Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine.


:We examined the effects of lansoprazole and famotidine on gastric basic fibroblast growth factor (bFGF) levels and ulcer healing in patients with gastric ulcer. Sixteen patients with active gastric ulcer were divided into two groups and received treatment with lansoprazole 30 mg/day or famotidine 40 mg/day. They were examined endoscopically at 2, 4, and 8 weeks to measure gastric bFGF levels at the ulcer margin and to assess ulcer healing. Helicobacter pylori infection was determined by a rapid urease test. The two groups were comparable with regard to age, male:female ratio, H. pylori infection rates, and bFGF levels. During treatment, bFGF levels did not change significantly in the famotidine group, whereas they increased by a factor of 2.2 to 2.6 in the lansoprazole group. Cumulative healing rates were also significantly lower in the famotidine group than in the lansoprazole group. These results indicate that lansoprazole increases tissue bFGF levels and promotes gastric ulcer healing in humans.


J Clin Gastroenterol


Tsuji S,Kawano S,Higashi T,Mukuda T,Imaizumi T,Tatsumi T,Miura N,Miyajima K,Fukuda M,Noguchi M




Has Abstract,Author List Incomplete


1995-01-01 00:00:00








20 Suppl 2


  • Effects of radiation on the human gastrointestinal tract.

    abstract::Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particul...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Novak JM,Collins JT,Donowitz M,Farman J,Sheahan DG,Spiro HM

    更新日期:1979-03-01 00:00:00

  • Acute hepatotoxicity from ingestion of yellow phosphorus-containing fireworks.

    abstract::We reviewed 15 cases of poisoning from ingestion of yellow phosphorus-containing fireworks and analyzed its associated acute hepatotoxic effects. Two patients (13%) had no clinical or biochemical evidence of hepatic damage, four (27%) had subclinical hepatic injury, five (33%) manifested varying degrees of hepatocellu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Fernandez OU,Canizares LL

    更新日期:1995-09-01 00:00:00

  • Rapid progression of Barrett's esophagus to metastatic esophageal carcinoma in a patient with chronic lymphocytic leukemia.

    abstract::Barrett's esophagus is a common premalignant condition that predisposes to the development of adenocarcinoma of the esophagus through a process of transformation from metaplasia to dysplasia and then carcinoma. Periodic endoscopic surveillance with multiple biopsies is adopted by most physicians to detect dysplasia or...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Hsu CW,Krevsky B,Sigman LM,Thomas RM

    更新日期:1998-10-01 00:00:00

  • Iatrogenic achalasia. A case series.

    abstract::Between 1984 and 1992, 14 cases of "secondary" achalasia were diagnosed at our institution, five due to malignancy and nine as a result of esophageal or paraesophageal surgery. Preoperative manometry had excluded preexistent achalasia in eight of nine of the latter patients. Dysphagia developed immediately postoperati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Ellingson TL,Kozarek RA,Gelfand MD,Botoman AV,Patterson DJ

    更新日期:1995-03-01 00:00:00

  • Clarithromycin for the eradication of Helicobacter pylori.

    abstract::Helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. Antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. Clarithromycin has potential advantages over other macrolides to which H. pylori is susceptible because of its acid...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Graham DY,Opekun AR,Klein PD

    更新日期:1993-06-01 00:00:00

  • Glycosphingolipid composition of the gastric mucosa. A role of sulfatides in gastrointestinal mucosal defense?

    abstract::The glycosphingolipid (GSL) compositions of the human, rabbit, and rat gastric mucosa were studied and compared. In neutral GSLs, although GalCer was the most abundant component in every tissue examined, species-specific differences were clearly observed in their composition. Acidic GSLs were composed of sulfatides an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Natomi H,Sugano K,Takaku F,Iwamori M

    更新日期:1990-01-01 00:00:00

  • Barrett's esophagus complicating achalasia after esophagomyotomy. A clinical, radiologic, and pathologic study of 70 patients with achalasia and related motor disorders.

