The Role of Insulin-like Growth Factor (IGF) Axis in Early Diagnosis of Pancreatic Adenocarcinoma (PDAC).

Abstract:

:New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development. In contrast, it is proved that new-onset DM among patients over 50 years old significantly increases the risk of PDAC recognition. Insulin-like growth factor 1 (IGF-1) and their complex proteins, IGF binding proteins, which comprise the IGF axis play a crucial role in carbohydrate metabolism disorders and, studies have shown that they may contribute to PDAC growth. Some studies confirm that IGF-1 is connected with early carcinogenesis in animals and humans. Assessing the levels of these proteins may thus be helpful in early recognition of PDAC in patients with recently detected endocrine disorders, especially pancreatic DM.

journal_name

J Clin Gastroenterol

authors

Wlodarczyk B,Gasiorowska A,Malecka-Panas E

doi

10.1097/MCG.0000000000001073

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

569-572

issue

7

eissn

0192-0790

issn

1539-2031

journal_volume

52

pub_type

杂志文章,评审
  • New regulatory trends for probiotics.

    abstract::The aim of this paper (presented in Rome, Italy, at the 2nd Congress of Probiotics, Prebiotics, and New Food, September 7-9, 2003) was to provide an objective view of the regulatory trends at the European level specifically referring to probiotics, because until now they have never been directly mentioned nor official...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000128733.79515.c4

    authors: Prevot MB

    更新日期:2004-07-01 00:00:00

  • The risk of bleeding after percutaneous liver biopsy: relation to platelet count.

    abstract::We sought to define the risk of bleeding after percutaneous aspiration liver biopsy in patients with low platelet counts but otherwise normal clotting factors. Eighty-seven patients underwent liver biopsy using the Menghini 1-second technique with either a 1.6-mm or a 1.2-mm needle. Bleeding occurred in three out of 1...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198210000-00011

    authors: Sharma P,McDonald GB,Banaji M

    更新日期:1982-10-01 00:00:00

  • Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults.

    abstract::In our study, we evaluated whether the combination of two endoscopic abnormalities in the duodenum (the "mosaic" appearance and loss of duodenal folds) is significantly associated with duodenal villous atrophy secondary to celiac sprue in adults. Fourteen patients referred for esophagogastroduodenoscopy for suspected ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199410000-00018

    authors: Magazzu G,Bottari M,Tuccari G,Arco A,Pallio S,Lucanto C,Tortora A,Barresi G

    更新日期:1994-10-01 00:00:00

  • The gut barrier: new acquisitions and therapeutic approaches.

    abstract::The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows nutrient absorption and second, it defends the body from dangerous macromolecule penetration. It is a complex multilayer system, consisting of an external "anatomic" barrier and an inner "functional" immunological b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31826ae849

    authors: Scaldaferri F,Pizzoferrato M,Gerardi V,Lopetuso L,Gasbarrini A

    更新日期:2012-10-01 00:00:00

  • Change in antibiotic resistance of Helicobacter pylori strains and the effect of A2143G point mutation of 23S rRNA on the eradication of H. pylori in a single center of Korea.

    abstract:BACKGROUND:The current prevalence of primary antibiotic resistance of H. pylori is not known in Korea. This study was done to evaluate the prevalence of primary antibiotic resistance of H. pylori, and to evaluate the effect of point mutations of 23S rRNA on the rate of eradication of H. pylori. METHODS:H. pylori were ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181d04592

    authors: Hwang TJ,Kim N,Kim HB,Lee BH,Nam RH,Park JH,Lee MK,Park YS,Lee DH,Jung HC,Song IS

    更新日期:2010-09-01 00:00:00

  • Heterotopic liver of the jejunum. Report of a case and a review.

    abstract::A case of heterotopic liver of the jejunum confirmed by electron microscopy in a 2-year-old girl is described. We review the literature regarding heterotopic liver and discuss its embryogenesis. We suggest that in our case, there was trapping of hepatocyte-destined mesenchyme prior to biliary tree development. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-198908000-00024

    authors: Newland JR,Markin RS,Wilson RB,Jones JW

    更新日期:1989-08-01 00:00:00

  • The strictures, sinuses, and fissures of Crohn's disease.

