An update on clinical trials in the treatment of advanced hepatocellular carcinoma.

Abstract:

:Despite the successful FDA approval of sorafenib as the standard of care therapy in patients with advanced hepatocellular carcinoma (HCC), its clinical benefits have been modest. The mortality rate remains high and prognosis poor for patients with advanced-stage HCC. The exact mechanism of sorafenib in the treatment of HCC and its resistance at the molecular levels are largely unknown. There are no other treatment options in first-line therapy and there is currently no standard of care second-line therapies available. Thus, there is a critical need for novel therapeutic approaches for the treatment of advanced HCC, and thus a clear justification for the already reported, currently ongoing, and planned clinical trials.

journal_name

J Clin Gastroenterol

authors

Lee JK,Abou-Alfa GK

doi

10.1097/MCG.0b013e31827d77a2

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

S16-9

eissn

0192-0790

issn

1539-2031

pii

00004836-201307001-00006

journal_volume

47 Suppl

pub_type

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