Therapy of NAFLD: insulin sensitizing agents.

Abstract:

:Insulin resistance is an integral part of the underlying pathophysiology in most patients with nonalcoholic fatty liver disease (NAFLD). Insulin-sensitizing agents are therefore likely to be of key importance in the treatment of this disorder, especially in the histologically more severe form known as nonalcoholic steatohepatitis. Here we have reviewed the current literature on the two major insulin-sensitizing agents that have been studied in patients with NAFLD: the thiazolidinediones (or PPAR-gamma agonists) and metformin, the only available biguanide. Thiazolidinedione administration in human NAFLD has been shown to decrease hepatic fat by several different global measures and to decrease evidence of cellular injury, but it has also been associated with increased peripheral fat and weight gain. In contrast, metformin has been shown to improve biochemical markers without weight gain, but with more variable improvement in histology. Neither agent has been FDA approved for treating NAFLD, but existing studies have provided much hope for incorporating these medications into NAFLD management strategies in selected patients.

journal_name

J Clin Gastroenterol

authors

Caldwell SH,Argo CK,Al-Osaimi AM

doi

10.1097/01.mcg.0000168647.71411.48

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

S61-6

eissn

0192-0790

issn

1539-2031

pii

00004836-200603001-00011

journal_volume

40 Suppl 1

pub_type

杂志文章,评审
  • Nortriptyline-induced fulminant hepatic failure.

    abstract::We describe, to our knowledge, the first reported case of nortriptyline-induced fulminant hepatic failure. This tricyclic antidepressant drug was taken by a postmenopausal woman for 64 days before her presentation. The absence of fever, rash, or marked eosinophilia, the predominant zone 3 necrosis with bridging, and t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199501000-00014

    authors: Berkelhammer C,Kher N,Berry C,Largosa A

    更新日期:1995-01-01 00:00:00

  • Angiodysplasia of the upper gastrointestinal tract. Clinical spectrum in 41 cases.

    abstract::Over a 3-year period, arteriovenous malformations (angiodysplasia) were identified at upper gastrointestinal endoscopy in 41 patients. The lesions were multiple in one-third of patients and were predominantly situated in the proximal stomach. We considered angiodysplasia to be the cause of upper gastrointestinal bleed...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198608000-00004

    authors: Marwick T,Kerlin P

    更新日期:1986-08-01 00:00:00

  • Subclinical Ascites Does Not Affect the Long-term Prognosis in Hepatitis B Virus-related Cirrhosis Patients Receiving Antivirals.

    abstract:BACKGROUND AND AIMS:This study evaluated the clinical significance of subclinical ascites in patients with hepatitis B virus-related cirrhosis treated with lamivudine (LMV) or entecavir (ETV). METHODS:This multicenter retrospective study involved 8 hospitals. Patients were classified by degree of ascites: (1) no ascit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000529

    authors: Yim SY,Lee JH,Ahn H,Kim SU,Kim SG,Kim YS,Kim JH,Choe WH,Kim TY,Jung YK,Suh SJ,Suk KT,An H,Yim HJ,Seo YS,Um SH

    更新日期:2016-09-01 00:00:00

  • Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.

    abstract:BACKGROUND:Urinary tract infections (UTIs) are the most common bacterial infection in women. Most UTIs are acute uncomplicated cystitis caused by Escherichia coli (86%). This study was undertaken to assess the effectiveness of an association of a cranberry dry extract, D-mannose, a gelling complex composed of the exopo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCG.0000000000000224

    authors: Vicariotto F

    更新日期:2014-11-01 00:00:00

  • Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis.

    abstract:GOALS:We performed a systematic review with meta-analysis to examine the efficacy and safety of oral fecal microbiota transplantation (FMT) capsules for recurrent Clostridioides difficile infection (rCDI). BACKGROUND:FMT through colonoscopy is established as effective and safe in treating multiple recurrences of CDI, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001495

    authors: Du C,Luo Y,Walsh S,Grinspan A

    更新日期:2021-01-19 00:00:00

  • Higher Thioguanine Nucleotide Metabolite Levels are Associated With Better Long-term Outcomes in Patients With Inflammatory Bowel Diseases.