    abstract::One hundred forty-six consecutive specimens of excised bowel from patients with Crohn's disease were studied to determine the relationships between strictures, sinuses, and "fissures." A significant coincidence of sinuses and strictures was observed and sinuses tended to arise proximal to the point of maximal strictur...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198610000-00024

    authors: Kelly JK,Siu TO

    更新日期:1986-10-01 00:00:00

  • Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors.

    abstract::Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms comprising only 1% to 2% of all pancreatic tumors. In recent years, the number of incidentally discovered PNETs has greatly increased given the widespread use of axial imaging. However, a significant proportion of PNETs may not be visualized on con...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000152

    authors: Rustagi T,Farrell JJ

    更新日期:2014-11-01 00:00:00

  • Lactic acidosis associated with cirrhosis, hepatoma, hemoperitoneum, and hyperphosphatemia.

    abstract::A patient with cirrhosis developed hemoperitoneum, lactic acidosis, and hyperphosphatemia in the absence of shock. At post-mortem examination occult multicentric hepatocellular carcinoma eroding the liver capsule was present. The case emphasizes the central role of the liver in lactic acidosis, indicates that hemoperi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198604000-00025

    authors: Berenson MM,Lee RG

    更新日期:1986-04-01 00:00:00

  • Hepatitis C virus RNA assays: a comparison of SuperQuant and Monitor.

    abstract::Hepatitis C RNA testing has been used extensively to assess the efficacy of antiviral therapy and has increasingly become an integral part of clinical management of patients with chronic hepatitis C. A variety of commercially available hepatitis C virus (HCV) RNA tests are used to detect HCV RNA qualitatively or quant...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200107000-00011

    authors: Hadziyannis E,Hadziyannis A,Yen-Lieberman B,Kiwi ML,Hodnick S,Spanou F,Starkey C,Younossi ZM

    更新日期:2001-07-01 00:00:00

  • High Rates of Mortality in Geriatric Patients Admitted for Inflammatory Bowel Disease Management.

    abstract:GOAL:The goal of this study was to evaluate the inpatient mortality risk among geriatric patients with inflammatory bowel disease (IBD). BACKGROUND:The challenges of caring for elderly patients with IBD will increase with the aging of the US population. Given the complications of hospitalization, we set to examine if ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001458

    authors: Schwartz J,Stein DJ,Lipcsey M,Li B,Feuerstein JD

    更新日期:2020-11-23 00:00:00

  • In-practice predictors of response to proton pump inhibitor therapy in primary care patients with dyspepsia in an Asian population.

    abstract:BACKGROUND:Data on Asian patients who present to primary care physicians with dyspepsia are limited. AIM:To determine predictors of response to a trial of proton pump inhibitor therapy. METHOD:One hundred ninety patients presenting to their general practitioners with dyspeptic symptoms but without alarm symptoms, und...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225620.02094.c3

    authors: Gwee KA,Hwang JE,Ho KY,Yeoh KG,Lum CF,Ang PK

    更新日期:2008-02-01 00:00:00

  • Enteral self-expandable metal stent for malignant luminal obstruction of the upper and lower gastrointestinal tract: a prospective multicentric study.

    abstract:BACKGROUND:Self-expanding metal stents (SEMSs) are used to treat malignant stenosis of the gastrointestinal (GI) tract, as a safe, feasible, and minimally invasive option for reestablishing luminal patency. However, the literature offers scant prospective data on the clinical outcome of these patients. AIM:To assess t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0b013e318033d30a

    authors: Masci E,Viale E,Mangiavillano B,Contin G,Lomazzi A,Buffoli F,Gatti M,Repaci G,Teruzzi V,Fasoli R,Ravelli P,Testoni PA

