Cyclic vomiting associated with excessive dopamine in Riley-day syndrome.

Abstract:

GOALS:To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome. BACKGROUND:One of the most disabling features of patients with Riley-day syndrome are recurrent attacks of severe nausea/retching/vomiting accompanied by hypertension, tachycardia, and skin flushing, usually triggered by emotional or other stresses. STUDY:We monitored blood pressure and heart rate and measured plasma catecholamines during typical dysautonomic crises triggered by emotionally charged situations. For comparison, measurements were repeated at follow-up after the symptoms had resolved and the patients were feeling calm and well. RESULTS:During a typical attack, patients were hypertensive and tachycardic. In all patients, circulating levels of norepinephrine (P < 0.002) and dopamine (P < 0.007) increased significantly. CONCLUSIONS:Activation of dopamine receptors in the chemoreceptor trigger zone may explain the cyclic nausea/retching/vomiting of patients with Riley-day syndrome.

journal_name

J Clin Gastroenterol

authors

Norcliffe-Kaufmann LJ,Axelrod FB,Kaufmann H

doi

10.1097/MCG.0b013e3182582cbf

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

136-8

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

47

pub_type

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