Clarithromycin for the eradication of Helicobacter pylori.

Abstract:

:Helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. Antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. Clarithromycin has potential advantages over other macrolides to which H. pylori is susceptible because of its acid stability and solubility at low pH. We evaluated clarithromycin therapy (250 mg four times daily for 14 days) in 12 H. pylori-infected patients. The 13C-urea breath test was used to evaluate the effectiveness of therapy. Eradication was defined as a negative urea breath test 4-6 weeks after the end of treatment. Suppression of H. pylori was demonstrated in 11 of 12 patients (92%) by a negative urea breath test 2 days after start of treatment. H. pylori was eradicated in five (42%) of 12 patients. Adverse events were intermittent and mild. Clarithromycin is the first antimicrobial agent that appears to offer promise as monotherapy for the eradication of H. pylori.

journal_name

J Clin Gastroenterol

authors

Graham DY,Opekun AR,Klein PD

doi

10.1097/00004836-199306000-00004

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

292-4

issue

4

eissn

0192-0790

issn

1539-2031

journal_volume

16

pub_type

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