    abstract::Of 70 patients with achalasia and related motor disorders, 3 developed Barrett's esophagus 5, 8, and 15 years after esophagomyotomy. One of the three had dysplastic changes in the Barrett's mucosa. Although an increased incidence of gastroesophageal reflux, esophagitis, and stricture are well-known complications after...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Agha FP,Keren DF

    更新日期:1987-04-01 00:00:00

  • Esophageal tuberculosis presenting as intramural esophagogastric hematoma in a hemophiliac patient.

    abstract::A spontaneous intramural esophagogastric hematoma developed in a patient with hemophilia A. The hematoma did not resolve after antihemophiliac factor replacement but ruptured into the stomach causing massive gastrointestinal bleeding. The associated enlarged right tracheobronchial gland and the histopathological findi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Intragumtornchai T,Israsena S,Benjacholamard V,Lerdlum S,Benjavongkulchai S

    更新日期:1992-03-01 00:00:00

  • Simultaneous appearance of a unique common epitope in fetal colon, skin, and biliary epithelial cells. A possible link for extracolonic manifestations in ulcerative colitis.

    abstract::The tissue distribution of a previously identified M(r) 40 K epithelial autoantigen in ulcerative colitis was examined in situ in the fetal tissue by immunocytochemical method, using an immunoglobulin M (IgM) monoclonal antibody (7E12H12). Fetal-autopsy tissue from 9 to 19 weeks of development (11-21 gestational weeks...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Das KM,Squillante L,Chitayet D,Kalousek DK

    更新日期:1992-12-01 00:00:00

  • Effects of probiotics for the prevention and treatment of radiation-induced diarrhea.

    abstract:BACKGROUND AND AIMS:Probiotic supplementation seems to provide beneficial effects in the prevention and treatment of radiation-induced diarrhea. We performed a systematic review and meta-analysis to estimate the efficacy of probiotic supplementation for prevention and treatment of radiation-induced diarrhea. METHODS:T...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Fuccio L,Guido A,Eusebi LH,Laterza L,Grilli D,Cennamo V,Ceroni L,Barbieri E,Bazzoli F

    更新日期:2009-07-01 00:00:00

  • Characterizing Abdominal Pain in Patients With Gastroparesis Into Neuropathic and Nociceptive Components.

    abstract:INTRODUCTION:The cause of abdominal pain (AP) in gastroparesis (Gp) is often not known; hence, its treatment can be challenging. Preoccupation with or increased attention (hypervigilance) to pain is associated with perceived pain severity and psychosocial disability. The aims of this study were to (1) characterize AP i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Jehangir A,Abdallah RT,Parkman HP

    更新日期:2019-07-01 00:00:00

  • Role of infectious agents in exacerbations of ulcerative colitis in India. A study of Clostridium difficile.

    abstract::Fifty patients with idiopathic ulcerative colitis--25 with acute exacerbation of the disease (Group I) and 25 in quiescent phase (Group II)--were studied. None of the patients had a history of recent exposure to antimicrobial drugs or hospitalization. Evidence of infection with protozoal and bacterial agents and/or pr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kochhar R,Ayyagari A,Goenka MK,Dhali GK,Aggarwal R,Mehta SK

    更新日期:1993-01-01 00:00:00

  • The GASTER project: building a computer network in digestive endoscopy: the experience of the European Society for Gastrointestinal Endoscopy. Gastrointestinal Endoscopy Application for Standards in Telecommunication, Education and Research.

    abstract::Digestive endoscopy is currently the main diagnostic procedure for investigation of the digestive tract whenever a digestive disease is suspected. From 1970 to 1985, digestive endoscopy was performed with endoscopes equipped with fiberoptic bundles, whereas the last decade was marked by the development of electronic e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Delvaux MM,Crespi M,Armengol-Miro JR,Hagenmüller F,Teuffel W

    更新日期:1999-09-01 00:00:00

  • Enterovesical fistula due to non-Hodgkin lymphoma in AIDS.