    更新日期:2008-04-01 00:00:00

  • Digital Chromoendoscopy With i-Scan for In Vivo Prediction of Advanced Colorectal Neoplasia: A Multicenter Study.

    abstract:BACKGROUND:Recent studies have analyzed the potential of advanced endoscopic imaging techniques for differentiating hyperplastic and adenomatous colorectal lesions. Latest endoscopic resection techniques now also allow for treatment of more advanced staged lesions including treatment of early cancerous lesions. AIMS:T...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000527

    authors: Albrecht H,Nägel A,Tasdelen H,Rath T,Grauer M,Vieth M,Neurath MF,Neumann H

    更新日期:2016-11-01 00:00:00

  • Steatocrit: a reliable semiquantitative method for detection of steatorrhea.

    abstract::Steatocrit is a semiquantitative method for determination of fat content in fecal samples. Previous studies, mostly performed in children, reported controversial results. The aim of our study was to compare the determination of fat content in 148 fecal samples by two methods: the conventional van de Kamer and the stea...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199410000-00007

    authors: Sugai E,Srur G,Vazquez H,Benito F,Mauriño E,Boerr LA,Bai JC

    更新日期:1994-10-01 00:00:00

  • Spontaneous umbilical fistula in Crohn's disease.

    abstract::Spontaneous umbilical fistula developed in two young women with Crohn's disease. This peculiar complication of Crohn's disease has been rarely reported. In view of the complete closure of the fistulas with medical treatment, we recommended conservative medical management, at least initially, in such patients. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-198904000-00016

    authors: Veloso FT,Cardoso V,Fraga J,Carvalho J,Dias LM

    更新日期:1989-04-01 00:00:00

  • Diverticular disease of the colon.

    abstract::Diverticular disease of the colon is quite common in developed countries, and its prevalence increases with age. Although present in perhaps two thirds of the elderly population, the large majority of patients will remain entirely asymptomatic. Nonetheless, an estimated 20% of those affected may manifest clinical illn...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199910000-00004

    authors: Stollman NH,Raskin JB

    更新日期:1999-10-01 00:00:00

  • Effect of paromomycin sulfate on endotoxemia in patients with cirrhosis.

    abstract::We evaluated, in a randomized double-blind trial, the efficacy of oral paromomycin sulfate administration in the prevention of endotoxemia in 24 cirrhotic patients with endotoxemia. Renal function was evaluated by glomerular-filtration rate and renal plasma flow at the beginning and at the end of the study period. Aft...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198206000-00013

    authors: Tarao K,Moroi T,Hirabayashi Y,Ikeuchi T,Endo O,Takamura Y

    更新日期:1982-06-01 00:00:00

  • Management of sporadic duodenal adenomas and the association with colorectal neoplasms: a retrospective cohort study.

    abstract:GOALS:To evaluate management, outcome, and follow-up of patients with sporadic duodenal adenomas and assess the presence of colorectal neoplasms. BACKGROUND:With the widespread use of esophagogastroduodenoscopy, an increasing number of sporadic duodenal adenomas are diagnosed. An optimal algorithm for management has n...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318238e72d

    authors: van Heumen BW,Mul K,Nagtegaal ID,van Kouwen MC,Nagengast FM

    更新日期:2012-05-01 00:00:00

  • No decrease in duodenal ulcer surgery after cimetidine in Hong Kong.

    abstract::We undertook a 12-year review of the elective and emergency surgery for duodenal ulcer in Queen Mary Hospital, Hong Kong, to ascertain whether the introduction of cimetidine as treatment for duodenal ulcer had led to a reduction in the number of elective and emergency operations being performed for duodenal ulcer. The...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198802000-00007

    authors: Alagaratnam TT,Wong J

    更新日期:1988-02-01 00:00:00

  • Hypereosinophilic syndrome resembling chronic inflammatory bowel disease with primary sclerosing cholangitis.

