Genotypic variability of hepatitis viruses associated with chronic infection and the development of hepatocellular carcinoma.

Abstract:

:At least five hepatitis viruses are known to date. Infection by enterically transmitted viruses (HAV and HEV) is generally benign compared with the disease caused by parenterally transmitted viruses (HBV, HCV, and HDV). Chronic infection by HBV is common and may evolve to cirrhosis and hepatocellular carcinoma (HCC). Eight HBV genotypes (A-H) have been described, with the South American genotype F being the most divergent. Seven clades of HDV have been described; among them, the South American genotype III is associated to a high frequency of fulminant hepatitis. HCV infection leads to a high rate of chronicity and HCC. From the six HCV genotypes, infection with genotype 1 might have the worst prognostic. Chronic infection by HCV and HBV is the major risk factor for HCC, which occurs, in the majority of the cases, as a consequence of cirrhosis. However, there is growing evidence that some HBV and HCV proteins might contribute to the generation of HCC. Some HBV and HCV variants and specific mutations within the viral genomes might be more frequently associated with the evolution to HCC. Although more studies are needed, emerging evidence indicates that it might be important to address the genetic variability of these viruses and their contribution to the development of HCC.

journal_name

J Clin Gastroenterol

authors

Pujol FH,Devesa M

doi

10.1097/01.mcg.0000170770.49394.92

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

611-8

issue

7

eissn

0192-0790

issn

1539-2031

pii

00004836-200508000-00011

journal_volume

39

pub_type

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