    abstract::Enterovesical fistula associated with lymphoma is exceedingly rare. We report three patients with the acquired immunodeficiency syndrome who presented with fecaluria and pneumaturia. Non-Hodgkin lymphomas involving the intestine and the urinary bladder creating an enterovesical fistula were found at surgery in two pat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Genta RM,Ramchandani MK,Gyorkey F,Buzanis CT,Lahart CJ

    更新日期:1993-06-01 00:00:00

  • Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.

    abstract::Bleeding caused by ectopic varices is an uncommon but important and life-threatening complication of portal hypertension. Spontaneous external hemorrhage from a recanalized umbilical varix is an extremely rare source of ectopic variceal bleeding. We report on the acute presentation of a patient with a bleeding umbilic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Assis DN,Pollak J,Schilsky ML,Emre S

    更新日期:2012-02-01 00:00:00

  • Celiac Disease in Women With Infertility: A Meta-Analysis.

    abstract:BACKGROUND:Celiac disease (CeD) is a systemic disease with manifestations not limited to small intestine. The data on association between CeD and infertility is contradictory. There are no recommendations for the screening of female patients with infertility for CeD. AIM:We conducted a meta-analysis to find out whethe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Singh P,Arora S,Lal S,Strand TA,Makharia GK

    更新日期:2016-01-01 00:00:00

  • Role of Gut Microbiota in Liver Disease.

    abstract::Many lines of research have established a relationship between the gut microbiome and patients with liver disease. For example, patients with cirrhosis have increased bacteremia, increased blood levels of lipopolysaccharide, and increased intestinal permeability. Patients with cirrhosis have bacterial overgrowth in th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Brenner DA,Paik YH,Schnabl B

    更新日期:2015-11-01 00:00:00

  • Erythrocyte sedimentation as a measure of Crohn's disease activity: opposite trends in ileitis versus colitis.

    abstract::To test our hypothesis that the erythrocytic sedimentation rate (ESR) correlates well with clinical activity in inflammatory disease of the colon, but not of the small bowel, we stratified 49 Crohn's disease patients according to their anatomic involvement and then measured the correlations between ESR and clinical ac...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Sachar DB,Luppescu NE,Bodian C,Shlien RD,Fabry TL,Gumaste VV

    更新日期:1990-12-01 00:00:00

  • A long-term comparison of plication configurations for endoluminal gastroplication: circumferential versus helical.

    abstract:GOALS:To determine the long-term efficacy of endoluminal gastroplication (ELGP) and the most effective plication configuration. BACKGROUND:Endoluminal gastroplication is an intriguing therapy for gastroesophageal reflux disease. We conducted a retrospective review of a prospective experience of patient cohorts compari...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Davis RE,Iqbal A,Gerhardt JD,Welch RA,Turaga K,Tierney B,Haider M,Filipi CJ

    更新日期:2005-11-01 00:00:00

  • Excluding gastroesophageal reflux disease as the cause of chronic cough.

    abstract::Gastroesophageal reflux disease (GERD) is recognized to be present in 10-20% of cases of chronic cough. Proving that it is the cause of the cough is more difficult. This problem is illustrated by way of a case report demonstrating that GERD can still be the cause, even when the patient is unresponsive to conventional ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 社论,评审


    authors: Johnston BT,Gideon RM,Castell DO

    更新日期:1996-04-01 00:00:00

  • Impact of Knowledge and Risk Perceptions on Older Adults' Intention for Surveillance Colonoscopy.

    abstract:GOALS:The authors aimed to characterize older adults' intentions for future surveillance colonoscopy, knowledge of polyps, and predictors of colonoscopy plans. BACKGROUND:Guidelines recommend that the decision to continue or stop surveillance colonoscopy in older adults with colon polyps be "individualized." Although ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Calderwood AH,Carter C,Durand MA,O'Connor S,Boardman M

    更新日期:2020-07-29 00:00:00

  • Utility of hepatitis C virus RNA levels for predicting the therapeutic efficacy of interferon.

