Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue.

Abstract:

:Uncontrolled hemorrhage and multisystem organ failure developed in a patient with celiac sprue, lymphocytic gastritis, and diffuse gastric ulceration. A proximal small bowel biopsy showed villous atrophy and lymphoplasmacytic infiltration consistent with celiac sprue. At autopsy, there were no gross or histologic findings to suggest lymphoma. The intestinal lymphocytic infiltrate was not monoclonal, and gene rearrangements were not detected. Lymphocytic gastritis is a rare cause of upper gastrointestinal hemorrhage, which may be the result of sensitivity to gluten or other luminal antigens. This diagnosis should be considered in cases of diffuse gastric ulceration with bleeding in which the endoscopic appearances are not typical of peptic ulcer disease or drug-induced erosions. Ideally, biopsies of gastric and duodenal mucosa should be performed to establish the diagnosis.

journal_name

J Clin Gastroenterol

authors

Weiss AA,Yoshida EM,Poulin M,Gascoyne RD,Owen DA

doi

10.1097/00004836-199707000-00013

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

354-7

issue

1

eissn

0192-0790

issn

1539-2031

journal_volume

25

pub_type

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