Age-related changes in the microvessels of the human stomach: an ultrastructural study.

Abstract:

:The ultrastructure of microvessels in the gastric mucosa of patients with atrophic gastritis was investigated. In the gastric mucosa of atrophic gastritis, the endothelial cells of microvessels were irregularly swollen and subendothelial spaces were enlarged. The basement membrane underlying the endothelium was thickened. Degeneration of smooth-muscle cells was also evident in the media. These changes appear to correspond to sclerosis or aging of the microvessels. Such sclerotic changes in microvessels may initiate deterioration of the microenvironment in the gastric mucosa and may consequently affect metabolic activity of the gastric mucosal cells. Those sequences might induce degeneration or abnormal differentiation of mucosal cells. Such vascular changes may advance slowly and increase in intensity with advancing age. The final result would be the histologic changes associated with atrophic gastritis.

journal_name

J Clin Gastroenterol

authors

Taniguchi Y,Kimura K,Yoshida Y,Seki M,Kumakura Y,Satoh K,Kihira K,Ido K,Mato M

doi

10.1097/00004836-199312001-00017

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

S92-8

eissn

0192-0790

issn

1539-2031

journal_volume

17 Suppl 1

pub_type

杂志文章
  • A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis.

    abstract:BACKGROUND:Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis. GOALS:To identify low-risk patients who can be spared upper endoscopy irrespective of a diagnosis of cirrhosis. STUDY:We evaluated 13 nonendosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318157464b

    authors: Gentile I,Viola C,Graf M,Liuzzi R,Quarto M,Cerini R,Piazza M,Borgia G

    更新日期:2009-01-01 00:00:00

  • Are antibiotics useful in the management of nontoxic severe ulcerative colitis?

    abstract::Severely ill patients with ulcerative colitis are usually treated with parenteral corticoids. Those with signs of systemic toxicity usually receive antibiotics as well. However, the role of antibiotics in patients without high fever, profound leukocytosis, peritoneal signs or megacolon is not clear. Since 1985, seven ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199307000-00005

    authors: Peppercorn MA

    更新日期:1993-07-01 00:00:00

  • Factors associated with failure of metronidazole in Clostridium difficile-associated disease.

    abstract:GOAL:To identify patients likely to fail metronidazole as initial treatment of C. difficile infection. BACKGROUND:For moderate to severe Clostridium difficile-associated diarrhea, metronidazole is the drug of choice for treatment. Oral vancomycin is given to patients who fail metronidazole or have intolerable side eff...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200405000-00005

    authors: Fernandez A,Anand G,Friedenberg F

    更新日期:2004-05-01 00:00:00

  • Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

    abstract:BACKGROUND:The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients. GOALS:We aimed to determine the incidence of and risk factors for meningitis in IBD patients. STUDY:We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001365

    authors: Kochar B,Jiang Y,Long MD

    更新日期:2020-05-29 00:00:00

  • Oral manifestations of Crohn's disease. An analysis of 79 cases.

    abstract::We report four new cases of oral manifestation in Crohn's disease (CD) and evaluate 75 reported cases for morphology and site of oral and intestinal manifestations of CD, clinical manifestation, and treatment. Oral CD was the presenting symptom in 43 of 72 (60%) patients and relapsed in 34 of 60 (57%). Median age at p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199102000-00008

    authors: Plauth M,Jenss H,Meyle J

    更新日期:1991-02-01 00:00:00

  • Clinical and Fecal Microbial Changes With Diet Therapy in Active Inflammatory Bowel Disease.

    abstract:GOAL:To determine the effect of the specific carbohydrate diet (SCD) on active inflammatory bowel disease (IBD). BACKGROUND:IBD is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Diet is a potential therapeutic option for IBD based on the hypothesis that changing the fecal dysbio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000772

    authors: Suskind DL,Cohen SA,Brittnacher MJ,Wahbeh G,Lee D,Shaffer ML,Braly K,Hayden HS,Klein J,Gold B,Giefer M,Stallworth A,Miller SI

    更新日期:2018-02-01 00:00:00

  • Probiotics for children: use in diarrhea.