    abstract::We studied the levels of serum hepatitis C virus (HCV)-RNA, the HCV genotype before interferon therapy, and the kinetics of serum HCV-RNA at the initial stages of therapy to determine their utility in predicting the therapeutic efficacy of interferon in 44 patients with chronic hepatitis C infection. We also looked at...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Kato J,Komatsu M,Ono T,Ishii T,Hoshino T,Toyoshima I,Chiba M,Masamune O

    更新日期:1997-10-01 00:00:00

  • Screening colonoscopy use among individuals at higher colorectal cancer risk.

    abstract:GOALS:To describe screening colonoscopy use in those with a family history of colorectal cancer (CRC). BACKGROUND:Colonoscopy is an effective means of screening for CRC and is preferred for individuals at higher risk. We therefore derived population-based estimates of colonoscopy use and analyzed how individual charac...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Longacre AV,Cramer LD,Gross CP

    更新日期:2006-07-01 00:00:00

  • Older Patients With Hepatocellular Carcinoma Have More Advanced Disease, Lower Rates of Treatment, and Lower Survival.

    abstract:GOALS:To evaluate age-specific disparities in cancer stage at diagnosis, receipt of treatment, and survival among adults with hepatocellular carcinoma (HCC). BACKGROUND:HCC has become the fastest rising cause of cancer-related deaths in the United States. The aging population coupled with the rising incidence of HCC w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yan M,Ha J,Aguilar M,Liu B,Frenette CT,Bhuket T,Wong RJ

    更新日期:2017-04-01 00:00:00

  • Cognitive-behavioral intervention for irritable bowel syndrome.

    abstract::A 41-year-old white man with a 2-year history of irritable bowel syndrome (IBS) was referred for psychological treatment. At the time of assessment he was being treated with Metamucil and Darvocet N-100s with little success. A detailed psychosocial assessment indicated several areas for cognitive-behavioral interventi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Litt MD,Baker LH

    更新日期:1987-04-01 00:00:00

  • More Severe Deficits in Performance Status at Time of Liver Transplant is Associated With Significantly Higher Risk of Death Following Liver Transplantation.

    abstract:GOAL:To evaluate the impact of Karnofsky Performance Status score (KPSS) at the time of liver transplantation (LT) on post-LT survival. BACKGROUND:While the Model for End-Stage Liver Disease (MELD) score is used to prioritize individuals for LT, it does not specifically incorporate functional status into patient asses...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: McCabe P,Gish RG,Cheung R,Wong RJ

    更新日期:2019-10-01 00:00:00

  • Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

    abstract::A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reporte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: O'Reilly DJ,Craig RM,Lorenzo G,Yokoo H

    更新日期:1983-04-01 00:00:00

  • Helicobacter pylori infection rate decreases in symptomatic children: a retrospective analysis of 13 years (1993-2005) from a gastroenterology clinic in West Virginia.

    abstract:BACKGROUND:The rate of Helicobacter pylori is decreasing in the developed countries, but few long-term studies are available from the United States. We retrospectively assessed the annual H. pylori infection rate in symptomatic children seen in our clinic over a 13-year study period. STUDY:A retrospective analysis of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Elitsur Y,Dementieva Y,Rewalt M,Lawrence Z

    更新日期:2009-02-01 00:00:00

  • Pathophysiology and Therapeutic Options for Fecal Incontinence.

    abstract::Fecal incontinence (FI), defined as the involuntary loss of solid or liquid feces through the anus is a prevalent condition with significant effects on quality of life. FI can affect individuals of all ages and in many cases greatly impairs quality of life but, incontinent patients should not accept their debility as ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Guillaume A,Salem AE,Garcia P,Chander Roland B

    更新日期:2017-04-01 00:00:00

  • Chronic pancreatitis: pathogenesis and management of pain.

    abstract::Abdominal pain, excruciating and recurrent, is the dominant feature of chronic pancreatitis that initially brings most of the patients to the physician's attention. The pathogenesis of pancreatic pain is often multifactorial and explains why not all patients respond to the same mode of therapy. Increased intraductal p...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Pitchumoni CS

    更新日期:1998-09-01 00:00:00