In-practice predictors of response to proton pump inhibitor therapy in primary care patients with dyspepsia in an Asian population.

Abstract:

BACKGROUND:Data on Asian patients who present to primary care physicians with dyspepsia are limited. AIM:To determine predictors of response to a trial of proton pump inhibitor therapy. METHOD:One hundred ninety patients presenting to their general practitioners with dyspeptic symptoms but without alarm symptoms, underwent endoscopy and were subsequently treated with 20 mg of esomeprazole twice a day for 2 weeks. Possible predictors of response were assessed before treatment. Dyspeptic symptoms were scored at baseline and at the end of treatment. Excellent response and poor response were defined as end of treatment score of or=50% reduction in symptom scores. RESULTS:On bivariate analysis male sex and having 2 dyspeptic symptoms, anxiety, and irritable bowel syndrome predicted poor response. On multivariate analysis, male sex and

journal_name

J Clin Gastroenterol

authors

Gwee KA,Hwang JE,Ho KY,Yeoh KG,Lum CF,Ang PK

doi

10.1097/01.mcg.0000225620.02094.c3

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

134-8

issue

2

eissn

0192-0790

issn

1539-2031

pii

00004836-200802000-00004

journal_volume

42

pub_type

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