1990-04-01 00:00:00

  • Gastric epithelial cells stimulate Helicobacter pylori growth.

    abstract::Helicobacter pylori infects only human gastric epithelium, causes gastritis, and is strongly associated with gastroduodenal ulceration and gastric cancer. Colonization of the stomach with H. pylori is accompanied in the acute stage by an increased number of neutrophils in the lamina propria, indicative of gastric infl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199800001-00021

    authors: Nakajima N,Kuwayama H,Ito Y,Iwasaki A,Arakawa Y

    更新日期:1998-01-01 00:00:00

  • Fulminant acute Budd-Chiari syndrome stemming from an adrenal tumor.

    abstract::Adrenal neoplasm is a rare cause of Budd-Chiari syndrome. We report a case of fulminant acute Budd-Chiari syndrome due to inferior vena cava thrombosis stemming from invasion by a clinically nonfunctioning adrenal neoplasm. We also review briefly the clinical characteristics of the seven previously reported cases. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199703000-00015

    authors: Moreira V,Aller R,De Luis DA,San Roman AL,Ferreiro A

    更新日期:1997-03-01 00:00:00

  • An update on clinical trials in the treatment of advanced hepatocellular carcinoma.

    abstract::Despite the successful FDA approval of sorafenib as the standard of care therapy in patients with advanced hepatocellular carcinoma (HCC), its clinical benefits have been modest. The mortality rate remains high and prognosis poor for patients with advanced-stage HCC. The exact mechanism of sorafenib in the treatment o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31827d77a2

    authors: Lee JK,Abou-Alfa GK

    更新日期:2013-07-01 00:00:00

  • Subclinical Ascites Does Not Affect the Long-term Prognosis in Hepatitis B Virus-related Cirrhosis Patients Receiving Antivirals.

    abstract:BACKGROUND AND AIMS:This study evaluated the clinical significance of subclinical ascites in patients with hepatitis B virus-related cirrhosis treated with lamivudine (LMV) or entecavir (ETV). METHODS:This multicenter retrospective study involved 8 hospitals. Patients were classified by degree of ascites: (1) no ascit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000529

    authors: Yim SY,Lee JH,Ahn H,Kim SU,Kim SG,Kim YS,Kim JH,Choe WH,Kim TY,Jung YK,Suh SJ,Suk KT,An H,Yim HJ,Seo YS,Um SH

    更新日期:2016-09-01 00:00:00

  • Small intestinal changes in enterocolitis complicating Hirschsprung's disease.

    abstract::Hirschsprung's disease is one of the more common causes of childhood bowel obstruction. The disease can cause enterocolitis which, untreated, may result in considerable mortality. We describe our evaluation of two infants who suffered from intractable diarrhea of infancy secondary to Hirschsprung's disease. We found t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-197909000-00009

    authors: Branski D,Lebenthal E

    更新日期:1979-09-01 00:00:00

  • Is smoking still important in the pathogenesis of peptic ulcer disease?

    abstract::The pathogenesis of peptic ulcer disease is multifactorial, including the effects of Helicobacter pylori, gastric acid, pepsin, gastroduodenal motility, smoking and nicotine, and the complex interaction of an array of other so-called aggressive and protective factors. Since the discovery and acceptance of H. pylori as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199700001-00003

    authors: Eastwood GL

    更新日期:1997-01-01 00:00:00

  • Dietary habits of gallstone patients in Northern India.

    abstract::Dietary intake and plasma lipids were estimated in 200 patients with gallstones and 98 control subjects from a hospital in Northern India and were matched for age, sex, and social class. The intake of total calories and carbohydrates and the plasma triglyceride values were higher in all gallstone patients as compared ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199601000-00007

    authors: Tandon RK,Saraya A,Paul S,Kapur BM

    更新日期:1996-01-01 00:00:00

  • Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases.

    abstract::Etiology of inflammatory bowel disease (IBD) is not yet completely understood, but it is hypothesized that a disruption of the immune tolerance to gut microbiota, due to several potential factors like an abnormal gut microbiota composition and activity, may lead to IBD occurrence. Manipulation of the intestinal microb...

    journal_title:Journal of clinical gastroenterology

    pub_type:

    doi:10.1097/MCG.0000000000001095

    authors: Scarpato E,Russo M,Staiano A

    更新日期:2018-11-01 00:00:00

  • Crohn's disease and the Jews.