    abstract::A patient who presented with chronic inflammation of the colon, and initially also the terminal ileum, accompanied by marked diarrhea, is described. Repeated high-dose steroid therapy was only temporarily successful, and symptoms recurred upon dose reduction. During the further course of the disease, a marked elevatio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199201000-00015

    authors: Scheurlen M,Mörk H,Weber P

    更新日期:1992-01-01 00:00:00

  • Liver disease in hereditary hemorrhagic telangiectasia.

    abstract::Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, is an hereditary disorder that results in fibrovascular dysplasia with the development of telangiectasias and arteriovenous malformations. It predominantly involves the skin, mucous membranes, viscera, lungs, and brain. Hereditary he...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200302000-00013

    authors: Larson AM

    更新日期:2003-02-01 00:00:00

  • Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.

    abstract:BACKGROUND:Urinary tract infections (UTIs) are the most common bacterial infection in women. Most UTIs are acute uncomplicated cystitis caused by Escherichia coli (86%). This study was undertaken to assess the effectiveness of an association of a cranberry dry extract, D-mannose, a gelling complex composed of the exopo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0000000000000224

    authors: Vicariotto F

    更新日期:2014-11-01 00:00:00

  • Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis.

    abstract::We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver tran...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199504000-00011

    authors: Jorgensen RA,Lindor KD,Sartin JS,LaRusso NF,Wiesner RH

    更新日期:1995-04-01 00:00:00

  • Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis.

    abstract:GOALS:We performed a systematic review with meta-analysis to examine the efficacy and safety of oral fecal microbiota transplantation (FMT) capsules for recurrent Clostridioides difficile infection (rCDI). BACKGROUND:FMT through colonoscopy is established as effective and safe in treating multiple recurrences of CDI, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001495

    authors: Du C,Luo Y,Walsh S,Grinspan A

    更新日期:2021-01-19 00:00:00

  • Clinical applications of magnetic resonance cholangiopancreatography.

    abstract::Magnetic resonance cholangiopancreatography (MRCP) is a novel imaging technique used for noninvasive work-up of patients with pancreaticobiliary disease. Magnetic resonance cholangiopancreatography is useful in the evaluation of a host of pancreaticobiliary disorders, such as congenital disorders, calculus disease, bi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200111000-00004

    authors: Prasad SR,Sahani D,Saini S

    更新日期:2001-11-01 00:00:00

  • Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding.

    abstract::In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS). Rebleeding was more common in the placebo group so that at 5 days bleeding remained under control in 54% of patients treated with terlipressin compared with o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198902000-00014

    authors: Freeman JG,Cobden I,Record CO

    更新日期:1989-02-01 00:00:00

  • Polymerase chain reaction in gastroenterology.

    abstract::Polymerase chain reaction (PCR) has had a major impact on molecular biology and is beginning to change our perception of certain disease processes and diagnostic tests. PCR allows the identification and amplification of very rare nucleic acid sequences. This is resulting in our identification of previously elusive inf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199306000-00014

    authors: Hayashi PH,Zeldis JB

    更新日期:1993-06-01 00:00:00

  • Mucosal healing in inflammatory bowel disease.

    abstract::It is becoming increasingly recognized that purely clinical endpoints may not be sufficient in the treatment of patients with inflammatory bowel disease. As such, mucosal disease assessment has become a prominent component of the majority of recent clinical trials in Crohn's disease and ulcerative colitis. There is mo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3182732ff5

    authors: Osterman MT

    更新日期:2013-03-01 00:00:00

  • HCV hepatitis associated with anticardiolipin antibody and a cerebrovascular accident. Response to interferon therapy.

    abstract::A 54-year-old man with chronic hepatitis C virus (HCV) developed quadrihemianopsia caused by lacunar brain infarction. Extensive evaluation revealed high titers of anticardiolipin antibodies (ACA). Following interferon treatment (6 x 10(6), three times a week for 2 months and 3 x 10(6) for another 7 months), liver tra...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199701000-00009

    authors: Malnick SD,Abend Y,Evron E,Sthoeger ZM

    更新日期:1997-01-01 00:00:00