    abstract:GOALS:The aim of this study was to assess whether sustained 6-thioguaninenucleotide (6-TGN) levels were associated with improved long-term outcomes in patients with inflammatory bowel diseases (IBD). BACKGROUND:Cross-sectional data have shown that thiopurine metabolites are correlated with clinical efficacy in patient...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000889

    authors: Yarur AJ,Gondal B,Hirsch A,Christensen B,Cohen RD,Rubin DT

    更新日期:2018-07-01 00:00:00

  • Helicobacter pylori infection rate decreases in symptomatic children: a retrospective analysis of 13 years (1993-2005) from a gastroenterology clinic in West Virginia.

    abstract:BACKGROUND:The rate of Helicobacter pylori is decreasing in the developed countries, but few long-term studies are available from the United States. We retrospectively assessed the annual H. pylori infection rate in symptomatic children seen in our clinic over a 13-year study period. STUDY:A retrospective analysis of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318157e4e7

    authors: Elitsur Y,Dementieva Y,Rewalt M,Lawrence Z

    更新日期:2009-02-01 00:00:00

  • The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis.

    abstract:BACKGROUND:There has been constant speculation about the association between metabolic syndrome (MetS) and colorectal neoplasia (CN); however, the published results are conflicting. The aims of this study are to conduct a systematic search, and assess the literature to determine the available evidence on the associatio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0b013e3182688c15

    authors: Jinjuvadia R,Lohia P,Jinjuvadia C,Montoya S,Liangpunsakul S

    更新日期:2013-01-01 00:00:00

  • Time trends of US hospitalization for esophageal disease.

    abstract:BACKGROUND AND AIMS:The occurrence of reflux disease seems to be rising in the United States. The aim of the present study was to follow the time trends of hospitalization for gastroesophageal reflux disease (GERD) and other esophageal disease during the past 4 decades. METHODS:US hospital utilization data were availa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000023

    authors: Sonnenberg A

    更新日期:2014-09-01 00:00:00

  • Comparison of distribution of intraesophageal pH during nighttime recumbency among patients with gastroesophageal reflux disease.

    abstract:BACKGROUND:Nighttime reflux has been demonstrated to be associated with a more aggressive presentation of gastroesophageal reflux disease (GERD). However, it has remained unknown until now if the difference in nighttime reflux between the different GERD groups is related to the distribution of intraesophageal pH level ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318248f631

    authors: Hershcovici T,Jha LK,Fass R

    更新日期:2012-08-01 00:00:00

  • The gut barrier: new acquisitions and therapeutic approaches.

    abstract::The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows nutrient absorption and second, it defends the body from dangerous macromolecule penetration. It is a complex multilayer system, consisting of an external "anatomic" barrier and an inner "functional" immunological b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31826ae849

    authors: Scaldaferri F,Pizzoferrato M,Gerardi V,Lopetuso L,Gasbarrini A

    更新日期:2012-10-01 00:00:00

  • Clinical Implications of Histologic Abnormalities in Ileocolonic Biopsies of Patients With Crohn's Disease in Remission.

    abstract:BACKGROUND:For patients with Crohn's disease (CD) who have colonoscopy during periods of clinical remission, the utility of taking ileocolonic biopsy specimens to assess disease activity is disputed. GOALS:We explored the clinical implications of histologic disease activity in such patients. STUDY:We reviewed medical...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000507

    authors: Brennan GT,Melton SD,Spechler SJ,Feagins LA

    更新日期:2017-01-01 00:00:00

  • Dysphagia as a primary manifestation of hyperthyroidism.

    abstract::A 69-year old woman suffered from severe dysphagia, abdominal pain, and weight loss. The dysphagia was accompanied by nasal speech, nasal regurgitation of food, weakness, and wasting of the proximal muscles of the upper and lower girdles. Laboratory data revealed T3 sephadex uptake 65.2%; T4 15.1 mcg%; and T3 250 ng%....