    abstract::Several epidemiologic studies of Crohn's Disease (CD) from the northern hemisphere show high rates of the disease among Jews. Israel has absorbed many Jews from those countries and the rates of CD in Israel are lower than in their place of birth. Important, too, among immigrants from the middle east Mediterranean coun...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论

    doi:

    authors: Shapira M,Tamir A

    更新日期:1992-12-01 00:00:00

  • Resolution of hereditary hemorrhagic telangiectasia and anemia with prolonged alpha-interferon therapy for chronic hepatitis C.

    abstract::Hereditary hemorrhagic telangiectasia is a group of autosomal dominant disorders, characterized by telangiectases that develop in the skin, mucous membranes, and visceral organs. Currently, there is no satisfactory treatment of hereditary hemorrhagic telangiectasia. Interferon has never been used for the treatment of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200404000-00015

    authors: Massoud OI,Youssef WI,Mullen KD

    更新日期:2004-04-01 00:00:00

  • Noncardiac chest pain.

    abstract:GOALS:Review of research directions in the etiology, evaluation, and treatment of patients with noncardiac chest pain. The author proposes a combined practical approach to noncardiac chest pain that incorporates these findings, which is useful in a clinical practice setting. BACKGROUND:Several major schools of thought...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200201000-00004

    authors: Botoman VA

    更新日期:2002-01-01 00:00:00

  • Eleven-year survey of safety and efficacy of endoscopic injection sclerotherapy using 2% sodium tetradecyl sulfate and contrast medium.

    abstract::We conducted a retrospective 11-year survey to evaluate the post-treatment course in 285 patients with esophagogastric varices following administration of endoscopic injection sclerotherapy as an emergency, elective, or prophylactic procedure using freshly prepared 2% sodium tetradecyl sulfate not containing benzyl al...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199601000-00017

    authors: Iwase H,Suga S,Shimada M,Yamada H,Horiuchi Y,Oohashi M

    更新日期:1996-01-01 00:00:00

  • Ursodeoxycholic acid for adjuvant therapy with extracorporeal shock wave lithotripsy of gallstones.

    abstract::Extracorporeal shock wave lithotripsy (ESWL) of gallstones is a new and experimental treatment. Recent data seem to indicate that the use of ursodeoxycholic acid (UDCA) after ESWL may optimize the results of the shock wave treatment. Most of the published data on the clinical use of such therapy emanate from two studi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Fromm H

    更新日期:1988-01-01 00:00:00

  • Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections.

    abstract::In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. Aminosalicylates (5-ASAs) are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. Si...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,杂志文章

    doi:10.1097/MCG.0000000000001371

    authors: Ehrenpreis ED,Kruchko DH

    更新日期:2020-08-01 00:00:00

  • Acetaminophen hepatotoxicity and acute liver failure.

    abstract::Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most eff...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31818a3854

    authors: Chun LJ,Tong MJ,Busuttil RW,Hiatt JR

    更新日期:2009-04-01 00:00:00

  • The parathyroids and the gut.

    abstract::This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck. Hyperparathyroidism is usually from adenomas or hyperplasia. Hypoparathyroidism is as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181cd9d4c

    authors: Ebert EC

    更新日期:2010-08-01 00:00:00

  • Diagnostic workup strategies for patients with HIV-related chronic diarrhea. What is the end result?

    abstract::The intensity of diagnostic workup of patients with human immunodeficiency virus (HIV)-related chronic diarrhea is controversial. In the ideal setting in which an enteric pathogen is detected with minimal evaluation (stool tests) and in which specific treatment clears the diarrhea, eradicates the pathogen, and improve...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199304000-00018

    authors: Rabeneck L

    更新日期:1993-04-01 00:00:00

  • Managing acid peptic disease in the Helicobacter pylori era.

    abstract::The advent of new diagnostic and therapeutic modalities for Helicobacter pylori allows any physician to offer curative antibiotic regimens to patients with peptic ulcer disease and gastritis. This article describes new management strategies and discusses the advantages of each. In the old strategy, endoscopy was perfo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Marshall BJ

    更新日期:1995-01-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200305000-00007

    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.

    abstract:OBJECTIVE:JC virus (JCV) is thought to infect approximately 80% of the human population. Antibodies against JCV can be found in the sera of many people with and without colorectal carcinoma (CRC). We hypothesized that JCV antibody titer will be higher in CRC patients than in healthy controls. AIM:To evaluate this hypo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181d7a347

    authors: Niv Y,Vilkin A,Levi Z

    更新日期:2010-08-01 00:00:00