    abstract::The use of probiotics in diarrheal diseases of children is increasing. Probiotics, mostly lactic acid bacteria such as Lactobacilli and Bifidobacteria, but also the yeast Saccharomyces boulardii, have been tried in many double-blinded, randomized, placebo-controlled studies, and several well-conducted meta-analyses ar...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200603000-00016

    authors: Guandalini S

    更新日期:2006-03-01 00:00:00

  • Clinical Profile and Natural Course in a Large Cohort of Patients With Hypertriglyceridemia and Pancreatitis.

    abstract:GOALS:To report the clinical profile and natural course in a large series of patients with hypertriglyceridemia (HTG) and acute pancreatitis (AP). BACKGROUND:The natural history of HTG-related pancreatitis is poorly defined. STUDY:Medical records of 121 patients with serum triglycerides (TG) levels of ≥500 mg/dL suff...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000579

    authors: Vipperla K,Somerville C,Furlan A,Koutroumpakis E,Saul M,Chennat J,Rabinovitz M,Whitcomb DC,Slivka A,Papachristou GI,Yadav D

    更新日期:2017-01-01 00:00:00

  • Rates of Suboptimal Preparation for Colonoscopy Differ Markedly Between Providers: Impact on Adenoma Detection Rates.

    abstract:GOALS:We sought to determine if providers who have higher standards for optimal bowel preparation might be more fastidious in their examination of the colon and, therefore, have higher adenoma detection rates (ADRs). BACKGROUND:ADRs are a reliable and objective marker of colonoscopy performance. Suboptimal bowel prepa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000210

    authors: Mahadev S,Green PH,Lebwohl B

    更新日期:2015-10-01 00:00:00

  • Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition.

    abstract:GOALS:To describe the epidemiology and microbiologic characteristics of bloodstream infections (BSIs) in patients receiving long-term total parenteral nutrition (TPN). BACKGROUND:Home TPN therapy has been reported as a risk factor for BSI. However, little knowledge exists regarding the epidemiology of BSIs in this pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000212606.13348.f7

    authors: Marra AR,Opilla M,Edmond MB,Kirby DF

    更新日期:2007-01-01 00:00:00

  • Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis.

    abstract:BACKGROUND AND AIMS:The efficacy of 6-mercaptopurine (6-MP) in the treatment and long-term maintenance of remission of inflammatory bowel disease and prevention of recurrence after resection in Crohn's disease have been established. Concern about 6-MP toxicity remains, especially the development of neoplasm. The aim of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200309000-00006

    authors: Warman JI,Korelitz BI,Fleisher MR,Janardhanam R

    更新日期:2003-09-01 00:00:00

  • Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells.

    abstract:AIM:To define whether human colonic mucosa exposure to Lactobacillus rhamnosus GG (LGG), American Type Culture Collection (ATCC) 53103, may influence intestinal muscle cell contractility. METHODS:Human colon specimens were obtained from disease-free margins of resected segments for cancer. The mucosa and submucosa, af...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31817e1cac

    authors: Guarino MP,Altomare A,Stasi E,Marignani M,Severi C,Alloni R,Dicuonzo G,Morelli L,Coppola R,Cicala M

    更新日期:2008-09-01 00:00:00

  • Capsule Endoscopy Crohn's Disease Activity Index (CECDAIic or Niv Score) for the Small Bowel and Colon.

    abstract:BACKGROUND AND THE STUDY AIM:Crohn's disease (CD) is a chronic inflammatory disorder defined as a transmural inflammation of the bowel wall, affecting the small and large intestine. The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI or Niv score) was devised to measure mucosal disease activity. We extended th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000720

    authors: Niv Y,Gal E,Gabovitz V,Hershkovitz M,Lichtenstein L,Avni I

    更新日期:2018-01-01 00:00:00

  • The Use of Capsule Endoscopy For Diagnosis of Iron Deficiency Anemia: A Retrospective Analysis.

    abstract:BACKGROUND:There was some ambiguity in the recent guidelines on the use of capsule endoscopy (CE) in cases of iron deficiency anemia (IDA). GOAL:We aimed to examine the yield of CE in diagnosing the cause of IDA and to define clinical parameters that predict higher diagnostic yields. MATERIALS AND METHODS:A total of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001255

    authors: Stone J,Grover K,Bernstein CN

    更新日期:2020-05-01 00:00:00

  • GERD evaluation: time for a new paradigm?

