Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine.

Abstract:

:We examined the effects of lansoprazole and famotidine on gastric basic fibroblast growth factor (bFGF) levels and ulcer healing in patients with gastric ulcer. Sixteen patients with active gastric ulcer were divided into two groups and received treatment with lansoprazole 30 mg/day or famotidine 40 mg/day. They were examined endoscopically at 2, 4, and 8 weeks to measure gastric bFGF levels at the ulcer margin and to assess ulcer healing. Helicobacter pylori infection was determined by a rapid urease test. The two groups were comparable with regard to age, male:female ratio, H. pylori infection rates, and bFGF levels. During treatment, bFGF levels did not change significantly in the famotidine group, whereas they increased by a factor of 2.2 to 2.6 in the lansoprazole group. Cumulative healing rates were also significantly lower in the famotidine group than in the lansoprazole group. These results indicate that lansoprazole increases tissue bFGF levels and promotes gastric ulcer healing in humans.

journal_name

J Clin Gastroenterol

authors

Tsuji S,Kawano S,Higashi T,Mukuda T,Imaizumi T,Tatsumi T,Miura N,Miyajima K,Fukuda M,Noguchi M

doi

10.1097/00004836-199506002-00002

subject

Has Abstract,Author List Incomplete

pub_date

1995-01-01 00:00:00

pages

S1-4

eissn

0192-0790

issn

1539-2031

journal_volume

20 Suppl 2

pub_type

临床试验,杂志文章,随机对照试验
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