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198410000-00009

    authors: Branski D,Levy J,Globus M,Aviad I,Keren A,Chowers I

    更新日期:1984-10-01 00:00:00

  • Clinical features of patients with negative results from traditional diagnostic work-up and Crohn's disease findings from capsule endoscopy.

    abstract:INTRODUCTION:Capsule endoscopy (CE) can detect Crohn's disease in patients with suggestive symptoms but with negative results from the traditional diagnostic work-up (ileocolonoscopy and small bowel follow-through). The objective of this study was to determine which clinical features predict the diagnosis of Crohn's di...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200609000-00006

    authors: Valle J,Alcántara M,Pérez-Grueso MJ,Navajas J,Muñoz-Rosas C,Legaz ML,Cuena R,Carrobles JM

    更新日期:2006-09-01 00:00:00

  • The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleeding.

    abstract:GOALS:The aim of this study was to determine the effect ofoctreotide on active or recent gastrointestinal bleeding from benign peptic ulcers. STUDY:This is a prospective, randomized study including 110 patients with gastric or duodenal peptic ulcers presenting with active spurting or oozing bleeding or nonbleeding vis...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200403000-00009

    authors: Nikolopoulou VN,Thomopoulos KC,Katsakoulis EC,Vasilopoulos AG,Margaritis VG,Vagianos CE

    更新日期:2004-03-01 00:00:00

  • Cytomegalovirus-associated perianal ulcerations in AIDS.

    abstract::We report two patients with the acquired immune deficiency syndrome and cytomegalovirus associated perianal ulcerations. Both complained of chronic, painful, nonhealing ulcers that required surgical intervention for diagnosis and palliation. One patient developed diffuse cytomegalovirus infection and both had poor res...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199203000-00006

    authors: Kamel PL

    更新日期:1992-03-01 00:00:00

  • Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. The objective of this study was to describe the recent trend of health care resource utilization and short-term mortality of Medicare beneficiaries with NAFLD. METHODS:This study utilized data from a ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000071

    authors: Younossi ZM,Zheng L,Stepanova M,Henry L,Venkatesan C,Mishra A

    更新日期:2015-03-01 00:00:00

  • Detailed history and examination assist positive clinical diagnosis of the irritable bowel syndrome.

    abstract::A detailed history and examination removes much of the vagueness from the symptoms of irritable bowel syndrome patients. The syndrome is much more homogeneous than suggested by the patient's complaints. Detailed questioning and examination contribute to further information in over two-thirds of patients. Examination r...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198312000-00005

    authors: Fielding JF

    更新日期:1983-12-01 00:00:00

  • Barrett esophagus in sexagenarian identical twins.

    abstract::Identical twins presented as sexagenarians with heartburn, regurgitation, and dysphagia; each had a Barrett esophagus remarkably similar to the other. This instance suggests a hereditary influence upon the development of mucosal dysplasia in some patients with this condition. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198306000-00011

    authors: Gelfand MD

    更新日期:1983-06-01 00:00:00

  • A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection.

    abstract:GOAL:To assess the number of chronic hepatitis C patients eligible for therapy. BACKGROUND:Recent studies have shown improved response rates to treatment of chronic hepatitis C infection. However, treatment with interferon alfa has major side effects, and many patients may not be eligible for therapy. STUDY:One hundr...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200203000-00015

    authors: Muir AJ,Provenzale D

    更新日期:2002-03-01 00:00:00

  • Fecal Impaction in the Emergency Department: An Analysis of Frequency and Associated Charges in 2011.

    abstract:GOALS:The aim of this study was to analyze the incidence and associated charges of fecal impaction for trends in hospital and patient demographics in emergency departments (ED) across the United States. BACKGROUND:In 2010, an ICD-9-CM code (560.32) for fecal impaction was introduced, allowing for assessment of fecal i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000458

    authors: Corban C,Sommers T,Sengupta N,Jones M,Cheng V,Friedlander E,Bollom A,Lembo A

    更新日期:2016-08-01 00:00:00

  • Psychosocial factors are the most common contraindications for antiviral therapy at initial evaluation in veterans with chronic hepatitis C.

    abstract:GOALS:To understand the degree to which psychosocial factors were preventing veterans with chronic hepatitis C virus from being eligible for antiviral treatment. BACKGROUND:Nearly 2% of the US population is infected with hepatitis C. Antiviral treatment requires substantial adherence despite challenging side effects. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000123203.36471.70

    authors: Rowan PJ,Tabasi S,Abdul-Latif M,Kunik ME,El-Serag HB

    更新日期:2004-07-01 00:00:00

  • Macrophage activation syndrome: why and what should a gastroenterologist know.