    abstract::In the past there has been reliance on heartburn and acid regurgitation as the cardinal symptoms of gastro-esophageal reflux. Now it is recognized that diverse additional symptoms including extraesophageal manifestations are essential components of gastroesophageal reflux disease (GERD). Furthermore, previous reliance...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000225693.69745.49

    authors: Modlin IM,Malfertheiner P,Hunt RH,Armstrong D,Holtmann G,Quigley EM,Spechler SJ

    更新日期:2007-03-01 00:00:00

  • Immunoproliferative small intestinal disease in Mexico. Report of four cases and review of the literature.

    abstract::The clinicopathologic findings in eight Mexican patients with immunoproliferative small intestinal disease (IPSID) are analyzed. Four of these cases have been previously reported and the remainder were found in a retrospective review of 42 lymphoproliferative disorders of the small bowel (9.5% of the cases at our inst...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199401000-00016

    authors: Arista-Nasr J,González-Romo MA,Mantilla-Morales A,Lazos-Ochoa M,Ortiz-Hidalgo C

    更新日期:1994-01-01 00:00:00

  • Persistent Increased Enteric Glial Expression of S100β is Associated With Low-grade Inflammation in Patients With Diverticular Disease.

    abstract:BACKGROUND:Diverticular disease (DD) is a common gastrointestinal inflammatory disorder associated with an enteric neuropathy. Although enteric glial cells (EGCs) are essential regulators of intestinal inflammation and motility functions, their contribution to the pathophysiology of DD remains unclear. Therefore, we an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001011

    authors: Cossais F,Leuschner S,Barrenschee M,Lange C,Ebsen M,Vogel I,Böttner M,Wedel T

    更新日期:2019-07-01 00:00:00

  • Prevalence of hepatitis-B viral markers in patients with inflammatory bowel disease in a hepatitis-B-endemic area: inadequate protective antibody levels in young patients.

    abstract:BACKGROUND:There are few data regarding the prevalence of hepatitis-B virus (HBV) markers in inflammatory bowel disease (IBD) patients in Korea, which is a hepatitis-B-endemic area. The aim of this study was to assess the prevalence of HBV markers in IBD patients in comparison with controls. METHODS:We enrolled 513 IB...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.mcg.0000436435.75392.23

    authors: Kim ES,Cho KB,Park KS,Jang BI,Kim KO,Jeon SW,Kim EY,Yang CH,Kim WJ,Daegugyeongbuk Gastrointestinal Study Group (DGSG).

    更新日期:2014-07-01 00:00:00

  • Co-occurrence of hepatocellular carcinoma and lymphoma in patients with hepatitis C virus cirrhosis.

    abstract::The association of hepatitis C virus (HCV) with neoplasia is not completely understood. Hepatitis C virus is hepatolymphotrophic. It is considered an inducing factor of hepatocellular carcinoma (HCC) and is associated with various types of lymphomas. We describe a patient with HCV cirrhosis who developed gastric lymph...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200104000-00023

    authors: Shapira MY,Muszkat M,Braunstein I,Gotsman I

    更新日期:2001-04-01 00:00:00

  • Jejunal adenocarcinoma in congenital heterotopic gastric mucosa.

    abstract::We describe an adenocarcinoma of the jejunum that developed in congenital heterotopic gastric mucosa, a rare event. In our patient, the absence of other intestinal malformation and the presence of gastric glands with variable grades of dysplasia, together with the histological pattern of the tumor, strongly favor the ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198802000-00020

    authors: Caruso ML,Marzullo F

    更新日期:1988-02-01 00:00:00

  • Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy.

    abstract:BACKGROUND:Moderate sedation has been standard for noninvasive gastrointestinal procedures for decades yet there are limited data on reversal agent use and outcomes associated with need for reversal of sedation. AIM:To determine prevalence and clinical significance of reversal agent use during endoscopies and colonosc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000291

    authors: Hung A,Marshall J,Barnett S,Falchuk ZM,Sawhney M,Leffler DA

    更新日期:2016-03-01 00:00:00

  • Open access endoscopy: a large-scale analysis of its use in dyspeptic patients.

    abstract::We examined 2,253 consecutive dyspeptic patients referred to our endoscopy service by general practitioners ("open" group) and hospital clinicians ("clinic" group) to study the prevalence of the various endoscopic findings according to patient age and the route of endoscopic referral. The results obtained are represen...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Mansi C,Mela GS,Savarino V,Mele MR,Valle F,Celle G

    更新日期:1993-03-01 00:00:00

  • Evaluation of the Esophagogastric Junction on High Resolution Manometry.

    abstract::The esophagogastric junction (EGJ) is a complex barrier between the thoracic and abdominal luminal gut compartments, comprised primarily of the lower esophageal sphincter (LES) and crural diaphragm. Although closed at rest, the EGJ relaxes to allow antegrade bolus transit and retrograde venting of air. Abnormal relaxa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001474

    authors: Rogers BD,Gyawali CP

    更新日期:2021-02-01 00:00:00

  • Iatrogenic achalasia. A case series.

    abstract::Between 1984 and 1992, 14 cases of "secondary" achalasia were diagnosed at our institution, five due to malignancy and nine as a result of esophageal or paraesophageal surgery. Preoperative manometry had excluded preexistent achalasia in eight of nine of the latter patients. Dysphagia developed immediately postoperati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199503000-00004

    authors: Ellingson TL,Kozarek RA,Gelfand MD,Botoman AV,Patterson DJ

    更新日期:1995-03-01 00:00:00

  • Characterizing Abdominal Pain in Patients With Gastroparesis Into Neuropathic and Nociceptive Components.

    abstract:INTRODUCTION:The cause of abdominal pain (AP) in gastroparesis (Gp) is often not known; hence, its treatment can be challenging. Preoccupation with or increased attention (hypervigilance) to pain is associated with perceived pain severity and psychosocial disability. The aims of this study were to (1) characterize AP i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001059

    authors: Jehangir A,Abdallah RT,Parkman HP

    更新日期:2019-07-01 00:00:00

  • Polymerase chain reaction in gastroenterology.

    abstract::Polymerase chain reaction (PCR) has had a major impact on molecular biology and is beginning to change our perception of certain disease processes and diagnostic tests. PCR allows the identification and amplification of very rare nucleic acid sequences. This is resulting in our identification of previously elusive inf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199306000-00014

    authors: Hayashi PH,Zeldis JB

    更新日期:1993-06-01 00:00:00

  • Surveillance for hepatocellular carcinoma in a Medicaid cirrhotic population.

    abstract:GOALS:To estimate the hepatocellular carcinoma surveillance in the Medicaid cirrhotic population. BACKGROUND:Most studies predate 2005 American Association for the Study of Liver Diseases surveillance recommendations and do not examine the primary target population, cirrhotics. STUDY:From 2006 to 2007, we identified ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318286fd97

    authors: Palmer LB,Kappelman MD,Sandler RS,Hayashi PH

    更新日期:2013-09-01 00:00:00

  • Modified barium swallow does not affect how often PEGs are placed after stroke.

    abstract::Dysphagia frequently follows stroke, but often resolves quickly. Percutaneous endoscopic gastrostomy (PEG) or other feeding tubes are placed to improve nutrition and hydration, and reduce the risk of aspiration pneumonitis. We evaluated the impact of modified barium swallow in determining PEG placements and the influe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199703000-00005

    authors: Akpunonu BE,Mutgi AB,Roberts C,Khuder SA,Federman DJ,Lee L

    更新日期:1997-03-01 00:00:00

  • Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C.

    abstract:GOALS:The goal of this study was to examine the effect of a standardized silybin and soy phosphatidylcholine complex (IdB 1016) on serum markers of iron status. BACKGROUND:Milk thistle and its components are widely used as an alternative therapy for liver disease because of purported antioxidant, anti-inflammatory, an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0b013e31815cff36

    authors: Bares JM,Berger J,Nelson JE,Messner DJ,Schildt S,Standish LJ,Kowdley KV

    更新日期:2008-09-01 00:00:00

  • Randomized Controlled Trial: Split-dose and Same-day Large Volume Bowel Preparation for Afternoon Colonoscopy Have Similar Quality of Preparation.

    abstract:GOALS:We compare bowel cleanliness in patients taking same-day versus split-dose 4-L polyethylene glycol laxative for afternoon colonoscopy. Secondary objectives included patient satisfaction, adverse effects and patient tolerability. BACKGROUND:Afternoon colonoscopies have been associated with inadequate bowel prepar...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000001213

    authors: Castro FJ,Al-Khairi B,Singh H,Mohameden M,Tandon K,Lopez R

    更新日期:2019-11-01 00:00:00