    abstract::We recently treated a patient with adult-onset Still's disease who developed macrophage activation syndrome (MAS) secondary to disseminated histoplasmosis while being treated with adalimumab. The gastroenterology service was consulted early, before diagnosis, as the patient presented with elevated liver enzymes and di...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181f6015f

    authors: Jayakar BA,Hashkes PJ

    更新日期:2011-03-01 00:00:00

  • Effects of sodium tetradecyl sulfate endoscopic variceal sclerotherapy on the esophagus. A prospective clinical and histopathologic study.

    abstract::A prospective clinical, endoscopic, and histopathologic study of the esophagus was carried out in 24 patients with advanced liver disease who underwent esophageal variceal sclerotherapy (EVS) and who eventually came to autopsy. Patients were arbitrarily divided into three groups: acute (group I), intermediate (group I...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198712000-00006

    authors: Kage M,Korula J,Harada A,Mucientes F,Kanel G,Peters RL

    更新日期:1987-12-01 00:00:00

  • Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats.

    abstract::This study was designed to clarify the role of leukotrienes (LTs) in gastric injury induced by ischemia-reperfusion in rats. Gastric lesions were produced by clamping of the celiac artery and by reoxygenation following clamping. Administration of AA-861, a lipoxygenase inhibitor, significantly inhibited the increase i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199206001-00012

    authors: Yoshikawa T,Ichikawa H,Naito Y,Kondo M

    更新日期:1992-01-01 00:00:00

  • Urease-based tests for Helicobacter pylori gastritis. Accurate for diagnosis but poor correlation with disease severity.

    abstract::To determine whether the urease-based CLOtest or low-dose 14C urea breath test can predict severity of gastritis or the presence of peptic ulcers, we studied 84 patients presenting for upper endoscopy. Antral biopsies were obtained for histologic analysis and CLOtesting, and urea breath testing was performed. The time...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199709000-00003

    authors: Lewis JD,Kroser J,Bevan J,Furth EE,Metz DC

    更新日期:1997-09-01 00:00:00

  • Can pancreatitis be associated with amiodarone hepatotoxicity?

    abstract::We report a patient with classical features of amiodarone hepatotoxicity who died of progressive liver failure. Throughout the course of his illness, he had epigastric pain, nausea, vomiting, and persistent mild to moderate elevation of amylase and lipase in his serum and peritoneal fluid. Pancreatitis due to amiodaro...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199002000-00018

    authors: Sastri SV,Diaz-Arias AA,Marshall JB

    更新日期:1990-02-01 00:00:00

  • Acute acalculous cholecystitis. A review.

    abstract::Acute acalculous cholecystitis is an uncommon but very serious illness, that, if undiagnosed, may lead to gallbladder perforation and death. The condition has numerous causes that result in bile stasis and ischemia leading to inflammation and infection in the gallbladder wall. The bedside diagnosis may be difficult, e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199210000-00014

    authors: Babb RR

    更新日期:1992-10-01 00:00:00

  • Iron deficiency anemia due to a Brunner's gland hamartoma.

    abstract::Brunner's gland hamartomas are rare benign duodenal tumors often discovered incidentally during endoscopy or on an upper gastrointestinal series. These tumors arise mainly in the duodenal bulb and can present with gastrointestinal bleeding or symptoms of intestinal obstruction. When symptomatic, surgical or endoscopic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199812000-00017

    authors: Zangara J,Kushner H,Drachenberg C,Daly B,Flowers J,Fantry G

    更新日期:1998-12-01 00:00:00

  • Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn's disease.

    abstract::Crohn's disease can be accompanied by extraintestinal manifestations. The authors report on a 39-year-old patient who presented with cheilitis granulomatosa as the first manifestation of Crohn's disease. Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from op...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200205000-00016

    authors: van de Scheur MR,van der Waal RI,van Bodegraven AA,Völker-Dieben HJ,Starink TM,van der Waal I

    更新日期:2002-05-01 00:00:00